Nitric oxide specifically reduces the permeability of Cx37-containing gap junctions to small molecules

Journal of Cellular Physiology

Volumn 203, Issue 1, 2005, Pages 233-242

  Kameritsch, Petra ^a   Khandoga, Natascha ^a   Nagel, Wolfram ^a   Hundhausen, Christina ^a   Lidington, Darcy ^a   Pohl, Ulrich ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 37; CONNEXIN 40; CONNEXIN 43; CYCLIC GMP; FLUORESCENT DYE; NITRIC OXIDE; SNARE PROTEIN;

ARTICLE; CELL COMMUNICATION; CONTROLLED STUDY; DRUG INHIBITION; GAP JUNCTION; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE;

CAPILLARY PERMEABILITY; CONNEXIN 43; CONNEXINS; CYCLIC GMP; ELECTRIC CONDUCTIVITY; ENDOTHELIUM, VASCULAR; FLUORESCENT DYES; GAP JUNCTIONS; HELA CELLS; HUMANS; MOLECULAR WEIGHT; NITRIC OXIDE; NITRIC OXIDE DONORS; PATCH-CLAMP TECHNIQUES; S-NITROSO-N-ACETYLPENICILLAMINE; TRANSFECTION; UMBILICAL VEINS;

ALEXA;

EID: 14744275510     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20218     Document Type: Article

References (51)

1. Ashton AW, Yokota R, John G, Zhao S, Suadicani SO, Spray DC, Ware JA. 1999. Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2). J Biol Chem 274:35562-35570.
2. Bennett MV, Verselis VK. 1992. Biophysics of gap junctions. Semin Cell Biol 3:29-47.
3. Bolanos JP, Medina JM. 1996. Induction of nitric oxide synthase inhibits gap junction permeability in cultured rat astrocytes. J Neurochem 66:2091-2099.
4. Cao F, Eckert R, Elfgang C, Nitsche JM, Snyder SA, Hulser DF, Willecke K, Nicholson BJ. 1998. A quantitative analysis of connexin-specific permeability differences of gap junctions expressed in HeLa transfectanfs and Xenopus oocytes. J Cell Sci 111(Pt 1):31-43.
5. Cottrell GT, Wu Y, Burt JM. 2002. Cx40 and Cx43 expression ratio influences heteromeric/heterotypic gap junction channel properties. Am J Physiol Cell Physiol 282:C1469-C1482.
6. de Wit C, Roos F, Bolz SS, Pohl U. 2003. Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion. Physiol Genomics 13:169-177.
7. Donaldson JG. 1998. Immunfluorescence staining. In: Morgan KS, editor. Current protocols in cell biology. New York: John Wiley & Sons, Inc. 4.3.1p.
8. Dora KA, Sandow SL, Gallagher NT, Takano H, Rummery NM, Hill CE, Garland CJ. 2003. Myoendothelial gap junctions may provide the pathway for EDHF in mouse mesenteric artery. J Vasc Res 40:480-490.
9. Elfgang C, Eckert R, Lichtenberg-Frate H, Butterweck A, Traub O, Klein RA, Hulser DF, Willecke K. 1995. Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J Cell Biol 129:805-817.
10. Frame MD, Sarelius IH. 1993. Regulation of capillary perfusion by small arterioles is spatially organized. Circ Res 73:155-163.
11. Haefliger JA, Nicod P, Meda P. 2004. Contribution of connexins to the function of the vascular wall. Cardiovasc Res 62:345-356.
12. Hill CE, Rummery N, Hickey H, Sandow SL. 2002. Heterogeneity in the distribution of vascular gap junctions and connexins: Implications for function. Clin Exp Pharmacol Physiol 29:620-625.
13. Hoffmann A, Gloe T, Pohl U, Zahler S. 2003. Nitric oxide enhances de novo formation of endothelial gap junctions. Cardiovasc Res 60:421-430.
14. Hu J, Cotgreave IA. 1997. Differential regulation of gap junctions by proinflammatory mediators in vitro. J Clin Invest 99:2312-2316.
15. Hutcheson IR, Chaytor AT, Evans WH, Griffith TM. 1999. Nitric oxide-independent relaxations to acetylcholine and A23187 involve different routes of heterocellular communication. Role of Gap junctions and phospholipase A2. Circ Res 84:53-63.
16. Jaffe EA, Nachman RL, Becker CG, Minick CR. 1973. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52:2745-2756.
17. Kameritsch P, Hoffmann A, Pohl U. 2003. Opposing effects of nitric oxide on different connexins expressed in the vascular system. Cell Commun Adhes 10:305-309.
18. Kwak BR, Pepper MS, Gros DB, Meda P. 2001. Inhibition of endothelial wound repair by dominant negative connexin inhibitors. Mol Biol Cell 12:831-845.
19. Kwak BR, Mulhaupt F, Veillard N, Gros DB, Mach F. 2002. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler Thromb Vasc Biol 22:225-230.
20. Lampe PD, Lau AF. 2000. Regulation of gap junctions by phosphorylation of connexins. Arch Biochem Biophys 384:205-215.
21. Larson DM, Kam EY, Sheridan JD. 1983. Junctional transfer in cultured vascular endothelium: I. Electrical coupling. J Membr Biol 74:103-113.
22. Liao Y, Day KH, Damon DN, Duling BR. 2001. Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice. Proc Natl Acad Sci 98:9989-9994.
23. Lidington D, Ouellette Y, Li F, Tyml K. 2003. Conducted vasoconstriction is reduced in a mouse model of sepsis. J Vasc Res 40:149-158.
24. Lin R, Warn-Cramer BJ, Kurata WE, Lau AF. 2001. v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication. J Cell Biol 154:815-827.
25. Little TL, Xia J, Duling BR. 1995. Dye tracers define differential endothelial and smooth muscle coupling patterns within the arteriolar wall. Circ Res 76:498-504.
26. Lu C, McMahon DG. 1997. Modulation of hybrid bass retinal gap junctional channel gating by nitric oxide. J Physiol 499(Pt 3):689-699.
27. Matchkov VV, Rahman A, Peng H, Nilsson H, Aalkjaer C. 2004. Junctional and nonjunctional effects of heptanol and glycyrrhetinic acid derivates in rat mesenteric small arteries. Br J Pharmacol (online).
28. Moreno AP, Saez JC, Fishman GI, Spray DC. 1994. Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation. Circ Res 74:1050-1057.
29. Pacicca C, Schaad O, Beny JL. 1996. Electrotonic propagation of kinin-induced, endothelium-dependent hyperpolarizations in pig coronary smooth muscles. J Vasc Res 33:380-385.
30. Pepper MS, Spray DC, Chanson M, Montesano R, Orci L, Meda P. 1989. Junctional communication is induced in migrating capillary endothelial cells. J Cell Biol 109:3027-3038.
31. Reed KE, Westphale EM, Larson DM, Wang HZ, Veenstra RD, Beyer EC. 1993. Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein. J Clin Invest 91:997-1004.
32. Roh CR, Heo JH, Yang SH, Bae DS. 2002. Regulation of connexin 43 by nitric oxide in primary uterine myocytes from term pregnant women. Am J Obstet Gynecol 187:434-440.
33. Rook MB, van Ginneken AC, de Jonge B, el Aoumari A, Gros D, Jongsma HJ. 1992. Differences in gap junction channels between cardiac myocytes, fibroblasts, and heterologous pairs. Am J Physiol 263:C959-C977.
34. Rummery NM, Hickey H, McGurk G, Hill CE. 2002. Connexin37 is the major connexin expressed in the media of caudal artery. Arterioscler Thromb Vasc Biol 22:1427-1432.
35. Sandow SL, Goto K, Rummery NM, Hill CE. 2004. Developmental changes in myoendothelial gap junction mediated vasodilator activity in the rat saphenous artery. J Physiol 556:875-886.
36. Segal SS. 1994. Cell-to-cell communication coordinates blood flow control. Hypertension 23:1113-1120.
37. Segal SS, Damon DN, Duling BR. 1989. Propagation of vasomotor responses coordinates arteriolar resistances. Am J Physiol 256:H832-H837.
38. Seki K, Komuro T. 2001. Immunocytochemical demonstration of the gap junction proteins connexin 43 and connexin 45 in the musculature of the rat small intestine. Cell Tissue Res 306:417-422.
39. Severs NJ, Rothery S, Dupont E, Coppen SR, Yeh HI, Ko YS, Matsushita T, Kaba R, Halliday D. 2001. Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular system. Microsc Res Tech 52:301-322.
40. Shibata Y, Kumai M, Nishii K, Nakamura K. 2001. Diversity and molecular anatomy of gap junctions. Med Electron Microsc 34:153-159.
41. Simon AM, McWhorter AR. 2002. Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40. Dev Biol 251:206-220.
42. Sohn HY, Krötz F, Zahler S, Gloe T, Keller M, Theisen K, Schiele TM, Klauss V, Pohl U. 2003. Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation. Cardiovasc Res 57:804-815.
43. Spray DC, White RL, de Carvalho AC, Harris AL, Bennett MV. 1984. Gating of gap junction channels. Biophys J 45:219-230.
44. Takens-Kwak BR, Jongsma HJ. 1992. Cardiac gap junctions: Three distinct single channel conductances and their modulation by phosphorylating treatments. Pflugers Arch 422:198-200.
45. Traub O, Hertlein B, Kasper M, Eckert R, Krisciukaitis A, Hulser DF, Willecke K. 1998. Characterization of the gap junction protein connexin37 in murine endothelium, respiratory epithelium, and after transfection in human HeLa cells. Eur J Cell Biol 77:313-322.
46. Tremblay J, Desjardins R, Hum D, Gutkowska J, Hamet P. 2002. Biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclases. Mol Cell Biochem 230:31-47.
47. van Rijen HV, van Kempen MJ, Analbers LJ, Rook MB, van Ginneken AC, Gros D, Jongsma HJ. 1997. Gap junctions in human umbilical cord endothelial cells contain multiple connexins. Am J Physiol 272:C117-C130.
48. Veenstra RD, Wang HZ, Beyer EC, Ramanan SV, Brink PR. 1994. Connexin37 forms high conductance gap junction channels with subconductance state activity and selective dye and ionic permeabilities. Biophys J 66:1915-1928.
49. Veenstra RD, Wang HZ, Beblo DA, Chilton MG, Harris AL, Beyer EC, Brink PR. 1995. Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ Res 77:1156-1165.
50. Warn-Cramer BJ, Lampe PD, Kurata WE, Kanemitsu MY, Loo LW, Eckhart W, Lau AF. 1996. Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem 271:3779-3786.
51. 2+ waves in lung capillary endothelium. Circ Res 79:898-908.