Safe cosmetics without animal testing? Contributions of the EU Project Sens-it-iv;Keine tierexperimente in der EU: Bleiben kosmetika sicher? Beiträge des EU-Projekts Sens-it-iv

Journal fur Verbraucherschutz und Lebensmittelsicherheit

Volumn 4, Issue 2 SUPPL, 2009, Pages

  Weltzien, Hans Ulrich ^a   Corsini, Emanuela ^b   Gibbs, Sue ^c   Lindstedt, Malin ^d   Borrebaeck, Carl ^d   Budde, Petra ^e   Schulz Knappe, Peter ^e   Thierse, Hermann Josef ^f   Martin, Stefan F ^g   Roggen, Erwin L ^h  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b UNIVERSITY OF MILAN   (Italy)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d LUND UNIVERSITY   (Sweden)

^e Proteome Sciences R and D GmbH and Co KG   (Germany)

^f University Medical Centre   (Germany)

^g UNIVERSITY OF FREIBURG   (Germany)

^h NOVOZYMES A S   (Denmark)

Author keywords

Allergy; Alternative; Animal; Contact; Cosmetic; In vitro; Sensitizer

Indexed keywords

EID: 78651301963     PISSN: 16615751     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00003-009-0510-5     Document Type: Article

References (15)

1. Corsini E, Mitjans M, Galbiati V, Lucchi L, Galli CL, Marinovich M (2009) Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens. Toxicol In Vitro 23: 769-796.
2. dos Santos GG, Reinders J, Ouwehand K, Rustemeyer T, Scheper RJ, Gibbs S (2009) Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol Appl Pharmacol 236: 372-382.
3. Geiger RT, Duhen T, Lanzavecchia A, Sallusto F (2009) Human naive and memory CD4?T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells. J Exp Med 206: 1525-1534.
4. Hartung T (2009) Toxicology for the twenty-first century. Nature 460: 208-212.
5. Karlberg AT, Bergström MA, Börje A, Luthman K, Nilsson JL (2008) Allergic contact dermatitis--formation, structural requirements, and reactivity of skin sensitizers. Chem Res Toxicol 21: 53-69.
6. Martin SF (2004) T lymphocyte-mediated immune responses to chemical haptens and metal ions: implications for allergic and autoimmune disease. Int Arch Allergy Immunol 134: 186-198.
7. Martinon F, Mayor A, Tschopp J (2009) The inflammasomes: guardians of the body. Annual Rev Immunol 27: 229-265.
8. Mitjans M, Viviani B, Lucchi L, Galli CL, Marinovich M, Corsini E (2008) Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in naive THp-1 cells. Toxicol In Vitro 22: 386-395.
9. Ouwehand K, Santegoets SJAM, Bruynzeel DP, Scheper RJ, de Gruijl TD, Gibbs S (2008) CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Eur J Immunol 38: 3050-3059.
10. Python F, Goebel C, Aeby P (2009) Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol Appl Pharmacol 239: 273-283.
11. Schrader M, Budde P, Rose H, Lamping N, Schulz-Knappe P, Zucht H-D (2006) Peptidomics technologies and applications in drug research. In: Hamacher M, Marcus K, Stühler K, van Hall A, Warscheid B, Meyer HE (eds) Proteomics in drug research. Wiley, Weinheim, pp 113-135.
12. Spiekstra SW, Spiekstra SW, dos Santos GG, Scheper RJ, Gibbs S (2009) Potential method to determine irritant potency in vitro--comparison of two reconstructed epidermal culture models with different barrier competency. Toxicol In Vitro 23: 349-355.
13. Toebak MJ, Gibbs S, Bruynzeel D, Scheper RJ, Rustemeyer T (2009) Dendritic cells: biology of the skin. Contact Derm 60: 2-20.
14. Van Och FM, Van Loveren H, Van Wolfswinkel JC, Machielsen AJ, Vandebriel RJ (2005) Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line. Toxicol Appl Pharmacol 210: 95-109.
15. Weltzien HU, Moulon C, Martin S, Padovan E, Hartmann U, Kohler J (1996) T cell immune responses to haptens. Structural models for allergic and autoimmune reactions. Toxicology 107: 141-151.