Clozapine and other competitive antagonists reactivate risperidone- inactivated h5-HT7 receptors: Radioligand binding and functional evidence for GPCR homodimer protomer interactions

Psychopharmacology

Volumn 212, Issue 4, 2010, Pages 687-697

  Teitler, Milt ^a   Toohey, Nicole ^a   Knight, Jessica A ^a   Klein, Michael T ^a   Smith, Carol ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

5 HT7; 9 OH risperidone; Clozapine; GPCR; Homodimer; Inactivation; Protomer protomer interactions; Reactivation; Risperidone; Serotonin; Serotonin receptor

Indexed keywords

2 [[2 (DIMETHYLAMINO)ETHYL]THIO] 3 PHENYLQUINOLINE; 3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; CLOZAPINE; CYCLIC AMP; CYPROHEPTADINE; G PROTEIN COUPLED RECEPTOR; HOMODIMER; ICI 69369; MESULERGINE; MIANSERIN; PALIPERIDONE; PROTEIN; PROTOMER; RADIOLIGAND; RISPERIDONE; SEROTONIN 7 RECEPTOR; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING;

BINDING, COMPETITIVE; BIOSENSING TECHNIQUES; CELL LINE; CLOZAPINE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOXAZOLES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; PYRIMIDINES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; RISPERIDONE; SEROTONIN ANTAGONISTS; TRANSFECTION;

EID: 78651281578     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-2001-x     Document Type: Article

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