Optimisation of cosolvent concentration for topical drug delivery - II: Influence of propylene glycol on ibuprofen permeation

Skin Pharmacology and Physiology

Volumn 22, Issue 4, 2009, Pages 225-230

  Watkinson, R M ^a   Guy, R H ^b   Hadgraft, J ^c   Lane, M E ^c  

^a Aesop   (Australia)

^b University of Bath   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Ibuprofen; Propylene glycol; Silicone; Skin; Vehicle composition

Indexed keywords

IBUPROFEN; PROPYLENE GLYCOL; SILICONE;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; HUMAN; PRIORITY JOURNAL;

ADMINISTRATION, CUTANEOUS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ETHANOL; HUMANS; IBUPROFEN; MEMBRANES, ARTIFICIAL; PERMEABILITY; PROPYLENE GLYCOL; SILICONES; SKIN ABSORPTION; SOLUBILITY; SOLVENTS; THERMODYNAMICS; WATER;

EID: 67749102207     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000231528     Document Type: Article

References (22)

1. Wurtz CA: Elements of Modern Chemistry, ed 3. Philadelphia, Lippincott, 1889, p 563.
2. Barrett CW, Hadgraft JW, Caron GA, Sarkany I: The effect of particle size on the percutaneous absorption of fluocinolone acetonide. Br J Dermatol 1965; 77: 576-578.
3. Poulsen BJ, Young E, Coquilla V, Katz: Effect of topical vehicle composition on the in vitro release of fluocinolone acetonide. J Pharmacol Sci 1968; 57: 928-933.
4. Davis SS, Hadgraft J, Al-Khamis K: Percutaneous absorption of methyl salicylate from polyethylene glycol vehicles. J Pharm Pharmacol 1981; 33(suppl):97.
5. Arellano A, Santoyo S, Martin C, Ygartua P: Influence of PG and isopropyl myristate on the in vitro percutaneous penetration of diclofenac sodium from carbopol gels. Eur J Pharm Sci 1999; 7: 129-135.
6. Nicolazzo JA, Morgan TM, Reed BL, Finnin BC: Synergistic enhancement of testosterone transdermal delivery. J Control Release 2000; 103: 577-585.
7. Aguiar AJ, Weiner MA: Percutaneous absorption studies of chloramphenicol solutions. J Pharm Sci 1969; 58: 210-215.
8. Ostrenga J, Steinmetz C, Poulsen B, Yett S: Significance of vehicle composition. II. Prediction of optimal vehicle composition. J Pharm Sci 1971; 60: 1180-1183.
9. Zatz JL, Dalvi UG: Evaluation of solventskin interaction in percutaneous absorption. J Soc Cosmet Chem 1983; 34: 327-334.
10. Hoelgaard A, Mollgaard B: Dermal drug delivery - improvement by choice of vehicle or drug derivative. J Control Release 1985; 2: 111-120.
11. Kasting GB, Francis WR, Roberts GE: Skin penetration enhancement of triprolidine base by propylene glycol. J Pharmacol Sci 1993; 82: 551-552.
12. Hadgraft J, Whitefield M, Rosher PH: Skin penetration of topical formulations of ibuprofen 5%: an in vitro comparative study. Skin Pharmacol Physiol 2003; 16: 137-142.
13. Schicksnus G, Müller-Goymann CC: Lateral diffusion of ibuprofen in human skin during permeation studies. Skin Pharmacol Physiol 2004; 17: 84-90.
14. Watkinson RM, Herkenne C, Guy RH, Hadgraft J, Oliveira G, Lane ME: Influence of ethanol on the solubility, ionisation and permeation characteristics of ibuprofen in silicone and human skin. Skin Pharmacol Physiol 2009; 22: 15-21.
15. Kligman AM, Christophers E: Preparation of isolated sheets of human stratum corneum. Arch Dermatol 1963; 88: 70-73.
16. Diez-Sales O, Watkinson AC, Herraez-Dominguez M, Javaloyes C, Hadgraft JA: Mechanistic investigation of the in vitro human skin permeation enhancing effect of Azone. Int J Pharm 1996; 129: 33-40.
17. Manrique YJ, Pacheco DP, Martinez F: Thermodynamics of mixing and solvation of ibuprofen and naproxen in propylene glycol + water cosolvent mixtures. J Solution Chem 2008; 37: 165-181.
18. Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH: Effect of PG on ibuprofen absorption into human skin in vivo. J Pharm Sci 2007; 97: 185-197.
19. Yalkowsky SH: Solubility and Solubilization in Aqueous Media. New York, American Chemical Society and Oxford University Press, 1999.
20. van der Merwe D, Riviere JE: Cluster analysis of the dermal permeability and stratum corneum/ solvent partitioning of ten chemicals in twenty-four chemical mixtures in porcine skin. Skin Pharmacol Physiol 2006; 19: 198-206.
21. Bommannan D, Potts RO, Guy RH: Examination of the effect of ethanol on human stratum corneum in vivo using infrared spectroscopy. J Control Release 1991; 16: 299-304.
22. Berner B, Juang RH, Mazzenga GC: Ethanol and water sorption into stratum corneum and model systems. J Pharm Sci 1989; 78: 472-476.