메뉴 건너뛰기




Volumn 26, Issue 6, 2010, Pages 1093-1102

Involvement of BMPs/smad signaling pathway in mechanical response in osteoblasts

Author keywords

Bone morphogenetic proteins; Mechanical strain; Osteoblasts; Smad; Smurf1

Indexed keywords

ALKALINE PHOSPHATASE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; MESSENGER RNA; NOGGIN; PROTEASOME; SMAD PROTEIN; SMAD1 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMALL INTERFERING RNA; SMURF1 PROTEIN; SMURF2 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 78651231027     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000323987     Document Type: Article
Times cited : (60)

References (50)
  • 1
    • 0033991383 scopus 로고    scopus 로고
    • Toward a unifying theory of bone remodeling
    • Martin RB: Toward a unifying theory of bone remodeling. Bone 2000;26:1-6.
    • (2000) Bone , vol.26 , pp. 1-6
    • Martin, R.B.1
  • 3
    • 77954527232 scopus 로고    scopus 로고
    • Bone morphoge-netic protein and growth differentiation factor cytokine families and their protein antagonists
    • Rider CC, Mulloy B: Bone morphoge-netic protein and growth differentiation factor cytokine families and their protein antagonists. Biochem J 2010;429:1-12.
    • (2010) Biochem J , vol.429 , pp. 1-12
    • Rider, C.C.1    Mulloy, B.2
  • 4
    • 75749094782 scopus 로고    scopus 로고
    • Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation
    • Mukherjee A, Wilson EM, Rotwein P: Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation. Mol Cell Biol 2010;30:1018-1027.
    • (2010) Mol Cell Biol , vol.30 , pp. 1018-1027
    • Mukherjee, A.1    Wilson, E.M.2    Rotwein, P.3
  • 5
    • 72149132820 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB
    • Yamazaki M, Fukushima H, Shin M, Katagiri T, Doi T, Takahashi T, Jimi E: Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB. J Biol Chem 2009;284:35987-35995.
    • (2009) J Biol Chem , vol.284 , pp. 35987-35995
    • Yamazaki, M.1    Fukushima, H.2    Shin, M.3    Katagiri, T.4    Doi, T.5    Takahashi, T.6    Jimi, E.7
  • 6
    • 78049421094 scopus 로고    scopus 로고
    • TGF-β signalling and tooth development
    • Huang XF, Chai Y: TGF-β signalling and tooth development. Clin J Dent Res 2010;13:7-15.
    • (2010) Clin J Dent Res , vol.13 , pp. 7-15
    • Huang, X.F.1    Chai, Y.2
  • 7
    • 0141527576 scopus 로고    scopus 로고
    • Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments
    • Tanno M, Furukawa KI, Ueyama K, Harata S, Motomura S: Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments. Bone 2003;33:475-484.
    • (2003) Bone , vol.33 , pp. 475-484
    • Tanno, M.1    Furukawa, K.I.2    Ueyama, K.3    Harata, S.4    Motomura, S.5
  • 8
    • 33646055172 scopus 로고    scopus 로고
    • Optimal compressive force induces bone formation via increasing bone morphogenetic proteins production and decreasing their antagonists production by Saos-2 cells
    • Mitsui N, Suzuki N, Maeno M, Yanagisawa M, Koyama Y, Otsuka K, Shimizu N: Optimal compressive force induces bone formation via increasing bone morphogenetic proteins production and decreasing their antagonists production by Saos-2 cells. Life Sci 2006;78:2697-2706.
    • (2006) Life Sci , vol.78 , pp. 2697-2706
    • Mitsui, N.1    Suzuki, N.2    Maeno, M.3    Yanagisawa, M.4    Koyama, Y.5    Otsuka, K.6    Shimizu, N.7
  • 9
    • 33646902229 scopus 로고    scopus 로고
    • Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear
    • Lau KH, Kapur S, Kesavan C, Baylink DJ: Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear. J Biol Chem 2006;81:9576-9588.
    • (2006) J Biol Chem , vol.81 , pp. 9576-9588
    • Lau, K.H.1    Kapur, S.2    Kesavan, C.3    Baylink, D.J.4
  • 10
    • 40249109986 scopus 로고    scopus 로고
    • Compressive forces induce osteogenic gene expression in calvarial osteoblasts
    • Rath B, Nam J, Knobloch TJ, Lannutti JJ, Agarwal S: Compressive forces induce osteogenic gene expression in calvarial osteoblasts. J Biomech 2008;41:1095-1103.
    • (2008) J Biomech , vol.41 , pp. 1095-1103
    • Rath, B.1    Nam, J.2    Knobloch, T.J.3    Lannutti, J.J.4    Agarwal, S.5
  • 11
    • 77954751082 scopus 로고    scopus 로고
    • Post-trans-lational protein modification as a tool for transcription reprogramming
    • Spoel SH, Tada Y, Loake GJ: Post-trans-lational protein modification as a tool for transcription reprogramming. New Phytol 2010;186:333-339.
    • (2010) New Phytol , vol.186 , pp. 333-339
    • Spoel, S.H.1    Tada, Y.2    Loake, G.J.3
  • 13
    • 1942534004 scopus 로고    scopus 로고
    • Regulation of the TGFbeta signaling pathway by ubiquitin-mediated degradation
    • Izzi L, Attisano L: Regulation of the TGFbeta signaling pathway by ubiquitin-mediated degradation. Oncogene 2004;23:2071-2078.
    • (2004) Oncogene , vol.23 , pp. 2071-2078
    • Izzi, L.1    Attisano, L.2
  • 14
    • 17044378584 scopus 로고    scopus 로고
    • Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling
    • Datto M, Wang XF: Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. Cell 2005;121:2-4.
    • (2005) Cell , vol.121 , pp. 2-4
    • Datto, M.1    Wang, X.F.2
  • 16
    • 1842477311 scopus 로고    scopus 로고
    • Smurf1 inhibits os-teoblast differentiation and bone formation in vitro and in vivo
    • Zhao M, Qiao M, Harris SE, Oyajobi BO, Mundy GR, Chen D: Smurf1 inhibits os-teoblast differentiation and bone formation in vitro and in vivo. J Biol Chem 2004;279:12854-12859.
    • (2004) J Biol Chem , vol.279 , pp. 12854-12859
    • Zhao, M.1    Qiao, M.2    Harris, S.E.3    Oyajobi, B.O.4    Mundy, G.R.5    Chen, D.6
  • 17
    • 17044414102 scopus 로고    scopus 로고
    • Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
    • Yamashita M, Ying SX, Zhang GM, Li C, Cheng S Y, Deng CX, Zhang YE: Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 2005;121:101-113.
    • (2005) Cell , vol.121 , pp. 101-113
    • Yamashita, M.1    Ying, S.X.2    Zhang, G.M.3    Li, C.4    Cheng, S.Y.5    Deng, C.X.6    Zhang, Y.E.7
  • 18
    • 0020678843 scopus 로고
    • In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria
    • Sudo H, Kodama HA, Amagai Y, Yamamoto S, Kasai S: In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 1983;96:191-198.
    • (1983) J Cell Biol , vol.96 , pp. 191-198
    • Sudo, H.1    Kodama, H.A.2    Amagai, Y.3    Yamamoto, S.4    Kasai, S.5
  • 19
    • 0026543172 scopus 로고
    • Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells
    • Franceschi RT, Iyer BS: Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J Bone Miner Res 1992;7:235-246.
    • (1992) J Bone Miner Res , vol.7 , pp. 235-246
    • Franceschi, R.T.1    Iyer, B.S.2
  • 20
    • 0346996700 scopus 로고    scopus 로고
    • The effect of step-wise increased stretching on rat calvarial osteoblast collagen production
    • Tang LL, Wang YL, Pan J, Cai SX: The effect of step-wise increased stretching on rat calvarial osteoblast collagen production. J Biomech 2004;37:157-161.
    • (2004) J Biomech , vol.37 , pp. 157-161
    • Tang, L.L.1    Wang, Y.L.2    Pan, J.3    Cai, S.X.4
  • 21
    • 39349083877 scopus 로고    scopus 로고
    • Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells
    • Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Yamamoto M, Sugimoto T: Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells. BMC Cell Biol 2007;8:51.
    • (2007) BMC Cell Biol , vol.8 , pp. 51
    • Kanazawa, I.1    Yamaguchi, T.2    Yano, S.3    Yamauchi, M.4    Yamamoto, M.5    Sugimoto, T.6
  • 22
    • 5644292078 scopus 로고    scopus 로고
    • Expression of brain and platelet serotonin transporters in sublines of rats with constitutionally altered serotonin homeostasis
    • Bordukalo-Niksic T, Cicin-Sain L, Jernej B: Expression of brain and platelet serotonin transporters in sublines of rats with constitutionally altered serotonin homeostasis. Neurosci Lett 2004;369:44-49.
    • (2004) Neurosci Lett , vol.369 , pp. 44-49
    • Bordukalo-Niksic, T.1    Cicin-Sain, L.2    Jernej, B.3
  • 24
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcrip-tional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffory V, Ridall AL, Karsenty G: Osf2/Cbfa1: a transcrip-tional activator of osteoblast differentiation. Cell 1997;89:747-754.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffory, V.3    Ridall, A.L.4    Karsenty, G.5
  • 25
    • 69249153489 scopus 로고    scopus 로고
    • Smad, PI3K/Akt, and Wnt-dependent signaling pathways are involved in BMP-4-induced ESC self-renewal
    • Lee MY, Lim HW, Lee SH, Han HJ: Smad, PI3K/Akt, and Wnt-dependent signaling pathways are involved in BMP-4-induced ESC self-renewal. Stem Cells 2009;8:1858-1868.
    • (2009) Stem Cells , vol.8 , pp. 1858-1868
    • Lee, M.Y.1    Lim, H.W.2    Lee, S.H.3    Han, H.J.4
  • 26
    • 4644360723 scopus 로고    scopus 로고
    • Coordinate regulation of neural tube patterning and proliferation by TGFbeta and WNT activity
    • Chesnutt C, Burrus LW, Brown AM, Niswander L: Coordinate regulation of neural tube patterning and proliferation by TGFbeta and WNT activity. Dev Biol 2004;2:334-347.
    • (2004) Dev Biol , vol.2 , pp. 334-347
    • Chesnutt, C.1    Burrus, L.W.2    Brown, A.M.3    Niswander, L.4
  • 27
    • 0021322767 scopus 로고
    • Regulation of bone formation by applied dynamic loads
    • Rubin CT, Lanyon LE: Regulation of bone formation by applied dynamic loads. J Bone Joint Surg Am 1984;66:397-402.
    • (1984) J Bone Joint Surg Am , vol.66 , pp. 397-402
    • Rubin, C.T.1    Lanyon, L.E.2
  • 28
    • 0021676239 scopus 로고
    • Static versus dynamic loads as an influence on bone remodelling
    • Lanyon LE, Rubin CT: Static versus dynamic loads as an influence on bone remodelling. J Biomech 1984;17:897-905.
    • (1984) J Biomech , vol.17 , pp. 897-905
    • Lanyon, L.E.1    Rubin, C.T.2
  • 29
    • 0024241605 scopus 로고
    • Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading
    • Pead MJ, Skerry TM, Lanyon JE: Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading. J Bone Miner Res 1988;3:647-656.
    • (1988) J Bone Miner Res , vol.3 , pp. 647-656
    • Pead, M.J.1    Skerry, T.M.2    Lanyon, J.E.3
  • 30
    • 0022626718 scopus 로고
    • Modulation of bone loss during calcium insufficiency by controlled dynamic loading
    • Lanyon LE, Rubin CT, Baust G: Modulation of bone loss during calcium insufficiency by controlled dynamic loading. Calcif Tissue Int 1986;38:209-216.
    • (1986) Calcif Tissue Int , vol.38 , pp. 209-216
    • Lanyon, L.E.1    Rubin, C.T.2    Baust, G.3
  • 31
    • 0027055120 scopus 로고
    • Control of bone architecture by functional load bearing
    • Lanyon LE: Control of bone architecture by functional load bearing. J Bone Miner Res 1992;2:S369-375.
    • (1992) J Bone Miner Res , vol.2
    • Lanyon, L.E.1
  • 32
    • 0031770558 scopus 로고    scopus 로고
    • Mechanotransduction and functional response of the skeleton to physical stress: The mechanisms and mechanics of bone adaptation
    • Turner CH, Pavalko FM: Mechanotransduction and functional response of the skeleton to physical stress: the mechanisms and mechanics of bone adaptation. J Orthop Sci 1998;3:346-355.
    • (1998) J Orthop Sci , vol.3 , pp. 346-355
    • Turner, C.H.1    Pavalko, F.M.2
  • 33
    • 77954825449 scopus 로고    scopus 로고
    • Biological underpinnings of Frost's mechanostat thresholds: The importance of osteocytes
    • Hughes JM, Petit MA: Biological underpinnings of Frost's mechanostat thresholds: the importance of osteocytes. J Musculoskelet Neuronal Inter act 2010;10:128-135.
    • (2010) J Musculoskelet Neuronal Inter Act , vol.10 , pp. 128-135
    • Hughes, J.M.1    Petit, M.A.2
  • 34
    • 50949132946 scopus 로고    scopus 로고
    • Cell-cell communication in the osteoblast/osteocyte lineage
    • Civitelli R: Cell-cell communication in the osteoblast/osteocyte lineage. Arch Biochem Biophys 2008;473:188-192.
    • (2008) Arch Biochem Biophys , vol.473 , pp. 188-192
    • Civitelli, R.1
  • 36
    • 21844442343 scopus 로고    scopus 로고
    • Mechanical strain opens connexin 43 hemichannels in osteocytes: A novel mechanism for the release of prostag-landin
    • Cherian PP, Siller-Jackson AJ, Gu S, Wang X, Bonewald LF, Sprague E, Jiang JX: Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostag-landin. Mol Biol Cell 2006;16:3100-3106.
    • (2006) Mol Biol Cell , vol.16 , pp. 3100-3106
    • Cherian, P.P.1    Siller-Jackson, A.J.2    Gu, S.3    Wang, X.4    Bonewald, L.F.5    Sprague, E.6    Jiang, J.X.7
  • 39
    • 42949147543 scopus 로고    scopus 로고
    • Mechanical strain induces osteogenic differentiation: Cbfa1 and Ets-1expression in stretched rat mesenchy-mal stem cells
    • Qi MC, Hu J, Zou SJ, Chen HQ, Zhou HX, Han LC: Mechanical strain induces osteogenic differentiation: Cbfa1 and Ets-1expression in stretched rat mesenchy-mal stem cells. Int J Oral Maxillofac Surg 2008;37:453-458.
    • (2008) Int J Oral Maxillofac Surg , vol.37 , pp. 453-458
    • Qi, M.C.1    Hu, J.2    Zou, S.J.3    Chen, H.Q.4    Zhou, H.X.5    Han, L.C.6
  • 40
    • 0033990270 scopus 로고    scopus 로고
    • Dynamic cell stretching increases human osteoblast proliferation and CICP synthesis but decreases osteocalcin synthesis and alkaline phos-phatase activity
    • Kaspar D, Seidl W, Neidlinger-Wilke C, Ignatius A, Claes L: Dynamic cell stretching increases human osteoblast proliferation and CICP synthesis but decreases osteocalcin synthesis and alkaline phos-phatase activity. J Biomech 2000;33:45-51.
    • (2000) J Biomech , vol.33 , pp. 45-51
    • Kaspar, D.1    Seidl, W.2    Neidlinger-Wilke, C.3    Ignatius, A.4    Claes, L.5
  • 41
    • 13444313194 scopus 로고    scopus 로고
    • The role of bone morphoge-netic proteins BMP-2 and BMP-4 and their related postreceptor signaling system (Smads) in distraction osteogenesis of the mandible
    • Farhadieh RD, Gianoutsos MP, Yu Y, Walsh WR: The role of bone morphoge-netic proteins BMP-2 and BMP-4 and their related postreceptor signaling system (Smads) in distraction osteogenesis of the mandible. J Craniofac Surg 2004;15:714-718.
    • (2004) J Craniofac Surg , vol.15 , pp. 714-718
    • Farhadieh, R.D.1    Gianoutsos, M.P.2    Yu, Y.3    Walsh, W.R.4
  • 43
    • 33645118984 scopus 로고    scopus 로고
    • Immuno-histochemical localization of bone mor-phogenetic protein-signaling Smads during long-bone distraction osteogenesis
    • Haque T, Mandu-Hrit M, Rauch F, Lauzier D, Tabrizian M, Hamdy RC: Immuno-histochemical localization of bone mor-phogenetic protein-signaling Smads during long-bone distraction osteogenesis. J Histochem Cytochem 2006;54:407-415.
    • (2006) J Histochem Cytochem , vol.54 , pp. 407-415
    • Haque, T.1    Mandu-Hrit, M.2    Rauch, F.3    Lauzier, D.4    Tabrizian, M.5    Hamdy, R.C.6
  • 44
  • 45
    • 18544384985 scopus 로고    scopus 로고
    • Regulation of bone morphogenetic protein-2 expression in endothelial cells: Role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure
    • Csiszar A, Smith KE, Koller A, Kaley G, Edwards JG, Ungvari Z: Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure. Circulation 2005;111:2364-2372.
    • (2005) Circulation , vol.111 , pp. 2364-2372
    • Csiszar, A.1    Smith, K.E.2    Koller, A.3    Kaley, G.4    Edwards, J.G.5    Ungvari, Z.6
  • 46
    • 0015403020 scopus 로고
    • Osteoinduction in undemineralized bone implants modified by chemical inhibitors of endogenous matrix enzymes. A preliminary report
    • Urist MR: Osteoinduction in undemineralized bone implants modified by chemical inhibitors of endogenous matrix enzymes. A preliminary report. Clin Orthop Relat Res 1972;87:132-137.
    • (1972) Clin Orthop Relat Res , vol.87 , pp. 132-137
    • Urist, M.R.1
  • 47
    • 0033549789 scopus 로고    scopus 로고
    • A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    • Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH: A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 1999;400:687-693.
    • (1999) Nature , vol.400 , pp. 687-693
    • Zhu, H.1    Kavsak, P.2    Abdollah, S.3    Wrana, J.L.4    Thomsen, G.H.5
  • 48
    • 0141866700 scopus 로고    scopus 로고
    • Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation
    • Ying SX, Hussain ZJ, Zhang YE: Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation. J Biol Chem 2003;278:39026-39036.
    • (2003) J Biol Chem , vol.278 , pp. 39026-39036
    • Ying, S.X.1    Hussain, Z.J.2    Zhang, Y.E.3
  • 50
    • 44349141125 scopus 로고    scopus 로고
    • Bone morphogenetic protein signalling is required for the anti-mi-togenic effect of the proteasome inhibitor MG-132 on colon cancer cells
    • Wu WK, Sung JJ, Wu YC, Li ZJ, Yu L, Cho CH: Bone morphogenetic protein signalling is required for the anti-mi-togenic effect of the proteasome inhibitor MG-132 on colon cancer cells. Br J Pharmacol 2008;154:632-638.
    • (2008) Br J Pharmacol , vol.154 , pp. 632-638
    • Wu, W.K.1    Sung, J.J.2    Wu, Y.C.3    Li, Z.J.4    Yu, L.5    Cho, C.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.