Impact of systemic immuno-suppression after solid organ transplantation on allergen-specific responses

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 66, Issue 2, 2011, Pages 271-278

  Eiwegger, T ^a,b   Gruber, S ^a   Geiger, C ^a   Mayer, E ^a   Dehlink, E ^a   Bannert, C ^a   Frischer, T ^a   Kasper, D ^a   Jaksch, P ^c   Klepetko, W ^c   Akdis, C ^b   Szepfalusi Z ^a  

^a UNIV KLIN KINDER JUGENDHEILKUNDE   (Austria)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

allergy; children; cyclosporin A; IgE; immunosuppression; rapamycin; regulatory T cells; tacrolimus; transplantation

Indexed keywords

AZATHIOPRINE; CD3 ANTIGEN; CD4 ANTIGEN; CORTICOSTEROID; CYCLOSPORIN A; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ADOLESCENT; ADULT; ARTICLE; CELL COMPARTMENTALIZATION; CELL RESPIRATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; LUNG LAVAGE; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SYSTEMIC THERAPY; TH1 CELL;

ADOLESCENT; ALLERGENS; CASE-CONTROL STUDIES; CELL PROLIFERATION; CHILD; CYTOKINES; HUMANS; HYPERSENSITIVITY; IMMUNOSUPPRESSION; ORGAN TRANSPLANTATION; RNA, MESSENGER; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; YOUNG ADULT;

EID: 78651098950     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2010.02475.x     Document Type: Article

References (26)

1. Akdis CA, Akdis M,. Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 2009; 123: 735-746. quiz 47-8.
2. Akdis M, Akdis CA,. Therapeutic manipulation of immune tolerance in allergic disease. Nat Rev Drug Discov 2009; 8: 645-660.
3. Dehlink E, Gruber S, Eiwegger T, Gruber D, Mueller T, Huber WD, et al. Immunosuppressive therapy does not prevent the occurrence of immunoglobulin E-mediated allergies in children and adolescents with organ transplants. Pediatrics 2006; 118: e764-e770.
4. Gruber S, Dehlink E, Eiwegger T, Gut S, Jaksch P, Klepetko W, et al. Immunoglobulin e-mediated allergies in lung-transplanted adults. Transplantation 2007; 84: 275-279.
5. Atkins FM,. Systemic FK506 and post transplant food allergy in children. J Pediatr Gastroenterol Nutr 2003; 37: 525-526.
6. Chehade M, Nowak-Wegrzyn A, Kaufman SS, Fishbein TM, Tschernia A, LeLeiko NS,. De novo food allergy after intestinal transplantation: a report of three cases. J Pediatr Gastroenterol Nutr 2004; 38: 545-547.
7. Lykavieris P, Frauger E, Habes D, Bernard O, Debray D,. Angioedema in pediatric liver transplant recipients under tacrolimus immunosuppression. Transplantation 2003; 75: 152-155.
8. Ozbek OY, Ozcay F, Avci Z, Haberal A, Haberal M,. Food allergy after liver transplantation in children: a prospective study. Pediatr Allergy Immunol 2009; 20: 741-747.
9. Lacaille F, Laurent J, Bousquet J,. Life-threatening food allergy in a child treated with FK506. J Pediatr Gastroenterol Nutr 1997; 25: 228-229.
10. Dumont FJ, Staruch MJ, Fischer P, DaSilva C, Camacho R,. Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production. J Immunol 1998; 160: 2579-2589.
11. Kawamura N, Furuta H, Tame A, Kobayashi I, Ariga T, Okano M, et al. Extremely high serum level of IgE during immunosuppressive therapy: paradoxical effect of cyclosporine A and tacrolimus. Int Arch Allergy Immunol 1997; 112: 422-424.
12. Levy Y, Davidovits M, Cleper R, Shapiro R,. New-onset post-transplantation food allergy in children-is it attributable only to the immunosuppressive protocol? Pediatr Transplant 2009; 13: 63-69.
13. Presser D, Sester U, Mohrbach J, Janssen M, Kohler H, Sester M,. Differential kinetics of effector and regulatory T cells in patients on calcineurin inhibitor-based drug regimens. Kidney Int 2009; 76: 557-566.
14. Zeiser R, Nguyen VH, Beilhack A, Buess M, Schulz S, Baker J, et al. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006; 108: 390-399.
15. Legendre C, Caillat-Zucman S, Samuel D, Morelon S, Bismuth H, Bach JF, et al. Transfer of symptomatic peanut allergy to the recipient of a combined liver-and-kidney transplant. N Engl J Med 1997; 337: 822-824.
16. Vagefi PA, Blazick E, Hamilos D, Ades A, Cosimi AB, Hertl M,. Transference of food allergy after adult liver transplantation. Transplantation 2009; 87: 1426.
17. Gabe SM, Bjarnason I, Tolou-Ghamari Z, Tredger JM, Johnson PG, Barclay GR, et al. The effect of tacrolimus (FK506) on intestinal barrier function and cellular energy production in humans. Gastroenterology 1998; 115: 67-74.
18. Frischmeyer-Guerrerio PA, Wisniewski J, Wood RA, Nowak-Wegrzyn A,. Manifestations and long-term outcome of food allergy in children after solid organ transplantation. J Allergy Clin Immunol 2008; 122: 1031-1033.
19. Nowak-Wegrzyn AH, Sicherer SH, Conover-Walker MK, Wood RA,. Food allergy after pediatric organ transplantation with tacrolimus immunosuppression. J Allergy Clin Immunol 2001; 108: 146-147.
20. Asher MI, Weiland SK,. The International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Steering Committee. Clin Exp Allergy 1998; 28 (Suppl 5): 52-66; discussion 90-1.
21. Eiwegger T, Rigby N, Mondoulet L, Bernard H, Krauth MT, Boehm A, et al. Gastro-duodenal digestion products of the major peanut allergen Ara h 1 retain an allergenic potential. Clin Exp Allergy 2006; 36: 1281-1288.
22. Eiwegger T, Stahl B, Schmitt J, Boehm G, Gerstmayr M, Pichler J, et al. Human milk-derived oligosaccharides and plant-derived oligosaccharides stimulate cytokine production of cord blood T-cells in vitro. Pediatr Res 2004; 56: 536-540.
23. Linhart B, Bigenzahn S, Hartl A, Lupinek C, Thalhamer J, Valenta R, et al. Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy. J Immunol 2007; 178: 3924-3931.
24. Wood KJ, Sakaguchi S,. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003; 3: 199-210.
25. Amarnath S, Flomerfelt FA, Costanzo CM, Foley JE, Mariotti J, Konecki DM, et al. Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD. Autophagy 2010; 6: 523-541.
26. Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM, et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008; 29: 565-577.