Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway

FEBS Journal

Volumn 278, Issue 2, 2011, Pages 354-370

  Lin, Yao ^a   Henderson, Paul ^a   Pettersson, Susanne ^a   Satsangi, Jack ^a   Hupp, Ted ^a   Stevens, Craig ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

DAPK; degradation; lysosome; mTORC1; TSC2

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE; DEATH ASSOCIATED PROTEIN KINASE 1; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; RHEB PROTEIN; SMALL INTERFERING RNA; TUBERIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME REGULATION; ENZYME STABILITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYSOSOME; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; STEADY STATE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CARRIER PROTEINS; CELL LINE; CELL LINE, TUMOR; CHLOROQUINE; FIBROBLASTS; GENE EXPRESSION; HEK293 CELLS; HUMANS; LEUPEPTINS; LYSOSOMES; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MONOMERIC GTP-BINDING PROTEINS; MUTATION, MISSENSE; NEUROPEPTIDES; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; RNA, SMALL INTERFERING; SEQUENCE DELETION; SIROLIMUS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA;

EID: 78651094160     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07959.x     Document Type: Article

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