The effect of glycaemic control and glycaemic variability on mortality in patients hospitalized with congestive heart failure

Diabetes/Metabolism Research and Reviews

Volumn 27, Issue 1, 2011, Pages 85-93

  Dungan, Kathleen M ^a   Binkley, Philip ^b   Nagaraja, Haikady N ^a   Schuster, Dara ^a   Osei, Kwame ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Glucose; Glycaemic variability; Heart failure; Hospital; Inpatient

Indexed keywords

GLUCOSE;

ADULT; AGED; ARTICLE; CONGESTIVE HEART FAILURE; DIABETES MELLITUS; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; GLYCEMIC INDEX; HUMAN; HYPOGLYCEMIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RESPIRATORY FAILURE;

AGED; BLOOD GLUCOSE; COMORBIDITY; DIABETES MELLITUS, TYPE 2; FEMALE; GLYCEMIC INDEX; HEART FAILURE; HOSPITALIZATION; HUMANS; MALE; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 78651090250     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1155     Document Type: Article

References (34)

1. Adams KF Jr, Fonarow GC, Emerman CL, et al.; ADHERE Scientific Advisory Committee and Investigators. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100, 000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J 2005; 149: 209-216.
2. Dries DL, Sweitzer NK, Drazner MH, Stevenson LW, Gersh BJ. Prognostic impact of diabetes mellitus in patients with heart failure according to the etiology of left ventricular systolic dysfunction. J Am Coll Cardiol 2001; 38: 421-480.
3. Gustafsson I, Brendorp B, Seibaek M, et al.; Danish Investigators of Arrhythmia and Mortality on Dofetilde Study Group. Influence of diabetes and diabetes-gender interaction on the risk of death in patients hospitalized with congestive heart failure. J Am Coll Cardiol 2004; 43: 771-777.
4. Gorelik O, Almoznino-Sarafian D, Alon I, et al. Heart failure in diabetes mellitus: clinical features and prognostic implications. Cardiology 2005; 103: 161-166.
5. Barsheshet A, Garty M, Grossman E, et al. Admission blood glucose level and mortality among hospitalized nondiabetic patients with heart failure. Arch Intern Med 2006; 166: 1613-1619.
6. Kosiborod M, Inzucchi SE, Spertus JA, et al. Elevated admission glucose and mortality in elderly patients hospitalized with heart failure. Circulation 2009; 119: 1800-1807.
7. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345: 1359-1367.
8. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2001; 354: 449-518.
9. Quagliaro L, Piconi L, Assaloni R, Martinelli L, Motz E, Ceriello A. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 2003; 52: 2795-2804.
10. Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 2006; 295: 1681-1687.
11. Desouza C, Salazar H, Cheong B, Murgo J, Fonseca V. Association of hypoglycemia and cardiac ischemia: a study based on continuous monitoring. Diabetes Care 2003; 26: 1485-1489.
12. Egi M, Bellomo R, Stachowski E, French CJ, Hart G. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology 2006; 105: 244-252.
13. Vogelzang M, van der Horst IC, Nijsten MW. Hyperglycaemic index as a tool to assess glucose control: a retrospective study. Crit Care 2004; 8: R122-R127.
14. Hermanides J, Vriesendorp TM, Bosman RJ. Glucose variability is associated with intensive care unit mortality. Crit Care Med 2010; 38: 838-842.
15. Krinsley JS. Glycemic variability: a strong independent predictor of mortality in critically ill patients. Crit Care Med 2008; 36: 3008-3013.
16. Meyfroidt G, Keenan DM, Wang X, Wouters PJ, Veldhuis JD, Van den Berghe G. Dynamic characteristics of blood glucose time series during the course of critical illness: effects of intensive insulin therapy and relative association with mortality. Crit Care Med 2010; 38: 1021-1029.
17. Dungan K, Chapman J, Braithwaite SS, Buse JB. Glucose measurement: confounding issues in setting targets for inpatient management. Diabetes Care 2007; 30: 403-409.
18. Finfer S, Chittock DR, Su SY, et al; NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360: 283-297.
19. Ryan EA, Shandro T, Green K, et al. Assessment of the severity of hypoglycemia and glycemic lability in type 1 diabetic subjects undergoing islet transplantation. Diabetes 2004; 53: 955-962.
20. Goldberg PA. Memoirs of a root canal salesman: the successful implementation of a hospital-wide intravenous insulin infusion protocol. Endocr Pract 2006; 12(Suppl. 3): 79-85.
21. Ali NA, O'Brien JM, Dungan K, et al. Glucose variability and mortality in patients with sepsis. Crit Care Med 2008; 36: 2316-2321.
22. Kudva YC, Basu A, Jenkins GD, et al. Glycemic variation and hypoglycemia in patients with well-controlled type 1 diabetes on a multiple daily insulin injection program with use of glargine and ultralente as basal insulin. Endocr Pract 2007; 13: 244-250.
23. Umpierrez GE, Palacio A, Smiley D. Sliding scale insulin use: myth or insanity? Am J Med 2007; 120: 563-567.
24. Kosiborod M, Inzucchi SE, Goyal A, et al. Relationship between spontaneous and iatrogenic hypoglycemia and mortality in patients hospitalized with acute myocardial infarction. JAMA 2009; 301: 1556-1564.
25. Krinsley JS. Glycemic variability and mortality in critically ill patients: the impact of diabetes. J Diabetes Sci Technol 2009; 3: 1292-1301.
26. Graham BB, Keniston A, Gajic O, Trillo Alvarez CA, Medvedev S, Douglas IS. Diabetes mellitus does not adversely affect outcomes from a critical illness. Crit Care Med 2010; 38: 16-24.
27. Robbins JM. Diagnosing diabetes and preventing rehospitalizations: the urban diabetes study. Med Care 2006; 44: 292-296.
28. Fonseca C, Sarmento PM, Marques F, Ceia F. Validity of a discharge diagnosis of heart failure: implications of misdiagnosing. Congest Heart Fail 2008; 14: 187-191.
29. Ishihara M, Kojima S, Sakamoto T; Japanese Acute Coronary Syndrome Study (JACSS) Investigators. Comparison of blood glucose values on admission for acute myocardial infarction in patients with versus without diabetes mellitus. Am J Cardiol 2009; 104: 769-774.
30. Kosiborod M, Inzucchi SE, Krumholz HM. Glucometrics in patients hospitalized with acute myocardial infarction: defining the optimal outcomes-based measure of risk. Circulation 2008; 117: 1018-1027.
31. Eshaghian S, Horwich TB, Fonarow GC. An unexpected inverse relationship between HbA1c levels and mortality in patients with diabetes and advanced systolic heart failure. Am Heart J 2006; 151: 91.e1-91.e6.
32. Gerstein HC, Swedberg K, Carlsson J, et al.; CHARM Program Investigators. The hemoglobin A1c level as a progressive risk factor for cardiovascular death, hospitalization for heart failure, or death in patients with chronic heart failure: an analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program. Arch Intern Med 2008; 168: 1699-1704.
33. Garber AJ, Moghissi ES, Bransome ED Jr, et al. The American College of Endocrinology Task Force on inpatient diabetes metabolic control: American College of Endocrinology position statement on inpatient diabetes and metabolic control. Endocr Pract 2004; 10(Suppl. 2): 4-9.
34. Preiser JC, Devos P, Ruiz-Santana S, et al. A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the glucontrol study. Intensive Care Med 2009; 35: 1738-1748.