Glycemic variability and mortality in critically Ill patients: The impact of diabetes

Journal of Diabetes Science and Technology

Volumn 3, Issue 6, 2009, Pages 1292-1301

  Krinsley, James Stephen ^a,b  

^a STAMFORD HOSPITAL   (United States)

^b Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

Diabetes; Glucose; Intensive care unit; Mortality; Variability

Indexed keywords

ANTIDIABETIC AGENT; INSULIN;

AGED; APACHE; ARTICLE; BLOOD; CHI SQUARE DISTRIBUTION; CRITICAL ILLNESS; DIABETES MELLITUS; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HOSPITALIZATION; HUMAN; HYPERGLYCEMIA; INTENSIVE CARE; METABOLISM; MIDDLE AGED; MORTALITY; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL; SURVIVAL;

AGED; APACHE; BLOOD GLUCOSE; CHI-SQUARE DISTRIBUTION; CRITICAL ILLNESS; DIABETES MELLITUS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INTENSIVE CARE; LOGISTIC MODELS; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS;

EID: 77950253961     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229680900300609     Document Type: Conference Paper

References (40)

1. Wass CT, Lanier WL. Glucose modulation of ischemic brain injury: review and clinical recommendations. Mayo Clin Proc. 1996;71(8):801-12.
2. Capes SE, Hunt D, Malmberg K, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001;32(10):2426-32. (Pubitemid 32954818)
3. Foo K, Cooper J, Deaner A, Knight C, Suliman A, Ranjadayalan K, Timmis AD. A single serum glucose measurement predicts adverse outcomes across the whole range of acute coronary syndromes. Heart. 2003;89(5):512-6. (Pubitemid 36520800)
4. Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000;355(9206):773-8. (Pubitemid 30128815)
5. Kosiborod M, Inzucchi SE, Krumholz HM, Xiao L, Jones PG, Fiske S, Masoudi FA, Marso SP, Spertus JA. Glucometrics in patients hospitalized with acute myocardial infarction: defining the optimal outcomes-based measure of risk. Circulation. 2008;117(8):1018-27.
6. Furnary AP, Wu Y. Eliminating the diabetic disadvantage: the Portland Diabetic Project. Semin Thorac Cardiovasc Surg. 2006;18(4):302-8. (Pubitemid 46464509)
7. Smith CE, Styn NR, Kalhan S, Pinchak AC, Gill IS, Kramer RP, Sidhu T. Intraoperative glucose control in diabetic and nondiabetic patients during cardiac surgery. J Cardiothorac Vasc Anesth. 2005;19(2):201-8. (Pubitemid 40544450)
8. Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc. 2003;78(12):1471-8. (Pubitemid 37475630)
9. Rady MY, Johnson DJ, Patel BM, Larson JS, Helmers RA. Influence of individual characteristics on outcome of glycemic control in intensive care unit patients with or without diabetes mellitus. Mayo Clin Proc. 2005;80(12):1558-67. (Pubitemid 41747057)
10. Krinsley JS. Glycemic control, diabetic status and mortality in a heterogeneous population of critically ill patients before and during the era of intensive glycemic management: six and one-half years experience at a university-affiliated community hospital. Semin Thorac Cardiovasc Surg. 2006;18(4):317-25. (Pubitemid 46464513)
11. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasslaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345(19):1359-67.
12. American College of Endocrinology position statement on inpatient diabetes and metabolic control. Endoc Prac. 2004;10:77-82.
13. Krinsley JS. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc. 2004;79(8):992-1000. (Pubitemid 39007018)
14. Scalea TM, Bochicchio GV, Bochicchio KM, Johnson SB, Joshi M, Pyle A. Tight glycemic control in critically injured trauma patients. Ann Surg. 2007;246(4):605-10. (Pubitemid 47480608)
15. Lazar HL, Chipkin SR, Fitzgerald CA, Bao Y, Cabral H, Apstein CS. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation. 2004;109(12):1497-502. (Pubitemid 38420177)
16. Reed CC, Stewart RM, Sherman M, Myers JG, Corneille MG, Larson N, Gerhardt S, Beadle R, Gamboa C, Dent D, Cohn SM, Pruitt BA Jr. Intensive insulin protocol improves glucose control and is associated with a reduction in intensive care unit mortality. J Am Coll Surg. 2007;204(5):1048-54. (Pubitemid 46661216)
17. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354(5):449-61. (Pubitemid 43200296)
18. Krinsley JS, Grover A. Severe hypoglycemia in critically ill patients: risk factors and outcomes. Crit Care Med. 2007;35(10):2262-7. (Pubitemid 47476221)
19. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K, German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Eng J Med. 2008;358(2):125-39.
20. Devos P, Preiser JC, Melot C. Impact of tight glycemic control by intensive insulin therapy on ICU mortality and the rate of hypoglycaemia: final results of the Glucontrol study. Intensive Care Med. 2007;33(Suppl 2):S189.
21. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, Hébert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283-97.
22. Van den Berghe G, Bouillon, R, Mesotten D. Glucose control in critically ill patients. N Engl J Med. 2009;361(1):89;letter.
23. Egi M, Bellomo R, Stachowski E, French CJ, Hart G. Variability of blood glucose concentration and short-term mortality of critically ill patients. Anesthesiology. 2006;105(2):244-52. (Pubitemid 44148168)
24. Ali NA, O'Brien JM Jr, Dungan K, Phillips G, Marsh CB, Lemeshow S, Connors AF Jr, Preiser JC. Glucose variability and mortality in patients with sepsis. Crit Care Med. 2008;36(8): 2316-21.
25. Dossett LA, Cao H, Mowery NT, Dortch MJ, Morris JM Jr, May AK. Blood glucose variability is associated with mortality in the surgical intensive care unit. Am Surg. 2008;74(8):679-85.
26. Krinsley JS. Glycemic variability: a strong, independent predictor of mortality in critically ill patients. Crit Care Med. 2008;36(11):3008-13.
27. Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002;87(3):978-82. (Pubitemid 36121050)
28. Conner TM, Flesner-Gurley KR, Barner JC. Hyperglycemia in the hospital setting: the case for improved control among nondiabetics. Ann Pharmacother. 2005;39(3):492-501. (Pubitemid 40270915)
29. Egi M, Bellomo R, Stachowski E, French CJ, Hart GK, Hegarty C, Bailey M. Blood glucose concentration and outcome of critical illness: the impact of diabetes. Crit Care Med. 2008;36(8):2249-55.
30. Ryan EA, Shandro T, Green K, Paty BW, Senior PA, Bigam D, Shapiro AM, Vantyghem MC. Assessment of the severity of hypoglycemia and glycemic lability in type 1 diabetic subjects undergoing islet transplantation. Diabetes. 2004;53(4):955-62. (Pubitemid 38436607)
31. Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP, Colette C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295(14):1681-7.
32. Risso A, Mercuri F, Quagliaro L, Damante G, Ceriello A. Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in culture. Am J Physiol Endocrinol Metab. 2001;281(5):E924-30.
33. Quagliaro L, Piconi L, Assaloni R, Martinelli L, Motz E, Ceriello A. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes. 2003;52(11):2795-804. (Pubitemid 37339710)
34. Hirsch IB. Glycemic variability: it's not just about A1C anymore! Diabetes Technol Ther. 2005;7(5):780-3. (Pubitemid 41572082)
35. Kanji S, Buffie J, Hutton B, Bunting PS, Singh A, McDonald K, Fergusson D, McIntyre LA, Hebert PC. Reliability of point-of-care testing for glucose measurement in critically ill adults. Crit Care Med. 2005;33(12):2778-85. (Pubitemid 41816412)
36. Critchell CD, Savarese V, Callahan A, Aboud C, Jabbour S, Marik P. Accuracy of bedside capillary blood glucose measurements in critically ill patients. Intensive Care Med. 2007;33(12):2079-84. (Pubitemid 350164561)
37. Desachy A, Vuagnat AC, Ghazali AD, Baudin OT, Longuet OH, Calvat SN, Gissot V. Accuracy of bedside glucometry in critically ill patients: influence of clinical characteristics and perfusion index. Mayo Clin Proc. 2008;83(4):400-5. (Pubitemid 351536465)
38. Service FJ, Molnar GD, Rosevear JW, Ackerman E, Gatewood LC, Taylor WF. Mean amplitude of glycemic excursions, a measure of diabetic instability. Diabetes. 1970;19(9):644-55.
39. De Block C, Manuel-Y-Keenoy B, Rogiers P, Jorens P, Van Gaal L. Glucose control and use of continuous glucose monitoring in the intensive care unit: a critical review. Curr Diabetes Rev. 2008;4(3):234-44.
40. Krinsley JS, Preiser JC. Moving beyond tight glycemic control to safe effective glucose control. Crit Care. 2008;12(3):149.