Exercise-induced lipid peroxidation: Implications for deoxyribonucleic acid damage and systemic free radical generation

Environmental and Molecular Mutagenesis

Volumn 52, Issue 1, 2011, Pages 35-42

  Fogarty, Mark C ^a   Hughes, Ciara M ^a   Burke, George ^a   Brown, John C ^a   Trinick, Tom R ^b   Duly, Ellie ^b   Bailey, Damian M ^c   Davison, Gareth W ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b ULSTER HOSPITAL   (United Kingdom)

^c UNIVERSITY OF GLAMORGAN   (United Kingdom)

Author keywords

Aerobic exercise; DNA damage; Free radicals; Lipid peroxidation

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE; CELL DNA; FREE RADICAL; GAMMA TOCOPHEROL; LIPID HYDROPEROXIDE; LYCOPENE; N TERT BUTYL ALPHA PHENYLNITRONE; RETINOL; XANTHOPHYLL;

ADULT; AEROBIC EXERCISE; ARTICLE; DNA DAMAGE; GENETIC ASSOCIATION; HUMAN; HUMAN EXPERIMENT; LIPID PEROXIDATION; MALE; PROTEIN CARBONYLATION;

ADULT; CYCLIC N-OXIDES; DNA DAMAGE; ELECTRON SPIN RESONANCE SPECTROSCOPY; EXERCISE; FREE RADICALS; HUMANS; LIPID PEROXIDATION; LIPID PEROXIDES; MALE; PROTEIN CARBONYLATION; YOUNG ADULT;

EID: 78651077240     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20572     Document Type: Article

References (48)

1. Adams AK, Best TM. 2002. The role of antioxidants in exercise and disease prevention. Phys Sports Med 30: 37-44.
2. Adamski A, Sojka TS. 2003. Application of EPR spectroscopy for elucidation of vanadium speciation in VOx/ZrO2 catalysts subject to redox treatment. Res Chem Intermediates 29: 793-804.
3. Alessio HM, Hagerman AE, Fulkerson BK, Ambrose J, Rice RE, Wiley RL. 2000. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Med Sci Sports Exer 32: 1576-1581.
4. Altman DG. 1980. Statistics and ethics in medical research. III. How large a sample? BJM 281: 1336-1338.
5. Ashton T, Rowlands CC, Jones E, Young IS, Jackson SK, Davies B, Peters JR. 1998. Electron spin resonance spectroscopic detection of oxygen-centred radicals in human serum following exhaustive exercise. Eur J Appl Physiol Occup Physiol 77: 498-502.
6. 2 flux. Adv Exp Med Biol 540: 297-303.
7. Basu AK, Marnett LJ. 1983. Unequivocal demonstration that malondialdehyde is a mutagen. Carcinogenesis 4: 331-333.
8. Bloomer RJ, Goldfarb AH, Wideman L, McKenzie MJ, Consitt LA. 2005. Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress. J Strength Cond Res 19: 276-285.
9. Collins AR, Oscoz AA, Brunborg G, Gaivao I, Giovannelli L, Kruszewski M, Smith CC, Stetina R. 2008. The comet assay: Topical issues. Mutagen 23: 143-151.
10. Cooke MS, Evans MD, Dizdaroglu M, Lunec J. 2003. Oxidative DNA damage: Mechanisms, mutation, and disease. FASEB 17: 1195-1214.
11. Davison GW, George L, Jackson SK, Young IS, Davies B, Bailey DM, Petert JR, Ashton T. 2002. Exercise, free radicals, and lipid peroxidation in type 1 diabetes mellitus. Free Radic Biol Med 33: 1543-1551.
12. Davison GW, Hughes CM, Bell RA. 2005. Exercise and mononuclear cell DNA damage: The effects of antioxidant supplementation. Int J Sport Nutr Exerc Metab 15: 480-492.
13. Davison GW, Morgan RM, Hiscock N, Garcia JM, Grace F, Boisseau N, Davies B, Castell L, McEneny J, Young IS, Hullin D, Ashton T, Bailey DM. 2006. Manipulation of systemic oxygen flux by acute exercise and normobaric hypoxia: Implications for reactive oxygen species generation. Clin Sci 110: 133-141.
14. Davison GW, Ashton T, Davies B, Bailey DM. 2008. In vitro electron paramagnetic resonance characterisation of free radical: Relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis. Free Radic Res 42: 1-8.
15. Dill DB, Costill DL. 1974. Calculation of the percentage changes in volumes of blood, plasma and red cells in dehydration. J Appl Physiol 1: 247-248.
16. Gandhi, G, Chopra G. 2009. DNA damage in peripheral blood leukocytes of physically active individuals as measured by the alkaline single cell gel electrophoresis assay. Environ Mol Mutagen 50: 291-303.
17. Hartmann A, Plappert U, Raddatz K, Grunert-Fuchs M, Speit G. 1994. Does physical activity induce DNA damage? Mutagen 9: 269-272.
18. Jackson MJ. 1998. Free radical mechanisms in exercise-related muscle damage. In: Reznick AZ, Sen C, Holloszy JO, Jackson MJ, editors. Oxidative Stress in Skeletal Muscle. Boston: Basal. pp 75-87.
19. Jackson MJ. 1999. An overview of methods for assessment of free radical activity in biology. Proc Nutr Soc 58: 1001-1006.
20. Jenkins R. 1993. Exercise, oxidative stress, and antioxidants: A review. Int J Sport Nutr 3: 356-375.
21. Ji LL. 1996. Exercise, oxidative stress, and antioxidants. Am J Sports Med 24: 20-24.
22. Levine RL. 2002. Carbonyl modified proteins in cellular regulation, aging, and disease. Free Radic Biol Med 32: 790-796.
23. Loft S, Astrup A, Buemann B, Poulsen HE. 1994. Oxidative DNA damage correlates with oxygen consumption in humans. FASEB 8: 534-537.
24. Long WIII, Wells K, Englert V, Schmidt S, Hickey MS, Melby CL. 2008. Does prior acute exercise affect postexercise substrate oxidation in response to a high carbohydrate meal. Nutr Metab 5: 2
25. Lovlin R, Cottle W, Pyke I, Kavanagh M, Belcastro AN. 1987. Are indicies of free radical damage related to exercise intensity. Eur J Appl Physiol 56: 313-316.
26. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
27. Marnett LJ. 1999. Lipid peroxidation-DNA damage by malondialdehyde. Mutat Res 424: 83-95.
28. Marnett LJ. 2002. Oxy radicals, lipid peroxidation and DNA damage. Toxicology 181: 219-222.
29. Mastaloudis A, Yu TW, O'Donnell RP, Frei B, Dashwood RH, Traber MG. 2004. Endurance exercise results in DNA damage as detected by the comet assay. Free Radic Biol Med 36: 966-975.
30. Niess AM, Baumann M, Roecker K, Horstmann T, Mayer F, Dickhuth HH. 1998. Effects of intensive endurance exercise on DNA damage in leucocytes. J Sports Med Phys Fitness 38: 111-115.
31. Orhan H,. 2007. Analyses of representative biomarkers of exposure and effect by chromatographic, mass spectrometric, and nuclear magnetic resonance techniques: Method development and application in life sciences. J Sep Sci 30: 149-174.
32. Pedersen BK, Rohde T, Zacho M. 1996. Immunity in athletes. J Sports Med Phys Fitness 36: 236-245.
33. Poulsen HE, Loft S, Vistisen K. 1996. Extreme exercise and oxidative DNA modification. J Sports Sci 14: 343-346.
34. Quindry JC, Stone WL, King J, Broeder CE. 2003. The effects of acute exercise on neutrophils and plasma oxidative stress. Med Sci Sports Exerc 35: 1139-1145.
35. Radak Z, Asano K, Lee KC, Ohno H, Nakamura A, Nakamoto H, Goto S. 1997. High altitude training increases reactive carbonyl derivatives but not lipid peroxidation in skeletal muscle of rats. Free Radic Biol Med 22: 1109-1114.
36. Radak Z, Pucsuk J, Boros S, Josfai L, Taylor AW. 2000. Changes in urine 8-hydroxydeoxyguanosine levels of super-marathon runners during a four-day race period. Life Sci 66: 1763-1767.
37. Radak Z, Apor P, Pucsok J, Berkes I, Ogonovszky H, Pavlik G, Nakamoto H, Goto S. 2003. Marathon running alters the DNA base excision repair in human skeletal muscle. Life Sci 72: 1627-1633.
38. Rasheed MH, Beevi SS, Geetha A. 2007. Enhanced lipid peroxidation and nitric oxide products with deranged antioxidant status in patients with head and neck squamous cell carcinoma. Oral Oncol 43: 333-338.
39. Sachdev S, Davies KJ. 2008. Production, detection, and adaptive responses to free radicals in exercise. Free Radic Biol Med 44: 215-223.
40. Sen CK. 2001. Antioxidants in exercise nutrition. Sports Med 31: 891-908.
41. Singh NP, McCoy MT, Tice RR, Schneider EL. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175: 184-191.
42. Smith JA, Gray AB, Pyne DB, Baker MS, Telford RD, Weidemann MJ. 1996. Moderate exercise triggers both priming and activation of neutrophil subpopulations. Am J Physiol 270: 838-845.
43. Sumida S, Doi T, Sakurai M, Yoshioka Y, Okamura K. 1997. Effect of a single bout of exercise and beta-carotene supplementation on the urinary excretion of 8-hydroxy-deoxyguanosine in humans. Free Radic Res 27: 607-618.
44. Thurnham DI, Smith E, Flora PS. 1988. Concurrent liquid-chromatographic assay of retinol, alpha-tocopherol, beta-carotene, alpha-carotene, lycopene, and beta-cryptoxanthin in plasma, with tocopherol acetate as internal standard. Clin Chem 34: 377-381.
45. Tsai K, Hsu TG, Hsu KM, Cheng H, Liu TY, Hsu CF, Kong CW. 2001. Oxidative DNA damage in human peripheral leukocytes induced by massive aerobic exercise. Free Radic Biol Med 31: 1465-1472.
46. Vollaard NB, Shearman JP, Cooper CE. 2005. Exercise-induced oxidative stress: myths, realities and physiological relevance. Sports Med 35: 1045-1062.
47. Wagner JR, Hu CC, Ames BN. 1992. Endogenous oxidative damage of deoxycytidine in DNA. Proc Natl Acad Sci USA 89: 3380-3384.
48. Wolff SP. 1994. Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hypoperoxides. Methods Enzymol 233: 183-189.