Effect of a single bout of exercise and β-carotene supplementation on the urinary excretion of 8-hydroxy-deoxyguanosine in humans

Free Radical Research

Volumn 27, Issue 6, 1997, Pages 607-618

  Sumida, Satoshi ^a   Doi, Tatsuya ^b   Sakurai, Masao ^b   Yoshioka, Yasuyuki ^b   Okamura, Koji ^b  

^a OSAKA GAKUIN UNIVERSITY   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

8 hydroxy deoxyguanosine; DNA damage; Exercise; Urine; carotene

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BETA CAROTENE; HYPOXANTHINE; LACTIC ACID; PYRUVIC ACID; XANTHINE;

ADULT; ARTICLE; BICYCLE ERGOMETRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA DAMAGE; DOUBLE BLIND PROCEDURE; EXERCISE; HUMAN; HUMAN EXPERIMENT; LACTATE BLOOD LEVEL; MALE; NORMAL HUMAN; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; URINARY EXCRETION;

EID: 0031446604     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.3109/10715769709097864     Document Type: Article

References (39)

1. Kasai, H. and Nishimura, S. (1984). Hydroxylation of deoxyguanosine at C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Research, 12, 2137-2145.
2. Loft, S., Vistisen, K., Ewertz, M., Tjønneland, A., Overvad, K. and Poulsen, H. E. (1992). Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis, 13, 2241-2247.
3. Adelman, R., Saul, R. L. and Ames, B. N. (1988). Oxidative damage to DNA: Relation to species metabolic rate and life span. Proceedings of the National Academy of Sciences of the United States of America, 85, 2706-2708.
4. Shigenaga, M. K., Gimeno, C. J. and Ames, B. N. (1989). Urinary 8-hydroxy- 2′-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proceedings of the National Academy of Sciences of the United States of America, 86, 9697-9701.
5. Tajiri, T., Maki, H. and Sekiguchi, M. (1995). Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli. Mutation Research, 336, 257-267.
6. Hayakawa, H., Taketomi, A., Sakumi, K., Kuwano, M. and Sekiguchi, M. (1995). Generation and elimination of 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate, a mutagenic substrate for DNA synthesis, in human cells. Biochemistry, 34, 89-95.
7. Chance, B., Sies, H. and Boveris, A. (1979). Hydroperoxide metabolism in mammalian organs. Physiological Reviews, 59, 527-605.
8. Loft, S., Astrup, A., Buemann, B. and Poulsen, H. E. (1994). Oxidative DNA damage correlates with oxygen consumption in humans. The FASEB Journal, 8, 534-537.
9. Davies, K. J. A., Quintanilha, A. T., Brooks, G. A. and Packer, L. (1982). Free radicals and tissue damage produced by exercise. Biochemical and Biophysical Research Communications, 107, 1198-1205.
10. Lovlin, R., Cottl, W., Pike, I., Kavanaugh, M. and Belcastro, A. N. (1987). Are indices of free radical damage related to exercise intensity? European Journal of Applied Physiology and Occupational Physiology, 56, 313-316.
11. Pincemail, J., Camus, G., Roesgen, A., Dreezen, E., Bertrand, Y., Lismonde, M., Deby-Dupont, G. and Deby, C. (1990). Exercise induces pentane production and neutrophil activation in humans: effect of propranol. European Journal of Applied Physiology and Occupational Physiology, 61, 319-322.
12. Suzuki, K., Sato, H., Kikuchi, T., Abe, T., Nakaji, S., Sugawara, K., Totsuka, M., Sato, K. and Yamaya, K. (1996). Capacity of circulating neutrophils to produce reactive oxygen species after exhaustive exercise. Journal of Applied Physiology, 81, 1213-1222.
13. Bendich, A. (1991). Exercise and free radicals: effects of antioxidant vitamins. Medicine and Sport Science, 32, 59-78.
14. Maughan, R. J., Donnely, A. E., Gleeson, M., Whiting, P. H., Walker, K. A. and Clough, P. J. (1989). Delayed onset muscle damage and lipid peroxisation in man after a downhill run. Muscle and Nerve, 12, 332-336.
15. Sumida, S., Tanaka, K., Kitao, H. and Nakadomo, F. (1989). Exercise-induced lipid peroxidation and leakage of enzymes before and after vitamin E supplementation. The International Journal of Biochemistry, 21, 835-838.
16. Alessio, H. M. (1993). Exercise-induced oxidative stress. Medicine and Science in Sports and Exercise, 25, 218-224.
17. Inoue, T., Mu, Z., Sumikawa, K., Adachi, K. and Okochi, T. (1993). Effect of physical exercise on the content of 8-hydroxydeoxyguanosine in nuclear DNA prepared from human lymphocytes. Japanese Journal of Cancer Research, 84, 720-725.
18. Viguie, C. A., Frei, B., Shigenaga, M. K., Ames, B. N., Packer, L. and Brooks, G. A. (1993). Antioxidant status and indexes of oxidative stress during consecutive days of exercise. Journal of Applied Physiology, 75, 566-572.
19. Sies, H. and Stahl, W. (1995). Vitamin E and C, β-carotene, and other carotenoids as antioxidants. American Journal of Clinical Nutrition, 62(suppl), 1315S-1321S.
20. van Poppel, G. and Goldbohm, R. A. (1995). Epidemiologic evidence for β-carotene and cancer prevention. American Journal of Clinical Nutrition, 62(suppl), 1393S-1402S.
21. Albanes, D., Heinonen, O. P., Huttunen, J. K., Taylor, P. R., Virtamo, J., Edwards, B. K., Haapakoski, J., Rautalahti, M., Hartman, A. M., Palmgren, J. and Greenwald, P. (1995). Effects of α-tocopherol and β-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study. American Journal of Clinical Nutrition, 62(suppl), 1427S-1430S.
22. Hennekens, C. H., Buring, J. E., Manson, J. E., Stampfer, M., Rosner, B., Cook, N. R., Belanger, C., Lamotte, F., Gaziano, J. M., Ridker, P. M., Willett, W. and Peto, R. (1996). Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. New England Journal of Medicine, 334, 1145-1149.
23. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994). The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New England Journal of Medicine, 330, 1029-1035.
24. Kanter, M. M., Nolte, L. A. and Holloszy, J. O. (1993). Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise. Journal of Applied Physiology, 74, 965-969.
25. Witt, E. H., Reznick, A. Z., Viguie, C. A., Starke-Reed, P. and Packer, L. (1992). Exercise, oxidative damage and effects of antioxidant manipulation. Journal of Nutrition, 122, 766-773.
26. Miller, K. W. and Yang, C. S. (1985). An isocratic high-performance liquid chromatography method for the simultaneous analysis of plasma retinol, α-tocopherol, and various carotenoids. Analytical Biochemistry, 145, 21-26.
27. Wung, W. E. and Howell, S. B. (1980). Simultaneous liquid chromatography of 5-fluorouracil, uridine, hypoxanthine, xanthine, uric acid, allopurinol, and oxipurinol in plasma. Clinical Chemistry, 26, 1704-1708.
28. Costill, D. L. and Fink, W. J. (1974). Plasma volume changes following exercise and thermal dehydration. Journal of Applied Physiology, 37, 521-525.
29. Mo, J.-Y., Maki, H. and Sekiguchi, M. (1992). Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: Sanitization of nucleotide pool. Proceedings of the National Academy of Sciences of the United States of America, 89, 11021-11025.
30. Sakumi, K., Furuichi, M., Tsuzuki, T., Kakuma, T., Kawabata, S., Maki, H. and Sekiguchi, M. (1993). Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. Journal of Biological Chemistry, 268, 23524-23530.
31. Brown, R. K., Mcburney, A., Lunec, J. and Kelly, F. J. (1995). Oxidative damage to DNA in patients with cystic fibrosis. Free Radical Biology and Medicine, 18, 801-806.
32. Lagorio, S., Tagesson, C., Forastiere, F., Iavarone, I., Axelson, O. and Carere, A. (1994). Exposure to benzene and urinary concentrations of 8-hydroxydeoxyguanosine, a biological marker of oxidative damage to DNA. Occupational and Environmental Medicine, 51, 739-743.
33. Tagesson, C., Kallberg, M., Klintenberg, C. and Starkhammar, H. (1995). Determination of urinary 8-hydroxydeoxyguanosine by automated coupled-column high performance liquid chromatography: a powerful technique for assaying in viva oxidative DNA damage in cancer patients. European Journal of Cancer, 31A, 934-940.
34. Sen, C., Atalay, M. and Hänninen, O. (1994). Exerciseinduced oxidative stress: glutathione supplementation and deficiency. Journal of Applied Physiology, 77, 2177-2187.
35. Hellsten, Y. (1994). Xanthine dehydrogenase and purine metabolism in man-with special reference to exercise. Acta Physiologica Scandinavica, 151 (Suppl 621), 1-73.
36. Richter, C., Park, J.-W. and Ames, B. N. (1988). Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proceedings of the National Academy of Sciences of the United States of America, 85, 6465-6467.
37. Hartmann, A., Plappert, U., Raddatz, K., Grünert-Fuchs, M. and Speit, G. (1994). Does physical activity-induce DNA damage? Mutagenesis, 9, 269-272.
38. Loft, S, and Poulsen, H. E. (1996). Cancer risk and oxidative DNA damage in man. Journal of Molecular Medicine, 74, 297-312.
39. Okamura, K., Doi, T., Hamada, K., Sakurai, M., Yoshioka, Y., Mitsuzono, R., Migita, T., Sumida, S. and Sugawa-Katayama, Y. (1997). Effect of repeated exercise on urinary 8-hydroxy-deoxyguanosine excretion in humans. Free Radical Research, 26, 507-514.