Enhanced hepatotoxicity induced by repeated exposure to polychlorinated biphenyls and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in combination in male rats

Journal of Environmental Sciences

Volumn 23, Issue 1, 2011, Pages 119-124

  Wang, Yimei ^a   Lu, Chunfeng ^a,c   Sheng, Zhiguo ^b   Liu, Gang ^a   Fu, Ze ^a   Zhu, Benzhan ^b   Peng, Shuangqing ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

^c JIAMUSI UNIVERSITY   (China)

Author keywords

2, 3, 7, 8 tetrachlorodibenzo p dioxin; Combined exposure; Hepatotoxicity; Polychlorinated biphenyls

Indexed keywords

2 ,3 ,7 ,8 TETRACHLORODIBENZO P DIOXINS; AROCLORS; COMBINED EXPOSURE; COMPLEX MIXTURE; CYTOCHROME P450; HEPATOTOXICITY; INTRAGASTRIC ADMINISTRATION; MALE RATS; POTENTIAL MECHANISM; SPRAGUE-DAWLEY RATS;

AROMATIC HYDROCARBONS; ORGANIC POLLUTANTS; RATS;

POLYCHLORINATED BIPHENYLS;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROCLOR 1254; CYTOCHROME P450 1A1;

DOSE-RESPONSE RELATIONSHIP; EXPERIMENTAL STUDY; HISTOPATHOLOGY; LABORATORY METHOD; PCB; RODENT; TCDD; TOXICITY TEST;

ANIMAL; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; LIVER; MALE; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; CHLORODIPHENYL (54% CHLORINE); CYTOCHROME P-450 CYP1A1; ENZYME INDUCTION; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; TETRACHLORODIBENZODIOXIN;

RATTUS;

EID: 78651071290     PISSN: 10010742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1001-0742(10)60382-8     Document Type: Article

References (28)

1. Arisawa K, Takeda H, Mikasa H Background exposure to PCDDs/PCDFs/PCBs and its potential health effects: a review of epidemiologic studies. The Journal of Medical Investigation 2005, 52(1-2):10-21.
2. Bannister R, Safe S Synergistic interactions of 2,3,7,8-TCDD and 2,2′,4,4′,5,5′-hexachlorobiphenyl in C57BL/6J and DBA/2J mice: role of the Ah receptor. Toxicology 1987, 44(2):159-169.
3. Boverhof DR, Burgoon LD, Tashiro C, Sharratt B, Chittim B, Harkema JR, et al. Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice. Toxicological Sciences 2006, 94(2):398-416.
4. Chen G, Bunce NJ Interaction between halogenated aromatic compounds in the Ah receptor signal transduction pathway. Environmental Toxicology 2004, 19(5):480-489.
5. Chu I, Lecavalier P, Håkansson H, Yagminas A, Valli VE, Poon P, Feeley M Mixture effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated biphenyls congeners in rats. Chemosphere 2001, 43(4-7):807-814.
6. Chubb LS, Andersen ME, Broccardo CJ, Legare ME, Billings RE, Dean CE, et al. Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153. Toxicologic Pathology 2004, 32(4):467-473.
7. Cogliano VJ Assessing the cancer risk from environmental PCBs. Environmental Health Perspectives 1998, 106(6):317-323.
8. Cole P, Trichopoulos D, Pastides H, Starr T, Mandel JS Dioxin and cancer: a critical review. Regulatory Toxicology and Pharmacology 2003, 38(3):378-388.
9. Crofton KM, Craft ES, Hedge JM, Simmons JE, Carchman RA, Carter WH, et al. Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism. Environmental Health Perspectives 2005, 113(11):1549-1554.
10. Fujii-Kuriyama Y, Mimura J Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes. Biochemical and Biophysical Research Communications 2005, 338(1):311-317.
11. Humblet O, Birnbaum L, Rimm E, Mittleman MA, Hauser R Dioxins and cardiovascular disease mortality. Environmental Health Perspectives 2008, 116(11):1443-1448.
12. Knerr S, Schaefer J, Both S, Mally A, Dekant W, Schrenk D 2,3,7,8-Tetrachlorodibenzo-p-dioxin induced cy-tochrome P450s alter the formation of reactive oxygen species in liver cells. Molecular Nutrition & Food Research 2006, 50(4-5):378-384.
13. Korenaga T, Fukusato T, Ohta M, Asaoka K, Murata N, Arima A, et al. Long-term effects of subcutaneously injected 2,3,7,8-tetrachlorodibenzo-p-dioxin on the liver of rhesus monkeys. Chemosphere 2007, 67(9):S399-S404.
14. Kutlu S, Colakoglu N, Halifeoglu I, Sandal S, Seyran AD, Aydin M, et al. Comparative evaluation of hepatotoxic and nephrotoxic effects of aroclors 1221 and 1254 in female rats. Cell Biochemistry and Function 2007, 25(2):167-172.
15. Larsen JC Risk assessments of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxinlike polychlorinated biphenyls in food. Molecular Nutrition & Food Research 2006, 50(10):885-896.
16. Leung YK, Lau KM, Mobley J, Jiang Z, Ho SM Over-expression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer Research 2005, 65(9):3726-3734.
17. Li MH, Hansen LG Enzyme induction and acute endocrine effects in prepubertal female rats receiving environmental PCB/PCDF/PCDD mixtures. Environmental Health Perspectives 1996, 104(7):712-722.
18. Mandal PK Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology. Journal of Comparative Physiology B 2005, 175(4):221-230.
19. Nagayama J, Tsuji H, Iida T, Nakagawa R, Matsueda T, Hirakawa H, et al. Immunologic effects of perinatal exposure to dioxins, PCBs and organochlorine pesticides in Japanese infants. Chemosphere 2007, 67(9):393-398.
20. Safe SH Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Critical Reviews in Toxicology 1994, 24(2):87-149.
21. Schecter A, Birnbaum L, Ryan JJ, Constable JD Dioxins: An overview. Environmental Research 2006, 101(3):419-428.
22. Stack AS, Altman-Hamamdzic S, Morris PJ, London SD, London L Polychlorinated biphenyl mixtures (Aro-clors) inhibit LPS-induced murine splenocyte proliferation in vitro. Toxicology 1999, 139(1-2):137-154.
23. van Birgelen AP, Fase KM, van der Kolk J, Poiger H, Brouwer A, Seinen W, et al. Synergistic effect of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic porphyrin levels in the rat. Environmental Health Perspectives 1996, 104(5):550-557.
24. van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, et al. The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicological Sciences 2006, 93(2):223-241.
25. van der Plas SA, Lutkeschipholt I, Spenkelink B, Brouwer A Effects of subchronic exposure to complex mixtures of dioxin-like and non-dioxin-like polyhalogenated aromatic compounds on thyroid hormone and vitamin A levels in female Sprague-Dawley rats. Toxicological Sciences 2001, 59(1):92-100.
26. Wade MG, Foster WG, Younglai EV, McMahon A, Leingartner K, Yagminas A, et al. Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: systemic, immune, and reproductive effects. Toxicological Sciences 2002, 67(1):131-143.
27. Walker NJ, Crockett PW, Nyska A, Brix AE, Jokinen MP, Sells DM, et al. Dose-additive carcinogenicity of a defined mixture of " dioxin-like compounds" Environmental Health Perspectives 2005, 113(1):43-48.
28. Zoeller RT, Dowling AL, Vas AA Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain. Endocrinology 2000, 141(1):181-189.