Activation of stress-regulated transcription factors by triethylene glycol dimethacrylate monomer

Biomaterials

Volumn 32, Issue 7, 2011, Pages 1787-1795

  Krifka, Stephanie ^a   Petzel, Christine ^a   Bolay, Carola ^a   Hiller, Karl Anton ^a   Spagnuolo, Gianrico ^b   Schmalz, Gottfried ^a   Schweikl, Helmut ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Resin monomer; Stress response; TEGDMA; Transcription factor

Indexed keywords

APOPTOSIS; CAMPTOTHECINS; CELL CYCLE; CELL LINES; CELL RESPONSE; CELLULAR PATHWAY; CELLULAR REACTIONS; DNA DAMAGES; EXPERIMENTAL EVIDENCE; GENOTOXICITIES; HELA CELL; HELA CELL CULTURE; IN-CELL; INNATE IMMUNE SYSTEMS; LINEAR MODEL; MINERALIZATION PROCESS; MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR MECHANISM; NUCLEAR FRACTIONS; ORAL TISSUES; POLYMERIZATION PROCESS; REACTIVE OXYGEN SPECIES; REGULATED TRANSCRIPTION FACTORS; RESIN MONOMER; SIGNALING PATHWAYS; STRESS RESPONSE; TEGDMA; TRIETHYLENE GLYCOL DIMETHACRYLATE; WESTERN BLOTTING;

ACRYLIC MONOMERS; ANIMAL CELL CULTURE; BODY FLUIDS; CELL DEATH; DENTAL COMPOSITES; GLYCOLS; MACROPHAGES; OXYGEN; PHOSPHORYLATION; RESINS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

CELL CULTURE;

ACTIVATING TRANSCRIPTION FACTOR 3; MONOMER; P21 ACTIVATED KINASE; PROTEIN C JUN; PROTEIN P53; TRANSCRIPTION FACTOR; TRIETHYLENE GLYCOL DIMETHACRYLATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELLULAR STRESS RESPONSE; HUMAN; HUMAN CELL; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; HELA CELLS; HUMANS; MICE; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; TRANSCRIPTION FACTORS;

EID: 78650995171     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.11.031     Document Type: Article

References (47)

1. Seiss M., Langer C., Hickel R., Reichl F.X. Quantitative determination of TEGDMA, BHT, and DMABEE in eluates from polymerized resin-based dental restorative materials by use of GC/MS. Arch Toxicol 2009, 83:1109-1115.
2. Santerre J.P., Shajii L., Leung B.W. Relation of dental composite formulations to their degradation and the release of hydrolyzed polymeric-resin-derived products. Crit Rev Oral Biol Med 2001, 12:136-151.
3. Schweikl H., Spagnuolo G., Schmalz G. Genetic and cellular toxicology of dental resin monomers. J Dent Res 2006, 85:870-877.
4. Stanislawski L., Lefeuvre M., Bourd K., Soheili-Majd E., Goldberg M., Perianin A. TEGDMA-induced toxicity in human fibroblasts is associated with early and drastic glutathione depletion with subsequent production of oxygen reactive species. J Biomed Mater Res A 2003, 66:476-482.
5. Spagnuolo G., Mauro C., Leopardi A., Santillo M., Paterno R., Schweikl H., et al. NF-kappaB protection against apoptosis induced by HEMA. J Dent Res 2004, 83:837-842.
6. Eckhardt A., Gerstmayr N., Hiller K.A., Bolay C., Waha C., Spagnuolo G., et al. TEGDMA-induced oxidative DNA damage and activation of ATM and MAP kinases. Biomaterials 2009, 30:2006-2014.
7. Chang H.H., Guo M.K., Kasten F.H., Chang M.C., Huang G.F., Wang Y.L., et al. Stimulation of glutathione depletion, ROS production and cell cycle arrest of dental pulp cells and gingival epithelial cells by HEMA. Biomaterials 2005, 26:745-753.
8. Schweikl H., Hartmann A., Hiller K.-A., Spagnuolo G., Bolay C., Brockhoff G., et al. Inhibition of TEGDMA and HEMA-induced genotoxicity and cell cycle arrest by N-acetylcysteine. Dent Mater 2007, 23:688-695.
9. Yamada M., Kojima N., Paranjpe A., Att W., Aita H., Jewett A., et al. N-acetyl cysteine (NAC)-assisted detoxification of PMMA resin. J Dent Res 2008, 87:372-377.
10. Galler K, Schweikl H, Hiller KA, Cavender A, Bolay C, D'Souza R, et al. TEGDMA reduces the expression of genes involved in biomineralization, J Dent Res, in press.
11. Yamada M., Ueno T., Minamikawa H., Sato N., Iwasa F., Hori N., et al. N-acetyl cysteine alleviates cytotoxicity of bone substitute. J Dent Res 2010, 89:411-416.
12. Eckhardt A., Harorli T., Limtanyakul J., Hiller K.A., Bosl C., Bolay C., et al. Inhibition of cytokine and surface antigen expression in LPS-stimulated murine macrophages by triethylene glycol dimethacrylate. Biomaterials 2009, 30:1665-1674.
13. Mantellini M.G., Botero T.M., Yaman P., Dennison J.B., Hanks C.T., Nör J.E. Adhesive resin induces apoptosis and cell-cycle arrest of pulp cells. J Dent Res 2003, 82:592-596.
14. Matsuzawa A., Ichijo H. Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid Redox Signal 2005, 7:472-481.
15. Samuelsen J.T., Dahl J.E., Karlsson S., Morisbak E., Becher R. Apoptosis induced by the monomers HEMA and TEGDMA involves formation of ROS and differential activation of the MAP-kinases p38, JNK and ERK. Dent Mater 2007, 23:34-39.
16. Spagnuolo G., D'Antò V., Valletta R., Strisciuglio C., Schmalz G., Schweikl H., et al. Effect of HEMA on human pulp cells survival pathways ERK and Akt. J Endod 2008, 34:684-688.
17. Krifka S., Petzel C., Hiller K.A., Frank E.M., Bosl C., Spagnuolo G., et al. Resin monomer-induced differential activation of MAP kinases and apoptosis in mouse macrophages and human pulp cells. Biomaterials 2010, 31:2964-2975.
18. Lavin M.F., Gueven N. The complexity of p53 stabilization and activation. Cell Death Differ 2006, 13:941-950.
19. Zhou B.P., Liao Y., Xia W., Spohn B., Lee M.H., Hung M.C. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing. Nat Cell Biol 2001, 3:245-252.
20. Whitmarsh A.J. Regulation of gene transcription by mitogen-activated protein kinase signaling pathways. Biochim Biophys Acta 2007, 1773:1285-1298.
21. Brenner D.A., O'Hara M., Angel P., Chojkier M., Karin M. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature 1989, 337:661-663.
22. Devary Y., Gottlieb R.A., Lau L.F., Karin M. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol 1991, 11:2804-2811.
23. Derijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994, 76:1025-1037.
24. Bhoumik A., Pablo Lopez-Bergami P., Ronai Z. ATF2 on the double - activating transcription factor and DNA damage response protein. Pigment Cell Res 2007, 20:498-506.
25. Maekawa T., Shinagawa T., Sano Y., Sakuma T., Nomura S., Nagasaki K., et al. Reduced levels of ATF-2 predispose mice to mammary tumors. Mol Cell Biol 2007, 27:1730-1744.
26. Bhoumik A., Ronai Z. ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities. Cell Cycle 2008, 7:2341-2345.
27. Yan C., Lu D., Hai T., Boyd D.D. Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J 2005, 24:2425-2435.
28. Yoshii E. Cytotoxic effects of acrylates and methacrylates: relationships of monomer structures and cytotoxicity. J Biomed Mater Res 1997, 37:517-524.
29. Galler K., Schweikl H., Thonemann B., Schmalz G. Human pulp-derived cells immortalized with SV40. Eur J Oral Sci 2006, 114:138-146.
30. Vermes I., Haanen C., Steffens-Nakken H., Reutelingsperger C. A novel assay for apoptosis. flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 1995, 184:39-51.
31. Legarza K., Yang L.X. New molecular mechanisms of action of camptothecin-type drugs. Anticancer Res 2006, 26(5A):3301-3305.
32. Janke V., von Neuhoff N., Schlegelberger B., Leyhausen G., Geurtsen W. TEGDMA causes apoptosis in primary human gingival fibroblasts. J Dent Res 2003, 82:814-818.
33. Spagnuolo G., Galler K., Schmalz G., Cosentino C., Rengo S., Schweikl H. Inhibition of phosphatidylinositol 3-kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells. J Dent Res 2004, 83:703-707.
34. Nyberg K.A., Michelson R.J., Putnam C.W., Weinert T.A. Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet 2002, 36:617-656.
35. Roos W.P., Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol Med 2006, 12:440-450.
36. Gartel A.L. p21(WAF1/CIP1) and cancer: a shifting paradigm?. Biofactors 2009, 35:161-164.
37. Yu J., Zhang L.P.U.M.A. A potent killer with or without p53. Oncogene 2009, 27:S71-S83.
38. Samuelsen J.T., Holme J.A., Becher R., Karlsson S., Morisbak E., Dahl J.E. HEMA reduces cell proliferation and induces apoptosis in vitro. Dent Mater 2008, 24:134-140.
39. Asada M., Yamada T., Ichijo H., Delia D., Miyazono K., Fukumuro K., et al. p21Cip1/TI: apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J 1991, 18:1223-1234.
40. Zhan J., Easton J.B., Huang S., Mishra A., Xiao L., Lacy E.R., et al. Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo. Mol Cell Biol 2007, 27:3530-3541.
41. Rao L., Perez D., White E. Lamin proteolysis facilitates nuclear events during apoptosis. J Cell Biol 1996, 135(6 Pt 1):1441-1455.
42. Wagner E.F., Nebreda A.R. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 2009, 9:537-549.
43. Guo X., Zhang J., Fu X., Wei Q., Lu Y., Li Y., et al. Analysis of common gene expression patterns in four human tumor cell lines exposed to camptothecin using cDNA microarray: identification of topoisomerase-mediated DNA damage response pathways. Fron Biosci 2006, 11:1924-1931.
44. Hirose N., Maekawa T., Shinagawa T., Ishii S. ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells. Biochem Biophys Res Commun 2009, 385:72-77.
45. Takii R., Inouye S., Fujimoto M., Nakamura T., Shinkawa T., Prakasam R., et al. Heat shock transcription factor 1 inhibits expression of IL-6 through activating transcription factor 3. J Immunol 2010, 184:1041-1048.
46. Lu D., Chen J., Hai T. The regulation of ATF3 gene expression by mitogen-activated protein kinases. Biochem J 2007, 401:559-567.
47. Thompson M.R., Xu D., Williams B.R. ATF3 transcription factor and its emerging roles in immunity and cancer. J Mol Med 2009, 87:1053-1060.