Is the Epstein-Barr virus EBNA-1 protein an oncogen?

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 7, 2009, Pages 2091-2092

  Schulz, Thomas F ^a   Cordes, Susann ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN; EPSTEIN BARR VIRUS ANTIGEN 1; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; B LYMPHOCYTE; BURKITT LYMPHOMA; EPSTEIN BARR VIRUS; GENE EXPRESSION; GENE LOCUS; GENOMIC INSTABILITY; HODGKIN DISEASE; NASOPHARYNX CARCINOMA; NONHUMAN; NOTE; PRIORITY JOURNAL; STOMACH CANCER; VIRUS GENE;

ANIMALS; DISEASE MODELS, ANIMAL; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; GENOMIC INSTABILITY; HERPESVIRUS 4, HUMAN; HUMANS; LYMPHOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NEOPLASMS; ONCOGENES; SIGNAL TRANSDUCTION;

HUMAN HERPESVIRUS 4;

EID: 60549117106     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812575106     Document Type: Note

References (20)

1. Epstein MA, Achong BG, Barr YM (1964) Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet 15:702-703.
2. Klein E, Kis LL, Klein G (2007) Epstein-Barr virus infection in humans: From harmless to life endangering virus-lymphocyte interactions. Oncogene 26:1297-1305.
3. Young LS, Rickinson AB (2004) Epstein-Barr virus: 40 years on. Nat Rev Cancer 4:757-768.
4. Gruhne B, et al. (2009) The Epstein-Barr virus nuclear antigen-1 promotes genetic instability via induction of reactive oxygen species. Proc Natl Acad Sci USA 106:2313-2318
5. Pope JH, Horne MK, Scott W (1968) Transformation of foetal human leukocytes in vitro by filtrates of ahuman leukaemic cell line containing herpes-like virus. Int J Cancer 3:857-866.
6. Humme S, et al. (2003) The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold. Proc Natl Acad Sci USA 100:10989-10994.
7. Dirmeier U, et al. (2003) Latent membrane protein 1 is critical for efficient growth transformation of human B cells by Epstein-Barr virus. Cancer Res 63:2982-2989.
8. Burrows SR, Sculley TB, Misko IS, Schmidt C, Moss DJ (1990) An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3). J Exp Med 171:345-349.
9. Niens M, et al. (2007) HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma. Blood 110:3310-3315.
10. McAulay KA, et al. (2007) HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection. J Clin Invest 117:3042-3048.
11. Polack A, et al. (1996) C-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1. Proc Natl Acad Sci USA 93:10411-10416.
12. Kelly GL, Milner AE, Baldwin GS, Bell AI, Rickinson AB (2006) Three restricted forms of Epstein-Barr virus latency counteracting apoptosis in c-myc-expressing Burkitt lymphoma cells. Proc Natl Acad Sci USA 103:14935-14940.
13. Kamranvar SA, Gruhne B, Szeles A, Masucci MG (2007) Epstein-Barr virus promotes genomic instability in Burkitt's lymphoma. Oncogene 26:5115-5123.
14. Kube D, et al. (1999) Expression of Epstein-Barr virus nuclear antigen 1 is associated with enhanced expression of CD25 in the Hodgkin cell line L428. J Virol 73:1630-1636.
15. Wilson JB, Bell JL, Levine AJ (1996) Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice. EMBO J 15:3117-3126.
16. Kang MS, et al. (2005) Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice. Proc Natl Acad Sci USA 102:820-825.
17. Srinivas SK, Sixbey JW (1995) Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2. J Virol 69:8155-8158.
18. Kuhn-Hallek I, Sage DR, Stein L, Groelle H, Fingeroth JD (1995) Expression of recombination activating genes (RAG-1 and RAG-2) in Epstein-Barr virus-bearing B cells. Blood 85:1289-1299.
19. Tsimbouri P, Drotar ME, Coy JL, Wilson JB (2002) bcl-xL and RAG genes are induced and the response to IL-2 enhanced in EmuEBNA-1 transgenic mouse lymphocytes. Oncogene 21:5182-5187.
20. Hammerschmidt W, Sugden B (1989) Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes. Nature 340:393-397.