A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor- dependent and independent mechanisms of toxicity

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Mongan, M Ann ^a   Dunn, Robert T ^a   Vonderfecht, Steven ^a   Everds, Nancy ^a   Chen, Guang ^b   Su, Cheng ^b   Higgins Garn, Marnie ^a   Chen, Yuan ^a   Afshari, Cynthia A ^a   Williamson, Toni L ^a   Carlock, Linda ^a   Dipalma, Christopher ^a   Moss, Suzanne ^a   Bussiere, Jeanine ^a   Charles Jr, Qualls ^a   He, Yudong D ^a   Hamadeh, Hisham K ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE TRANSFER RNA LIGASE; ALDEHYDE DEHYDROGENASE; AMINO ACID TRANSFER RNA LIGASE; ARGININE TRANSFER RNA LIGASE; BETA SECRETASE 1; BETA SECRETASE INHIBITOR; CARNITINE PALMITOYLTRANSFERASE; CHECKPOINT KINASE 1; CMP 013; CYCLIN B1; CYCLIN B2; CYCLIN D1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 3; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE MU; INITIATION FACTOR 2ALPHA; PREGNANE X RECEPTOR; PROTEASOME; RETINOBLASTOMA PROTEIN; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR E2F3; TRANSCRIPTION FACTOR E2F6; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; SECRETASE; STEROID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRESS; CONTROLLED STUDY; DRUG RESEARCH; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HEPATOMEGALY; INTERMETHOD COMPARISON; KNOCKOUT MOUSE; LIPID METABOLISM; LIVER TOXICITY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NONPARAMETRIC TEST; PROTEIN EXPRESSION; SAMPLE SIZE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TOXICITY TESTING; WILD TYPE; ALGORITHM; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; DNA MICROARRAY; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; LIVER; METABOLISM; MOUSE MUTANT; STATISTICAL MODEL; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ALGORITHMS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, GENETIC; MODELS, STATISTICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, STEROID;

EID: 78650971775     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015595     Document Type: Article

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