Vitamin K3 attenuates cerulein-induced acute pancreatitis through inhibition of the autophagic pathway

Pancreas

Volumn 40, Issue 1, 2011, Pages 84-94

  Chinzei, Ryo ^a   Masuda, Atsuhiro ^a,b   Nishiumi, Shin ^a   Nishida, Masayuki ^a   Onoyama, Mitsuko ^a   Sanuki, Tsuyoshi ^a   Fujita, Tsuyoshi ^a   Moritoh, Satoshi ^c   Itoh, Tomoo ^c   Kutsumi, Hiromu ^a   Mizuno, Shigeto ^b   Azuma, Takeshi ^a   Yoshida, Masaru ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^c KOBE UNIVERSITY HOSPITAL   (Japan)

Author keywords

acute pancreatitis; autophagy; vitamin K3

Indexed keywords

CERULETIDE; GREEN FLUORESCENT PROTEIN; MENADIONE; PROTEIN LC3; RAPAMYCIN; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONFOCAL MICROSCOPY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; HELA CELL; HISTOLOGY; HUMAN; HUMAN CELL; INFLAMMATION; LYSOSOME; MOUSE; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ACUTE DISEASE; ANIMALS; AUTOPHAGY; CAERULEIN; FEMALE; HELA CELLS; HUMANS; LYSOSOMES; MICE; MICE, INBRED C57BL; PANCREATITIS; PHAGOSOMES; SIROLIMUS; VITAMIN K 2; VITAMIN K 3;

EID: 78650926523     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181f69fc9     Document Type: Article

References (35)

1. Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet. 2008;371:143-152.
2. Gudgeon AM, Heath DI, Hurley P, et al. Trypsinogen activation peptides assay in the early prediction of severity of acute pancreatitis. Lancet. 1990;335:4-8.
3. Whitcomb DC, Gorry MC, Preston RA, et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996;14:141-145.
4. Halangk W, Lerch MM, Brandt-Nedelev B, et al. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest. 2000;106:773-781.
5. Hashimoto D, Ohmuraya M, Hirota M, et al. Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J Cell Biol. 2008;181:1065-1072.
6. Lamson DW, Plaza SM. The anticancer effects of vitamin K. Altern Med Rev. 2003;8:303-318.
7. Hockenbery DM, Oltvai ZN, Yin XM, et al. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 1993;75:241-251.
8. Criddle DN, Gillies S, Baumgartner-Wilson HK, et al. Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. J Biol Chem. 2006;281:40485-40492.
9. Reddi K, Henderson B, Meghji S, et al. Interleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by naphthoquinone (vitamin K) compounds. Cytokine. 1995;7: 287-290.
10. Ohsaki Y, Shirakawa H, Hiwatashi K, et al. Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat. Biosci Biotechnol Biochem. 2006;70:926-932.
11. Nakagawa I, Amano A, Mizushima N, et al. Autophagy defends cells against invading group A Streptococcus. Science. 2004;306:1037-1040.
12. Ogawa M, Yoshimori T, Suzuki T, et al. Escape of intracellular Shigella from autophagy. Science. 2005;307:727-731.
13. Mizushima N, Yamamoto A, Matsui M, et al. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell. 2004;15:1101-1111.
14. Van Acker GJ, Weiss E, Steer ML, et al. Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1738YG1746.
15. Ropolo A, Grasso D, Pardo R, et al. The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells. J Biol Chem. 2007;282:37124-37133.
16. Iwai-Kanai E, Yuan H, Huang C, et al. A method to measure cardiac autophagic flux in vivo. Autophagy. 2008;4:322-329.
17. Hughes CB, el-Din AB, Kotb M, et al. Calcium channel blockade inhibits release of TNF alpha and improves survival in a rat model of acute pancreatitis. Pancreas. 1996;13:22-28.
18. Kamimoto T, Shoji S, Hidvegi T, et al. Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem. 2006;281:4467-4476.
19. Sou YS, Tanida I, Komatsu M, et al. Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem. 2006;281:3017-3024.
20. Fujita N, Hayashi-Nishino M, Fukumoto H, et al. An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell. 2008;19:4651-4659.
21. Fujita N, Noda T, Yoshimori T. Atg4B(C74A) hampers autophagosome closure: a useful protein for inhibiting autophagy. Autophagy. 2009;5:88-89.
22. Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000;19:5720-5728.
23. Saluja A, Saluja M, Villa A, et al. Pancreatic duct obstruction in rabbits causes digestive zymogen and lysosomal enzyme colocalization. J Clin Invest. 1989;84:1260-1266.
24. Ravikumar B, Vacher C, Berger Z, et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet. 2004;36:585-595.
25. Bhatia M. Apoptosis of pancreatic acinar cells in acute pancreatitis: is it good or bad? J Cell Mol Med. 2004;8:402-409.
26. Bhatia M, Wallig MA, Hofbauer B, et al. Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis. Biochem Biophys Res Commun. 1998;246:476-483.
27. Mareninova OA, Sung KF, Hong P, et al. Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J Biol Chem. 2006;281:3370-3381.
28. Gukovskaya AS, Gukovsky I, Jung Y, et al. Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis. J Biol Chem. 2002;277:22595-22604.
29. Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights disease through cellular self-digestion. Nature. 2008;451:1069-1075.
30. Maiuri MC, Zalckvar E, Kimchi A, et al. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007;8:741-752.
31. Fortunato F, Burgers H, Bergmann F, et al. Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis. Gastroenterology. 2009;137:350-360.
32. Mareninova OA, Hermann K, French SW, et al. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. J Clin Invest. 2009;119:3340-3355.
33. Enomoto M, Tsuchida A, Miyazawa K, et al. Vitamin K2Yinduced cell growth inhibition via autophagy formation in cholangiocellular carcinoma cell lines. Int J Mol Med. 2007;20:801-808.
34. Yokoyama T, Miyazawa K, Naito M, et al. Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells. Autophagy. 2008;4:629-640.
35. Kawakita H, Tsuchida A, Miyazawa K, et al. Growth inhibitory effects of vitamin K2 on colon cancer cell lines via different types of cell death including autophagy and apoptosis. Int J Mol Med. 2009;23:709-716.