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Volumn 22, Issue 4, 2010, Pages 245-252

Methylation and demethylation of Ink4 locus in cancer development

Author keywords

CpG island; Ink4; Ink4 gene; Methylation

Indexed keywords

AZACITIDINE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; POLYCOMB GROUP PROTEIN;

EID: 78650921504     PISSN: 10009604     EISSN: 19930631     Source Type: Journal    
DOI: 10.1007/s11670-010-0245-y     Document Type: Review
Times cited : (3)

References (58)
  • 1
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • DOI 10.1038/366704a0
    • M. Serrano G. Hannon D. Beach 1993 A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4[J] Nature 366 704 707 1:CAS:528:DyaK2cXhsFOgu7Y%3D 10.1038/366704a0 8259215 (Pubitemid 24036021)
    • (1993) Nature , vol.366 , Issue.6456 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 2
    • 0028121279 scopus 로고
    • A cell cycle regulator potentially involved in genesis of many tumor types[J]
    • 1:CAS:528:DyaK2cXktVKhtb0%3D 10.1126/science.8153634 8153634
    • A. Kamb N. Gruis J. Weaver-Feldhaus, et al. 1994 A cell cycle regulator potentially involved in genesis of many tumor types[J] Science 264 436 440 1:CAS:528:DyaK2cXktVKhtb0%3D 10.1126/science.8153634 8153634
    • (1994) Science , vol.264 , pp. 436-440
    • Kamb, A.1    Gruis, N.2    Weaver-Feldhaus, J.3
  • 3
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF[J]
    • 1:CAS:528:DyaK2sXnvFWrsbg%3D 10.1016/S0092-8674(00)80452-3 9393858
    • T. Kamijo F. Zindy M. Roussel, et al. 1997 Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF[J] Cell 91 649 659 1:CAS:528:DyaK2sXnvFWrsbg%3D 10.1016/S0092-8674(00)80452-3 9393858
    • (1997) Cell , vol.91 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.3
  • 5
    • 44949173041 scopus 로고    scopus 로고
    • ARF in melanoma
    • DOI 10.1093/jnci/djn156
    • G. Peters 2008 Tumor suppression for ARFicionados: the relative contributions of p16INK4a and p14ARF in melanoma[J] J Natl Cancer Inst 100 757 759 1:CAS:528:DC%2BD1cXmvFWksrY%3D 10.1093/jnci/djn156 18505965 (Pubitemid 351809671)
    • (2008) Journal of the National Cancer Institute , vol.100 , Issue.11 , pp. 757-759
    • Peters, G.1
  • 6
    • 69349103956 scopus 로고    scopus 로고
    • The Ink4/Arf locus is a barrier for iPS cell reprogramming[J]
    • 1:CAS:528:DC%2BD1MXps1ahtLg%3D 10.1038/nature08290 19668188
    • H. Li M. Collado A. Villasante, et al. 2009 The Ink4/Arf locus is a barrier for iPS cell reprogramming[J] Nature 460 1136 1139 1:CAS:528: DC%2BD1MXps1ahtLg%3D 10.1038/nature08290 19668188
    • (2009) Nature , vol.460 , pp. 1136-1139
    • Li, H.1    Collado, M.2    Villasante, A.3
  • 8
    • 62549158651 scopus 로고    scopus 로고
    • P53 Deficiency leads to compensatory up-regulation of p16INK4a[J]
    • 1:CAS:528:DC%2BD1MXjtF2js7s%3D 10.1158/1541-7786.MCR-08-0373 19240179
    • W. Leong J. Chau B. Li 2009 p53 Deficiency leads to compensatory up-regulation of p16INK4a[J] Mol Cancer Res 7 354 360 1:CAS:528: DC%2BD1MXjtF2js7s%3D 10.1158/1541-7786.MCR-08-0373 19240179
    • (2009) Mol Cancer Res , vol.7 , pp. 354-360
    • Leong, W.1    Chau, J.2    Li, B.3
  • 9
    • 0033985151 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status[J]
    • 1:CAS:528:DC%2BD3cXnt1aguw%3D%3D 10646864
    • M. Esteller S. Tortola M. Toyota, et al. 2000 Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status[J] Cancer Res 60 129 133 1:CAS:528:DC%2BD3cXnt1aguw%3D%3D 10646864
    • (2000) Cancer Res , vol.60 , pp. 129-133
    • Esteller, M.1    Tortola, S.2    Toyota, M.3
  • 10
    • 0037373891 scopus 로고    scopus 로고
    • A systematic profile of DNA methylation in human cancer cell lines[J]
    • 1:CAS:528:DC%2BD3sXhs1agtLo%3D 12615730
    • M. Paz M. Fraga S. Avila, et al. 2003 A systematic profile of DNA methylation in human cancer cell lines[J] Cancer Res 63 1114 1121 1:CAS:528:DC%2BD3sXhs1agtLo%3D 12615730
    • (2003) Cancer Res , vol.63 , pp. 1114-1121
    • Paz, M.1    Fraga, M.2    Avila, S.3
  • 11
    • 0029993450 scopus 로고    scopus 로고
    • Role of the INK4a locus in tumor suppression and cell mortality
    • DOI 10.1016/S0092-8674(00)81079-X
    • M. Serrano H. Lee L. Chin, et al. 1996 Role of the INK4a locus in tumor suppression and cell mortality[J] Cell 85 27 37 1:CAS:528:DyaK28Xit1aksb8%3D 10.1016/S0092-8674(00)81079-X 8620534 (Pubitemid 26116804)
    • (1996) Cell , vol.85 , Issue.1 , pp. 27-37
    • Serrano, M.1    Lee, H.-W.2    Chin, L.3    Cordon-Cardo, C.4    Beach, D.5    DePinho, R.A.6
  • 12
    • 18244388241 scopus 로고    scopus 로고
    • DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis[J]
    • 1:CAS:528:DC%2BD38XnsVGhtw%3D%3D 10.1093/hmg/10.26.3001 11751682
    • M. Esteller M. Fraga M. Guo, et al. 2001 DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis[J] Hum Mol Genet 10 3001 3007 1:CAS:528:DC%2BD38XnsVGhtw%3D%3D 10.1093/hmg/10.26.3001 11751682
    • (2001) Hum Mol Genet , vol.10 , pp. 3001-3007
    • Esteller, M.1    Fraga, M.2    Guo, M.3
  • 14
    • 0029011539 scopus 로고
    • 5 CpG island methylation is associated with transcriptional silencing of the tumor-suppressor p16/cdkn2/mts1 in human cancers[J]
    • 1:CAS:528:DyaK2MXms1Kgtr4%3D 10.1038/nm0795-686 7585152
    • A. Merlo J.G. Herman L. Mao, et al. 1995 5 CpG island methylation is associated with transcriptional silencing of the tumor-suppressor p16/cdkn2/mts1 in human cancers[J] Nat Med 1 686 692 1:CAS:528:DyaK2MXms1Kgtr4%3D 10.1038/nm0795-686 7585152
    • (1995) Nat Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3
  • 15
    • 0033816924 scopus 로고    scopus 로고
    • Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer[J]
    • 1:CAS:528:DC%2BD3cXmsVKkur0%3D 10.1038/79120 10973239
    • W. Grady J. Willis P. Guilford, et al. 2000 Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer[J] Nat Genet 26 16 17 1:CAS:528:DC%2BD3cXmsVKkur0%3D 10.1038/79120 10973239
    • (2000) Nat Genet , vol.26 , pp. 16-17
    • Grady, W.1    Willis, J.2    Guilford, P.3
  • 16
    • 60849089645 scopus 로고    scopus 로고
    • Aberrant DNA methylation is a dominant mechanism in MDS progression to AML[J]
    • 1:CAS:528:DC%2BD1MXitV2ru78%3D 10.1182/blood-2008-06-163246 18832655
    • Y. Jiang A. Dunbar L. Gondek, et al. 2009 Aberrant DNA methylation is a dominant mechanism in MDS progression to AML[J] Blood 113 1315 1325 1:CAS:528:DC%2BD1MXitV2ru78%3D 10.1182/blood-2008-06-163246 18832655
    • (2009) Blood , vol.113 , pp. 1315-1325
    • Jiang, Y.1    Dunbar, A.2    Gondek, L.3
  • 17
    • 54949134514 scopus 로고    scopus 로고
    • Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer[J]
    • 1:STN:280:DC%2BD1cnosVKmsg%3D%3D 10.1093/annonc/mdn409 18647968
    • K. Suijkerbuijk M. Fackler S. Sukumar, et al. 2008 Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer[J] Ann Oncol 19 1870 1874 1:STN:280:DC%2BD1cnosVKmsg%3D%3D 10.1093/annonc/mdn409 18647968
    • (2008) Ann Oncol , vol.19 , pp. 1870-1874
    • Suijkerbuijk, K.1    Fackler, M.2    Sukumar, S.3
  • 18
    • 0037105785 scopus 로고    scopus 로고
    • Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia[J]
    • 1:CAS:528:DC%2BD38Xnt1ynsb0%3D 12234999
    • L.A. Kresty S.R. Mallery T.J. Knobloch, et al. 2002 Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia[J] Cancer Res 62 5295 5300 1:CAS:528:DC%2BD38Xnt1ynsb0%3D 12234999
    • (2002) Cancer Res , vol.62 , pp. 5295-5300
    • Kresty, L.A.1    Mallery, S.R.2    Knobloch, T.J.3
  • 19
    • 0029929885 scopus 로고    scopus 로고
    • Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment
    • DOI 10.1038/nm0696-682
    • L. Mao J. Lee Y. Fan 1996 Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment[J] Nat Med 2 682 685 1:CAS:528:DyaK28XjsVSjtbk%3D 10.1038/nm0696-682 8640560 (Pubitemid 26191956)
    • (1996) Nature Medicine , vol.2 , Issue.6 , pp. 682-685
    • Mao, L.1    Lee, J.S.2    Fan, Y.H.3    Ro, J.Y.4    Batsakis, J.G.5    Lippman, S.6    Hittelman, W.7    Hong, W.K.8
  • 20
    • 0032523011 scopus 로고    scopus 로고
    • Methylation of the p15(INK4b) gene in myelody-splastic syndromes is frequent and acquired during disease progression[J]
    • 1:CAS:528:DyaK1cXisVWlurY%3D 9531610
    • B. Quesnel G. Guillerm R. Vereecque, et al. 1998 Methylation of the p15(INK4b) gene in myelody-splastic syndromes is frequent and acquired during disease progression[J] Blood 91 2985 2990 1:CAS:528:DyaK1cXisVWlurY%3D 9531610
    • (1998) Blood , vol.91 , pp. 2985-2990
    • Quesnel, B.1    Guillerm, G.2    Vereecque, R.3
  • 21
    • 58249084931 scopus 로고    scopus 로고
    • Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: A population-based study[J]
    • 1:CAS:528:DC%2BD1MXhvFeisg%3D%3D 10.1002/ijc.23891 18821580
    • C.X. Dong D.J. Deng K.F. Pan, et al. 2009 Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: A population-based study[J] Int J Cancer 124 434 439 1:CAS:528: DC%2BD1MXhvFeisg%3D%3D 10.1002/ijc.23891 18821580
    • (2009) Int J Cancer , vol.124 , pp. 434-439
    • Dong, C.X.1    Deng, D.J.2    Pan, K.F.3
  • 22
    • 33751113282 scopus 로고    scopus 로고
    • Helicobacter pylori and the progression of gastric cancer: A 10-year cohort study[J]
    • 16324316
    • J. Ma L. Zhang K. Pan, et al. 2005 Helicobacter pylori and the progression of gastric cancer: a 10-year cohort study[J] Zhonghua Yi Xue Za Zhi 85 2758 2761 16324316
    • (2005) Zhonghua Yi Xue Za Zhi , vol.85 , pp. 2758-2761
    • Ma, J.1    Zhang, L.2    Pan, K.3
  • 23
    • 4143063626 scopus 로고    scopus 로고
    • Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study
    • DOI 10.1158/1078-0432.CCR-03-0622
    • Y. Sun D.J. Deng W.C. You, et al. 2004 Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study[J] Clin Cancer Res 10 5087 5093 1:CAS:528: DC%2BD2cXmtlSit7g%3D 10.1158/1078-0432.CCR-03-0622 15297411 (Pubitemid 39099783)
    • (2004) Clinical Cancer Research , vol.10 , Issue.15 , pp. 5087-5093
    • Sun, Y.1    Deng, D.2    You, W.-C.3    Bai, H.4    Zhang, L.5    Zhou, J.6    Shen, L.7    Ma, J.-L.8    Xie, Y.-Q.9    Li, J.-Y.10
  • 24
    • 0036868960 scopus 로고    scopus 로고
    • Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinoma[J]
    • 1:CAS:528:DC%2BD3sXnvVCkuw%3D%3D 12460459
    • T. Osawa J. Chong M. Sudo, et al. 2002 Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinoma[J] Jpn J Cancer Res 93 1195 1200 1:CAS:528:DC%2BD3sXnvVCkuw%3D%3D 12460459
    • (2002) Jpn J Cancer Res , vol.93 , pp. 1195-1200
    • Osawa, T.1    Chong, J.2    Sudo, M.3
  • 25
    • 21644473614 scopus 로고    scopus 로고
    • INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma
    • DOI 10.1158/1078-0432.CCR-04-1715
    • X. Li A. Hui L. Sun, et al. 2004 p16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma[J] Clin Cancer Res 10 7484 7489 1:CAS:528:DC%2BD2cXhtVanur7E 10.1158/1078-0432.CCR- 04-1715 15569978 (Pubitemid 39557509)
    • (2004) Clinical Cancer Research , vol.10 , Issue.22 , pp. 7484-7489
    • Li, X.1    Hei, A.-M.2    Sun, L.3    Hasegawa, K.4    Torzilli, G.5    Minagawa, M.6    Takayama, T.7    Makuuchi, M.8
  • 27
    • 0037419739 scopus 로고    scopus 로고
    • p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N′-nitro-N-nitrosoguanidine
    • DOI 10.1016/S1383-5718(02)00288-7, PII S1383571802002887
    • H. Bai L.K. Gu J. Zhou, et al. 2003 p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N-nitro-N-nitrosoguanidine[J] Mutat Res-Genet Toxicol Environ Mutag 535 73 78 1:CAS:528:DC%2BD3sXkvFaltw%3D%3D 10.1016/S1383-5718(02)00288-7 (Pubitemid 36120761)
    • (2003) Mutation Research - Genetic Toxicology and Environmental Mutagenesis , vol.535 , Issue.1 , pp. 73-78
    • Bai, H.1    Gu, L.2    Zhou, J.3    Deng, D.4
  • 28
    • 33645521023 scopus 로고    scopus 로고
    • Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort[J]
    • 1:CAS:528:DC%2BD28Xitlertb8%3D 10.1158/0008-5472.CAN-05-3408 16540689
    • S.A. Belinsky K.C. Liechty F.D. Gentry, et al. 2006 Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort[J] Cancer Res 66 3338 3344 1:CAS:528:DC%2BD28Xitlertb8%3D 10.1158/0008-5472.CAN-05-3408 16540689
    • (2006) Cancer Res , vol.66 , pp. 3338-3344
    • Belinsky, S.A.1    Liechty, K.C.2    Gentry, F.D.3
  • 29
    • 66249114998 scopus 로고    scopus 로고
    • A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus[J]
    • 1:CAS:528:DC%2BD1MXlvFWltrs%3D 10.1158/0008-5472.CAN-09-0028 19435894
    • Z. Jin Y. Cheng W. Gu, et al. 2009 A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus[J] Cancer Res 69 4112 4115 1:CAS:528:DC%2BD1MXlvFWltrs%3D 10.1158/0008-5472.CAN-09-0028 19435894
    • (2009) Cancer Res , vol.69 , pp. 4112-4115
    • Jin, Z.1    Cheng, Y.2    Gu, W.3
  • 30
    • 54049086674 scopus 로고    scopus 로고
    • P16 Promoter methylation is a potential predictor of malignant transformation in oral epithelial dysplasia[J]
    • 1:CAS:528:DC%2BD1cXpvFKmsbY%3D 10.1158/1055-9965.EPI-07-2867 18708411
    • G. Hall R. Shaw E. Field, et al. 2008 p16 Promoter methylation is a potential predictor of malignant transformation in oral epithelial dysplasia[J] Cancer Epidemiol Biomarkers Prev 17 2174 2179 1:CAS:528:DC%2BD1cXpvFKmsbY%3D 10.1158/1055-9965.EPI-07-2867 18708411
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 2174-2179
    • Hall, G.1    Shaw, R.2    Field, E.3
  • 31
    • 69349084287 scopus 로고    scopus 로고
    • Methylation of p16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study[J]
    • 1:CAS:528:DC%2BD1MXpvFeisbg%3D 10.1158/1078-0432.CCR-09-0580 19671846
    • J. Cao J. Zhou Y. Gao, et al. 2009 Methylation of p16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study[J] Clin Cancer Res 15 5178 5183 1:CAS:528: DC%2BD1MXpvFeisbg%3D 10.1158/1078-0432.CCR-09-0580 19671846
    • (2009) Clin Cancer Res , vol.15 , pp. 5178-5183
    • Cao, J.1    Zhou, J.2    Gao, Y.3
  • 32
    • 0034683576 scopus 로고    scopus 로고
    • A novel function for the tumor suppressor p16(INK4a): Induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor[J]
    • 1:CAS:528:DC%2BD3cXmslGmu7g%3D 10.1083/jcb.150.6.1467 10995450
    • T. Plath K. Detjen M. Welzel, et al. 2000 A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor[J] J Cell Biol 150 1467 1478 1:CAS:528:DC%2BD3cXmslGmu7g%3D 10.1083/jcb.150.6.1467 10995450
    • (2000) J Cell Biol , vol.150 , pp. 1467-1478
    • Plath, T.1    Detjen, K.2    Welzel, M.3
  • 33
    • 34548496015 scopus 로고    scopus 로고
    • INK4A-silencing augments DNA damage-induced apoptosis in cervical cancer cells
    • DOI 10.1038/sj.onc.1210405, PII 1210405
    • W. Lau T. Ho K. Hui 2007 p16INK4A-silencing augments DNA damage-induced apoptosis in cervical cancer cells[J] Oncogene 26 6050 6060 1:CAS:528: DC%2BD2sXpvFWmtb8%3D 10.1038/sj.onc.1210405 17369842 (Pubitemid 47373800)
    • (2007) Oncogene , vol.26 , Issue.41 , pp. 6050-6060
    • Lau, W.M.1    Ho, T.H.2    Hui, K.M.3
  • 34
    • 33747587608 scopus 로고    scopus 로고
    • Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
    • DOI 10.1038/nrm1987, PII NRM1987
    • J. Gil G. Peters 2006 Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all[J] Nat Rev Mol Cell Biol 7 667 677 1:CAS:528:DC%2BD28Xot12ju7o%3D 10.1038/nrm1987 16921403 (Pubitemid 44268212)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.9 , pp. 667-677
    • Gil, J.1    Peters, G.2
  • 35
    • 33645460360 scopus 로고    scopus 로고
    • Oncogenic activity of Cdc6 through repression of the INK4/ARF locus[J]
    • 1:CAS:528:DC%2BD28XivFWgtbc%3D 10.1038/nature04585 16572177
    • S. Gonzalez P. Klatt S. Delgado, et al. 2006 Oncogenic activity of Cdc6 through repression of the INK4/ARF locus[J] Nature 440 702 706 1:CAS:528:DC%2BD28XivFWgtbc%3D 10.1038/nature04585 16572177
    • (2006) Nature , vol.440 , pp. 702-706
    • Gonzalez, S.1    Klatt, P.2    Delgado, S.3
  • 36
    • 66249109644 scopus 로고    scopus 로고
    • Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence[J]
    • 10.1371/journal.pone.0005622 19462008
    • H. Agherbi A. Gaussmann-Wenger C. Verthuy, et al. 2009 Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence[J] PLoS One 4 e5622 10.1371/journal.pone.0005622 19462008
    • (2009) PLoS One , vol.4 , pp. 5622
    • Agherbi, H.1    Gaussmann-Wenger, A.2    Verthuy, C.3
  • 37
    • 33845799903 scopus 로고    scopus 로고
    • Polycomb silencing mechanisms and the management of genomic programmes
    • DOI 10.1038/nrg1981, PII NRG1981
    • Y. Schwartz V. Pirrotta 2007 Polycomb silencing mechanisms and the management of genomic programmes[J] Nat Rev Genet 8 9 22 1:CAS:528: DC%2BD28Xhtlakt7fM 10.1038/nrg1981 17173055 (Pubitemid 46006046)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.1 , pp. 9-22
    • Schwartz, Y.B.1    Pirrotta, V.2
  • 38
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • DOI 10.1038/nrc1991, PII NRC1991
    • A. Sparmann M. van Lohuizen 2006 Polycomb silencers control cell fate, development and cancer[J] Nat Rev Cancer 6 846 856 1:CAS:528:DC%2BD28XhtFWhs7bE 10.1038/nrc1991 17060944 (Pubitemid 44629896)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 846-856
    • Sparmann, A.1    Van Lohuizen, M.2
  • 39
    • 0037268947 scopus 로고    scopus 로고
    • The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing
    • DOI 10.1242/dev.00204
    • J. Brown C. Fritsch J. Mueller, et al. 2003 The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing[J] Development 130 285 294 1:CAS:528: DC%2BD3sXhtFaksLo%3D 10.1242/dev.00204 12466196 (Pubitemid 36175927)
    • (2003) Development , vol.130 , Issue.2 , pp. 285-294
    • Brown, J.L.1    Fritsch, C.2    Mueller, J.3    Kassis, J.A.4
  • 41
    • 70349952171 scopus 로고    scopus 로고
    • Role of the polycomb protein EED in the propagation of repressive histone marks[J]
    • 1:CAS:528:DC%2BD1MXhtFGjt73N 10.1038/nature08398 19767730
    • R. Margueron N. Justin K. Ohno, et al. 2009 Role of the polycomb protein EED in the propagation of repressive histone marks[J] Nature 461 762 767 1:CAS:528:DC%2BD1MXhtFGjt73N 10.1038/nature08398 19767730
    • (2009) Nature , vol.461 , pp. 762-767
    • Margueron, R.1    Justin, N.2    Ohno, K.3
  • 43
    • 78650864167 scopus 로고    scopus 로고
    • Initiation of H3K9me3 of the Ink4a locus by polycomb protein CBX7[J]
    • in press
    • Li Q, Wang X, Lu Z, et al. Initiation of H3K9me3 of the Ink4a locus by polycomb protein CBX7[J]. PLoS One 2010, in press
    • (2010) PLoS One
    • Li, Q.1    Wang, X.2    Lu, Z.3
  • 44
    • 34848812584 scopus 로고    scopus 로고
    • Polycomb Group proteins: An evolutionary perspective
    • DOI 10.1016/j.tig.2007.08.006, PII S0168952507002727
    • S. Whitcomb A. Basu C. Allis, et al. 2007 Polycomb Group proteins: an evolutionary perspective[J] Trends Genet 23 494 502 1:CAS:528:DC%2BD2sXhtFeiu7bM 10.1016/j.tig.2007.08.006 17825942 (Pubitemid 47503450)
    • (2007) Trends in Genetics , vol.23 , Issue.10 , pp. 494-502
    • Whitcomb, S.J.1    Basu, A.2    Allis, C.D.3    Bernstein, E.4
  • 45
    • 68049137611 scopus 로고    scopus 로고
    • Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation[J]
    • 1:CAS:528:DC%2BD1MXpt1Cgurc%3D 10.1158/0008-5472.CAN-09-0065 19602592
    • H.P. Mohammad Y. Cai K.M. McGarvey, et al. 2009 Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation[J] Cancer Res 69 6322 6330 1:CAS:528:DC%2BD1MXpt1Cgurc%3D 10.1158/0008-5472.CAN-09-0065 19602592
    • (2009) Cancer Res , vol.69 , pp. 6322-6330
    • Mohammad, H.P.1    Cai, Y.2    McGarvey, K.M.3
  • 46
    • 33644770293 scopus 로고    scopus 로고
    • RNAi components are required for nuclear clustering of polycomb group response elements
    • DOI 10.1016/j.cell.2006.01.036, PII S0092867406001711
    • C. Grimaud F. Bantignies M. Pal-Bhadra, et al. 2006 RNAi components are required for nuclear clustering of Polycomb group response elements[J] Cell 124 957 971 1:CAS:528:DC%2BD28XislyjtbY%3D 10.1016/j.cell.2006.01.036 16530043 (Pubitemid 43344236)
    • (2006) Cell , vol.124 , Issue.5 , pp. 957-971
    • Grimaud, C.1    Bantignies, F.2    Pal-Bhadra, M.3    Ghana, P.4    Bhadra, U.5    Cavalli, G.6
  • 47
    • 33645231102 scopus 로고    scopus 로고
    • Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin[J]
    • 1:CAS:528:DC%2BD28XivFSrsbo%3D 10.1128/MCB.26.7.2560-2569.2006 16537902
    • E. Bernstein E.M. Duncan O. Masui, et al. 2006 Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin[J] Mol Cell Biol 26 2560 2569 1:CAS:528: DC%2BD28XivFSrsbo%3D 10.1128/MCB.26.7.2560-2569.2006 16537902
    • (2006) Mol Cell Biol , vol.26 , pp. 2560-2569
    • Bernstein, E.1    Duncan, E.M.2    Masui, O.3
  • 48
    • 38049155825 scopus 로고    scopus 로고
    • Epigenetic silencing of tumor suppressor gene p15 by its antisense RNA[J]
    • 1:CAS:528:DC%2BD1cXksVGgtw%3D%3D 10.1038/nature06468 18185590
    • W. Yu D. Gius P. Onyango, et al. 2008 Epigenetic silencing of tumor suppressor gene p15 by its antisense RNA[J] Nature 451 202 206 1:CAS:528:DC%2BD1cXksVGgtw%3D%3D 10.1038/nature06468 18185590
    • (2008) Nature , vol.451 , pp. 202-206
    • Yu, W.1    Gius, D.2    Onyango, P.3
  • 49
    • 67649540498 scopus 로고    scopus 로고
    • NcRNA transcription makes its mark[J]
    • 1:CAS:528:DC%2BD1MXotlSnsLc%3D 10.1038/emboj.2009.136 19532144
    • G. Hartzog J. Martens 2009 ncRNA transcription makes its mark[J] EMBO J 28 1679 1680 1:CAS:528:DC%2BD1MXotlSnsLc%3D 10.1038/emboj.2009.136 19532144
    • (2009) EMBO J , vol.28 , pp. 1679-1680
    • Hartzog, G.1    Martens, J.2
  • 50
    • 77953096072 scopus 로고    scopus 로고
    • Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a[J]
    • 1:CAS:528:DC%2BC3cXotFGkt7Y%3D 10.1016/j.molcel.2010.03.021 20541999
    • K.L. Yap S. Li A.M. Muñoz-Cabello, et al. 2010 Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a[J] Mol Cell 38 662 674 1:CAS:528:DC%2BC3cXotFGkt7Y%3D 10.1016/j.molcel.2010.03.021 20541999
    • (2010) Mol Cell , vol.38 , pp. 662-674
    • Yap, K.L.1    Li, S.2    Muñoz-Cabello, A.M.3
  • 51
    • 0035834382 scopus 로고    scopus 로고
    • Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene
    • DOI 10.1126/science.1065683
    • S. Petruk Y. Sedkov S. Smith, et al. 2001 Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene[J] Science 294 1331 1334 1:CAS:528:DC%2BD3MXotlKmtLY%3D 10.1126/science.1065683 11701926 (Pubitemid 33063097)
    • (2001) Science , vol.294 , Issue.5545 , pp. 1331-1334
    • Petruk, S.1    Sedkov, Y.2    Smith, S.3    Tillib, S.4    Kraevski, V.5    Nakamura, T.6    Canaani, E.7    Croce, C.M.8    Mazo, A.9
  • 52
    • 59049083922 scopus 로고    scopus 로고
    • Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression[J]
    • 1:CAS:528:DC%2BD1MXhsFyju7w%3D 10.1073/pnas.0809669106 19144915
    • M. Tariq U. Nussbaumer Y. Chen, et al. 2009 Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression[J] Proc Natl Acad Sci USA 106 1157 1162 1:CAS:528:DC%2BD1MXhsFyju7w%3D 10.1073/pnas.0809669106 19144915
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1157-1162
    • Tariq, M.1    Nussbaumer, U.2    Chen, Y.3
  • 53
    • 43249130490 scopus 로고    scopus 로고
    • SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus
    • DOI 10.1128/MCB.02019-07
    • S. Kia M. Gorski S. Giannakopoulos, et al. 2008 SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus[J] Mol Cell Biol 28 3457 3464 1:CAS:528:DC%2BD1cXlvFeqs7g%3D 10.1128/MCB.02019-07 18332116 (Pubitemid 351657107)
    • (2008) Molecular and Cellular Biology , vol.28 , Issue.10 , pp. 3457-3464
    • Kia, S.K.1    Gorski, M.M.2    Giannakopoulos, S.3    Verrijzer, C.P.4
  • 54
    • 61349113967 scopus 로고    scopus 로고
    • Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle[J]
    • 1:CAS:528:DC%2BD1MXjsFWgt7s%3D 10.1111/j.1742-4658.2009.06895.x 19220463
    • B. Mishra K. Ansari S. Mandal 2009 Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle[J] FEBS J 276 1629 1640 1:CAS:528:DC%2BD1MXjsFWgt7s%3D 10.1111/j.1742-4658.2009. 06895.x 19220463
    • (2009) FEBS J , vol.276 , pp. 1629-1640
    • Mishra, B.1    Ansari, K.2    Mandal, S.3
  • 56
    • 14044264220 scopus 로고    scopus 로고
    • A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes
    • DOI 10.1128/MCB.25.5.1891-1899.2005
    • W. Krajewski T. Nakamura A. Mazo, et al. 2005 A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes[J] Mol Cell Biol 25 1891 1899 1:CAS:528:DC%2BD2MXhvFGqtL4%3D 10.1128/MCB.25.5.1891-1899.2005 15713643 (Pubitemid 40280152)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.5 , pp. 1891-1899
    • Krajewski, W.A.1    Nakamura, T.2    Mazo, A.3    Canaani, E.4
  • 57
    • 33846444355 scopus 로고    scopus 로고
    • Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2′-deoxycytidine treatment
    • DOI 10.1158/0008-5472.CAN-06-2845
    • G. Egger A.M. Aparicio S.G. Escobar, et al. 2007 Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2-deoxycytidine treatment[J] Cancer Res 67 346 353 1:CAS:528:DC%2BD2sXisFSrug%3D%3D 10.1158/0008-5472.CAN-06-2845 17210717 (Pubitemid 46142794)
    • (2007) Cancer Research , vol.67 , Issue.1 , pp. 346-353
    • Egger, G.1    Aparicio, A.M.2    Escobar, S.G.3    Jones, P.A.4


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