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note
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Control experiments showed no difference in yield of the reaction when racemic BINAP was used instead of (R)-BINAP. The chiral ligand was only used as large amounts were available in our lab.
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27
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78650901658
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note
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For mechanistic studies illustrating the role of bidentate phosphine ligands in C-N cross-coupling reactions, see for example
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78650894947
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note
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Though variations in the temperature only led to a moderate decrease in yield, a switch from toluene to dioxane completely inhibited product formation.
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78650863123
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note
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2-Methyl-1-phenyl-1H-benzoimidazol-5-carboxylic acid methyl ester was prepared on a 5-g scale from 4-chloro-3-nitrobenzoic acid methyl ester and phenylacetamide.
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