A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors

Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2001, Pages 851-856

  Robl, J A ^a   Sulsky, R ^a   Sun, C Q ^a   Simpkins, L M ^a   Wang, T ^a   Dickson Jr , J K ^a   Chen, Y ^a   Magnin, D R ^a   Taunk, P ^a   Slusarchyk, W A ^a   Biller, S A ^a   Lan, S J ^a   Connolly, F ^a   Kunselman, L K ^a   Sabrah, T ^a   Jamil, H ^a   Gordon, D ^a   Harrity, T W ^a   Wetterau, J R ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 [4 [2,5 DIMETHYL 4 [[[4' (TRIFLUOROMETHYL)[1,1' BIPHENYL] 2 YL]CARBONYL]AMINO] 1H BENZIMIDAZOL 1 YL]BUTYL] N (2,2,2 TRIFLUOROETHYL) 9H FLUORENE 9 CARBOXAMIDE; BENZIMIDAZOLE DERIVATIVE; BMS 201038; BMS 212122; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HAMSTER; LIPOPROTEIN BLOOD LEVEL; MONKEY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRIACYLGLYCEROL BLOOD LEVEL;

ADMINISTRATION, ORAL; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTILIPEMIC AGENTS; APOLIPOPROTEINS B; BENZIMIDAZOLES; BIOLOGICAL AVAILABILITY; CARRIER PROTEINS; CELL LINE; CHOLESTEROL; CRICETINAE; FLUORENES; HUMANS; LIPOPROTEINS, LDL; MACACA FASCICULARIS; MICROSOMES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

EID: 0035866584     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000494a     Document Type: Article

References (7)

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