A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency

Molecular Nutrition and Food Research

Volumn 55, Issue 1, 2011, Pages 96-108

  Schwalfenberg, Gerry K ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cathelicidin; Defensins; Epithelial barrier; Innate immunity; Vitamin D

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE BINDING PROTEIN; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; DEFENSIN; VITAMIN D;

DIET SUPPLEMENTATION; EYE DISEASE; GASTROINTESTINAL DISEASE; HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PATHOPHYSIOLOGY; PERIODONTAL DISEASE; RESPIRATORY TRACT INFECTION; REVIEW; SKIN DISEASE; UROGENITAL SYSTEM; VITAMIN D DEFICIENCY;

ANTIMICROBIAL CATIONIC PEPTIDES; DEFENSINS; DIETARY SUPPLEMENTS; EYE DISEASES; GASTROINTESTINAL DISEASES; HUMANS; IMMUNE SYSTEM; IMMUNITY, INNATE; PERIODONTAL DISEASES; RESPIRATORY TRACT INFECTIONS; SKIN DISEASES; UROGENITAL SYSTEM; VITAMIN D; VITAMIN D DEFICIENCY;

BACTERIA (MICROORGANISMS);

EID: 78650883355     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000174     Document Type: Review

References (142)

1. Holick, M. F., Chen, T. C., Vitamin D deficiency: a worldwide problem with health consequences. Am. J. Clin. Nutr. 2008, 87, 1080S-1086S.
2. Schwalfenberg, G., Not enough vitamin D: health consequences for Canadians. Can. Fam. Physician 2007, 53, 841-854.
3. Genuis, S. J., Schwalfenberg, G. K., Hiltz, M. N., Vaselenak, S. A., Vitamin D status of clinical practice populations at higher latitudes: analysis and applications. Int. J. Environ. Res. Public Health 2009, 6, 151-173.
4. Holick, M. F., Resurrection of vitamin D deficiency and rickets. J. Clin. Invest. 2006, 116, 2062-2072.
5. Holick, M. F., High prevalence of vitamin D inadequacy and implications for health. Mayo Clin. Proc. 2006, 81, 353-373.
6. Hewison, M., Zehnder, D., Chakraverty, R., Adams, J. S., Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. Mol. Cell. Endocrinol. 2004, 215, 31-38.
7. Norman, A. W., From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am. J. Clin. Nutr. 2008, 88, 491S-499S.
8. Hewison, M., Vitamin D and innate immunity. Curr. Opin. Investig. Drugs 2008, 9, 485-490.
9. Adams, J. S., Hewison, M., Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat. Clin. Pract. Endocrinol. Metab. 2008, 4, 80-90.
10. White, J. H., Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect. Immun. 2008, 76, 3837-3843.
11. Clairmont, A., Tessman, D., Stock, A., Nicolai, S. et al., Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor. Carcinogenesis 1996, 17, 1389-1391.
12. Gniadecki, R., Gajkowska, B., Hansen, M., 1, 25-dihydroxyvitamin D3 stimulates the assembly of adherens junctions in keratinocytes: involvement of protein kinase C. Endocrinology 1997, 138, 2241-2248.
13. Palmer, H. G., Gonzalez-Sancho, J. M., Espada, J., Berciano, M. T. et al., Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J. Cell. Biol. 2001, 154, 369-387.
14. Chun, R. F., Adams, J. S., Hewison, M., Back to the future: a new look at 'old' vitamin D. J. Endocrinol. 2008, 198, 261-269.
15. Wang, T. T., Nestel, F. P., Bourdeau, V., Nagai, Y. et al., Cutting edge: 1, 25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J. Immunol. 2004, 173, 2909-2912.
16. Hewison, M., Burke, F., Evans, K. N., Lammas, D. A. et al., Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J. Steroid Biochem. Mol. Biol. 2007, 103, 316-321.
17. Yim, S., Dhawan, P., Ragunath, C., Christakos, S., Diamond, G., Induction of cathelicidin in normal and CF bronchial epithelial cells by 1, 25-dihydroxyvitamin D(3). J. Cyst. Fibros. 2007, 6, 403-410.
18. Chromek, M., Slamova, Z., Bergman, P., Kovacs, L. et al., The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat. Med. 2006, 12, 636-641.
19. Weber, G., Heilborn, J. D., Chamorro Jimenez, C. I., Hammarsjo, A. et al., Vitamin D induces the antimicrobial protein hCAP18 in human skin. J. Invest. Dermatol. 2005, 124, 1080-1082.
20. Gombart, A. F., Borregaard, N., Koeffler, H. P., Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyvitamin D3. FASEB J. 2005, 19, 1067-1077.
21. Komatsuzawa, H., Ouhara, K., Yamada, S., Fujiwara, T. et al., Innate defences against methicillin-resistant Staphylococcus aureus (MRSA) infection. J. Pathol. 2006, 208, 249-260.
22. Klotman, M. E., Chang, T. L., Defensins in innate antiviral immunity. Nat. Rev. Immunol. 2006, 6, 447-456.
23. Lopez-Garcia, B., Lee, P. H., Yamasaki, K., Gallo, R. L., Anti-fungal activity of cathelicidins and their potential role in Candida albicans skin infection. J. Invest. Dermatol. 2005, 125, 108-115.
24. Medzhitov, R., Toll-like receptors and innate immunity. Nat. Rev. Immunol. 2001, 1, 135-145.
25. Niyonsaba, F., Nagaoka, I., Ogawa, H., Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties. Crit. Rev. Immunol. 2006, 26, 545-576.
26. Otte, J. M., Zdebik, A. E., Brand, S., Chromik, A. M. et al., Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity. Regul. Pept. 2009, 156, 104-117.
27. Niyonsaba, F., Ogawa, H., Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme. J. Dermatol. Sci. 2005, 40, 157-168.
28. Zheng, Y., Niyonsaba, F., Ushio, H., Nagaoka, I. et al., Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils. Br. J. Dermatol. 2007, 157, 1124-1131.
29. Chen, X., Niyonsaba, F., Ushio, H., Okuda, D. et al., Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J. Dermatol. Sci. 2005, 40, 123-132.
30. Nijnik, A., Hancock, R. E., The roles of cathelicidin LL-37 in immune defences and novel clinical applications. Curr. Opin. Hematol. 2009, 16, 41-47.
31. Cohen, M. S., Mesler, D. E., Snipes, R. G., Gray, T. K., 1, 25-Dihydroxyvitamin D3 activates secretion of hydrogen peroxide by human monocytes. J. Immunol. 1986, 136, 1049-1053.
32. Heilborn, J. D., Nilsson, M. F., Kratz, G., Weber, G. et al., The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. J. Invest. Dermatol. 2003, 120, 379-389.
33. Heilborn, J. D., Weber, G., Gronberg, A., Dieterich, C., Stahle, M., Topical treatment with the vitamin D analogue calcipotriol enhances the upregulation of the antimicrobial protein hCAP18/LL-37 during wounding in human skin in vivo. Exp. Dermatol. 2010, 19, 332-338.
34. von Essen, M. R., Kongsback, M., Schjerling, P., Olgaard, K. et al., Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat. Immunol. 2010, 11, 344-349.
35. Hewison, M., Freeman, L., Hughes, S. V., Evans, K. N. et al., Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. J. Immunol. 2003, 170, 5382-5390.
36. Cantorna, M. T., Yu, S., Bruce, D., The paradoxical effects of vitamin D on type 1 mediated immunity. Mol. Aspects Med. 2008, 29, 369-375.
37. Bion, E. R., Mean annual hours of sunshine and the incidence of dental caries. Am. J. Public Health 1939, 29, 777-780.
38. Kaiser, H., East, B. R., Relation of dental caries in rural children to sex, age and environment. Am. J. Dis. Child. 1940, 60, 1289-1303.
39. Rozier, R. G., The prevalence and severity of enamel fluorosis in North American children. J. Public Health Dent. 1999, 59, 239-246.
40. Clark, D. C., Trends in prevalence of dental fluorosis in North America. Community Dent. Oral Epidemiol. 1994, 22, 148-152.
41. Hargreaves, J. A., Thompson, G. W., Ultraviolet light and dental caries in children. Caries Res. 1989, 23, 389-392.
42. McBeath, E. C., Zucker, T. F., The role of vitamin D in the control dental caries. Am. J. Public Health 1938, 15, 547-564.
43. Krall, E. A., Osteoporosis and the risk of tooth loss. Clin. Calcium 2006, 16, 287-290.
44. Krall, E. A., Wehler, C., Garcia, R. I., Harris, S. S., Dawson-Hughes, B., Calcium and vitamin D supplements reduce tooth loss in the elderly. Am. J. Med. 2001, 111, 452-456.
45. Dietrich, T., Joshipura, K. J., Dawson-Hughes, B., Bischoff-Ferrari, H. A., Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Am. J. Clin. Nutr. 2004, 80, 108-113.
46. Lee, S. H., Jun, H. K., Lee, H. R., Chung, C. P., Choi, B. K., Antibacterial and lipopolysaccharide (LPS)-neutralising activity of human cationic antimicrobial peptides against periodontopathogens. Int. J. Antimicrob. Agents 2010, 35, 138-145.
47. Cosseau, C., Devine, D. A., Dullaghan, E., Gardy, J. L. et al., The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis. Infect. Immun. 2008, 76, 4163-4175.
48. Fanali, C., Inzitari, R., Cabras, T., Pisano, E. et al., Alpha-defensin levels in whole saliva of totally edentulous subjects. Int. J. Immunopathol. Pharmacol. 2008, 21, 845-849.
49. Sun, L., Finnegan, C. M., Kish-Catalone, T., Blumenthal, R. et al., Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. J. Virol. 2005, 79, 14318-14329.
50. Robyn, R. L., Robert, J. M., John, D. R., Pucker up: the effects of sour candy on your patients' oral health. A review of the dental erosion literature and pH values for popular candies. Northwest Dent. 2008, 87, 20-21, 4-5, 8-9 passim.
51. Falco, M. A., The lifetime impact of sugar excess and nutrient depletion on oral health. Gen. Dent. 2001, 49, 591-595.
52. Wehkamp, J., Schauber, J., Stange, E. F., Defensins and cathelicidins in gastrointestinal infections. Curr. Opin. Gastroenterol. 2007, 23, 32-38.
53. Tollin, M., Bergman, P., Svenberg, T., Jornvall, H. et al., Antimicrobial peptides in the first line defence of human colon mucosa. Peptides 2003, 24, 523-530.
54. Bruce, M. G., Maaroos, H. I., Epidemiology of Helicobacter pylori infection. Helicobacter 2008, 13, 1-6.
55. Hase, K., Murakami, M., Iimura, M., Cole, S. P. et al., Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology 2003, 125, 1613-1625.
56. George, J. T., Boughan, P. K., Karageorgiou, H., Bajaj-Elliott, M., Host anti-microbial response to Helicobacter pylori infection. Mol. Immunol. 2003, 40, 451-456.
57. Nasri, H., Baradaran, A., The influence of serum 25-hydroxy vitamin D levels on Helicobacter pylori infections in patients with end-stage renal failure on regular hemodialysis. Saudi J. Kidney Dis. Transpl. 2007, 18, 215-219.
58. Kawaura, A., Inhibitory effect of long term 1α-hydroxyvitamin D3 administration on Helicobacter pylori infection. J. Clin. Biochem. Nutr. 2006, 38, 103-106.
59. Liu, N., Nguyen, L., Chun, R. F., Lagishetty, V. et al., Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology 2008, 149, 4799-4808.
60. Wang, T. T., Dabbas, B., Laperriere, D., Bitton, A. J. et al., Direct and indirect induction by 1, 25-dihydroxyvitamin D3 of the NOD2/CARD15-beta defensin 2 innate immune pathway defective in Crohn&apos, s disease. J. Biol. Chem. 2010, 285, 2227-2231.
61. Hugot, J. P., Chamaillard, M., Zouali, H., Lesage, S. et al., Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001, 411, 599-603.
62. Lim, W. C., Hanauer, S. B., Li, Y. C., Mechanisms of disease: vitamin D and inflammatory bowel disease. Nat. Clin. Pract. Gastroenterol. Hepatol. 2005, 2, 308-315.
63. Petta, S., Camma, C., Scazzone, C., Tripodo, C. et al., Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C. Hepatology 2010, 51, 1158-1167.
64. Abu-Mouch, S., Abstract LB20. 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD. 2009). The Liver Meeting 2009.
65. Wayse, V., Yousafzai, A., Mogale, K., Filteau, S., Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur. J. Clin. Nutr. 2004, 58, 563-567.
66. Janssens, W., Bouillon, R., Claes, B., Carremans, C. et al., Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D binding gene. Thorax 2010, 65, 215-220.
67. Herr, C., Beisswenger, C., Hess, C., Kandler, K. et al., Suppression of pulmonary innate host defence in smokers. Thorax 2009, 64, 144-149.
68. Banajeh, S. M., Nutritional rickets and vitamin D deficiency - association with the outcomes of childhood very severe pneumonia: a prospective cohort study. Pediatr. Pulmonol. 2009, 44, 1207-1215.
69. Litonjua, A. A., Childhood asthma may be a consequence of vitamin D deficiency. Curr. Opin. Allergy Clin. Immunol. 2009, 9, 202-207.
70. Sutherland, E. R., Goleva, E., Jackson, L. P., Stevens, A. D., Leung, D. Y., Vitamin D levels, lung function and steroid response in adult asthma. Am. J. Respir. Crit. Care Med. 2010, 181, 699-704.
71. Grant, W. B., The roles of vitamin D, temperature, and viral infections in seasonal risk of acquiring asthma. Am. J. Respir. Crit. Care Med. 2009, 179, 1072, author reply -3.
72. Hope-Simpson, R. E., The role of season in the epidemiology of influenza. J. Hyg. (Lond). 1981, 86, 35-47.
73. Cannell, J. J., Vieth, R., Umhau, J. C., Holick, M. F. et al., Epidemic influenza and vitamin D. Epidemiol. Infect. 2006, 134, 1129-1140.
74. White, M. R., Helmerhorst, E. J., Ligtenberg, A., Karpel, M. et al., Multiple components contribute to ability of saliva to inhibit influenza viruses. Oral Microbiol. Immunol. 2009, 24, 18-24.
75. Hansdottir, S., Monick, M. M., Hinde, S. L., Lovan, N. et al., Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J. Immunol. 2008, 181, 7090-7099.
76. Kota, S., Sabbah, A., Chang, T. H., Harnack, R. et al., Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappaB-mediated innate antiviral response against human respiratory syncytial virus. J. Biol. Chem. 2008, 283, 22417-22429.
77. Proud, D., Sanders, S. P., Wiehler, S., Human rhinovirus infection induces airway epithelial cell production of human beta-defensin 2 both in vitro and in vivo. J. Immunol. 2004, 172, 4637-4645.
78. Aloia, J. F., Li-Ng, M., Re: epidemic influenza and vitamin D. Epidemiol. Infect. 2007, 135, 1095-1096, author reply 7-8.
79. Li-Ng, M., Aloia, J. F., Pollack, S., Cunha, B. A. et al., A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections. Epidemiol. Infect. 2009, 137, 1396-1404.
80. Urashima, M., Segawa, T., Okazaki, M., Kurihara, M. et al., Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am. J. Clin. Nutr. 2010, 91, 1255-1260.
81. Golec, M., Cathelicidin LL-37: LPS-neutralizing, pleiotropic peptide. Ann. Agric. Environ. Med. 2007, 14, 1-4.
82. Hughes, D. A., Norton, R., Vitamin D and respiratory health. Clin. Exp. Immunol. 2009, 158, 20-25.
83. Glaziou, P., Floyd, K., Raviglione, M., Global burden and epidemiology of tuberculosis. Clin. Chest Med. 2009, 30, 621-636, vii.
84. Zager, E. M., McNerney, R., Multidrug-resistant tuberculosis. Biomed. Chromatogr. Infect. Dis. 2008, 8, 10.
85. Fabri, M., Modlin, R. L., A vitamin for autophagy. Cell. Host Microbe 2009, 6, 201-203.
86. Liu, P. T., Stenger, S., Tang, D. H., Modlin, R. L., Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J. Immunol. 2007, 179, 2060-2063.
87. Waters, W. R., Nonnecke, B. J., Rahner, T. E., Palmer, M. V. et al., Modulation of Mycobacterium bovis-specific responses of bovine peripheral blood mononuclear cells by 1, 25-dihydroxyvitamin D(3). Clin. Diagn. Lab Immunol. 2001, 8, 1204-1212.
88. Holick, M. F., Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am. J. Clin. Nutr. 2004, 80, 1678S-1688S.
89. Nursyam, E. W., Amin, Z., Rumende, C. M., The effect of vitamin D as supplementary treatment in patients with moderately advanced pulmonary tuberculous lesion. Acta Med. Indones. 2006, 38, 3-5.
90. Wejse, C., Gomes, V. F., Rabna, P., Gustafson, P. et al., Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. Am. J. Respir. Crit. Care Med. 2009, 179, 843-850.
91. Allsworth, J. E., Peipert, J. F., Prevalence of bacterial vaginosis: 2001-2004 National Health and Nutrition Examination Survey data. Obstet. Gynecol. 2007, 109, 114-120.
92. Svare, J. A., Schmidt, H., Hansen, B. B., Lose, G., Bacterial vaginosis in a cohort of Danish pregnant women: prevalence and relationship with preterm delivery, low birthweight and perinatal infections. Br. J. Obstet. Gynecol. 2006, 113, 1419-1425.
93. Davis, L. M., Chang, S. C., Mancini, J., Nathanson, M. S. et al., Vitamin D insufficiency is prevalent among pregnant African American adolescents. J. Pediatr. Adolesc. Gynecol. 2010, 23, 45-52.
94. Bodnar, L. M., Krohn, M. A., Simhan, H. N., Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J. Nutr. 2009, 139, 1157-1161.
95. Venkataraman, N., Cole, A. L., Svoboda, P., Pohl, J., Cole, A. M., Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid. J. Immunol. 2005, 175, 7560-7567.
96. Sorensen, O. E., Gram, L., Johnsen, A. H., Andersson, E. et al., Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina. J. Biol. Chem. 2003, 278, 28540-28546.
97. Mueller, N. J., Fux, C. A., Ledergerber, B., Elzi, L. et al., High prevalence of severe vitamin D deficiency in combined antiretroviral therapy-naive and successfully treated Swiss HIV patients. AIDS 2010, 24, 1127-1134.
98. Van Den Bout-Van Den Beukel, C. J., Fievez, L., Michels, M., Sweep, F. C. et al., Vitamin D deficiency among HIV type 1-infected individuals in the Netherlands: effects of antiretroviral therapy. AIDS Res. Hum. Retroviruses 2008, 24, 1375-1382.
99. Bergman, P., Walter-Jallow, L., Broliden, K., Agerberth, B., Soderlund, J., The antimicrobial peptide LL-37 inhibits HIV-1 replication. Curr. HIV Res. 2007, 5, 410-415.
100. Conner, R. I., Rigby, W. F., 1 Alpha, 25-dihydroxyvitamin D3 inhibits productive infection of human monocytes by HIV-1. Biochem. Biophys. Res. Commun. 1991, 176, 852-859.
101. Kizaki, M., Ikeda, Y., Simon, K. J., Nanjo, M., Koeffler, H. P., Effect of 1, 25-dihydroxyvitamin D3 and its analogs on human immunodeficiency virus infection in monocytes/macrophages. Leukemia 1993, 7, 1525-1530.
102. Meyer-Hoffert, U., Schwarz, T., Schroder, J. M., Glaser, R., Expression of human beta-defensin-2 and -3 in verrucae vulgares and condylomata acuminata. J. Eur. Acad. Dermatol. Venereol. 2008, 22, 1050-1054.
103. Conner, K., Nern, K., Rudisill, J., O'Grady, T., Gallo, R. L., The antimicrobial peptide LL-37 is expressed by keratinocytes in condyloma acuminatum and verruca vulgaris. J. Am. Acad. Dermatol. 2002, 47, 347-350.
104. Jeevan, A., Ullrich, S. E., De Gracia, M., Shah, R., Sun, Y., Mechanism of UVB-induced suppression of the immune response to Mycobacterium bovis bacillus Calmette-Guerin: role of cytokines on macrophage function. Photochem. Photobiol. 1996, 64, 259-266.
105. Schwalfenberg, G., Genuis, S., Vitamin D supplementation in a nursing home population. Mol. Nutr. Food Res.. 2010 (in press).
106. Etzioni, A., Hochberg, Z., Pollak, S., Meshulam, T. et al., Defective leukocyte fungicidal activity in end-organ resistance to 1, 25-dihydroxyvitamin D. Pediatr Res. 1989, 25, 276-279.
107. Carretero, M., Escamez, M. J., Garcia, M., Duarte, B. et al., In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37. J. Invest. Dermatol. 2008, 128, 223-236.
108. Bhat, S., Milner, S., Antimicrobial peptides in burns and wounds. Curr. Protein Pept. Sci. 2007, 8, 506-520.
109. Bischoff-Ferrari, H. A., Dawson-Hughes, B., Platz, A., Orav, E. J. et al., Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial. Arch. Intern. Med. 2010, 170, 813-820.
110. Frohm, M., Agerberth, B., Ahangari, G., Stahle-Backdahl, M. et al., The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J. Biol. Chem. 1997, 272, 15258-15263.
111. Braff, M. H., Zaiou, M., Fierer, J., Nizet, V., Gallo, R. L., Keratinocyte production of cathelicidin provides direct activity against bacterial skin pathogens. Infect. Immun. 2005, 73, 6771-6781.
112. Murakami, M., Ohtake, T., Dorschner, R. A., Schittek, B. et al., Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin. J. Invest. Dermatol. 2002, 119, 1090-1095.
113. Dorschner, R. A., Pestonjamasp, V. K., Tamakuwala, S., Ohtake, T. et al., Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. J. Invest. Dermatol. 2001, 117, 91-97.
114. Johansson, J., Gudmundsson, G. H., Rottenberg, M. E., Berndt, K. D., Agerberth, B., Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J. Biol. Chem. 1998, 273, 3718-3724.
115. Di Nardo, A., Yamasaki, K., Dorschner, R. A., Lai, Y., Gallo, R. L., Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin. J. Immunol. 2008, 180, 7565-7573.
116. Gibbs, S., Backendorf, C., Ponec, M., Regulation of keratinocyte proliferation and differentiation by all-trans-retinoic acid, 9-cis-retinoic acid and 1, 25-dihydroxy vitamin D3. Arch. Dermatol. Res. 1996, 288, 729-738.
117. Kaur, I., Saraswat, A., Kumar, B., Comparison of calcipotriol and coal tar in conjunction with sun exposure in chronic plaque psoriasis: a pilot study. J. Dermatol. 2001, 28, 448-450.
118. Henseler, T., Christophers E. Disease concomitance in psoriasis. J. Am. Acad. Dermatol. 1995, 32, 982-986.
119. Howell, M. D., Jones, J. F., Kisich, K. O., Streib, J. E. et al., Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum. J. Immunol. 2004, 172, 1763-1767.
120. Leung, D. Y., Infection in atopic dermatitis. Curr. Opin. Pediatr. 2003, 15, 399-404.
121. Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I. et al., Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 2002, 347, 1151-1160.
122. Egawa, K., Topical vitamin D3 derivatives in treating hyperkeratotic palmoplantar eczema: a report of five patients. J. Dermatol. 2005, 32, 381-386.
123. Hata, T. R., Kotol, P., Jackson, M., Nguyen, M. et al., Administration of oral vitamin D induces cathelicidin production in atopic individuals. J. Allergy Clin. Immunol. 2008, 122, 829-831.
124. Jury, C. S., McHenry, P., Burden, A. D., Lever, R., Bilsland, D., Narrowband ultraviolet B (UVB) phototherapy in children. Clin. Exp. Dermatol. 2006, 31, 196-199.
125. Yamasaki, K., Di Nardo, A., Bardan, A., Murakami, M. et al., Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat. Med. 2007, 13, 975-980.
126. Acharya, M. R., Venitz, J., Figg, W. D., Sparreboom, A., Chemically modified tetracyclines as inhibitors of matrix metalloproteinases. Drug Resist. Updat. 2004, 7, 195-208.
127. Schauber, J., Gallo, R. L., Antimicrobial peptides and the skin immune defense system. J. Allergy Clin. Immunol. 2009, 124, R13-R18.
128. Kalayciyan, A., Oguz, O., Bahar, H., Torun, M. M., Aydemir, E. H., In vitro bactericidal effect of low-dose ultraviolet B in patients with acne. J. Eur. Acad. Dermatol. Venereol. 2002, 16, 642-643.
129. Asgari, M. M., Tang, J., Warton, M. E., Chren, M. M. et al., Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma. J. Invest. Dermatol. 2010, 130, 1438-1443.
130. Shnitkind, E., Yaping, E., Geen, S., Shalita, A. R., Lee, W. L., Anti-inflammatory properties of narrow-band blue light. J. Drugs Dermatol. 2006, 5, 605-610.
131. Rodland, O., Aksnes, L., Nilsen, A., Morken, T., Serum levels of vitamin D metabolites in isotretinoin-treated acne patients. Acta Derm. Venereol. 1992, 72, 217-219.
132. Otremski, I., Lev-Ran, M., Salama, R., Edelstein, S., The metabolism of vitamin D3 in response to testosterone. Calcif. Tissue Int. 1997, 60, 485-487.
133. McDermott, A. M., The role of antimicrobial peptides at the ocular surface. Ophthalmic Res. 2009, 41, 60-75.
134. Overhage, J., Campisano, A., Bains, M., Torfs, E. C. et al., Human host defense peptide LL-37 prevents bacterial biofilm formation. Infect. Immun. 2008, 76, 4176-4182.
135. Wu, M., McClellan, S. A., Barrett, R. P., Zhang, Y., Hazlett, L. D., Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis. J. Immunol. 2009, 183, 8054-8060.
136. Li, Q., Kumar, A., Gui, J. F., Yu, F. S., Staphylococcus aureus lipoproteins trigger human corneal epithelial innate response through toll-like receptor-2. Microb. Pathog. 2008, 44, 426-434.
137. Grant, W. B., Cross, H. S., Garland, C. F., Gorham, E. D. et al., Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe. Prog. Biophys. Mol. Biol. 2009, 99, 104-113.
138. Mookherjee, N., Rehaume, L. M., Hancock, R. E., Cathelicidins and functional analogues as antisepsis molecules. Expert Opin. Ther. Targets 2007, 11, 993-1004.
139. Jeng, L., Yamshchikov, A. V., Judd, S. E., Blumberg, H. M. et al., Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J. Transl. Med. 2009, 7, 28.
140. Wigg, A. E., Prest, C., Slobodian, P., Need, A. G., Cleland, L. G., A system for improving vitamin D nutrition in residential care. Med. J. Aust. 2006, 185, 195-198.
141. Hathcock, J. N., Shao, A., Vieth, R., Heaney, R., Risk assessment for vitamin D. Am. J. Clin. Nutr. 2007, 85, 6-18.
142. Sanders, K. M., Stuart, A. L., Williamson, E. J., Simpson, J. A. et al., Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. J. Am. Med. Assoc. 2010, 303, 1815-1822.