A new, lineage specific, autoup-regulation mechanism for human glucocorticoid receptor gene expression in 697 pre-b-acute lymphoblastic leukemia cells

Molecular Endocrinology

Volumn 25, Issue 1, 2011, Pages 44-57

  Geng, Chuan Dong ^a   Vedeckis, Wayne V ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; PROTEIN C MYB; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR SPL B; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOREGULATION; BINDING AFFINITY; CELL ACTIVATION; CELL LINEAGE; CELL SPECIFICITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMIA CELL LINE; MEDIATOR; ONCOGENE C MYB; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION;

APOPTOSIS; BASE SEQUENCE; CELL LINEAGE; CHROMATIN IMMUNOPRECIPITATION; DEXAMETHASONE; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MYB; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; TRANSCRIPTION FACTORS; UP-REGULATION;

GRUS;

EID: 78650861866     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2010-0249     Document Type: Article

References (38)

1. Pui CH, Robison LL, Look AT 2008 Acute lymphoblastic leukaemia. Lancet 371: 1030-1043
2. Pui CH 2009 Acute lymphoblastic leukemia: Introduction. Semin Hematol 46: 1-2
3. Nanni P, Nicoletti G, Prodi G, Galli MC, De Giovanni C, Grilli S, Lollini PL, Gobbi M, Cavo M, Tura S 1982 Glucocorticoid receptor and in vitro sensitivity to steroid hormones in human lymphoproliferative diseases and myeloid leukemia. Cancer 49: 623-632
4. Gaynon PS, Carrel, AL 1999 Glucocorticosteroid therapy in childhood acute lymphoblastic leukemia. Adv Exp Med Biol 457: 593-605
5. Pui CH, Evans, WE 2006 Treatment of acute lymphoblastic leukemia. N Engl J Med 354: 166-178
6. Ploner C, Schmidt S, Presul E, Renner K, Schröcksnadel K, Rainer J, Riml S, Kofler R 2005 Glucocorticoid-induced apoptosis and glucocorticoid resistance in acute lymphoblastic leukemia. J Steroid Biochem Mol Biol 93: 153-160
7. Schmidt S, Rainer J, Ploner C, Presul E, Riml S, Kofler R 2004 Glucocorticoid-induced apoptosis and glucocorticoid resistance: Molecular mechanisms and clinical relevance. Cell Death Differ- (Suppl 1): S45-S55
8. Haarman EG, Kaspers, GJ, Veerman, AJ 2003 Glucocorticoid resistance in childhood leukaemia: Mechanisms and modulation. Br J Haematol 120: 919-929
9. Margolin JF, Steuber CP, Poplack DG 2006 Acute lymphoblastic leukemia. In: Principles and practice of pediatric oncology, 15th Ed. Pizzo PA and Poplack DG (Eds). Philadelphia, PA: Lippincott, Williams, and Wilkins; 538-590.
10. Adcock IM 2000 Molecular mechanisms of glucocorticosteroid actions. Pulm Pharmacol Ther 13: 115-126
11. Webster JC, Cidlowski JA 1999 Mechanisms of glucocorticoidreceptor- mediated repression of gene expression. Trends Endocrinol Metab 10: 396-402
12. Lee JW, Lee YC, Na SY, Jung DJ, Lee SK 2001 Transcriptional coregulators of the nuclear receptor superfamily: Coactivators and corepressors. Cell Mol Life Sci 58: 289-297
13. Xu J,WuRC, O'MalleyBW2009 Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer 9: 615-630
14. McKenna NJ, Xu J, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW 1999 Nuclear receptor coactivators: Multiple enzymes, multiple complexes, multiple functions. J Steroid Biochem Mol Biol 69: 3-12
15. Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L 1996 Nuclear receptor coactivators and corepressors. Mol Endocrinol 10: 1167-1177
16. Turner JD, Muller CP 2005 Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: Identification, and tissue distribution of multiple new human exon 1. J Mol Endocrinol 35: 283-292
17. Breslin MB, Geng CD, Vedeckis WV 2001 Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids. Mol Endocrinol 15: 1381-1395
18. Zong J, Ashraf J, Thompson EB 1990 The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites. Mol Cell Biol 10: 5580-5585
19. Encío IJ, Detera-Wadleigh SD 1991 The genomic structure of the human glucocorticoid receptor. J Biol Chem 266: 7182-7188
20. Nunez BS, VedeckisWV2002 Characterization of promoter 1B in the human glucocorticoid receptor gene. Mol Cell Endocrinol 189: 191-199
21. Breslin MB, Vedeckis WV 1998 The human glucocorticoid receptor promoter upstream sequences contain binding sites for the ubiquitous transcription factor yin yang 1. J Steroid Biochem Mol Biol 67: 369-381
22. Wei P, Vedeckis WV 1997 Regulation of the glucocorticoid receptor gene by the AP-1 transcription factor. Endocrine 7: 1-12
23. Geng CD, Vedeckis WV 2004 Steroid-responsive sequences in the human glucocorticoid receptor gene 1A promoter. Mol Endocrinol 18: 912-924
24. Geng CD, Schwartz JR, Vedeckis WV 2008 A conserved molecular mechanism is responsible for the auto-up-regulation of glucocorticoid receptor gene promoters. Mol Endocrinol 22: 2624-2642
25. Geng CD, Vedeckis WV 2005 c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter. J Biol Chem 280: 43264-43271
26. Findley JrHW,Cooper MD, Kim TH, Alvarado C, RagabAH1982 Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes. Blood 60: 1305-1309
27. Schwartz JR, Sarvaiya, PJ, Vedeckis, WV 2010 Glucocorticoid receptor knock down reveals a similar apoptotic threshold but differing gene regulation patterns in T-cell and pre-B-cell acute lymphoblastic leukemia. Mol Cell Endocrinol 320: 76-86
28. Pedersen KB, Vedeckis WV 2003 Quantification and glucocorticoid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines. Biochemistry 42: 10978-10990
29. Wasylyk B, Hahn SL, Giovane A 1993 The Ets family of transcription factors. Eur J Biochem 211: 7-18
30. Anderson MK, Hernandez-Hoyos G, Diamond RA, Rothenberg EV 1999 Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage. Development 126: 3131-3148
31. Su GH, Ip HS, Cobb BS, Lu MM, Chen HM, Simon MC 1996 The Ets protein Spi-B is expressed exclusively in B cells and T cells during development. J Exp Med 184: 203-214
32. Distelhorst CW 2002 Recent insights into the mechanism of glucocorticosteroid- induced apoptosis. Cell Death Differ 9: 6-19
33. Kalinyak JE, Dorin RI, Hoffman AR, Perlman AJ 1987 Tissuespecific regulation of glucocorticoid receptor mRNA by dexamethasone. J Biol Chem 262: 10441-10444
34. Eisen LP, Elsasser MS, Harmon JM 1988 Positive regulation of the glucocorticoid receptor in human T-cells sensitive to the cytolytic effects of glucocorticoids. J Biol Chem 263: 12044-12048
35. Okret S, Poellinger L, Dong Y, Gustafsson JA 1986 Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone. Proc Natl Acad Sci USA 83: 5899-5903
36. Rosewicz S, McDonald AR, Maddux BA, Goldfine ID, Miesfeld RL, Logsdon CD 1988 Mechanism of glucocorticoid receptor down-regulation by glucocorticoids. J Biol Chem 263: 2581-2584
37. Govindan MV, Pothier F, Leclerc S, Palaniswami R, Xie B 1991 Human glucocorticoid receptor gene promotor-homologous down regulation. J Steroid Biochem Mol Biol 40: 317-323
38. Ramdas J, Liu W, Harmon JM 1999 Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells. Cancer Res 59: 1378-1385