Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice

Infection and Immunity

Volumn 71, Issue 10, 2003, Pages 6058-6062

  Lembo, Annalisa ^a   Kalis, Christoph ^a   Kirschning, Carsten J ^b   Mitolo, Vincenzo ^c   Jirillo, Emilio ^c   Wagner, Hermann ^b   Galanos, Chris ^a   Freudenberg, Marina A ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GRAM NEGATIVE BACTERIUM; MACROPHAGE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SALMONELLA ENTERICA; STAPHYLOCOCCUS AUREUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; CYTOKINES; INTERLEUKIN-6; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0141668946     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.10.6058-6062.2003     Document Type: Article

References (33)

1. Adachi, O., T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M. Sakagami, K. Nakanishi, and S. Akira. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9:143-150.
2. Aggarwal, B. B., W. J. Kohr, P. E. Hass, B. Moffat, S. A. Spencer, W. J. Henzel, T. S. Bringman, G. E. Nedwin, D. V. Goeddel, and R. N. Harkins. 1985. Human tumor necrosis factor. Production, purification, and characterization. J. Biol. Chem. 260:2345-2354.
3. Aliprantis, A. O., D. S. Weiss, J. D. Radolf, and A. Zychlinsky. 2001. Release of Toll-like receptor-2-activating bacterial lipoproteins in Shigella flexneri culture supernatants. Infect. Immun. 69:6248-6255.
4. Aliprantis, A. O., R. B. Yang, M. R. Mark, S. Suggett, B. Devaux, J. D. Radolf, G. R. Klimpel, P. Godowski, and A. Zychlinsky. 1999. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285:736-739.
5. Beutler, B., X. Du, and A. Poltorak. 2001. Identification of Toll-like receptor 4 (TIr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies. J. Endotoxin Res. 7:277-280.
6. Freudenberg, M. A., and C. Galanos. 1991. Tumor necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in D-galactosamine-treated mice. Infect. Immun. 59:2110-2115.
7. Freudenberg, M. A., D. Keppler, and C. Galanos. 1986. Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin. Infect. Immun. 51:891-895.
8. Freudenberg, M. A., M. Kopf, and C. Galanos. 1996. Lipopolysaccharide-sensitivity of interferon-gamma-receptor deficient mice. J. Endotoxin. Res. 3:291-295.
9. Freudenberg, M. A., T. Merlin, M. Gumenscheimer, C. Kalis, R. Landmann, and C. Galanos. 2001. Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection: LPS, a primary target for recognition of Gram-negative bacteria. Microbes Infect. 3:1213-1222.
10. Galanos, C., M. A. Freudenberg, M. Matsuura, and A. Coumbos. 1988. Hypersensitivity to endotoxin and mechanisms of host-response. Prog. Clin. Biol. Res. 272:295-308.
11. Galanos, C., M. Gumenscheimer, P. Muhlradt, E. Jirillo, and M. Freudenberg. 2000. MALP-2, a Mycoplasma lipopeptide with classical endotoxic properties: end of an era of LPS monopoly? J. Endotoxin Res. 6:471-476.
12. Galanos, C., O. Luderitz, and O. Westphal. 1979. Preparation and properties of a standardized lipopolysaccharide from Salmonella abortus equi (Novo-Pyrexal). Zentbl. Bakteriol. Orig A 243:226-244.
13. Halpern, B. N., A.-R. Prévot, G. Biozzi, C. Stifel, D. Mouton, J. C. Morard, Y. Bouthillier, and C. Decreusefond. 1964. Stimulation de l'activité phagocytaire du systéme réticuloendothé lial provoquée par Corynebacterium parvum RES. J. Reticuloendothel. Soc. 1:77-96.
14. Janeway, C. A., Jr. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harbor Symp. Quant. Biol. 54:1-13.
15. Kalis, C., B. Kanzler, A. Lembo, A. Poltorak, C. Galanos, and M. A. Freudenberg. 2003. Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice. Eur. J. Immunol. 33:798-805.
16. Katschinski, T., C. Galanos, A. Coumbos, and M. A. Freudenberg. 1992. Gamma interferon mediates Propionibacterium acnes-induced hypersensitivity to lipopolysaccharide in mice. Infect. Immun. 60:1994-2001.
17. Kawai, T., O. Adachi, T. Ogawa, K. Takeda, and S. Akira. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115-122.
18. Laskin, D. L., B. Weinberger, and J. D. Laskin. 2001. Functional heterogeneity in liver and lung macrophages. J. Leukoc. Biol. 70:163-170.
19. Medzhitov, R., and C. A. Janeway, Jr. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91:295-298.
20. Merlin, T., M. Gumenscheimer, C. Galanos, and M. A. Freudenberg. 2001. TNF-alpha hyper-responses to Gram-negative and Gram-positive bacteria in Propionibacterium acnes primed or Salmonella typhimurium infected mice. J. Endotoxin Res. 7:157-163.
21. Merlin, T., A. Sing, P. J. Nielsen, C. Galanos, and M. A. Freudenberg. 2001. Inherited IL-12 unresponsiveness contributes to the high LPS resistance of the Lps(d) C57BL/10ScCr mouse. J. Immunol. 166:566-573.
22. Ozinsky, A., D. M. Underhill, J. D. Fontenot, A. M. Hajjar, K. D. Smith, C. B. Wilson, L. Schroeder, and A. Aderem. 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc. Natl. Acad. Sci. USA 97:13766-13771.
23. Poltorak, A., X. He, I. Smirnova, M. Y. Liu, C. V. Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, and B. Beutler. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TIr4 gene. Science 282:2085-2088.
24. Schwandner, R., R. Dziarski, H. Wesche, M. Rothe, and C. J. Kirschning. 1999. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274:17406-17409.
25. Sing, A., T. Merlin, H.-P. Knopf, P. J. Nielsen, H. Loppnow, C. Galanos, and M. A. Freudenberg. 2000. Bacterial induction of beta interferon in mice is a function of the lipopolysaccharide component. Infect. Immun. 68:1600-1607.
26. Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21:335-376.
27. Takeuchi, O., K. Hoshino, and S. Akira. 2000. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165:5392-5396.
28. Takeuchi, O., K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, and S. Akira. 1999. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11:443-451.
29. Vogel, S. N., C. T. Hansen, and D. L. Rosenstreich. 1979. Characterization of a congenitally LPS-resistant, athymic mouse strain. J. Immunol. 122:619-622.
30. Werts, C., R. I. Tapping, J. C. Mathison, T. H. Chuang, V. Kravchenko, I. Saint Girons, D. A. Haake, P. J. Godowski, F. Hayashi, A. Ozinsky, D. M. Underhill, C. J. Kirschning, H. Wagner, A. Aderem, P. S. Tobias, and R. J. Ulevitch. 2001. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat. Immunol. 2:346-352.
31. Wu, H. C. 1996. Biosynthesis of lipoproteins, p. 1005-1014. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella. Cellular and molecular biology, 2nd ed., vol. 1. ASM Press, Washington, D.C.
32. Yoshimura, A., E. Lien, R. R. Ingalls, E. Tuomanen, R. Dziarski, and D. Golenbock. 1999. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163:1-5.
33. Zhang, H., D. W. Niesel, J. W. Peterson, and G. R. Klimpel. 1998. Lipoprotein release by bacteria: potential factor in bacterial pathogenesis. Infect. Immun. 66:5196-5201.