Are neuronal voltage-gated calcium channels valid cellular targets for general anesthetics?

Channels

Volumn 4, Issue 6, 2010, Pages

  Orestes, Peihan ^a,b   Todorovic, Slobodan M ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Low threshold calcium channel; Nitrous oxide; Nociception

Indexed keywords

4 AMINOBUTYRIC ACID; ANESTHETIC AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CALCIUM CHANNEL R TYPE; CALCIUM CHANNEL T TYPE; HALOTHANE; ISOFLURANE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM CHANNEL;

ATTENTION; COGNITION; DRUG EFFECT; DRUG TARGETING; ELECTROENCEPHALOGRAM; GENERAL ANESTHESIA; LEARNING; MEMORY; REVIEW; SENSORY NERVE CELL; SLEEP; SPINAL CORD; SPINAL GANGLION; THALAMUS; ANIMAL; CELL MEMBRANE POTENTIAL; CHANNEL GATING; HUMAN; METABOLISM; NERVE CELL;

ANESTHETICS, GENERAL; ANIMALS; CALCIUM CHANNELS; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; NEURONS;

EID: 78650848951     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.4.6.12873     Document Type: Review

References (55)

1. 2+ channels. Annu Rev Cell Dev Biol 2000; 16:521-55; PMID: 11031246.
2. Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Wiliamson MP, et al. Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature 1998; 391:896-900; PMID: 9495342.
3. 2+ channel gene family. Circ Res 1998; 83:103-9; PMID: 9670923.
4. Lee JH, Daud AN, Cribbs LL, Lacerda AE, Pereverzev A, Klockner U, et al. Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J Neurosci 1999; 19:1912-21; PMID: 10066244. (Pubitemid 29133369)
5. Khosravani H, Zamponi GW. Voltage-gated calcium channels and idiopathic generalized epilepsies. Physiol Rev 2006; 86:941-66; PMID: 16816142.
6. Yasuda T, Chen L, Barr W, McRory JE, Lewis RJ, Adams DJ, et al. Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. Eur J Neurosci 2004; 20:1-13; PMID: 15245474.
7. 3) pituitary cells. J Neurosci 1991; 11:2226-40; PMID: 1648606.
8. rd. Volatile anesthetics reduce low-voltage-activated calcium currents in a thyroid C-cell line. Anesthesiol 1996; 85:1167-75; PMID: 8916835.
9. Study RE. Isoflurane inhibits multiple voltage-gated calcium current in hippocampal pyramidal neurons. Anesthesiol 1994; 81:104-16; PMID: 8042778.
10. Takenoshita M, Steinbach JH. Halothane blocks low-voltage-activated calcium current in rat sensory neurons. J Neurosci 1991; 11:1404-12; PMID: 1851220.
11. 2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. J Neurophysiol 1998; 79:240-52; PMID: 9425195.
12. Heinke W, Koelsch S. The effects of anesthetics on brain activity and cognitive function. Curr Op Anesth 2005; 18:625-31; PMID: 16534303.
13. Angel A. Adventures in anesthesia. Exp Physiol 1991; 76:1-38; PMID: 2015066.
14. Ito Y, Izumi H, Sato M, Karita K, Iwatsuki N. Suppression of parasympathetic reflex vasodilatation in the lower lip of the cat by isoflurane, propofol, ketamine and pentobarbital: implications for mechanisms underlying the production of anaesthesia. Br J Anaesth 1998; 81:563-8; PMID: 9924233.
15. Franks NP. General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 2008; 9:370-86; PMID: 18425091.
16. Jevtovic-Todorovic V, Todorovic SM, Mennerick S, Powell S, Dikranian K, Benshoff N, et al. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nature Medicine 1998; 4:460-3; PMID: 9546794.
17. Kress HG. Mechanisms of action of ketamine. Anaesthesist 1997; 46:8-19; PMID: 9163283.
18. rd. Volatile anesthetic inhibition of neuronal Ca channel currents expressed in Xenopus oocytes. Brain Res 1999; 831:85-96; PMID: 10411986.
19. 2+ channels through enhancement of current inactivation. Br J Anaesth 1999; 82:402-11; PMID: 10434825.
20. El Beheiry H, Ouanounou A, Carlen PL. L-type calcium channel blockade modifies anesthetic actions on aged hippocampal neurons. Neuroscience 2007; 147:117-26; PMID: 17507168.
21. rd. Differential sensitivity of expressed L-type calcium channels and muscarinic M1 receptors to volatile anesthetics in Xenopus oocytes. J Pharmacol and Exp Ther 2001; 297:981-90; PMID: 11356920.
22. Atlee JL, Bosnjak ZJ. Mechanisms for cardiac dysr-rhythmias during anesthesia. Anesthesiology 1990; 72:347-74; PMID: 2405744.
23. 2+ channel in human myocardium. Anesthesiology 1993; 79:332-9; PMID: 7688198.
24. 2+-currents mediated by N-type calcium channels. Br J Anesth 2005; 94:784-90; PMID: 15778267.
25. 2+ currents. Anesthesiology 2003; 99:392-9; PMID: 12883412.
26. Hall AC, Lieb WR, Franks NP. Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics. Anesthesiology 1994; 81:117-23; PMID: 8042779.
27. 2+ currents. Neuropharmacology 1998; 37:957-72; PMID: 9833625.
28. Schober A, Sokolova E, Gingrich KJ. Pentobarbital inhibition of human recombinant alpha1A P/Q-type voltage-gated calcium channels involves slow, open channel block. Br J Pharmacol 2010; 161:365-83; PMID: 20735421.
29. Joksovic PM, Weiergräber M, Lee W, Struck H, Schneider T, Todorovic SM. Isoflurane-sensitive presynaptic R-type calcium channels contribute to inhibitory synaptic transmission in the rat thalamus. J Neurosci 2009; 29:1434-45; PMID: 19193890.
30. Zamponi GW, Bourinet E, Snutch TP. Nickel block of a family of neuronal calcium channels: subtype- and subunit-dependent action at multiple sites. J Membr Biol 1996; 151:77-90; PMID: 8661496.
31. Todorovic SM, Jevtovic-Todorovic V, Meyenburg A, Mennerick S, Perez-Reyes E, Romano C, et al. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron 2001; 31:75-85; PMID: 11498052.
32. 2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors. J Neurosci 2005; 25:8766-75; PMID: 16177046.
33. Talley EM, Cribbs LL, Lee JH, Perez-Reyes E, Bayliss DA. Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J Neurosci 1999; 19:1895-911; PMID: 10066243.
34. V3.2 T-type channels. Genes, Brain and Behavior 2007; 6:425-31; PMID: 16939637.
35. V3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception. EMBO J 2005; 24:315-24; PMID: 15616581.
36. Rampil IJ. Anesthetic potency is not altered after hypothermic spinal cord transection in rats. Anesthesiology 1994; 80:606-10; PMID: 8141455.
37. McCormick DA, Bal T. Sleep and arousal: thalamocortical mechanisms. Annu Rev Neurosci 1997; 20:185- 215; PMID: 9056712.
38. Steriade M. Sleep, epilepsy and thalamic reticular inhibitory neurons. TINS 2005; 28:317-24. PMID: 15927688.
39. McKay BE, McRory JE, Molineux ML, Hamid J, Snutch TP, Zamponi GW, et al. Ca(V)3 T-type calcium channel isoforms differentially distribute to somatic and dendritic compartments in rat central neurons. Eur J Neurosci 2006; 24:2581-94; PMID: 17100846.
40. Alkire MT, Haier RJ, Fallon JH. Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness. Conscious Cogn 2000; 9:370-86; PMID: 10993665.
41. Rudolph U, Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci 2004; 5:709-20; PMID: 15322529.
42. Joksovic PM, Bayliss DA, Todorovic SM. Different kinetic properties of two T-type currents of rat reticular thalamic neurones and their modulation by enflurane. J Physiol 2005; 566:125-42; PMID: 15845580.
43. v3.3 channels. Br J Pharmacol 2005; 144:59-70; PMID: 15644869.
44. Ries CR, Puil E. Mechanisms of anesthesia revealed by shunting actions of isoflurane on thalamocortical neurons. J Neurophysiol 1999; 81:1795-801; PMID: 10200213.
45. Todorovic SM, Perez-Reyes E, Lingle CJ. Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants. Mol Pharmacol 2000; 58:98-108; PMID: 10860931.
46. v3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide. Mol Pharmacol 2001; 60:603-10; PMID: 11502893.
47. Orestes P, Bojadzic D, Chow RM, Todorovic SM. Mechanisms and functional significance of inhibition of neuronal T-type calcium channels by isoflurane. Mol Pharmacol 2009; 75:542-54; PMID: 19038845.
48. Pathirathna S, Todorovic SM, Covey DF, Jevtovic- Todorovic V. 5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain 2005; 117:326-39; PMID: 16150542.
49. V3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol 2010; In press; PMID: 21059758.
50. 2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci USA 2005; 102:1743-8; PMID: 15677322.
51. Lee J, Kim D, Shin HS. Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking alpha1G-subunit of T-type calcium channels. Proc Natl Acad Sci USA 2004; 101:18195-9; PMID: 15601764.
52. Petrenko AB, Tsujita M, Kohno T, Sakimura K, Baba H. Mutation of alpha1G T-type calcium channels in mice do not change the anesthetic requirements for loss of righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction. Anesthesiology 2007; 106:1177-85; PMID: 17525593.
53. Davies JN, Zamponi GW. Old proteins, developing roles: The regulation of calcium channels by synaptic proteins. Channels (Austin) 2008; 2:130-8; PMID: 18849653.
54. 2+ channels and NREM sleep. Cell Calcium 2006; 40:175-90; PMID: 16777223.
55. Todorovic SM, Jevtovic-Todorovic V. Modulation of T-type calcium channels in the peripheral pain pathway. Channels (Austin) 2007; 1:238-45. PMID: 18708751.