-
1
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J. Targeting RAS signalling pathways in cancer therapy. Nature Rev Cancer 2003; 3: 11-22.
-
(2003)
Nature Rev Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
2
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nature Rev Cancer 2007; 7: 295-308.
-
(2007)
Nature Rev Cancer
, vol.7
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
4
-
-
10744224787
-
Activation of Apoptosis Signal-Regulating Kinase 1 in Injured Artery and Its Critical Role in Neointimal Hyperplasia
-
DOI 10.1161/01.CIR.0000096486.01652.FC
-
Izumi Y, Kim S, Yoshiyama M, et al. Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia. Circulation 2003; 108: 2812-8. (Pubitemid 37498985)
-
(2003)
Circulation
, vol.108
, Issue.22
, pp. 2812-2818
-
-
Izumi, Y.1
Kim, S.2
Yoshiyama, M.3
Izumiya, Y.4
Yoshida, K.5
Matsuzawa, A.6
Koyama, H.7
Nishizawa, Y.8
Ichijo, H.9
Yoshikawa, J.10
Iwao, H.11
-
5
-
-
43249110658
-
Determinants of RASistance to anti-epidermal growth factor receptor agents
-
Baselga J, Rosen N. Determinants of RASistance to anti-epidermal growth factor receptor agents. J Clin Oncol 2008; 26: 1582-4.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1582-1584
-
-
Baselga, J.1
Rosen, N.2
-
6
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-67.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
7
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87: 159-70.
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
8
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002; 418: 934.
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
Velculescu, V.E.6
-
9
-
-
11144267126
-
Role of the kinase MST2 in suppression of apoptosis by the protooncogene product Raf-1
-
O'Neill E, Rushworth L, Baccarini M, et al. Role of the kinase MST2 in suppression of apoptosis by the protooncogene product Raf-1. Science 2004; 306: 2267-70.
-
(2004)
Science
, vol.306
, pp. 2267-2270
-
-
O'Neill, E.1
Rushworth, L.2
Baccarini, M.3
-
10
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949-54.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
11
-
-
0037112438
-
Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia
-
Yuen ST, Davies H, Chan TL, et al. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res 2002; 62: 6451-5.
-
(2002)
Cancer Res
, vol.62
, pp. 6451-6455
-
-
Yuen, S.T.1
Davies, H.2
Chan, T.L.3
-
12
-
-
9144271690
-
Activated BRAF Targets Proximal Colon Tumors with Mismatch Repair Deficiency and MLH1 Inactivation
-
DOI 10.1002/gcc.10310
-
Domingo E, Espin E, Armengol M, et al. Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation. Genes Chromosomes Cancer 2004; 39: 138-42. (Pubitemid 38056086)
-
(2004)
Genes Chromosomes and Cancer
, vol.39
, Issue.2
, pp. 138-142
-
-
Domingo, E.1
Espin, E.2
Armengol, M.3
Oliveira, C.4
Pinto, M.5
Duval, A.6
Brennetot, C.7
Seruca, R.8
Hamelin, R.9
Yamamoto, H.10
Schwartz Jr., S.11
-
13
-
-
32044455746
-
BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status
-
Li WQ, Kawakami K, Ruszkiewicz A, et al. BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status. Mol Cancer 2006; 5: 2.
-
(2006)
Mol Cancer
, vol.5
, pp. 2
-
-
Li, W.Q.1
Kawakami, K.2
Ruszkiewicz, A.3
-
14
-
-
34247849498
-
Methylation-sensitive high resolution melting (MS-HRM): A new approach for sensitive and high-throughput assessment
-
Wojdacz TK, Dobrovic A. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment. Nucleic Acids Res, 2007; 35: e41.
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Wojdacz, T.K.1
Dobrovic, A.2
-
15
-
-
36148947536
-
Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: Analysis based on tumour clinicopathological features
-
Harada K, Hiraoka S, Kato J, et al. Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features. Br J Cancer 2007; 97: 1425-31.
-
(2007)
Br J Cancer
, vol.97
, pp. 1425-1431
-
-
Harada, K.1
Hiraoka, S.2
Kato, J.3
-
17
-
-
33644864788
-
Compartmentalized Ras/MAPK signaling
-
Mor A, Philips MR. Compartmentalized Ras/MAPK signaling. Ann Rev Immunol 2006; 24: 771-800.
-
(2006)
Ann Rev Immunol
, vol.24
, pp. 771-800
-
-
Mor, A.1
Philips, M.R.2
-
19
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26: 1626-34.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
20
-
-
28844437927
-
Control of colorectal metastasis formation by K-Ras
-
DOI 10.1016/j.bbcan.2005.07.001, PII S0304419X05000375, The KRAS Oncogene
-
Smakman N, Borel Rinkes I H, Voest EE, et al. Control of colorectal metastasis formation by K-Ras. Biochim Biophys Acta 2005; 1756: 103-14. (Pubitemid 41773137)
-
(2005)
Biochimica et Biophysica Acta - Reviews on Cancer
, vol.1756
, Issue.2
, pp. 103-114
-
-
Smakman, N.1
Borel Rinkes, I.H.M.2
Voest, E.E.3
Kranenburg, O.4
-
21
-
-
0023256456
-
Prevalence of Ras gene mutations in human colorectal cancers
-
Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of Ras gene mutations in human colorectal cancers. Nature 1987; 327: 293-7.
-
(1987)
Nature
, vol.327
, pp. 293-297
-
-
Bos, J.L.1
Fearon, E.R.2
Hamilton, S.R.3
-
22
-
-
0033739215
-
Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: A population-based study
-
Samowitz WS, Curtin K, Schaffer D, et al. Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study. Cancer Epidemiol Biomarkers Prev 2000; 9: 1193-7.
-
(2000)
Cancer Epidemiol Biomarkers Prev
, vol.9
, pp. 1193-1197
-
-
Samowitz, W.S.1
Curtin, K.2
Schaffer, D.3
-
23
-
-
34248368818
-
Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer
-
Symvoulakis EK, Zaravinos A, Panutsopulos D, et al. Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer. Int J Biol Markers 2007; 22: 12-8. (Pubitemid 46730029)
-
(2007)
International Journal of Biological Markers
, vol.22
, Issue.1
, pp. 12-18
-
-
Symvoulakis, E.K.1
Zaravinos, A.2
Panutsopulos, D.3
Zoras, O.4
Papalambros, E.5
Sigala, F.6
Spandidos, D.A.7
-
24
-
-
33750211241
-
Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer
-
Miranda E, Destro A, Malesci A, et al. Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer. Br J Cancer 2006; 95: 1101-7.
-
(2006)
Br J Cancer
, vol.95
, pp. 1101-1107
-
-
Miranda, E.1
Destro, A.2
Malesci, A.3
-
25
-
-
33748032054
-
Associations of Kiras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics
-
Erratum in: Cancer Epidemiol Biomarkers Prev 2006; 15: 2016
-
Einspahr JG, Martinez ME, Jiang R, et al. Associations of Kiras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics. Cancer Epidemiol Biomarkers Prev 2006; 15: 1443-50. Erratum in: Cancer Epidemiol Biomarkers Prev 2006; 15: 2016.
-
(2006)
Cancer Epidemiol Biomarkers Prev
, vol.15
, pp. 1443-1450
-
-
Einspahr, J.G.1
Martinez, M.E.2
Jiang, R.3
-
26
-
-
24144499879
-
A comparison of high-resolution chromatography for mutation scanning: Cystic fibrosis transmembrane conductance regulator gene as a model
-
Chou LS, Lyon E, Wittwer CT. A comparison of high-resolution chromatography for mutation scanning: cystic fibrosis transmembrane conductance regulator gene as a model. Am J Clin Pathol 2005; 124: 330-8.
-
(2005)
Am J Clin Pathol
, vol.124
, pp. 330-338
-
-
Chou, L.S.1
Lyon, E.2
Wittwer, C.T.3
-
27
-
-
40749117206
-
Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis
-
Takano EA, Mitchell G, Fox SB, et al. Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis. BMC Cancer 2008, 8: 59.
-
(2008)
BMC Cancer
, vol.8
, pp. 59
-
-
Takano, E.A.1
Mitchell, G.2
Fox, S.B.3
-
28
-
-
33749340253
-
Detection of EGFR mutations in archived cytologic specimens of non-small cell lung cancer using high-resolution melting analysis
-
DOI 10.1309/N5PQ-NGW2-QKMX-09X7
-
Nomoto K, Tsuta K, Takano T, et al. Detection of EGFR mutations in archived cytologic specimens of non-small cell lung cancer using high-resolution melting analysis. Am J Clin Pathol 2006; 126: 608-15. (Pubitemid 44498512)
-
(2006)
American Journal of Clinical Pathology
, vol.126
, Issue.4
, pp. 608-615
-
-
Nomoto, K.1
Tsuta, K.2
Takano, T.3
Fukui, T.4
Yokozawa, K.5
Sakamoto, H.6
Yoshida, T.7
Maeshima, A.M.8
Shibata, T.9
Furuta, K.10
Ohe, Y.11
Matsuno, Y.12
-
29
-
-
33846641709
-
High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer
-
Krypuy M, Newnham GM, Thomas DM, et al. High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer. BMC Cancer 2006; 6: 295.
-
(2006)
BMC Cancer
, vol.6
, pp. 295
-
-
Krypuy, M.1
Newnham, G.M.2
Thomas, D.M.3
-
30
-
-
44649156362
-
High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies
-
Do H, Krypuy M, Mitchell PL, et al. High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies. BMC Cancer 2008, 8: 142.
-
(2008)
BMC Cancer
, vol.8
, pp. 142
-
-
Do, H.1
Krypuy, M.2
Mitchell, P.L.3
-
31
-
-
64249106774
-
Evaluation of high-resolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors
-
Pichler M, Balic M, Stadelmeyer E, et al. Evaluation of high-resolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors. J Mol Diagn 2009; 11: 140-7.
-
(2009)
J Mol Diagn
, vol.11
, pp. 140-147
-
-
Pichler, M.1
Balic, M.2
Stadelmeyer, E.3
-
32
-
-
70349653814
-
Detection of KRAS mutations in colorectal cancer by high-resolution melting analysis
-
Ma ES, Wong CL, Law FB, et al. Detection of KRAS mutations in colorectal cancer by high-resolution melting analysis. J Clin Pathol 2009; 62: 886-91.
-
(2009)
J Clin Pathol
, vol.62
, pp. 886-891
-
-
Ma, E.S.1
Wong, C.L.2
Law, F.B.3
-
33
-
-
67650082332
-
Fast simultaneous detection of K-RAS mutations in colorectal cancer
-
Chang YS, Yeh KT, Chang TJ, et al. Fast simultaneous detection of K-RAS mutations in colorectal cancer. BMC Cancer 2009, 9: 179.
-
(2009)
BMC Cancer
, vol.9
, pp. 179
-
-
Chang, Y.S.1
Yeh, K.T.2
Chang, T.J.3
-
34
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Medicine 2008; 359: 1757-65.
-
(2008)
N Engl J Medicine
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
|