EEG in the FEAB model: Measurement of electroencephalographical burst suppression and seizure liability in safety pharmacology

Journal of Pharmacological and Toxicological Methods

Volumn 63, Issue 1, 2011, Pages 96-101

  Van der Linde, H J ^a   Van Deuren, B ^a   Somers, Y ^a   Teisman, A ^a   Drinkenburg, W H ^b   Gallacher, D J ^a  

^a European Discovery Capability Organization   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Burst suppression; Depth of anaesthesia; Dog; EEG; Safety pharmacology; Seizures

Indexed keywords

AMFEBUTAMONE; BICUCULLINE; DIAZEPAM; ETOMIDATE; FENTANYL; PENTETRAZOLE; PENTOBARBITAL; PILOCARPINE; PROPOFOL;

ANESTHESIA LEVEL; ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DRUG SAFETY; ELECTROENCEPHALOGRAM; ELECTROENCEPHALOGRAPHICAL BURST SUPPRESSION; EPILEPTIC DISCHARGE; NERVOUS SYSTEM PARAMETERS; NONHUMAN; RESPIRATORY SYSTEM; SEIZURE;

ANESTHESIA; ANESTHETICS, INTRAVENOUS; ANIMALS; BICUCULLINE; CENTRAL NERVOUS SYSTEM; CONVULSANTS; DOGS; ELECTROENCEPHALOGRAPHY; ETOMIDATE; FEMALE; FENTANYL; MALE; MODELS, ANIMAL; PENTYLENETETRAZOLE; SEIZURES; TOXICITY TESTS;

ANIMALIA; CANIS FAMILIARIS;

EID: 78650761116     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2010.06.002     Document Type: Article

References (29)

1. Berendt M., Hogenhaven H., Flagstad A., Dam M. Electroencephalography in dogs with epilepsy: Similarities between humans and canine findings. Acta Neurologica Scandinavica 1999, 99:276-283.
2. Blum A.S. Respiratory physiology of seizures. Journal of Clinical Neurophysiology 2009, 26-5:309-315.
3. Chapple D.J., Miller A.A., Waed B.J., Wheatley P.L. Cardiovascular and neurological effects of laudanosine. British Journal of Anaesthesiology 1987, 58:218-225.
4. Doyle P.W., Matta B.F. Burst suppression or isoelectric encephalogram for cerebral protection: Evidence for metabolic suppression studies. British Journal of Anaesthesia 1999, 83:580-584.
5. Drinkenburg, W.H.I.M., & Ahnaou A. (2004). The use of pEEG in preclinical models in drug discovery. In: W.H.I.M. Drinkenburg, G.S.F. Ruigt, M. Jobert (Eds.), Essentials and applications of EEG research in preclinical and clinical pharmacology (pp. 131-148). Berlin: UniPublish.
6. Dürmüller N., Guillaume P., Lacroix P., Porsolt R.D., Moser P. The use of the dog electroencephalogram (EEG) in safety pharmacology to evaluate proconvulsant risk. Journal of Pharmacological and Toxicological Methods 2007, 56:234-238.
7. Easter A., Bell M.E., Damewood J.R., Redfern W.S., Valentin J.P., Winter M.J., et al. Approaches to seizure risk assessment in preclinical drug discovery. Drug Discovery Today 2009, 14:876-884.
8. Erdil F., Demirbilek S., Begec Z., Ozturk E., Ersoy M.O. Effects of propofol or etomidate on QT interval during electrconvulsive therapy. The Journal of ECT 2009, 25:174-177.
9. Fisher R.S., van Emde Boas W., Blume W., Elger C., Genton P., Lee P., et al. Epileptic seizure and epilepsy: Definitions proposed by the international league against epilepsy (ILAE) and the international bureau for epilepsy (IBE). Epilepsia 2005, 46-4:470-472.
10. Gastaut H. Clinical and electroencephalographical classification of epileptic seizures. Epilepsia 1970, 11:102-113.
11. Jordan K.G., Hirsch L.J. In nonconvulsive status epilepticus (NCSE), treat to burst-suppression: Pro and con. Epilepsia 2006, 47-1:41-45.
12. Kreuer S., Bieder A., Larsen R., Schoth S., Altmann S., Wilhelm W. The Narcotrend™ - A new EEG monitor designed to measure the depth of anaesthesia. A comparison with bispectral index monitoring during propofol-remifentanil-anaesthesia. Der Anaesthesist 2001, 12:921-925.
13. Kreuer S., Wilhelm W. The Narcotrend monitor. Best Practice & Research. Clinical Anaesthesiology 2006, 20-1:111-119.
14. Kumar S.S., Joshi B., Sharma S.S. CNS safety pharmacology: International guidelines and methods. Current Research & Information on Pharmaceutical Science 2007, 8:2-5.
15. Mandhane S.N., Aavula K., Rajamannar T. Timed pentylenetetrazol infusion test: A comparative analysis with s.c. PTZ and MES models of anticonvulsant screening in mice. Seizure 2007, 16:636-644.
16. Maromi N. Cardiac effects of seizures. Epilepsy Currents 2009, 9:91-95.
17. Modica P.A., Tempelhoff R. Intracranial pressure during induction of anaesthesia and tracheal intubation with etomidate-induced EEG burst suppression. Canadian Journal of Anaesthesiology 1992, 39:236-241.
18. Otto K.A. EEG power spectrum analysis for monitoring depth of anaesthesia during experimental surgery. Laboratory Animals 2008, 42:45-61.
19. Pollack G.M., Shen D.D. A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat. Journal of Pharmacological and Toxicological Methods 1985, 13:135-146.
20. Porsolt R.D., Lemaire M., Dürmüller N., Roux S. New perspectives in CNS safety pharmacology. Fundamental & Clinical Pharmacology 2002, 16:197-207.
21. Sebel P.S., Bovill J.G., Wauquier A., Rog P. Effects of high-dose fentanyl anaesthesia on the electroencephalogram. Anesthesiology 1981, 55:203-211.
22. Sloan T. Anaesthetic effects on electrophysiologic recordings. Journal of Clinical Neurophysiology 1998, 15-3:217-226.
23. Steriade M., Amzica F., Contreras D. Cortical and thalamic cellular correlates of electroencephalographic burst-suppression. Electroencephalography and Clinical Neurophysiology 1994, 90:1-16.
24. Tutka P., Mróz T., Klucha K., Piekarczyk M., Wielosz M.K. Bupropion-induced convulsions: Preclinical evaluation of antiepileptic drugs. Epilepsy Research 2005, 64:13-22.
25. Van Deuren B., Van Ammel K., Somers Y., Cools F., Straetemans R., van der Linde H.J., et al. The fentanyl/etomidate-anaesthetised beagle (FEAB) dog: A versatile in vivo model in Cardiovascular Safety Research. Journal of Pharmacological and Toxicological Methods 2009, 60-1:11-23.
26. Van Ness P.C. Pentobarbital and EEG burst suppression in treatment of status epilepticus refractory to benzodiazepines and phenytoin. Epilepsia 1990, 31-1:61-67.
27. Vijn P.C.M., Sneyd J.R. I.v. anaesthesia and EEG burst suppression in rats: Bolus injections and closed-loop infusions. British Journal of Anaesthesia 1998, 81:415-421.
28. Watson P.L., Shintani A.K., Tyson R., Pandharipande P.P., Pun B.T., Ely E.W. Presence of electroencephalogram burst suppression in sedated, critically ill patients is associated with increased mortality. Critical Care Medicine 2008, 36(12):3171-3177.
29. Zijlmans M., Flanagan D., Gotman J. Heart rate changes and ECG abnormalities during epileptic seizures: Prevalence and definition of an objective clinical sign. Epilepsia 2002, 43-8:847-854.