-
1
-
-
0034726720
-
Cell cycle dysregulation by green tea polyphenol epigallocatechin-3- gallate
-
Ahmad N, Cheng P, Mukhtar H (2000) Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate. Biochem Biophys Res Commun 275:328-334
-
(2000)
Biochem Biophys Res Commun
, vol.275
, pp. 328-334
-
-
Ahmad, N.1
Cheng, P.2
Mukhtar, H.3
-
2
-
-
33845425572
-
Design, synthesis antiproliferative and CDK2-cyclin A inhibitory activity of novel flavopiridol analogues
-
Ahn Y, Vogeti L, Liu C, Santhapuram H, White J, Vasandani V (2007) Design, synthesis, antiproliferative and CDK2-cyclin A inhibitory activity of novel flavopiridol analogues. Bioorg Med Chem 15:702-713
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 702-713
-
-
Ahn, Y.1
Vogeti, L.2
Liu, C.3
Santhapuram, H.4
White, J.5
Vasandani, V.6
-
3
-
-
0031742097
-
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity
-
Alessi F, Quarta S, Savio M, Riva F, Rossi L, Stivala LA, Scovassi AI, Meijer L, Prosperi E (1998) The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp Cell Res 245:8-18
-
(1998)
Exp Cell Res
, vol.245
, pp. 8-18
-
-
Alessi, F.1
Quarta, S.2
Savio, M.3
Riva, F.4
Rossi, L.5
Stivala, L.A.6
Scovassi, A.I.7
Meijer, L.8
Prosperi, E.9
-
4
-
-
0021724284
-
Breakage of single-stranded DNA by eukaryotic type 1 topoisomerase occurs only at regions with the potential for base-pairing
-
Been MD, Champoux JJ (1984) Breakage of single-stranded DNA by eukaryotic type 1 topoisomerase occurs only at regions with the potential for base-pairing. J Mol Biol 180:515-532
-
(1984)
J Mol Biol
, vol.180
, pp. 515-532
-
-
Been, M.D.1
Champoux, J.J.2
-
5
-
-
0035914138
-
Green tea constituent (-)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells
-
Berger SJ, Gupta S, Belfi CA, Gosky DM, Mukhtar H (2001) Green tea constituent (-)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells. Biochem Biophys Res Commun 288:101-105
-
(2001)
Biochem Biophys Res Commun
, vol.288
, pp. 101-105
-
-
Berger, S.J.1
Gupta, S.2
Belfi, C.A.3
Gosky, D.M.4
Mukhtar, H.5
-
6
-
-
0028948804
-
Flavonoids as DNA topoisomerase antagonists and poisons: Structure-activity relationships
-
Constantinou A, Mehta R, Runyan C, Rao K, Vaughan A, Moon R (1995) Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships. J Nat Prod 58:217-225
-
(1995)
J Nat Prod
, vol.58
, pp. 217-225
-
-
Constantinou, A.1
Mehta, R.2
Runyan, C.3
Rao, K.4
Vaughan, A.5
Moon, R.6
-
7
-
-
0042303844
-
Cyclin-dependent kinase inhibitors
-
Dai Y, Grant S (2003) Cyclin-dependent kinase inhibitors. Curr Opin Pharmacol 3:362-370
-
(2003)
Curr Opin Pharmacol
, vol.3
, pp. 362-370
-
-
Dai, Y.1
Grant, S.2
-
8
-
-
0034038110
-
A novel approach for the virtual screening and rational design of anticancer compounds
-
Estrada E, Uriarte E, Montero A, Teijeira M, Santana L, De Clercq E (2000) A novel approach for the virtual screening and rational design of anticancer compounds. J Med Chem 43:1975-1985
-
(2000)
J Med Chem
, vol.43
, pp. 1975-1985
-
-
Estrada, E.1
Uriarte, E.2
Montero, A.3
Teijeira, M.4
Santana, L.5
De Clercq, E.6
-
9
-
-
0024550507
-
Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships
-
Ferriola PC, Cody V, Middleton E Jr (1989) Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochem Pharmacol 38:1617-1624
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 1617-1624
-
-
Ferriola, P.C.1
Cody, V.2
Middleton Jr., E.3
-
10
-
-
1242342930
-
Telomerase down regulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing
-
Gomez D, Lemarteleur T, Lacroix L, Mailliet P, Mergny J, Riou J (2004) Telomerase down regulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing. Nucleic Acids Res 32:371-379
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 371-379
-
-
Gomez, D.1
Lemarteleur, T.2
Lacroix, L.3
Mailliet, P.4
Mergny, J.5
Riou, J.6
-
12
-
-
78650748289
-
Effects of quercetin on apoptosis and telomerase activity in NIH-3T3 cell lines compared with tamoxifen
-
Hatipoglu A, Basaran A, Dikmen M, Cosan D, Gunes HV, Degirmenci I (2007) Effects of quercetin on apoptosis and telomerase activity in NIH-3T3 cell lines compared with tamoxifen. Acta Physiol 190(Suppl 656):P44
-
(2007)
Acta Physiol
, vol.190
, Issue.SUPPL. 656
-
-
Hatipoglu, A.1
Basaran, A.2
Dikmen, M.3
Cosan, D.4
Gunes, H.V.5
Degirmenci, I.6
-
13
-
-
0034722884
-
Bcl-2 family proteins as targets for anticancer drug design
-
Huang Z (2000) Bcl-2 family proteins as targets for anticancer drug design. Oncogene 19:6627-6631
-
(2000)
Oncogene
, vol.19
, pp. 6627-6631
-
-
Huang, Z.1
-
14
-
-
0038245253
-
Small molecules as inhibitors of cyclin-dependent kinases
-
Huwe A, Mazitschek R, Giannis A (2003) Small molecules as inhibitors of cyclin-dependent kinases. Angew Chem Int Ed Engl 42:2122-2138
-
(2003)
Angew Chem Int Ed Engl
, vol.42
, pp. 2122-2138
-
-
Huwe, A.1
Mazitschek, R.2
Giannis, A.3
-
15
-
-
33645765580
-
Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols
-
Jo J, Mejia E, Lila M (2006) Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols. J Agric Food Chem 54:2083-2087
-
(2006)
J Agric Food Chem
, vol.54
, pp. 2083-2087
-
-
Jo, J.1
Mejia, E.2
Lila, M.3
-
16
-
-
0029871688
-
UCN-01, 7-Hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line
-
Kawakami K, Futami H, Takahara J, Yamaguchi K (1996) UCN-01, 7-Hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line. Biochem Biophys Res Commun 219:778-783
-
(1996)
Biochem Biophys Res Commun
, vol.219
, pp. 778-783
-
-
Kawakami, K.1
Futami, H.2
Takahara, J.3
Yamaguchi, K.4
-
17
-
-
0037731436
-
The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures
-
Kim M-Y, Gleason-Guzman M, Izbicka E, David Nishioka D, Hurley LH (2003) The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures. Cancer Res 63:3247-3256
-
(2003)
Cancer Res
, vol.63
, pp. 3247-3256
-
-
Kim, M-Y.1
Gleason-Guzman, M.2
Izbicka, E.3
David Nishioka, D.4
Hurley, L.H.5
-
18
-
-
33947578727
-
Molecular docking approach on the topoisomerase I inhibitors series included in the NCI anti-cancer agents mechanism database
-
Lauria A, Ippolito M, Almerico AM (2007) Molecular docking approach on the topoisomerase I inhibitors series included in the NCI anti-cancer agents mechanism database. J Mol Model 3:393-400
-
(2007)
J Mol Model
, vol.3
, pp. 393-400
-
-
Lauria, A.1
Ippolito, M.2
Almerico, A.M.3
-
19
-
-
0347626109
-
Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins
-
Leone M, Zhai D, Sareth S, Kitada S, Reed JC, Pellecchia M (2003) Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer Res 2003(63):8118-8121
-
(2003)
Cancer Res
, vol.2003
, Issue.63
, pp. 8118-8121
-
-
Leone, M.1
Zhai, D.2
Sareth, S.3
Kitada, S.4
Reed, J.C.5
Pellecchia, M.6
-
20
-
-
0028176485
-
Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275
-
Losiewicz MD, Carlson BA, Kaur G, Sausville EA, Worland PJ (1994) Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275. Biochem Biophys Res Commun 201:589-595
-
(1994)
Biochem Biophys Res Commun
, vol.201
, pp. 589-595
-
-
Losiewicz, M.D.1
Carlson, B.A.2
Kaur, G.3
Sausville, E.A.4
Worland, P.J.5
-
21
-
-
13444311605
-
Crystal structure of a human cyclindependent kinase 6 complex with a flavonol inhibitor, fisetin
-
Lu H, Chang DJ, Baratte B, Meijer L, Schulze-Gahmen U (2005) Crystal structure of a human cyclindependent kinase 6 complex with a flavonol inhibitor, fisetin. J Med Chem 48:737-743
-
(2005)
J Med Chem
, vol.48
, pp. 737-743
-
-
Lu, H.1
Chang, D.J.2
Baratte, B.3
Meijer, L.4
Schulze-Gahmen, U.5
-
22
-
-
4344560883
-
In vitro chemopreventive activity of Camellia sinensis, Ilex paraguariensis and Ardisia compressa tea extracts and selected polyphenols
-
Mares M, Chandra S, Mejia E (2004) In vitro chemopreventive activity of Camellia sinensis, Ilex paraguariensis and Ardisia compressa tea extracts and selected polyphenols. Mutat Res 554:53-65
-
(2004)
Mutat Res
, vol.554
, pp. 53-65
-
-
Mares, M.1
Chandra, S.2
Mejia, E.3
-
23
-
-
0031037714
-
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
-
Meijer L, Borgne A, Mulner O (1997) Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 243: 527-536
-
(1997)
Eur J Biochem
, vol.243
, pp. 527-536
-
-
Meijer, L.1
Borgne, A.2
Mulner, O.3
-
24
-
-
11644261806
-
Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
-
Morris GM, Goodsell DS, Halliday RS, Huey R, Hart WE, Belew RK, Olson AJ (1998) Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem 19:1639-1662
-
(1998)
J Comput Chem
, vol.19
, pp. 1639-1662
-
-
Morris, G.M.1
Goodsell, D.S.2
Halliday, R.S.3
Huey, R.4
Hart, W.E.5
Belew, R.K.6
Olson, A.J.7
-
25
-
-
0025700717
-
Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases
-
Ono K, Nakane H, Fukushima M, Chermann J-C, Barre-Sinoussi F (1990) Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. Eur J Biochem 190:469-476
-
(1990)
Eur J Biochem
, vol.190
, pp. 469-476
-
-
Ono, K.1
Nakane, H.2
Fukushima, M.3
Chermann, J.-C.4
Barre-Sinoussi, F.5
-
26
-
-
38049030699
-
Human telomere, oncogenic promoter and 50-UTR G-quadruplexes: Diverse higher order DNA and RNA targets for cancer therapeutics
-
Patel DJ, Phan AT, Kuryavyi V (2007) Human telomere, oncogenic promoter and 50-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res 35(22):7429-7455
-
(2007)
Nucleic Acids Res
, vol.35
, Issue.22
, pp. 7429-7455
-
-
Patel, D.J.1
Phan, A.T.2
Kuryavyi, V.3
-
27
-
-
7444229836
-
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibit tumor growth in severe combined immunodeficient mice
-
Pham N-A, Jacobberger JW, Schimmer AD, Cao P, Gronda M, Hedley DW (2004) The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibit tumor growth in severe combined immunodeficient mice. Mol Cancer Ther 3:1239-1248
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1239-1248
-
-
Pham, N.-A.1
Jacobberger, J.W.2
Schimmer, A.D.3
Cao, P.4
Gronda, M.5
Hedley, D.W.6
-
28
-
-
0032033603
-
Diversity of DNA topoisomerases I and inhibitors
-
Pommier Y (1998) Diversity of DNA topoisomerases I and inhibitors. Biochimie 80:255-270
-
(1998)
Biochimie
, vol.80
, pp. 255-270
-
-
Pommier, Y.1
-
29
-
-
0034033956
-
Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells
-
Salti G, Grewal S, Mehta R, das Gupta T, Boddie A Jr, Constantinou A (2000) Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells. Eur J Cancer 36: 796-802
-
(2000)
Eur J Cancer
, vol.36
, pp. 796-802
-
-
Salti, G.1
Grewal, S.2
Mehta, R.3
Das Gupta, T.4
Boddie Jr., A.5
Constantinou, A.6
-
30
-
-
0141543861
-
Reduction of genistein clastogenicity in Chinese hamster V79 cells by daidzein and other flavonoids
-
Snyder R, Gillies P (2003) Reduction of genistein clastogenicity in Chinese hamster V79 cells by daidzein and other flavonoids. Food Chem Toxicol 41:1291-1298
-
(2003)
Food Chem Toxicol
, vol.41
, pp. 1291-1298
-
-
Snyder, R.1
Gillies, P.2
-
31
-
-
33847405376
-
Pazopanib: A novel multitargeted tyrosine kinase inhibitor
-
Sonpavde G, Hutson T (2007) Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep 9:115-119
-
(2007)
Curr Oncol Rep
, vol.9
, pp. 115-119
-
-
Sonpavde, G.1
Hutson, T.2
-
32
-
-
8944248812
-
Flk-1 as a target for tumor growth inhibition
-
Strawn LM, McMahon G, App H, Schreck R, Kuchler WR, Longhi MP, Hui TH, Tang C, Levitzki A, Gazit A, Chen I, Keri G, Orfi L, Risau W, Flamme I, Ullrich A, Hirth KP, Shawver LK (1996) Flk-1 as a target for tumor growth inhibition. Cancer Res 56:3540-3545
-
(1996)
Cancer Res
, vol.56
, pp. 3540-3545
-
-
Strawn, L.M.1
McMahon, G.2
App, H.3
Schreck, R.4
Kuchler, W.R.5
Longhi, M.P.6
Hui, T.H.7
Tang, C.8
Levitzki, A.9
Gazit, A.10
Chen, I.11
Keri, G.12
Orfi, L.13
Risau, W.14
Flamme, I.15
Ullrich, A.16
Hirth, K.P.17
Shawver, L.K.18
-
33
-
-
0036205282
-
The specific anti-cancer activity of green tea (-)-epigallocatechin-3- gallate (EGCG)
-
Wang Y-C, Bachrach U (2002) The specific anti-cancer activity of green tea (-)-epigallocatechin-3-gallate (EGCG). Amino acids 22:131-143
-
(2002)
Amino acids
, vol.22
, pp. 131-143
-
-
Wang, Y.-C.1
Bachrach, U.2
-
34
-
-
33750112776
-
Structure-based design of potent smallmolecule inhibitors of anti-apoptotic Bcl-2 proteins
-
Wang G, Coleska Z, Yang C, Wang R, Tang G, Guo J (2006) Structure-based design of potent smallmolecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem 49:6139-6142
-
(2006)
J Med Chem
, vol.49
, pp. 6139-6142
-
-
Wang, G.1
Coleska, Z.2
Yang, C.3
Wang, R.4
Tang, G.5
Guo, J.6
|