Benzothieno[3,2-b]quinolinium and 3-(phenylthio)quinolinium compounds: Synthesis and evaluation against opportunistic fungal pathogens

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 458-470

  Boateng, Comfort A ^a   Eyunni, Suresh V K ^a   Zhu, Xue Y ^a   Etukala, Jagan R ^a   Bricker, Barbara A ^a   Ashfaq, M K ^b   Jacob, Melissa R ^b   Khan, Shabana I ^b   Walker, Larry A ^b   Ablordeppey, Seth Y ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Antifungal agents; Benzothienoquinoline; Benzothienoquinolinium salts; Cryptolepine isostere; Opportunistic infection agents; Quinolinium salts; Sulfur isostere

Indexed keywords

1 (5 CYCLOHEXYLPENTYL) 3 (PHENYLTHIO)QUINOLINIUM; 1 CHLORO 5 METHYLBENZOTHIENO[3,2 B]QUINOLIN 5 IUM TRIFLATE; 1 CHLOROBENZOTHIENO[3,2 B]QUINOLIN 11(5H) ONE; 1 CHLOROBENZOTHIENO[3,2 B]QUINOLINE; 1 HYDROXYBENZOTHIENO[3,2 B]QUINOLINE; 1 METHOXY 11 CHLOROBENZOTHIENO[3,2 B]QUINOLINE; 1 METHOXY 5 METHYLBENZOTHIENO[3,2 B]QUINOLIN 5 IUM TRIFLATE; 1 METHOXYBENZOTHIENO[3,2 B]QUINOLIN 11 (5H) ONE; 1 METHOXYBENZOTHIENO[3,2 B]QUINOLINE; 1,11 DICHLOROBENZOTHIENO[3,2 B]QUINOLINE; 3 CHLORO 5 METHYLBENZOTHIENO[3,2 B]QUINOLIN 5 IUM TRIFLATE; 3 CHLOROBENZOTHIENO[3,2 B]QUINOLIN 11(5H) ONE; 3 CHLOROBENZOTHIENO[3,2 B]QUINOLINE; 3 METHOXY 11 CHLOROBENZOTHIENO[3,2 B]QUINOLINE; 3 METHOXY 5 METHYLBENZOTHIENO[3,2 B]QUINOLIN 5 IUM TRIFLATE; 3 METHOXYBENZOTHIENO[3,2 B]QUINOLIN 11(5H) ONE; 3 METHOXYBENZOTHIENO[3,2 B]QUINOLINE; 3,11 DICHLOROBENZOTHIENO[3,2 B]QUINOLINE; 4 CHLORO 5 METHYLBENZOTHIENO[3,2 B]QUINOLIN 5 IUM TRIFLATE; 4 CHLOROBENZOTHIENO[3,2 B]QUINOLIN 11(5H) ONE; 4 CHLOROBENZOTHIENO[3,2 B]QUINOLINE; 4 HYDROXY 5 METHYLBENZOTHIENO[3,2 B]QUINOLIN 5 IUM TRIFLATE; 4 METHOXY 11 CHLOROBENZOTHIENO[3,2 B]QUINOLINE; 4 METHOXY 5 METHYLBENZOTHIENO[3,2 B]QUINOLIN 5 IUM TRIFLATE; 4 METHOXYBENZOTHIENO[3,2 B]QUINOLIN 11(5H) ONE; 4 METHOXYBENZOTHIENO[3,2 B]QUINOLINE; 4,11 DICHLOROBENZOTHIENO[3,2 B]QUINOLINE; AMPHOTERICIN B; ANTIFUNGAL AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BLOOD BRAIN BARRIER; BRAIN CRYPTOCOCCOSIS; BRAIN INFECTION; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGICIDAL ACTIVITY; GRAFT RECIPIENT; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; OPPORTUNISTIC INFECTION; SUBSTITUTION REACTION;

ANIMALS; BLOOD-BRAIN BARRIER; CANDIDIASIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; FUNGI; MAGNETIC RESONANCE SPECTROSCOPY; MAXIMUM TOLERATED DOSE; MICE; MICROBIAL SENSITIVITY TESTS; QUINOLINES;

ASPERGILLUS; ASPERGILLUS FUMIGATUS; MURINAE; MUS;

EID: 78650747033     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.008     Document Type: Article

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