Role of hepatocyte nuclear factor 4α in controlling copper-responsive transcription

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1813, Issue 1, 2011, Pages 102-108

  Song, Min Ok ^a   Freedman, Jonathan H ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

ATF3; Copper; Gene expression; HepG2 cell; HNF4 ; P53; Transcription

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; COPPER; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; PROTEIN P53; RNA;

ARTICLE; DNA BINDING; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RNA INTERFERENCE;

ACTIVATING TRANSCRIPTION FACTOR 3; BLOTTING, WESTERN; COPPER; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 78650742770     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2010.09.009     Document Type: Article

References (48)

1. Linder M. Biochemistry of Copper 1991, Plenum, New York.
2. Pena M.M., Lee J., Thiele D.J. A delicate balance: homeostatic control of copper uptake and distribution. J. Nutr. 1999, 129:1251-1260.
3. Camakaris J., Voskoboinik I., Mercer J.F. Molecular mechanisms of copper homeostasis. Biochem. Biophys. Res. Commun. 1999, 261:225-232.
4. Halliwell B., Gutteridge J.M. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 1984, 219:1-14.
5. Letelier M.E., Lepe A.M., Faundez M., Salazar J., Marin R., Aracena P., Speisky H. Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity. Chem. Biol. Interact. 2005, 151:71-82.
6. Valko M., Morris H., Cronin M.T. Metals, toxicity and oxidative stress. Curr. Med. Chem. 2005, 12:1161-1208.
7. Koch K.A., Pena M.M., Thiele D.J. Copper-binding motifs in catalysis, transport, detoxification and signaling. Chem. Biol. 1997, 4:549-560.
8. Urani C., Calini V., Melchioretto P., Morazzoni F., Canevali C., Camatini M. Different induction of metallothioneins and Hsp70 and presence of the membrane transporter ZnT-1 in HepG2 cells exposed to copper and zinc. Toxicol. In Vitro 2003, 17:553-559.
9. Murata M., Gong P., Suzuki K., Koizumi S. Differential metal response and regulation of human heavy metal-inducible genes. J. Cell. Physiol. 1999, 180:105-113.
10. Song M.O., Li J., Freedman J.H. Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol. Genomics 2009, 38:386-401.
11. Lazarevich N.L., Cheremnova O.A., Varga E.V., Ovchinnikov D.A., Kudrjavtseva E.I., Morozova O.V., Fleishman D.I., Engelhardt N.V., Duncan S.A. Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors. Hepatology 2004, 39:1038-1047.
12. Tronche F., Yaniv M. HNF1, a homeoprotein member of the hepatic transcription regulatory network. Bioessays 1992, 14:579-587.
13. Li J., Ning G., Duncan S.A. Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. Genes Dev. 2000, 14:464-474.
14. Parviz F., Matullo C., Garrison W.D., Savatski L., Adamson J.W., Ning G., Kaestner K.H., Rossi J.M., Zaret K.S., Duncan S.A. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat. Genet. 2003, 34:292-296.
15. Odom D.T., Dowell R.D., Jacobsen E.S., Nekludova L., Rolfe P.A., Danford T.W., Gifford D.K., Fraenkel E., Bell G.I., Young R.A. Core transcriptional regulatory circuitry in human hepatocytes. Mol. Syst. Biol. 2006, 2:2006 0017.
16. Chen W.S., Manova K., Weinstein D.C., Duncan S.A., Plump A.S., Prezioso V.R., Bachvarova R.F., Darnell J.E. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 1994, 8:2466-2477.
17. Alfarano C., Andrade C.E., Anthony K., Bahroos N., Bajec M., Bantoft K., Betel D., Bobechko B., Boutilier K., Burgess E., Buzadzija K., Cavero R., D'Abreo C., Donaldson I., Dorairajoo D., Dumontier M.J., Dumontier M.R., Earles V., Farrall R., Feldman H., Garderman E., Gong Y., Gonzaga R., Grytsan V., Gryz E., Gu V., Haldorsen E., Halupa A., Haw R., Hrvojic A., Hurrell L., Isserlin R., Jack F., Juma F., Khan A., Kon T., Konopinsky S., Le V., Lee E., Ling S., Magidin M., Moniakis J., Montojo J., Moore S., Muskat B., Ng I., Paraiso J.P., Parker B., Pintilie G., Pirone R., Salama J.J., Sgro S., Shan T., Shu Y., Siew J., Skinner D., Snyder K., Stasiuk R., Strumpf D., Tuekam B., Tao S., Wang Z., White M., Willis R., Wolting C., Wong S., Wrong A., Xin C., Yao R., Yates B., Zhang S., Zheng K., Pawson T., Ouellette B.F., Hogue C.W. The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res. 2005, 33:D418-D424.
18. Hayhurst G.P., Lee Y.H., Lambert G., Ward J.M., Gonzalez F.J. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 2001, 21:1393-1403.
19. Sladek F.M. Hepatocyte nuclear factor 4 1994, R. G. Landes Company, Austin, Tx.
20. F.M. Sladek, S.D. Seidel, Hepatocyte Nuclear Factor 4alpha 2001.
21. Maeda Y., Hwang-Verslues W.W., Wei G., Fukazawa T., Durbin M.L., Owen L.B., Liu X., Sladek F.M. Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene. Biochem. J. 2006, 400:303-313.
22. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Meth. Duluth. 2001, 25:402-408.
23. Song M.O., Freedman J.H. Expression of copper-responsive genes in HepG2 cells. Mol. Cell. Biochem. 2005, 279:141-147.
24. Rozen S., Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Meth. Mol. Biol. 2000, 132:365-386.
25. Abramoff M.D., Magelhaes P.J., Ram S.J. Image Processing with Image. J. Biophotonics Int. 2004, 11:36-42.
26. Rajas F., Gautier A., Bady I., Montano S., Mithieux G. Polyunsaturated fatty acyl coenzyme A suppress the glucose-6-phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4 alpha. J. Biol. Chem. 2002, 277:15736-15744.
27. Naiki T., Nagaki M., Shidoji Y., Kojima H., Imose M., Kato T., Ohishi N., Yagi K., Moriwaki H. Analysis of gene expression profile induced by hepatocyte nuclear factor 4alpha in hepatoma cells using an oligonucleotide microarray. J. Biol. Chem. 2002, 277:14011-14019.
28. Pluquet O., Hainaut P. Genotoxic and non-genotoxic pathways of p53 induction. Cancer Lett. 2001, 174:1-15.
29. Yan C., Lu D., Hai T., Boyd D.D. Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J. 2005, 24:2425-2435.
30. Muller P., van Bakel H., van de Sluis B., Holstege F., Wijmenga C., Klomp L.W. Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genes. J. Biol. Inorg. Chem. 2007.
31. Svensson P.A., Englund M.C., Markstrom E., Ohlsson B.G., Jernas M., Billig H., Torgerson J.S., Wiklund O., Carlsson L.M., Carlsson B. Copper induces the expression of cholesterogenic genes in human macrophages. Atherosclerosis 2003, 169:71-76.
32. Ostrakhovitch E.A., Cherian M.G. Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells. Apoptosis 2005, 10:111-121.
33. Meyer T.E., Habener J.F. Cyclic adenosine 3′, 5′-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocr. Rev. 1993, 14:269-290.
34. Hai T., Hartman M.G. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 2001, 273:1-11.
35. Hai T., Wolfgang C.D., Marsee D.K., Allen A.E., Sivaprasad U. ATF3 and stress responses. Gene Expr. 1999, 7:321-335.
36. Stohs S.J., Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 1995, 18:321-336.
37. Theophanides T., Anastassopoulou J. Copper and carcinogenesis. Crit. Rev. Oncol. Hematol. 2002, 42:57-64.
38. Lavin M.F., Gueven N. The complexity of p53 stabilization and activation. Cell Death Differ. 2006, 13:941-950.
39. Hainaut P., Rolley N., Davies M., Milner J. Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)/Cu(I) redox mechanism. Oncogene 1995, 10:27-32.
40. Verhaegh G.W., Richard M.J., Hainaut P. Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper. Mol. Cell. Biol. 1997, 17:5699-5706.
41. Bartee M.Y., Lutsenko S. Hepatic copper-transporting ATPase ATP7B: function and inactivation at the molecular and cellular level. Biometals 2007, 20:627-637.
42. Brewer G.J. Wilson disease and canine copper toxicosis. Am. J. Clin. Nutr. 1998, 67:1087S-1090S.
43. Langner C., Denk H. Wilson disease. Virchows Arch. 2004, 445:111-118.
44. Huster D., Lutsenko S. Wilson disease: not just a copper disorder. Analysis of a Wilson disease model demonstrates the link between copper and lipid metabolism,. Mol. Biosyst. 2007, 3:816-824.
45. Huster D., Purnat T.D., Burkhead J.L., Ralle M., Fiehn O., Stuckert F., Olson N.E., Teupser D., Lutsenko S. High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease. J. Biol. Chem. 2007.
46. Misawa K., Horiba T., Arimura N., Hirano Y., Inoue J., Emoto N., Shimano H., Shimizu M., Sato R. Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes. J. Biol. Chem. 2003, 278:36176-36182.
47. Yamamoto T., Shimano H., Nakagawa Y., Ide T., Yahagi N., Matsuzaka T., Nakakuki M., Takahashi A., Suzuki H., Sone H., Toyoshima H., Sato R., Yamada N. SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes. J. Biol. Chem. 2004, 279:12027-12035.
48. -/- (Wilson disease gene) knockout mice. Am. J. Pathol. 2006, 168:423-434.