Mode of action of epoxyphomalins a and b and characterization of related metabolites from the marine-derived fungus Paraconiothyrium sp.

Journal of Natural Products

Volumn 73, Issue 12, 2010, Pages 2053-2056

  Mohamed, Ietidal E ^a   Kehraus, Stefan ^b   Krick, Anja ^b   König, Gabriele M ^b   Kelter, Gerhard ^c   Maier, Armin ^c   Fiebig, Heinz Herbert ^c   Kalesse, Markus ^d,e   Malek, Nisar P ^f   Gross, Harald ^b  

^a UNIVERSITY OF KHARTOUM   (Sudan)

^b UNIVERSITY OF BONN   (Germany)

^c CHARLES RIVER LABORATORIES   (United States)

^d LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^e HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^f HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CHYMOTRYPSIN; CYCLOHEXENE DERIVATIVE; DECALIN; EPOXYPHOMALIN A; EPOXYPHOMALIN B; EPOXYPHOMALIN C; EPOXYPHOMALIN D; EPOXYPHOMALIN E; NATURAL PRODUCT; PROTEASOME; TRYPSIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; FUNGUS; HUMAN; HUMAN CELL; IC 50; OXIDATION; PARACONIOTHYRIUM;

ANTINEOPLASTIC AGENTS; ASCOMYCOTA; CASPASES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MACROLIDES; MALE; MARINE BIOLOGY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEASOME ENDOPEPTIDASE COMPLEX;

FUNGI; PARACONIOTHYRIUM;

EID: 78650741235     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np100310k     Document Type: Article

References (26)

1. Mohamed, I. E., Gross, H., Pontius, A., Kehraus, S., Krick, A., Kelter, G., Maier, A., Fiebig, H.-H., and König, G. M. Org. Lett. 2009, 11, 5014-5017
2. Zamir, L. O. In The Biosynthesis of Mycotoxins. A Study in Secondary Metabolism; Steyn, P. S., Ed.; Academic Press: New York, 1980; Chapter 7, pp 223 - 268.
3. Turner, W. B. and Aldridge, D. C. Fungal Metabolites II; Academic Press: New York, 1983; pp 60 - 67.
4. CS Chem 3D Pro 10.0; Cambridge Soft, 2006.
5. Burkert, U. and Allinger, N. L. Molecular Mechanics; ACS Monograph 177: Washington DC, 1982.
6. Dudek, M. J. and Ponder, J. W. J. Comput. Chem. 1995, 16, 791-816
7. MestReJ v1.1. Navarro-Vázquez, A., Cobas, J. C., Sardina, F. J., Casanueva, J., and Diez, E. J. Chem. Inf. Comput. Sci. 2004, 44, 1680-1685
8. Ichihara, A., Kimura, R., and Sakamura, S. Agr. Biol. Chem. 1975, 39, 555-556
9. Nakamori, K., Matsuura, H., Yoshihara, T., Ichihara, A., and Koda, Y. Phytochemistry 1994, 35, 835-839
10. Kamikubo, T. and Ogasawara, K. Tetrahedron Lett. 1995, 36, 1685-1688
11. Barros, M. T., Maycock, C. D., and Ventura, M. R. Tetrahedron 1999, 55, 3233-3244
12. Barros, M. T., Maycock, C. D., and Ventura, M. R. Chem. - Eur. J. 2000, 6, 3991-3996
13. Arimoto, H., Shimano, T., and Uemura, D. J. Agr. Food Chem. 2005, 53, 3863-3866
14. Mennucci, B., Claps, M., Evidente, A., and Rosini, C. J. Org. Chem. 2007, 72, 6680-6691
15. Kitaoka, N., Nabeta, K., and Matsuura, H. Biosci. Biotechnol. Biochem. 2009, 73, 1890-1892
16. Burger, A. M. and Seth, A. K. Eur. J. Cancer 2004, 40, 2217-2229
17. Khan, T., Stauffer, J. K., Williams, R., Hixon, J. A., Salcedo, R., Lincoln, E., Back, T. C., Powell, D., Lockett, S., Arnold, A. C., Sayers, T. J., and Wigginton, J. M. J. Immunol. 2006, 176, 6302-6312
18. Ciechanover, A. Cell 1994, 79, 13-21
19. Adams, J. Cancer Cell 2004, 5, 417-421
20. Moore, B. S., Eustáquio, A. S., and McGlinchey, R. P. Curr. Opin. Chem. Biol. 2008, 12, 434-400
21. Höller, U. Isolation, biological activity, and secondary metabolite investigations of marine-derived fungi and selected host sponges. Ph.D. Thesis, Braunschweig University of Technology, Germany, 1999.
22. Höller, U., König, G. M., and Wright, A. D. J. Nat. Prod. 1999, 62, 114-118
23. Höller, U., Wright, A. D., Matthée, G. F., König, G. M., Draeger, S., Aust, H.-J., and Schulz, B. Mycol. Res. 2000, 104, 1354-1365
24. Kralj, A., Kehraus, S., Krick, A., van Echten-Deckert, G., and König, G. M. Planta Med. 2007, 73, 366-371
25. Kralj, A., Gurgui, M., König, G. M., and van Echten-Deckert, G. Toxicol. Appl. Pharmacol. 2007, 225, 113-122
26. Nickeleit, I., Zender, S., Sasse, F., Geffers, R., Brandes, G., Sörensen, I., Steinmetz, H., Kubicka, S., Carlomagno, T., Menche, D., Gütgemann, I., Buer, J., Gossler, A., Manns, M. P., Kalesse, M., Frank, R., and Malek, N. P. Cancer Cell 2008, 14, 23-35