-
1
-
-
72449193680
-
4 receptor pharmacology
-
Sanger GJ. Translating 5-HT4 receptor pharmacology. Neurogastroenterol Motil. 2009;21:1235-8.
-
(2009)
Neurogastroenterol Motil
, vol.21
, pp. 1235-1238
-
-
Sanger, G.J.1
-
3
-
-
33746925213
-
4 receptor agonists enhance both cholinergic and nitrergic activity in human isolated colon circular muscle
-
Cellek S, John AK, Thangiah R, et al. 5-HT4 receptor agonists enhance both cholinergic and nitrergic activity in human isolated colon circular muscle. Neurogastroenterol Motil. 2006;18:853-61.
-
(2006)
Neurogastroenterol Motil
, vol.18
, pp. 853-861
-
-
Cellek, S.1
John, A.K.2
Thangiah, R.3
-
4
-
-
84898701009
-
Characterisation of motor nerve responses to electrical feld stimulation in human isolated colon
-
Broad J, Boundouki G, Knowles, CH, Sanger GJ. Characterisation of motor nerve responses to electrical feld stimulation in human isolated colon. Gut. 2010;59 Suppl 1:A140.
-
(2010)
Gut
, vol.59
, Issue.1 SUPPL.
-
-
Broad, J.1
Boundouki, G.2
Knowles, C.H.3
Sanger, G.J.4
-
5
-
-
77950640571
-
4 receptor activation on acetylcholine release in human large intestine with endometriosis
-
Lefebvre RA, Ferrero S, van Colen I, et al. Infuence of 5-HT4 receptor activation on acetylcholine release in human large intestine with endometriosis. Neurogastroenterol Motil. 2010;22:557-63.
-
(2010)
Neurogastroenterol Motil
, vol.22
, pp. 557-563
-
-
Lefebvre, R.A.1
Ferrero, S.2
van Colen, I.3
-
6
-
-
0033709510
-
4 receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle
-
Prins NH, Akkermans LM, Lefebvre RA, Schuurkes JA. 5-HT4 receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle. Br J Pharmacol. 2000;131:927-32.
-
(2000)
Br J Pharmacol
, vol.131
, pp. 927-932
-
-
Prins, N.H.1
Akkermans, L.M.2
Lefebvre, R.A.3
Schuurkes, J.A.4
-
7
-
-
0026612267
-
4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus
-
Kilbinger H, Wolf D. Effects of 5-HT4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus. Naunyn Schmiedebergs Arch Pharmacol. 1992;345:270-5.
-
(1992)
Naunyn Schmiedebergs Arch Pharmacol
, vol.345
, pp. 270-275
-
-
Kilbinger, H.1
Wolf, D.2
-
8
-
-
33746427538
-
4 receptors in intestine
-
Poole DP, Xu B, Koh SL, et al. Identifcation of neurons that express 5- hydroxytryptamine4 receptors in intestine. Cell Tissue Res. 2006;325: 413-22.
-
(2006)
Cell Tissue Res
, vol.325
, pp. 413-422
-
-
Poole, D.P.1
Xu, B.2
Koh, S.L.3
-
9
-
-
0029058239
-
4 receptors in human colon, rat oesophagus and rat ileum
-
McLean PG, Coupar IM, Molenaar P. A comparative study of functional 5-HT4 receptors in human colon, rat oesophagus and rat ileum. Br J P harmacol. 1995;115:47-56.
-
(1995)
Br J P Harmacol
, vol.115
, pp. 47-56
-
-
McLean, P.G.1
Coupar, I.M.2
Molenaar, P.3
-
10
-
-
0028989385
-
4-like receptor in human colon circular smooth muscle
-
Tam FS, Hillier K, Bunce KT, Grossman C. Differences in response to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle. Br J Pharmacol. 1995;115:172-6.
-
(1995)
Br J Pharmacol
, vol.115
, pp. 172-176
-
-
Tam, F.S.1
Hillier, K.2
Bunce, K.T.3
Grossman, C.4
-
11
-
-
0033998810
-
4 receptors in the human isolated large intestinal circular muscle
-
Prins NH, Shankley NP, Welsh NJ, et al. An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestinal circular muscle. Br J Pharmacol. 2000;129:1601-8.
-
(2000)
Br J Pharmacol
, vol.129
, pp. 1601-1608
-
-
Prins, N.H.1
Shankley, N.P.2
Welsh, N.J.3
-
12
-
-
33847247864
-
7 receptor expression and function in the circular muscle of the human colon
-
Irving HR, Tan YY, Tochon-Danguy N, et al. Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon. Life Sci. 2007;80:1198-205.
-
(2007)
Life Sci
, vol.80
, pp. 1198-1205
-
-
Irving, H.R.1
Tan, Y.Y.2
Tochon-Danguy, N.3
-
14
-
-
0019732199
-
Action of 5-hydroxytryptamine on intestinal ion transport in the rat
-
Hardcastle J, Hardcastle PT, Redfern JS. Action of 5-hydroxytryptamine on intestinal ion transport in the rat. J Physiol. 1981;320:41-55.
-
(1981)
J Physiol
, vol.320
, pp. 41-55
-
-
Hardcastle, J.1
Hardcastle, P.T.2
Redfern, J.S.3
-
17
-
-
0030742061
-
Heterogeneity of 5-HT receptors mediating secretion in the human intestine
-
Borman RA, Burleigh DE. Heterogeneity of 5-HT receptors mediating secretion in the human intestine. Ann NY Acad Sci. 1997;812:224-5.
-
(1997)
Ann NY Acad Sci
, vol.812
, pp. 224-225
-
-
Borman, R.A.1
Burleigh, D.E.2
-
19
-
-
0031801939
-
Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro
-
Schwörer H, Ramadori G. Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro. Naunyn Schmiedeberg's Arch Pharmacol. 1998;357:548-52.
-
(1998)
Naunyn Schmiedeberg's Arch Pharmacol
, vol.357
, pp. 548-552
-
-
Schwörer, H.1
Ramadori, G.2
-
21
-
-
37249010617
-
Human 5-HT4 and 5-HTsub7/sub splice variants: Are they important?
-
Coupar IM, Desmond PV, Irving HR. Human 5-HT4 and 5-HTsub7/sub splice variants: Are they important? Curr Neuropharmacol. 2007;5: 224-31.
-
(2007)
Curr Neuropharmacol
, vol.5
, pp. 224-231
-
-
Coupar, I.M.1
Desmond, P.V.2
Irving, H.R.3
-
22
-
-
0035919155
-
4 receptor in the central nervous system by TaqMan real time RT-PCR
-
Medhurst AD, Lezoualc'h F, Fischmeister R, Middlemiss DN, Sanger GJ. Quantitative mRNA analysis of fve C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR. Mol Brain Res. 2001;90:125-34.
-
(2001)
Mol Brain Res
, vol.90
, pp. 125-134
-
-
Medhurst, A.D.1
Lezoualc'h, F.2
Fischmeister, R.3
Middlemiss, D.N.4
Sanger, G.J.5
-
23
-
-
0035223924
-
4(d) receptor splice variant stably expressed in Chinese hamster ovary cells
-
Mialet J, Berque-Bestal I, Sicsic S, Langlois M, Fischmeister R, Lezoualc'h F. Pharmacological characterization of the human 5-HT4(d) receptor splice variant stably expressed in Chinese hamster ovary cells. Br J Pharmacol. 2000;131:827-35.
-
(2000)
Br J Pharmacol
, vol.131
, pp. 827-835
-
-
Mialet, J.1
Berque-Bestal, I.2
Sicsic, S.3
Langlois, M.4
Fischmeister, R.5
Lezoualc'h, F.6
-
24
-
-
0035967979
-
The in vitro pharmacological profle of prucalopride, a novel enterokinetic compound
-
Briejer MR, Bosmans JP, van Daele P, et al. The in vitro pharmacological profle of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001;423:71-83.
-
(2001)
Eur J Pharmacol
, vol.423
, pp. 71-83
-
-
Briejer, M.R.1
Bosmans, J.P.2
van Daele, P.3
-
26
-
-
77955457389
-
4) receptor agonist, for the treatment of chronic constipation
-
Wong BS, Manabe N, Camilleri M. Role of prucalopride, a serotonin (5-HT4) receptor agonist, for the treatment of chronic constipation. Clin Exp Gastroenterol. 2010;3:49-56.
-
(2010)
Clin Exp Gastroenterol
, vol.3
, pp. 49-56
-
-
Wong, B.S.1
Manabe, N.2
Camilleri, M.3
-
27
-
-
33746335649
-
5-hydroxytryptamine receptors in the human cardiovascular system
-
Kaumann AJ, Levy FO. 5-hydroxytryptamine receptors in the human cardiovascular system. Pharmacol Ther. 2006;111:674-706.
-
(2006)
Pharmacol Ther
, vol.111
, pp. 674-706
-
-
Kaumann, A.J.1
Levy, F.O.2
-
29
-
-
33646758583
-
4 receptor agonists at gastric versus cardiac receptors: An operational framework to explain and quantify organ-specifc behavior
-
De Maeyer JH, Prins NH, Schuurkes JAJ, Lefebvre RA. Differential effects of 5-hydroxytryptamine4 receptor agonists at gastric versus cardiac receptors: An operational framework to explain and quantify organ-specifc behavior. J Pharmacol Exp Ther. 2006;317:955-64.
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 955-964
-
-
de Maeyer, J.H.1
Prins, N.H.2
Schuurkes, J.A.J.3
Lefebvre, R.A.4
-
30
-
-
67650270527
-
4 receptor-mediated response in pig atrium but not in the stomach
-
De Maeyer JH, Lefebvre RA, Schuurkes JAJ. Selective desensitization of the 5-HT4 receptor-mediated response in pig atrium but not in the stomach. Br J Pharmacol. 2009;156:362-76.
-
(2009)
Br J Pharmacol
, vol.156
, pp. 362-376
-
-
de Maeyer, J.H.1
Lefebvre, R.A.2
Schuurkes, J.A.J.3
-
33
-
-
8744318249
-
2B receptor antagonist in vitro and in vivo
-
Beattie DT, Smith JA, Marquess D, et al. The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004;143:549-60.
-
(2004)
Br J Pharmacol
, vol.143
, pp. 549-560
-
-
Beattie, D.T.1
Smith, J.A.2
Marquess, D.3
-
34
-
-
74549184061
-
2B receptor antagonist inhibits visceral hypersensitivity in rats
-
Ohashi-Doi K, Himaki D, Nagao K, et al. A selective, high affnity 5-HT2B receptor antagonist inhibits visceral hypersensitivity in rats. Neurogastroen-terol Motil. 2010;22:e69-76.
-
(2010)
Neurogastroen-terol Motil
, vol.22
-
-
Ohashi-Doi, K.1
Himaki, D.2
Nagao, K.3
-
35
-
-
77950681549
-
2B receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction
-
O'Mahony SM, Bulmer DC, Coelho AM, et al. 5-HT2B receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction. Neurogastroenterol Motil. 2010;22:573-8.
-
(2010)
Neurogastroenterol Motil
, vol.22
, pp. 573-578
-
-
O'Mahony, S.M.1
Bulmer, D.C.2
Coelho, A.M.3
-
36
-
-
33644943622
-
4 receptors attenuates colonic sensitivity to intraluminal distension
-
Greenwood-van Meerveld B, Venkova K, Hicks G, Dennis E, Crowell MD. Activation of peripheral 5-HT4 receptors attenuates colonic sensitivity to intraluminal distension. Neurogastroenterol Motil. 2000;18:76-86.
-
(2000)
Neurogastroenterol Motil
, vol.18
, pp. 76-86
-
-
van meerveld, B.G.1
Venkova, K.2
Hicks, G.3
Dennis, E.4
Crowell, M.D.5
-
37
-
-
69249230884
-
2B receptor in rodent large bowel physiology
-
Bassil AK, Taylor CM, Bolton VJN, et al. Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. Br J Pharmacol. 2009;158:252-8.
-
(2009)
Br J Pharmacol
, vol.158
, pp. 252-258
-
-
Bassil, A.K.1
Taylor, C.M.2
Bolton, V.J.N.3
-
38
-
-
0036199452
-
2B receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro
-
Borman RA, Tilford NS, Harmer DW, et al. 5-HT2B receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro. Br J Pharmacol. 2002;135:1144-51.
-
(2002)
Br J Pharmacol
, vol.135
, pp. 1144-1151
-
-
Borman, R.A.1
Tilford, N.S.2
Harmer, D.W.3
-
39
-
-
0024478044
-
Physician visits in the United States for constipation: 1958 to 1986
-
Sonnenberg A, Koch TR. Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci. 1989;34:606-11.
-
(1989)
Dig Dis Sci
, vol.34
, pp. 606-611
-
-
Sonnenberg, A.1
Koch, T.R.2
-
40
-
-
0027185528
-
US householder survey of functional gastrointestinal disorders. Prevalence, sociodemography and health impact
-
Drossman DA, Li Z, Andruzzi E, et al. US householder survey of functional gastrointestinal disorders. Prevalence, sociodemography and health impact. Dig Dis Sci. 1993;38:1569-80.
-
(1993)
Dig Dis Sci
, vol.38
, pp. 1569-1580
-
-
Drossman, D.A.1
Li, Z.2
Andruzzi, E.3
-
41
-
-
0026567833
-
Prevalence of gastrointestinal symptoms in the elderly: A population-based study
-
Talley NJ, O'Keefe EA, Zinsmeister AR, et al. Prevalence of gastrointestinal symptoms in the elderly: a population-based study. Gastroenterology. 1992;102:895-901.
-
(1992)
Gastroenterology
, vol.102
, pp. 895-901
-
-
Talley, N.J.1
O'Keefe, E.A.2
Zinsmeister, A.R.3
-
42
-
-
33646201684
-
Functional bowel disorders
-
Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology. 2006;130:1480-91.
-
(2006)
Gastroenterology
, vol.130
, pp. 1480-1491
-
-
Longstreth, G.F.1
Thompson, W.G.2
Chey, W.D.3
Houghton, L.A.4
Mearin, F.5
Spiller, R.C.6
-
43
-
-
22844441856
-
Evidence-Based Position Statement on the Management of Chronic Constipation in North America
-
Brandt LJ, Schoenfeld P, Prather CM, Quigley EMM, Schiller LR, Talley NJ. Evidence-Based Position Statement on the Management of Chronic Constipation in North America. Am J Gastroenterol. 2005; 100(Suppl 1):S5-21.
-
(2005)
Am J Gastroenterol
, vol.100
, Issue.SUPPL. 1
-
-
Brandt, L.J.1
Schoenfeld, P.2
Prather, C.M.3
Quigley, E.M.M.4
Schiller, L.R.5
Talley, N.J.6
-
44
-
-
67649537590
-
American College of Gastroen-terology IBS Task Force. An evidence-based systematic review of the management of irritable bowel syndrome
-
Brandt LJ, Chey WD, Schiller LR, et al. American College of Gastroen-terology IBS Task Force. An evidence-based systematic review of the management of irritable bowel syndrome. Am J Gastroenterol. 2009;104: S1-35.
-
(2009)
Am J Gastroenterol
, vol.104
-
-
Brandt, L.J.1
Chey, W.D.2
Schiller, L.R.3
-
45
-
-
70449513263
-
An evidence-based approach to the management of irritable bowel syndrome in Europe
-
Quigley EMM, Bergmann JF, Bytzer P, et al. An evidence-based approach to the management of irritable bowel syndrome in Europe. Eur J Gastroenterol Hepatol. 2007;19(Suppl 1):S1-37.
-
(2007)
Eur J Gastroenterol Hepatol
, vol.19
, Issue.SUPPL. 1
-
-
Quigley, E.M.M.1
Bergmann, J.F.2
Bytzer, P.3
-
46
-
-
20844450744
-
Measurement of gastrointestinal transit
-
Lin HC, Prather C, Fisher RS, et al. Measurement of gastrointestinal transit. Dig Dis Sci. 2005;50:989-1004.
-
(2005)
Dig Dis Sci
, vol.50
, pp. 989-1004
-
-
Lin, H.C.1
Prather, C.2
Fisher, R.S.3
-
47
-
-
63049140085
-
Selected interventions in nuclear medicine: Gastrointestinal motor functions
-
Odunsi ST, Camilleri M. Selected interventions in nuclear medicine: gastrointestinal motor functions. Semin Nucl Med. 2009;39:186-94.
-
(2009)
Semin Nucl Med
, vol.39
, pp. 186-194
-
-
Odunsi, S.T.1
Camilleri, M.2
-
48
-
-
0026469867
-
Measurement of small bowel and colonic transit: Indications and methods
-
von der Ohe MR, Camilleri M. Measurement of small bowel and colonic transit: indications and methods. Mayo Clin Proc. 1992;67:1169-79.
-
(1992)
Mayo Clin Proc
, vol.67
, pp. 1169-1179
-
-
von der Ohe, M.R.1
Camilleri, M.2
-
49
-
-
56549111183
-
American Neurogas-troenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice
-
Camilleri M, Bharucha AE, di Lorenzo C, et al. American Neurogas-troenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice. Neurogastroenterol Motil. 2008;20:1269-82.
-
(2008)
Neurogastroenterol Motil
, vol.20
, pp. 1269-1282
-
-
Camilleri, M.1
Bharucha, A.E.2
Di Lorenzo, C.3
-
50
-
-
0031704916
-
Measurement of gastrointestinal motility in the GI laboratory
-
Camilleri M, Hasler WL, Parkman HP, Quigley EM, Soffer E. Measurement of gastrointestinal motility in the GI laboratory. Gastroenterology. 1998;115: 747-62.
-
(1998)
Gastroenterology
, vol.115
, pp. 747-762
-
-
Camilleri, M.1
Hasler, W.L.2
Parkman, H.P.3
Quigley, E.M.4
Soffer, E.5
-
51
-
-
0037613276
-
Current concepts of the irritable bowel syndrome
-
Quigley EM. Current concepts of the irritable bowel syndrome. Scand J Gastroenterol Suppl. 2003:1-8.
-
(2003)
Scand J Gastroenterol Suppl
, pp. 1-8
-
-
Quigley, E.M.1
-
52
-
-
0027385325
-
Quigley EMM. Intestinal motility in irritable bowel syndrome: Is IBS a motility disorder? Part 1: Defnition of IBS and colonic motility
-
McKee DP, Quigley EMM. Intestinal motility in irritable bowel syndrome: Is IBS a motility disorder? Part 1: Defnition of IBS and colonic motility. Dig Dis Sci. 1993;38:1761-72.
-
(1993)
Dig Dis Sci
, vol.38
, pp. 1761-1772
-
-
McKee, D.P.1
-
53
-
-
0036079899
-
Rectal distension testing in patients with the irritable bowel syndrome: Sensitivity, specifcity, and predictive values of pain sensory thresholds
-
Bouin M, Plourde V, Boivin M, et al. Rectal distension testing in patients with the irritable bowel syndrome: sensitivity, specifcity, and predictive values of pain sensory thresholds. Gastroenterology. 2002;122:1771-7.
-
(2002)
Gastroenterology
, vol.122
, pp. 1771-1777
-
-
Bouin, M.1
Plourde, V.2
Boivin, M.3
-
54
-
-
38849092560
-
Development of drugs for gastrointestinal motor disorders: Translating science to clinical need
-
Sanger GJ, Alpers D. Development of drugs for gastrointestinal motor disorders: Translating science to clinical need. Neurogastroenterol Motil. 2008:20:177-84.
-
(2008)
Neurogastroenterol Motil
, vol.20
, pp. 177-184
-
-
Sanger, G.J.1
Alpers, D.2
-
55
-
-
34250210742
-
Lubiprostone: A chloride channel activator for treatment of chronic constipation
-
Ambizas EM, Ginzburg R. Lubiprostone: a chloride channel activator for treatment of chronic constipation. Ann Pharmacother. 2007;41:957-64.
-
(2007)
Ann Pharmacother
, vol.41
, pp. 957-964
-
-
Ambizas, E.M.1
Ginzburg, R.2
-
56
-
-
43049156188
-
Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon
-
Bassil AK, Borman RA, Jarvie EM, et al. Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br J Pharmacol. 2008;154:126-35.
-
(2008)
Br J Pharmacol
, vol.154
, pp. 126-135
-
-
Bassil, A.K.1
Borman, R.A.2
Jarvie, E.M.3
-
58
-
-
0033005188
-
Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans
-
Bouras EP, Camilleri M, Burton DD, McKinzie S. Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans. Gut. 1999;44:682-686.
-
(1999)
Gut
, vol.44
, pp. 682-686
-
-
Bouras, E.P.1
Camilleri, M.2
Burton, D.D.3
McKinzie, S.4
-
59
-
-
0035121508
-
Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder
-
Bouras EP, Camilleri M, Burton DD, et al. Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder. Gastroenterology. 2001;120:354-60.
-
(2001)
Gastroenterology
, vol.120
, pp. 354-360
-
-
Bouras, E.P.1
Camilleri, M.2
Burton, D.D.3
-
60
-
-
0031950380
-
Effect of a novel proki-netic drug, R093877, on gastrointestinal transit in healthy volunteers
-
Emmanuel AV, Kamm MA, Roy AJ, Antonelli K. Effect of a novel proki-netic drug, R093877, on gastrointestinal transit in healthy volunteers. Gut. 1998;42:511-516.
-
(1998)
Gut
, vol.42
, pp. 511-516
-
-
Emmanuel, A.V.1
Kamm, M.A.2
Roy, A.J.3
Antonelli, K.4
-
61
-
-
0032589966
-
Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers
-
Poen AC, Felt-Bersma RJ, van Dongen PA, Meuwissen SG. Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers. Aliment Pharmacol Ther. 1999;13: 1493-1497.
-
(1999)
Aliment Pharmacol Ther
, vol.13
, pp. 1493-1497
-
-
Poen, A.C.1
Felt-Bersma, R.J.2
van Dongen, P.A.3
Meuwissen, S.G.4
-
62
-
-
0036109163
-
Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation
-
Sloots CE, Poen AC, Kerstens R, et al. Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation. Aliment Pharmacol Ther. 2002;16:759-767.
-
(2002)
Aliment Pharmacol Ther
, vol.16
, pp. 759-767
-
-
Sloots, C.E.1
Poen, A.C.2
Kerstens, R.3
-
63
-
-
0036024222
-
Prucalopride, a systemic enterokinetic, for the treatment of constipation
-
Emmanuel AV, Roy AJ, Nicholls TJ, Kamm MA. Prucalopride, a systemic enterokinetic, for the treatment of constipation. Aliment Pharmacol Ther. 2002;16:1347-1356.
-
(2002)
Aliment Pharmacol Ther
, vol.16
, pp. 1347-1356
-
-
Emmanuel, A.V.1
Roy, A.J.2
Nicholls, T.J.3
Kamm, M.A.4
-
64
-
-
0036186167
-
The effects of the spe-cifc 5HT(4) receptor agonist, prucalopride, on colonic motility in healthy volunteers
-
De Schryver AM, Andriesse GI, Samsom M, et al. The effects of the spe-cifc 5HT(4) receptor agonist, prucalopride, on colonic motility in healthy volunteers. Aliment Pharmacol Ther. 2002;16:603-612.
-
(2002)
Aliment Pharmacol Ther
, vol.16
, pp. 603-612
-
-
de Schryver, A.M.1
Andriesse, G.I.2
Samsom, M.3
-
65
-
-
44349130441
-
A placebo-controlled trial of prucalopride for severe chronic constipation
-
Camilleri M, Kerstens R, Rykx A, Vandeplassche L. A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med. 2008; 358:2344-2354.213.
-
(2008)
N Engl J Med
, vol.358
, pp. 2344-2354
-
-
Camilleri, M.1
Kerstens, R.2
Rykx, A.3
Vandeplassche, L.4
-
66
-
-
58149084950
-
Clinical trial: The eff-cacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation-a 12-week, randomized, double-blind, placebo-controlled study
-
Quigley EM, Vandeplassche L, Kerstens R, Ausma J. Clinical trial: the eff-cacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation-a 12-week, randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2009;29:315-328. 214.
-
(2009)
Aliment Pharmacol Ther
, vol.29
, Issue.214
, pp. 315-328
-
-
Quigley, E.M.1
Vandeplassche, L.2
Kerstens, R.3
Ausma, J.4
-
67
-
-
61649119045
-
Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfed with laxatives
-
Tack J, van Outryve M, Beyens G, Kerstens R, Vandeplassche L. Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfed with laxatives. Gut. 2009;58:357-365.
-
(2009)
Gut
, vol.58
, pp. 357-365
-
-
Tack, J.1
van Outryve, M.2
Beyens, G.3
Kerstens, R.4
Vandeplassche, L.5
-
68
-
-
74549216986
-
Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation-Quality of Life questionnaire in prucalopride (RESOLOR) trials for chronic constipation
-
Dubois D, Gilet H, Viala-Danten M, Tack J. Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation-Quality of Life questionnaire in prucalopride (RESOLOR) trials for chronic constipation. Neurogastroenterol Motil. 2010;22:e54-63.
-
(2010)
Neurogastroenterol Motil
, vol.22
-
-
Dubois, D.1
Gilet, H.2
Viala-Danten, M.3
Tack, J.4
-
69
-
-
77955493094
-
A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation
-
Müller-Lissner S, Rykx A, Kerstens R, Vandeplassche L. A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation. Neurogastroenterol Motil. 2010;22:991-998.
-
(2010)
Neurogastroenterol Motil
, vol.22
, pp. 991-998
-
-
Müller-Lissner, S.1
Rykx, A.2
Kerstens, R.3
Vandeplassche, L.4
-
70
-
-
0037540068
-
Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial
-
Coremans G, Kerstens R, de Pauw M, Stevens M. Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial. Digestion. 2003;67:82-89.
-
(2003)
Digestion
, vol.67
, pp. 82-89
-
-
Coremans, G.1
Kerstens, R.2
de Pauw, M.3
Stevens, M.4
-
71
-
-
77957924970
-
Effcacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation
-
Sloots CE, Rykx A, Cools M, Kerstens R, de Pauw M. Effcacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation. Dig Dis Sci. 2010;55:2912-2921.
-
(2010)
Dig Dis Sci
, vol.55
, pp. 2912-2921
-
-
Sloots, C.E.1
Rykx, A.2
Cools, M.3
Kerstens, R.4
de Pauw, M.5
-
72
-
-
0036212168
-
Effcacy and tolerability of prucalopride in patients with constipation due to spinal cord injury
-
Krogh K, Jensen MB, Gandrup P, et al. Effcacy and tolerability of prucalopride in patients with constipation due to spinal cord injury. Scand J Gastroenterol. 2002;37:431-436.
-
(2002)
Scand J Gastroenterol
, vol.37
, pp. 431-436
-
-
Krogh, K.1
Jensen, M.B.2
Gandrup, P.3
-
75
-
-
84898694618
-
-
Accessed 2010 Nov 19th
-
http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafety InformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm051284.htm (Accessed 2010 Nov 19th).
-
-
-
-
76
-
-
77951902634
-
Tegaserod and the risk of cardiovascular ischemic events: An observational cohort study
-
Loughlin J, Quinn S, Rivero E, et al. Tegaserod and the risk of cardiovascular ischemic events: an observational cohort study. J Cardiovasc Pharmacol Ther. 2010;15:151-7.
-
(2010)
J Cardiovasc Pharmacol Ther
, vol.15
, pp. 151-157
-
-
Loughlin, J.1
Quinn, S.2
Rivero, E.3
-
77
-
-
78649673553
-
Investigations on 5-HT4 Receptor Expression and Effects of Tegaserod on Human Platelet Aggregation In Vitro
-
Serebruany VL, Mouelhi ME, Pfannkuche HJ, Rose K, Marro M, Angiolillo DJ. Investigations on 5-HT4 Receptor Expression and Effects of Tegaserod on Human Platelet Aggregation In Vitro. Am J Ther. 2010;17: 543-52.
-
(2010)
Am J Ther
, vol.17
, pp. 543-552
-
-
Serebruany, V.L.1
Mouelhi, M.E.2
Pfannkuche, H.J.3
Rose, K.4
Marro, M.5
Angiolillo, D.J.6
-
79
-
-
72449142246
-
Cardiovascular safety of prucalopride in healthy subjects: Results from two randomized, double-blind, placebo-controlled, cross-over trials
-
Boyce M, Kerstens R, Beyens G, Ausma J, Vandeplassche L. Cardiovascular safety of prucalopride in healthy subjects: results from two randomized, double-blind, placebo-controlled, cross-over trials. Gastroenterology. 2009;136(Suppl 1): T1265.
-
(2009)
Gastroenterology
, vol.136
, Issue.SUPPL. 1
-
-
Boyce, M.1
Kerstens, R.2
Beyens, G.3
Ausma, J.4
Vandeplassche, L.5
-
81
-
-
72049090263
-
Safety assessment of prucalopride in elderly patients with constipation: A double-blind, placebo-controlled study
-
Camilleri M, Beyens G, Kerstens R, Robinson P, Vandeplassche L. Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study. Neurogastroenterol Motil. 2009;21:1256-e117.
-
(2009)
Neurogastroenterol Motil
, vol.21
-
-
Camilleri, M.1
Beyens, G.2
Kerstens, R.3
Robinson, P.4
Vandeplassche, L.5
-
83
-
-
58949101090
-
5-Hydroxytryptamine and the gastrointestinal tract: Where next?
-
Sanger GJ. 5-Hydroxytryptamine and the gastrointestinal tract: Where next? Trends Pharmacol Res. 2008;29:465-71.
-
(2008)
Trends Pharmacol Res
, vol.29
, pp. 465-471
-
-
Sanger, G.J.1
-
84
-
-
33845656047
-
4 receptor agonist, ATI-7505, in humans
-
Camilleri M, Vazquez-Roque MI, Burton D, et al. Pharmacodynamic effects of a novel prokinetic 5-HT4 receptor agonist, ATI-7505, in humans. Neurogastroenterol Motil. 2007;19:30-8.
-
(2007)
Neurogastroenterol Motil
, vol.19
, pp. 30-38
-
-
Camilleri, M.1
Vazquez-Roque, M.I.2
Burton, D.3
-
85
-
-
45849108757
-
4 receptor agonist with high intrinsic activity. Naunyn-Schmiedeberg's
-
Smith JAM, Beattie DT, Marquess D, Shaw J-P, Vickery RG, Humphrey PPA. The in vitro pharmacological profle of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity. Naunyn-Schmiedeberg's. Arch Pharmacol. 2008;378:125-37.
-
(2008)
Arch Pharmacol
, vol.378
, pp. 125-137
-
-
Smith, J.A.M.1
Beattie, D.T.2
Marquess, D.3
Shaw, J.-P.4
Vickery, R.G.5
Humphrey, P.P.A.6
-
86
-
-
78649489728
-
4 agonist with high intrinsic activity, in chronic idiopathic constipation-a 4-week, randomized, double-blind, placebo-controlled, dose-response study
-
Goldberg M, Li Y-P, Johanson JF, et al. Clinical trial: the effcacy and toler-ability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation-a 4-week, randomized, double-blind, placebo-controlled, dose-response study. Aliment Pharmacol Ther. 2010; 32:1102-12.
-
(2010)
Aliment Pharmacol Ther
, vol.32
, pp. 1102-1112
-
-
Goldberg, M.1
Li, Y.-P.2
Johanson, J.F.3
-
87
-
-
77951897011
-
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
-
Bryant AP, Busby RW, Bartolini WP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010;86:760-5.
-
(2010)
Life Sci
, vol.86
, pp. 760-765
-
-
Bryant, A.P.1
Busby, R.W.2
Bartolini, W.P.3
-
88
-
-
0028031074
-
Distribution of membrane bound gua-nylyl cyclases in human intestine
-
Krause G, Bayerl A, Heim JM, et al. Distribution of membrane bound gua-nylyl cyclases in human intestine. Gut. 1994;35:1250-7.
-
(1994)
Gut
, vol.35
, pp. 1250-1257
-
-
Krause, G.1
Bayerl, A.2
Heim, J.M.3
-
89
-
-
0035021499
-
Guanylin family: New intestinal peptides regulating electrolyte and water homeostasis
-
Nakazato M. Guanylin family: new intestinal peptides regulating electrolyte and water homeostasis. J Gastroenterol. 2001;36:219-25.
-
(2001)
J Gastroenterol
, vol.36
, pp. 219-225
-
-
Nakazato, M.1
-
90
-
-
0033000111
-
Guanylin regulatory peptides: Structures, biological activities mediated by cyclic GMP and pathobiology
-
Forte LR. Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology. Regul Pept. 1999;81:25-39.
-
(1999)
Regul Pept
, vol.81
, pp. 25-39
-
-
Forte, L.R.1
-
91
-
-
76349088961
-
Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain
-
Eutamene H, Bradesi S, Larauche M, et al. Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain. Neurogastroenterol Motil. 2010;22:312-e84.
-
(2010)
Neurogastroenterol Motil
, vol.22
-
-
Eutamene, H.1
Bradesi, S.2
Larauche, M.3
-
92
-
-
34548500315
-
Effects of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome
-
Andresen V, Camilleri M, Busciglio IA, et al. Effects of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology. 2007;133:761-8.
-
(2007)
Gastroenterology
, vol.133
, pp. 761-768
-
-
Andresen, V.1
Camilleri, M.2
Busciglio, I.A.3
-
93
-
-
62249106417
-
Linaclotide signifcantly improved abdominal pain/discomfort and global assessments in adults with irritable bowel syndrome with constipation
-
Johnston JM, MacDougall JE, Lavins BJ, et al. Linaclotide signifcantly improved abdominal pain/discomfort and global assessments in adults with irritable bowel syndrome with constipation. Neurogastroenterol Motil. 2008;20:13 (abstract).
-
(2008)
Neurogastroenterol Motil
, vol.20
, pp. 13
-
-
Johnston, J.M.1
Macdougall, J.E.2
Lavins, B.J.3
-
94
-
-
0029619510
-
Gastrointestinal prokinetic benzamides: The pharmacology underlying stimulation of motility
-
Brejer MR, Akkermans LMA, Schuurkes JAJ. Gastrointestinal prokinetic benzamides: the pharmacology underlying stimulation of motility. Pharmacol Rev. 1995;47:631-51.
-
(1995)
Pharmacol Rev
, vol.47
, pp. 631-651
-
-
Brejer, M.R.1
Akkermans, L.M.A.2
Schuurkes, J.A.J.3
-
95
-
-
0031457583
-
4 Receptor Agonists on Gastrointestinal Motility In Vivo and In Vitro
-
Mine Y, Yoshikawa, Oku S, Nagai R, Yoshida N, Hosoki K. Comparison of Effect of Mosapride Citrate and Existing 5-HT4 Receptor Agonists on Gastrointestinal Motility In Vivo and In Vitro. J Pharmacol Exp Ther. 1997;283:1000-8.
-
(1997)
J Pharmacol Exp Ther
, vol.283
, pp. 1000-1008
-
-
Mine, Y.1
Yoshikawa2
Oku, S.3
Nagai, R.4
Yoshida, N.5
Hosoki, K.6
-
96
-
-
4644360205
-
Pharmacology of serotonin: What a clinician should know
-
De Ponti F, Pharmacology of serotonin: What a clinician should know. Gut. 2004;53:1520-35.
-
(2004)
Gut
, vol.53
, pp. 1520-1535
-
-
de Ponti, F.1
-
97
-
-
0027508263
-
Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals
-
Yoshida N, Omoya H, Kato S, Ito T. Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals. Arzneimittelforschung. 1993;43:1078-83.
-
(1993)
Arzneimittelforschung
, vol.43
, pp. 1078-1083
-
-
Yoshida, N.1
Omoya, H.2
Kato, S.3
Ito, T.4
-
98
-
-
41849095624
-
Balancing drug risk and beneft: Toward refning the process of FDA decisions affecting patient care
-
Schiller LR, Johnson DA. Balancing drug risk and beneft: toward refning the process of FDA decisions affecting patient care. Am J Gastroenterol. 2008;103:815-9.
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 815-819
-
-
Schiller, L.R.1
Johnson, D.A.2
-
100
-
-
84898693886
-
-
http://www.drugs.com/clinical_trials/results-renzapride-phase-iii-clinical trial-4052.html
-
-
-
|