메뉴 건너뛰기




Volumn 3, Issue , 2010, Pages 21-33

Constipation, IBS and the 5-HT4 receptor: What role for prucalopride?

Author keywords

Constipation; IBS; Prucalopride

Indexed keywords

CHLORIDE CHANNEL; CHLORIDE ION; CISAPRIDE; DELAYED RECTIFIER POTASSIUM CHANNEL; GUANYLATE CYCLASE C RECEPTOR; LINACLOTIDE; LUBIPROSTONE; MD 01100; PLACEBO; PRUCALOPRIDE; RECEPTOR PROTEIN; SEROTONIN 2B RECEPTOR; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; TEGASEROD; UNCLASSIFIED DRUG; VELUSETRAG;

EID: 78650734005     PISSN: 11795522     EISSN: 11795522     Source Type: Journal    
DOI: 10.4137/CGast.S4136     Document Type: Article
Times cited : (13)

References (100)
  • 1
    • 72449193680 scopus 로고    scopus 로고
    • 4 receptor pharmacology
    • Sanger GJ. Translating 5-HT4 receptor pharmacology. Neurogastroenterol Motil. 2009;21:1235-8.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 1235-1238
    • Sanger, G.J.1
  • 3
    • 33746925213 scopus 로고    scopus 로고
    • 4 receptor agonists enhance both cholinergic and nitrergic activity in human isolated colon circular muscle
    • Cellek S, John AK, Thangiah R, et al. 5-HT4 receptor agonists enhance both cholinergic and nitrergic activity in human isolated colon circular muscle. Neurogastroenterol Motil. 2006;18:853-61.
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 853-861
    • Cellek, S.1    John, A.K.2    Thangiah, R.3
  • 4
    • 84898701009 scopus 로고    scopus 로고
    • Characterisation of motor nerve responses to electrical feld stimulation in human isolated colon
    • Broad J, Boundouki G, Knowles, CH, Sanger GJ. Characterisation of motor nerve responses to electrical feld stimulation in human isolated colon. Gut. 2010;59 Suppl 1:A140.
    • (2010) Gut , vol.59 , Issue.1 SUPPL.
    • Broad, J.1    Boundouki, G.2    Knowles, C.H.3    Sanger, G.J.4
  • 5
    • 77950640571 scopus 로고    scopus 로고
    • 4 receptor activation on acetylcholine release in human large intestine with endometriosis
    • Lefebvre RA, Ferrero S, van Colen I, et al. Infuence of 5-HT4 receptor activation on acetylcholine release in human large intestine with endometriosis. Neurogastroenterol Motil. 2010;22:557-63.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 557-563
    • Lefebvre, R.A.1    Ferrero, S.2    van Colen, I.3
  • 6
    • 0033709510 scopus 로고    scopus 로고
    • 4 receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle
    • Prins NH, Akkermans LM, Lefebvre RA, Schuurkes JA. 5-HT4 receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle. Br J Pharmacol. 2000;131:927-32.
    • (2000) Br J Pharmacol , vol.131 , pp. 927-932
    • Prins, N.H.1    Akkermans, L.M.2    Lefebvre, R.A.3    Schuurkes, J.A.4
  • 7
    • 0026612267 scopus 로고
    • 4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus
    • Kilbinger H, Wolf D. Effects of 5-HT4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus. Naunyn Schmiedebergs Arch Pharmacol. 1992;345:270-5.
    • (1992) Naunyn Schmiedebergs Arch Pharmacol , vol.345 , pp. 270-275
    • Kilbinger, H.1    Wolf, D.2
  • 8
    • 33746427538 scopus 로고    scopus 로고
    • 4 receptors in intestine
    • Poole DP, Xu B, Koh SL, et al. Identifcation of neurons that express 5- hydroxytryptamine4 receptors in intestine. Cell Tissue Res. 2006;325: 413-22.
    • (2006) Cell Tissue Res , vol.325 , pp. 413-422
    • Poole, D.P.1    Xu, B.2    Koh, S.L.3
  • 9
    • 0029058239 scopus 로고
    • 4 receptors in human colon, rat oesophagus and rat ileum
    • McLean PG, Coupar IM, Molenaar P. A comparative study of functional 5-HT4 receptors in human colon, rat oesophagus and rat ileum. Br J P harmacol. 1995;115:47-56.
    • (1995) Br J P Harmacol , vol.115 , pp. 47-56
    • McLean, P.G.1    Coupar, I.M.2    Molenaar, P.3
  • 10
    • 0028989385 scopus 로고
    • 4-like receptor in human colon circular smooth muscle
    • Tam FS, Hillier K, Bunce KT, Grossman C. Differences in response to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle. Br J Pharmacol. 1995;115:172-6.
    • (1995) Br J Pharmacol , vol.115 , pp. 172-176
    • Tam, F.S.1    Hillier, K.2    Bunce, K.T.3    Grossman, C.4
  • 11
    • 0033998810 scopus 로고    scopus 로고
    • 4 receptors in the human isolated large intestinal circular muscle
    • Prins NH, Shankley NP, Welsh NJ, et al. An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestinal circular muscle. Br J Pharmacol. 2000;129:1601-8.
    • (2000) Br J Pharmacol , vol.129 , pp. 1601-1608
    • Prins, N.H.1    Shankley, N.P.2    Welsh, N.J.3
  • 12
    • 33847247864 scopus 로고    scopus 로고
    • 7 receptor expression and function in the circular muscle of the human colon
    • Irving HR, Tan YY, Tochon-Danguy N, et al. Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon. Life Sci. 2007;80:1198-205.
    • (2007) Life Sci , vol.80 , pp. 1198-1205
    • Irving, H.R.1    Tan, Y.Y.2    Tochon-Danguy, N.3
  • 14
    • 0019732199 scopus 로고
    • Action of 5-hydroxytryptamine on intestinal ion transport in the rat
    • Hardcastle J, Hardcastle PT, Redfern JS. Action of 5-hydroxytryptamine on intestinal ion transport in the rat. J Physiol. 1981;320:41-55.
    • (1981) J Physiol , vol.320 , pp. 41-55
    • Hardcastle, J.1    Hardcastle, P.T.2    Redfern, J.S.3
  • 17
    • 0030742061 scopus 로고    scopus 로고
    • Heterogeneity of 5-HT receptors mediating secretion in the human intestine
    • Borman RA, Burleigh DE. Heterogeneity of 5-HT receptors mediating secretion in the human intestine. Ann NY Acad Sci. 1997;812:224-5.
    • (1997) Ann NY Acad Sci , vol.812 , pp. 224-225
    • Borman, R.A.1    Burleigh, D.E.2
  • 19
    • 0031801939 scopus 로고    scopus 로고
    • Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro
    • Schwörer H, Ramadori G. Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro. Naunyn Schmiedeberg's Arch Pharmacol. 1998;357:548-52.
    • (1998) Naunyn Schmiedeberg's Arch Pharmacol , vol.357 , pp. 548-552
    • Schwörer, H.1    Ramadori, G.2
  • 21
    • 37249010617 scopus 로고    scopus 로고
    • Human 5-HT4 and 5-HTsub7/sub splice variants: Are they important?
    • Coupar IM, Desmond PV, Irving HR. Human 5-HT4 and 5-HTsub7/sub splice variants: Are they important? Curr Neuropharmacol. 2007;5: 224-31.
    • (2007) Curr Neuropharmacol , vol.5 , pp. 224-231
    • Coupar, I.M.1    Desmond, P.V.2    Irving, H.R.3
  • 22
    • 0035919155 scopus 로고    scopus 로고
    • 4 receptor in the central nervous system by TaqMan real time RT-PCR
    • Medhurst AD, Lezoualc'h F, Fischmeister R, Middlemiss DN, Sanger GJ. Quantitative mRNA analysis of fve C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR. Mol Brain Res. 2001;90:125-34.
    • (2001) Mol Brain Res , vol.90 , pp. 125-134
    • Medhurst, A.D.1    Lezoualc'h, F.2    Fischmeister, R.3    Middlemiss, D.N.4    Sanger, G.J.5
  • 24
    • 0035967979 scopus 로고    scopus 로고
    • The in vitro pharmacological profle of prucalopride, a novel enterokinetic compound
    • Briejer MR, Bosmans JP, van Daele P, et al. The in vitro pharmacological profle of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001;423:71-83.
    • (2001) Eur J Pharmacol , vol.423 , pp. 71-83
    • Briejer, M.R.1    Bosmans, J.P.2    van Daele, P.3
  • 26
    • 77955457389 scopus 로고    scopus 로고
    • 4) receptor agonist, for the treatment of chronic constipation
    • Wong BS, Manabe N, Camilleri M. Role of prucalopride, a serotonin (5-HT4) receptor agonist, for the treatment of chronic constipation. Clin Exp Gastroenterol. 2010;3:49-56.
    • (2010) Clin Exp Gastroenterol , vol.3 , pp. 49-56
    • Wong, B.S.1    Manabe, N.2    Camilleri, M.3
  • 27
    • 33746335649 scopus 로고    scopus 로고
    • 5-hydroxytryptamine receptors in the human cardiovascular system
    • Kaumann AJ, Levy FO. 5-hydroxytryptamine receptors in the human cardiovascular system. Pharmacol Ther. 2006;111:674-706.
    • (2006) Pharmacol Ther , vol.111 , pp. 674-706
    • Kaumann, A.J.1    Levy, F.O.2
  • 28
    • 52949128037 scopus 로고    scopus 로고
    • 6 receptors in learning and memory
    • King MV, Marsden CA, Fone KC. A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory. Trends Pharmacol Sci. 2008;29: 482-92.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 482-492
    • King, M.V.1    Marsden, C.A.2    Fone, K.C.3
  • 29
    • 33646758583 scopus 로고    scopus 로고
    • 4 receptor agonists at gastric versus cardiac receptors: An operational framework to explain and quantify organ-specifc behavior
    • De Maeyer JH, Prins NH, Schuurkes JAJ, Lefebvre RA. Differential effects of 5-hydroxytryptamine4 receptor agonists at gastric versus cardiac receptors: An operational framework to explain and quantify organ-specifc behavior. J Pharmacol Exp Ther. 2006;317:955-64.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 955-964
    • de Maeyer, J.H.1    Prins, N.H.2    Schuurkes, J.A.J.3    Lefebvre, R.A.4
  • 30
    • 67650270527 scopus 로고    scopus 로고
    • 4 receptor-mediated response in pig atrium but not in the stomach
    • De Maeyer JH, Lefebvre RA, Schuurkes JAJ. Selective desensitization of the 5-HT4 receptor-mediated response in pig atrium but not in the stomach. Br J Pharmacol. 2009;156:362-76.
    • (2009) Br J Pharmacol , vol.156 , pp. 362-376
    • de Maeyer, J.H.1    Lefebvre, R.A.2    Schuurkes, J.A.J.3
  • 31
    • 45849102374 scopus 로고    scopus 로고
    • 4 receptor agonist with high intrinsic activity
    • Beattie DT, Armstrong SR, Shaw JP, et al. The in vivo gastrointestinal activity of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity. Naunyn-Schmiedeberg's Arch Pharmacol. 2008;378:139-47.
    • (2008) Naunyn-Schmiedeberg's Arch Pharmacol , vol.378 , pp. 139-147
    • Beattie, D.T.1    Armstrong, S.R.2    Shaw, J.P.3
  • 33
    • 8744318249 scopus 로고    scopus 로고
    • 2B receptor antagonist in vitro and in vivo
    • Beattie DT, Smith JA, Marquess D, et al. The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004;143:549-60.
    • (2004) Br J Pharmacol , vol.143 , pp. 549-560
    • Beattie, D.T.1    Smith, J.A.2    Marquess, D.3
  • 34
    • 74549184061 scopus 로고    scopus 로고
    • 2B receptor antagonist inhibits visceral hypersensitivity in rats
    • Ohashi-Doi K, Himaki D, Nagao K, et al. A selective, high affnity 5-HT2B receptor antagonist inhibits visceral hypersensitivity in rats. Neurogastroen-terol Motil. 2010;22:e69-76.
    • (2010) Neurogastroen-terol Motil , vol.22
    • Ohashi-Doi, K.1    Himaki, D.2    Nagao, K.3
  • 35
    • 77950681549 scopus 로고    scopus 로고
    • 2B receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction
    • O'Mahony SM, Bulmer DC, Coelho AM, et al. 5-HT2B receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction. Neurogastroenterol Motil. 2010;22:573-8.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 573-578
    • O'Mahony, S.M.1    Bulmer, D.C.2    Coelho, A.M.3
  • 37
    • 69249230884 scopus 로고    scopus 로고
    • 2B receptor in rodent large bowel physiology
    • Bassil AK, Taylor CM, Bolton VJN, et al. Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. Br J Pharmacol. 2009;158:252-8.
    • (2009) Br J Pharmacol , vol.158 , pp. 252-258
    • Bassil, A.K.1    Taylor, C.M.2    Bolton, V.J.N.3
  • 38
    • 0036199452 scopus 로고    scopus 로고
    • 2B receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro
    • Borman RA, Tilford NS, Harmer DW, et al. 5-HT2B receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro. Br J Pharmacol. 2002;135:1144-51.
    • (2002) Br J Pharmacol , vol.135 , pp. 1144-1151
    • Borman, R.A.1    Tilford, N.S.2    Harmer, D.W.3
  • 39
    • 0024478044 scopus 로고
    • Physician visits in the United States for constipation: 1958 to 1986
    • Sonnenberg A, Koch TR. Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci. 1989;34:606-11.
    • (1989) Dig Dis Sci , vol.34 , pp. 606-611
    • Sonnenberg, A.1    Koch, T.R.2
  • 40
    • 0027185528 scopus 로고
    • US householder survey of functional gastrointestinal disorders. Prevalence, sociodemography and health impact
    • Drossman DA, Li Z, Andruzzi E, et al. US householder survey of functional gastrointestinal disorders. Prevalence, sociodemography and health impact. Dig Dis Sci. 1993;38:1569-80.
    • (1993) Dig Dis Sci , vol.38 , pp. 1569-1580
    • Drossman, D.A.1    Li, Z.2    Andruzzi, E.3
  • 41
    • 0026567833 scopus 로고
    • Prevalence of gastrointestinal symptoms in the elderly: A population-based study
    • Talley NJ, O'Keefe EA, Zinsmeister AR, et al. Prevalence of gastrointestinal symptoms in the elderly: a population-based study. Gastroenterology. 1992;102:895-901.
    • (1992) Gastroenterology , vol.102 , pp. 895-901
    • Talley, N.J.1    O'Keefe, E.A.2    Zinsmeister, A.R.3
  • 44
    • 67649537590 scopus 로고    scopus 로고
    • American College of Gastroen-terology IBS Task Force. An evidence-based systematic review of the management of irritable bowel syndrome
    • Brandt LJ, Chey WD, Schiller LR, et al. American College of Gastroen-terology IBS Task Force. An evidence-based systematic review of the management of irritable bowel syndrome. Am J Gastroenterol. 2009;104: S1-35.
    • (2009) Am J Gastroenterol , vol.104
    • Brandt, L.J.1    Chey, W.D.2    Schiller, L.R.3
  • 45
    • 70449513263 scopus 로고    scopus 로고
    • An evidence-based approach to the management of irritable bowel syndrome in Europe
    • Quigley EMM, Bergmann JF, Bytzer P, et al. An evidence-based approach to the management of irritable bowel syndrome in Europe. Eur J Gastroenterol Hepatol. 2007;19(Suppl 1):S1-37.
    • (2007) Eur J Gastroenterol Hepatol , vol.19 , Issue.SUPPL. 1
    • Quigley, E.M.M.1    Bergmann, J.F.2    Bytzer, P.3
  • 46
    • 20844450744 scopus 로고    scopus 로고
    • Measurement of gastrointestinal transit
    • Lin HC, Prather C, Fisher RS, et al. Measurement of gastrointestinal transit. Dig Dis Sci. 2005;50:989-1004.
    • (2005) Dig Dis Sci , vol.50 , pp. 989-1004
    • Lin, H.C.1    Prather, C.2    Fisher, R.S.3
  • 47
    • 63049140085 scopus 로고    scopus 로고
    • Selected interventions in nuclear medicine: Gastrointestinal motor functions
    • Odunsi ST, Camilleri M. Selected interventions in nuclear medicine: gastrointestinal motor functions. Semin Nucl Med. 2009;39:186-94.
    • (2009) Semin Nucl Med , vol.39 , pp. 186-194
    • Odunsi, S.T.1    Camilleri, M.2
  • 48
    • 0026469867 scopus 로고
    • Measurement of small bowel and colonic transit: Indications and methods
    • von der Ohe MR, Camilleri M. Measurement of small bowel and colonic transit: indications and methods. Mayo Clin Proc. 1992;67:1169-79.
    • (1992) Mayo Clin Proc , vol.67 , pp. 1169-1179
    • von der Ohe, M.R.1    Camilleri, M.2
  • 49
    • 56549111183 scopus 로고    scopus 로고
    • American Neurogas-troenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice
    • Camilleri M, Bharucha AE, di Lorenzo C, et al. American Neurogas-troenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice. Neurogastroenterol Motil. 2008;20:1269-82.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 1269-1282
    • Camilleri, M.1    Bharucha, A.E.2    Di Lorenzo, C.3
  • 51
    • 0037613276 scopus 로고    scopus 로고
    • Current concepts of the irritable bowel syndrome
    • Quigley EM. Current concepts of the irritable bowel syndrome. Scand J Gastroenterol Suppl. 2003:1-8.
    • (2003) Scand J Gastroenterol Suppl , pp. 1-8
    • Quigley, E.M.1
  • 52
    • 0027385325 scopus 로고
    • Quigley EMM. Intestinal motility in irritable bowel syndrome: Is IBS a motility disorder? Part 1: Defnition of IBS and colonic motility
    • McKee DP, Quigley EMM. Intestinal motility in irritable bowel syndrome: Is IBS a motility disorder? Part 1: Defnition of IBS and colonic motility. Dig Dis Sci. 1993;38:1761-72.
    • (1993) Dig Dis Sci , vol.38 , pp. 1761-1772
    • McKee, D.P.1
  • 53
    • 0036079899 scopus 로고    scopus 로고
    • Rectal distension testing in patients with the irritable bowel syndrome: Sensitivity, specifcity, and predictive values of pain sensory thresholds
    • Bouin M, Plourde V, Boivin M, et al. Rectal distension testing in patients with the irritable bowel syndrome: sensitivity, specifcity, and predictive values of pain sensory thresholds. Gastroenterology. 2002;122:1771-7.
    • (2002) Gastroenterology , vol.122 , pp. 1771-1777
    • Bouin, M.1    Plourde, V.2    Boivin, M.3
  • 54
    • 38849092560 scopus 로고    scopus 로고
    • Development of drugs for gastrointestinal motor disorders: Translating science to clinical need
    • Sanger GJ, Alpers D. Development of drugs for gastrointestinal motor disorders: Translating science to clinical need. Neurogastroenterol Motil. 2008:20:177-84.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 177-184
    • Sanger, G.J.1    Alpers, D.2
  • 55
    • 34250210742 scopus 로고    scopus 로고
    • Lubiprostone: A chloride channel activator for treatment of chronic constipation
    • Ambizas EM, Ginzburg R. Lubiprostone: a chloride channel activator for treatment of chronic constipation. Ann Pharmacother. 2007;41:957-64.
    • (2007) Ann Pharmacother , vol.41 , pp. 957-964
    • Ambizas, E.M.1    Ginzburg, R.2
  • 56
    • 43049156188 scopus 로고    scopus 로고
    • Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon
    • Bassil AK, Borman RA, Jarvie EM, et al. Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br J Pharmacol. 2008;154:126-35.
    • (2008) Br J Pharmacol , vol.154 , pp. 126-135
    • Bassil, A.K.1    Borman, R.A.2    Jarvie, E.M.3
  • 58
    • 0033005188 scopus 로고    scopus 로고
    • Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans
    • Bouras EP, Camilleri M, Burton DD, McKinzie S. Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans. Gut. 1999;44:682-686.
    • (1999) Gut , vol.44 , pp. 682-686
    • Bouras, E.P.1    Camilleri, M.2    Burton, D.D.3    McKinzie, S.4
  • 59
    • 0035121508 scopus 로고    scopus 로고
    • Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder
    • Bouras EP, Camilleri M, Burton DD, et al. Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder. Gastroenterology. 2001;120:354-60.
    • (2001) Gastroenterology , vol.120 , pp. 354-360
    • Bouras, E.P.1    Camilleri, M.2    Burton, D.D.3
  • 60
    • 0031950380 scopus 로고    scopus 로고
    • Effect of a novel proki-netic drug, R093877, on gastrointestinal transit in healthy volunteers
    • Emmanuel AV, Kamm MA, Roy AJ, Antonelli K. Effect of a novel proki-netic drug, R093877, on gastrointestinal transit in healthy volunteers. Gut. 1998;42:511-516.
    • (1998) Gut , vol.42 , pp. 511-516
    • Emmanuel, A.V.1    Kamm, M.A.2    Roy, A.J.3    Antonelli, K.4
  • 61
    • 0032589966 scopus 로고    scopus 로고
    • Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers
    • Poen AC, Felt-Bersma RJ, van Dongen PA, Meuwissen SG. Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers. Aliment Pharmacol Ther. 1999;13: 1493-1497.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 1493-1497
    • Poen, A.C.1    Felt-Bersma, R.J.2    van Dongen, P.A.3    Meuwissen, S.G.4
  • 62
    • 0036109163 scopus 로고    scopus 로고
    • Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation
    • Sloots CE, Poen AC, Kerstens R, et al. Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation. Aliment Pharmacol Ther. 2002;16:759-767.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 759-767
    • Sloots, C.E.1    Poen, A.C.2    Kerstens, R.3
  • 63
    • 0036024222 scopus 로고    scopus 로고
    • Prucalopride, a systemic enterokinetic, for the treatment of constipation
    • Emmanuel AV, Roy AJ, Nicholls TJ, Kamm MA. Prucalopride, a systemic enterokinetic, for the treatment of constipation. Aliment Pharmacol Ther. 2002;16:1347-1356.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1347-1356
    • Emmanuel, A.V.1    Roy, A.J.2    Nicholls, T.J.3    Kamm, M.A.4
  • 64
    • 0036186167 scopus 로고    scopus 로고
    • The effects of the spe-cifc 5HT(4) receptor agonist, prucalopride, on colonic motility in healthy volunteers
    • De Schryver AM, Andriesse GI, Samsom M, et al. The effects of the spe-cifc 5HT(4) receptor agonist, prucalopride, on colonic motility in healthy volunteers. Aliment Pharmacol Ther. 2002;16:603-612.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 603-612
    • de Schryver, A.M.1    Andriesse, G.I.2    Samsom, M.3
  • 65
    • 44349130441 scopus 로고    scopus 로고
    • A placebo-controlled trial of prucalopride for severe chronic constipation
    • Camilleri M, Kerstens R, Rykx A, Vandeplassche L. A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med. 2008; 358:2344-2354.213.
    • (2008) N Engl J Med , vol.358 , pp. 2344-2354
    • Camilleri, M.1    Kerstens, R.2    Rykx, A.3    Vandeplassche, L.4
  • 66
    • 58149084950 scopus 로고    scopus 로고
    • Clinical trial: The eff-cacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation-a 12-week, randomized, double-blind, placebo-controlled study
    • Quigley EM, Vandeplassche L, Kerstens R, Ausma J. Clinical trial: the eff-cacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation-a 12-week, randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2009;29:315-328. 214.
    • (2009) Aliment Pharmacol Ther , vol.29 , Issue.214 , pp. 315-328
    • Quigley, E.M.1    Vandeplassche, L.2    Kerstens, R.3    Ausma, J.4
  • 67
    • 61649119045 scopus 로고    scopus 로고
    • Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfed with laxatives
    • Tack J, van Outryve M, Beyens G, Kerstens R, Vandeplassche L. Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfed with laxatives. Gut. 2009;58:357-365.
    • (2009) Gut , vol.58 , pp. 357-365
    • Tack, J.1    van Outryve, M.2    Beyens, G.3    Kerstens, R.4    Vandeplassche, L.5
  • 68
    • 74549216986 scopus 로고    scopus 로고
    • Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation-Quality of Life questionnaire in prucalopride (RESOLOR) trials for chronic constipation
    • Dubois D, Gilet H, Viala-Danten M, Tack J. Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation-Quality of Life questionnaire in prucalopride (RESOLOR) trials for chronic constipation. Neurogastroenterol Motil. 2010;22:e54-63.
    • (2010) Neurogastroenterol Motil , vol.22
    • Dubois, D.1    Gilet, H.2    Viala-Danten, M.3    Tack, J.4
  • 69
    • 77955493094 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation
    • Müller-Lissner S, Rykx A, Kerstens R, Vandeplassche L. A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation. Neurogastroenterol Motil. 2010;22:991-998.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 991-998
    • Müller-Lissner, S.1    Rykx, A.2    Kerstens, R.3    Vandeplassche, L.4
  • 70
    • 0037540068 scopus 로고    scopus 로고
    • Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial
    • Coremans G, Kerstens R, de Pauw M, Stevens M. Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial. Digestion. 2003;67:82-89.
    • (2003) Digestion , vol.67 , pp. 82-89
    • Coremans, G.1    Kerstens, R.2    de Pauw, M.3    Stevens, M.4
  • 71
    • 77957924970 scopus 로고    scopus 로고
    • Effcacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation
    • Sloots CE, Rykx A, Cools M, Kerstens R, de Pauw M. Effcacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation. Dig Dis Sci. 2010;55:2912-2921.
    • (2010) Dig Dis Sci , vol.55 , pp. 2912-2921
    • Sloots, C.E.1    Rykx, A.2    Cools, M.3    Kerstens, R.4    de Pauw, M.5
  • 72
    • 0036212168 scopus 로고    scopus 로고
    • Effcacy and tolerability of prucalopride in patients with constipation due to spinal cord injury
    • Krogh K, Jensen MB, Gandrup P, et al. Effcacy and tolerability of prucalopride in patients with constipation due to spinal cord injury. Scand J Gastroenterol. 2002;37:431-436.
    • (2002) Scand J Gastroenterol , vol.37 , pp. 431-436
    • Krogh, K.1    Jensen, M.B.2    Gandrup, P.3
  • 73
    • 0036143629 scopus 로고    scopus 로고
    • Treatment of GI dysmotility in scleroderma with the new enterokinetic agent prucalopride
    • Boeckxstaens GE, Bartelsman JF, Lauwers L, Tytgat GN. Treatment of GI dysmotility in scleroderma with the new enterokinetic agent prucalopride. Am J Gastroenterol. 2002;97:194-197.
    • (2002) Am J Gastroenterol , vol.97 , pp. 194-197
    • Boeckxstaens, G.E.1    Bartelsman, J.F.2    Lauwers, L.3    Tytgat, G.N.4
  • 75
    • 84898694618 scopus 로고    scopus 로고
    • Accessed 2010 Nov 19th
    • http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafety InformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm051284.htm (Accessed 2010 Nov 19th).
  • 76
    • 77951902634 scopus 로고    scopus 로고
    • Tegaserod and the risk of cardiovascular ischemic events: An observational cohort study
    • Loughlin J, Quinn S, Rivero E, et al. Tegaserod and the risk of cardiovascular ischemic events: an observational cohort study. J Cardiovasc Pharmacol Ther. 2010;15:151-7.
    • (2010) J Cardiovasc Pharmacol Ther , vol.15 , pp. 151-157
    • Loughlin, J.1    Quinn, S.2    Rivero, E.3
  • 77
    • 78649673553 scopus 로고    scopus 로고
    • Investigations on 5-HT4 Receptor Expression and Effects of Tegaserod on Human Platelet Aggregation In Vitro
    • Serebruany VL, Mouelhi ME, Pfannkuche HJ, Rose K, Marro M, Angiolillo DJ. Investigations on 5-HT4 Receptor Expression and Effects of Tegaserod on Human Platelet Aggregation In Vitro. Am J Ther. 2010;17: 543-52.
    • (2010) Am J Ther , vol.17 , pp. 543-552
    • Serebruany, V.L.1    Mouelhi, M.E.2    Pfannkuche, H.J.3    Rose, K.4    Marro, M.5    Angiolillo, D.J.6
  • 79
    • 72449142246 scopus 로고    scopus 로고
    • Cardiovascular safety of prucalopride in healthy subjects: Results from two randomized, double-blind, placebo-controlled, cross-over trials
    • Boyce M, Kerstens R, Beyens G, Ausma J, Vandeplassche L. Cardiovascular safety of prucalopride in healthy subjects: results from two randomized, double-blind, placebo-controlled, cross-over trials. Gastroenterology. 2009;136(Suppl 1): T1265.
    • (2009) Gastroenterology , vol.136 , Issue.SUPPL. 1
    • Boyce, M.1    Kerstens, R.2    Beyens, G.3    Ausma, J.4    Vandeplassche, L.5
  • 80
    • 59149091346 scopus 로고    scopus 로고
    • ®) in patients with chronic constipation: Pooled data from three pivotal phase III studies
    • ®) in patients with chronic constipation: Pooled data from three pivotal phase III studies. Gastroenterology. 2008;134:A530-1.
    • (2008) Gastroenterology , vol.134
    • Tack, J.1    Ausma, J.2    Kerstens, R.3    Vandeplassche, L.4
  • 81
    • 72049090263 scopus 로고    scopus 로고
    • Safety assessment of prucalopride in elderly patients with constipation: A double-blind, placebo-controlled study
    • Camilleri M, Beyens G, Kerstens R, Robinson P, Vandeplassche L. Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study. Neurogastroenterol Motil. 2009;21:1256-e117.
    • (2009) Neurogastroenterol Motil , vol.21
    • Camilleri, M.1    Beyens, G.2    Kerstens, R.3    Robinson, P.4    Vandeplassche, L.5
  • 83
    • 58949101090 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine and the gastrointestinal tract: Where next?
    • Sanger GJ. 5-Hydroxytryptamine and the gastrointestinal tract: Where next? Trends Pharmacol Res. 2008;29:465-71.
    • (2008) Trends Pharmacol Res , vol.29 , pp. 465-471
    • Sanger, G.J.1
  • 86
    • 78649489728 scopus 로고    scopus 로고
    • 4 agonist with high intrinsic activity, in chronic idiopathic constipation-a 4-week, randomized, double-blind, placebo-controlled, dose-response study
    • Goldberg M, Li Y-P, Johanson JF, et al. Clinical trial: the effcacy and toler-ability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation-a 4-week, randomized, double-blind, placebo-controlled, dose-response study. Aliment Pharmacol Ther. 2010; 32:1102-12.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 1102-1112
    • Goldberg, M.1    Li, Y.-P.2    Johanson, J.F.3
  • 87
    • 77951897011 scopus 로고    scopus 로고
    • Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
    • Bryant AP, Busby RW, Bartolini WP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010;86:760-5.
    • (2010) Life Sci , vol.86 , pp. 760-765
    • Bryant, A.P.1    Busby, R.W.2    Bartolini, W.P.3
  • 88
    • 0028031074 scopus 로고
    • Distribution of membrane bound gua-nylyl cyclases in human intestine
    • Krause G, Bayerl A, Heim JM, et al. Distribution of membrane bound gua-nylyl cyclases in human intestine. Gut. 1994;35:1250-7.
    • (1994) Gut , vol.35 , pp. 1250-1257
    • Krause, G.1    Bayerl, A.2    Heim, J.M.3
  • 89
    • 0035021499 scopus 로고    scopus 로고
    • Guanylin family: New intestinal peptides regulating electrolyte and water homeostasis
    • Nakazato M. Guanylin family: new intestinal peptides regulating electrolyte and water homeostasis. J Gastroenterol. 2001;36:219-25.
    • (2001) J Gastroenterol , vol.36 , pp. 219-225
    • Nakazato, M.1
  • 90
    • 0033000111 scopus 로고    scopus 로고
    • Guanylin regulatory peptides: Structures, biological activities mediated by cyclic GMP and pathobiology
    • Forte LR. Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology. Regul Pept. 1999;81:25-39.
    • (1999) Regul Pept , vol.81 , pp. 25-39
    • Forte, L.R.1
  • 91
    • 76349088961 scopus 로고    scopus 로고
    • Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain
    • Eutamene H, Bradesi S, Larauche M, et al. Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain. Neurogastroenterol Motil. 2010;22:312-e84.
    • (2010) Neurogastroenterol Motil , vol.22
    • Eutamene, H.1    Bradesi, S.2    Larauche, M.3
  • 92
    • 34548500315 scopus 로고    scopus 로고
    • Effects of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome
    • Andresen V, Camilleri M, Busciglio IA, et al. Effects of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology. 2007;133:761-8.
    • (2007) Gastroenterology , vol.133 , pp. 761-768
    • Andresen, V.1    Camilleri, M.2    Busciglio, I.A.3
  • 93
    • 62249106417 scopus 로고    scopus 로고
    • Linaclotide signifcantly improved abdominal pain/discomfort and global assessments in adults with irritable bowel syndrome with constipation
    • Johnston JM, MacDougall JE, Lavins BJ, et al. Linaclotide signifcantly improved abdominal pain/discomfort and global assessments in adults with irritable bowel syndrome with constipation. Neurogastroenterol Motil. 2008;20:13 (abstract).
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 13
    • Johnston, J.M.1    Macdougall, J.E.2    Lavins, B.J.3
  • 94
    • 0029619510 scopus 로고
    • Gastrointestinal prokinetic benzamides: The pharmacology underlying stimulation of motility
    • Brejer MR, Akkermans LMA, Schuurkes JAJ. Gastrointestinal prokinetic benzamides: the pharmacology underlying stimulation of motility. Pharmacol Rev. 1995;47:631-51.
    • (1995) Pharmacol Rev , vol.47 , pp. 631-651
    • Brejer, M.R.1    Akkermans, L.M.A.2    Schuurkes, J.A.J.3
  • 95
    • 0031457583 scopus 로고    scopus 로고
    • 4 Receptor Agonists on Gastrointestinal Motility In Vivo and In Vitro
    • Mine Y, Yoshikawa, Oku S, Nagai R, Yoshida N, Hosoki K. Comparison of Effect of Mosapride Citrate and Existing 5-HT4 Receptor Agonists on Gastrointestinal Motility In Vivo and In Vitro. J Pharmacol Exp Ther. 1997;283:1000-8.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1000-1008
    • Mine, Y.1    Yoshikawa2    Oku, S.3    Nagai, R.4    Yoshida, N.5    Hosoki, K.6
  • 96
    • 4644360205 scopus 로고    scopus 로고
    • Pharmacology of serotonin: What a clinician should know
    • De Ponti F, Pharmacology of serotonin: What a clinician should know. Gut. 2004;53:1520-35.
    • (2004) Gut , vol.53 , pp. 1520-1535
    • de Ponti, F.1
  • 97
    • 0027508263 scopus 로고
    • Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals
    • Yoshida N, Omoya H, Kato S, Ito T. Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals. Arzneimittelforschung. 1993;43:1078-83.
    • (1993) Arzneimittelforschung , vol.43 , pp. 1078-1083
    • Yoshida, N.1    Omoya, H.2    Kato, S.3    Ito, T.4
  • 98
    • 41849095624 scopus 로고    scopus 로고
    • Balancing drug risk and beneft: Toward refning the process of FDA decisions affecting patient care
    • Schiller LR, Johnson DA. Balancing drug risk and beneft: toward refning the process of FDA decisions affecting patient care. Am J Gastroenterol. 2008;103:815-9.
    • (2008) Am J Gastroenterol , vol.103 , pp. 815-819
    • Schiller, L.R.1    Johnson, D.A.2
  • 100
    • 84898693886 scopus 로고    scopus 로고
    • http://www.drugs.com/clinical_trials/results-renzapride-phase-iii-clinical trial-4052.html


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.