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Volumn 19, Issue 1, 2011, Pages 374-383
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Molecular modeling based approach, synthesis and in vitro assay to new indole inhibitors of hepatitis C NS3/4A serine protease
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Author keywords
3 Aryl 1 (1H indol 3 yl) 2 propen 1 ones; HCV; Molecular modeling; Protease inhibitor
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Indexed keywords
2 (4 ACETAMIDOBENZOYL)BENZOIC ACID;
2 (4 AMINOOBENZOYL)BENZOIC ACID;
2 [2 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO]BENZOYL]BENZOIC ACID;
2 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO] 3 (1H IMIDAZOL 4 YL)PROPANOIC ACID;
2 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO] 3 (1H INDOL 3 YL)PROPANOIC ACID;
2 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO] 3 (4 HYDROXY PHENYL)PROPANOIC ACID;
2 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO]] 3 PHENYL PROPANOIC ACID;
2 [4 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO]BENZOYL]BENZOIC ACID;
2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY] N (5 CYANOPYRIMIDIN 4 YL)ACETAMIDE;
4 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO]PYRIMIDINE 5 CARBOXYLIC ACID;
ANTIVIRUS AGENT;
ETHYL 2 [2 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO]BENZOYL]BENZOATE;
ETHYL 2 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO] 3 (4 HYDROXY PHENYL)PROPANOATE;
ETHYL 2 [4 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO]BENZOYL]BENZOATE;
INDOLE DERIVATIVE;
METHYL 2 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO] 3 (1H IMIDAZOL 4 YL)PROPANOATE;
METHYL 2 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO] 3 (1H INDOL 3 YL)PROPANOATE;
METHYL 2 [2 [4 [3 (1H INDOL 3 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETAMIDO] 3 PHENYL PROPANOATE;
NONSTRUCTURAL PROTEIN 3;
NONSTRUCTURAL PROTEIN 4A;
SERINE PROTEINASE INHIBITOR;
UNCLASSIFIED DRUG;
ARTICLE;
BINDING ASSAY;
DRUG DETERMINATION;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME ACTIVE SITE;
HEPATITIS C;
IC 50;
IN VITRO STUDY;
MOLECULAR DOCKING;
MOLECULAR MODEL;
NONHUMAN;
PHARMACOPHORE;
SIMULATION;
STRUCTURE ACTIVITY RELATION;
INDOLES;
INHIBITORY CONCENTRATION 50;
MAGNETIC RESONANCE SPECTROSCOPY;
MODELS, MOLECULAR;
SERINE PROTEINASE INHIBITORS;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
STRUCTURE-ACTIVITY RELATIONSHIP;
VIRAL NONSTRUCTURAL PROTEINS;
HEPATITIS C VIRUS;
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EID: 78650729130
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmc.2010.11.017 Document Type: Article |
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Times cited : (18)
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References (31)
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