Synthesis of potent antitumor and antiviral benzofuran derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 9, 2009, Pages 2420-2428

  Galal, Shadia A ^a   Abd El All, Amira S ^a   Abdallah, Mohamed M ^b   El Diwani, Hoda I ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b Univet Pharmaceuticals Ltd   (Egypt)

Author keywords

Antitumor activity; Antiviral activity; Benzofuran; Cytotoxicity; Furochromones; HCV NS3 4A protease inhibitor activity; Heterocyclic amines; HIV and HIV 1 RT inhibitory activity

Indexed keywords

(1H BENZIMIDAZOL 2 YL)METHANAMINE DIHYOCHLORIDE; (6 HYDROXY 4,7 DIMETHOXYBENZOFURAN 5 YL)(8AH THIAZOLO[3,2 A]PYRIMIDINE 6 YL)METHANONE; (6 HYDROXY 4,7 DIMETHOXYBENZOFURAN 5 YL)[2 METHYL 3 AH(1,2,4)OXADIAZOLO[2,3 A]PYRIMIDIN 6 YL)METHANONE; (6 HYDROXY 4,7 DIMETHOXYBENZOFURAN 5 YL)[9AH PYRIDOL[1,2 A]PYRIMIDIN 3 YL)METHANONE; (6 HYDROXY 4,7 DIMETHOXYBENZOFURAN 5 YL)[BENZO(4,5)IMIDAZO(1,2 A)PYRIMIDIN 3 YL]METHANONE; 1 (6 HYDROXY 4,7 DIMETHOXYBENZOFURAN 5 YL) 3 (PYRIDIN 4 YLAMINO)PROP 2 EN 1 1; 5 OXO 5H FURO(3,2 G)CHROMENE 6 CARBALDEHYDE; [11H BENZO(4,5)IMIDAZO(1,2 A)(1,4)DIAZEPIN 4 YL](6 HYDROXY 4 METHOXY BENZOFURAN 5 YL)METHANONE; [11H BENZO(4,5)IMIDAZO(1,2 A)(1,4)DIAZEPIN 4 YL](6 HYDROXY 4,7 DIMETHOXY BENZOFURAN 5 YL)METHANONE; AMINE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; ATEVIRDINE; BENZOFURAN DERIVATIVE; CAPECITABINE; CARBONYL DERIVATIVE; CYTARABINE; DOXORUBICIN; FLUOROURACIL; FUROCHROMONE DERIVATIVE; GEMCITABINE; NONSTRUCTURAL PROTEIN 3; RECOMBINANT INTERLEUKIN 2; TELAPREVIR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; FETUS; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; LD 50; NONHUMAN;

ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; BENZOFURANS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HIV REVERSE TRANSCRIPTASE; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; OLIGOPEPTIDES; PIPERAZINES;

HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 64249104388     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.069     Document Type: Article

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