Synthesis of dammarane-type triterpene derivatives and their ability to inhibit HIV and HCV proteases

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 8, 2009, Pages 3003-3010

  Wei, Ying ^a,b   Ma, Chao Mei ^a   Hattori, Masao ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

2,3 seco Derivative; Dammarane; HCV protease; HIV 1 protease; Succinyl derivative; Triterpene

Indexed keywords

20,25 EPOXY 12 OXO 2,3 SECO DAMMARAN 2,3 DIOC ACID; 20,25 EPOXY 2ALPHA,12BETA DIHYDROXY 6 OXO A NORDAMMARAN 2 CARBOXYLIC ACID; 20,25 EPOXY 2ALPHA,12BETA DIHYDROXY A NORDAMMARAN 2 CARBOXYLIC ACID; 20,25 EPOXY 3,6 DI O(3',3' DIMETHYLSUCCINYL)DAMMARAN 12 ONE; 20,25 EPOXY 3BETA HYDROXYDAMMARAN 12 ONE 3 (3',3' DIMETHYL)SUCCINATE; 20,25 EPOXY DAMMARAN 3BETA,12BETA DIOL 3 (3',3' DIMETHYL)SUCCINATE; 20,25 EPOXY DAMMARAN 3BETA,6ALPHA,12BETA TRIOL 3,6 DI(3',3' DIMETHYL)SUCCINATE; 20,25 EPOXY DAMMARAN 3BETA,6ALPHA,12BETA TRIOL 6 (3',3' DIMETHYL)SUCCINATE; 20,25 EPOXY DAMMARAN 3BETA,6ALPHA,12BETABETA TRIOL 3 (3',3' DIMETHYL)SUCCINATE; DAMMARANE DERIVATIVE; PROTEINASE; RENIN; TRITERPENE DERIVATIVE; TRYPSIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; NONHUMAN; PROTEINASE INHIBITION; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; HEPACIVIRUS; HEPATITIS C; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; PROTEASE INHIBITORS; RENIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES; TRYPSIN;

HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 64049099458     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.019     Document Type: Article

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