The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease

Journal of Medicinal Chemistry

Volumn 47, Issue 26, 2004, Pages 6443-6446

  Ontoria, Jesus M ^a   Di Marco, Stefania ^a   Conte, Immacolata ^a   Di Francesco, M Emilia ^a   Gardelli, Cristina ^a   Koch, Uwe ^a   Matassa, Victor G ^b   Poma, Marco ^a   Steinkühler, Christian ^a   Volpari, Cinzia ^a   Harper, Steven ^a  

^a IRBM   (Italy)

^b Graffinity Pharmaceuticals AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; INDOLINE 2 CARBOXYLIC ESTER; INDOLINE DERIVATIVE; PROTEASE NS3; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HEPATITIS C VIRUS; NONHUMAN;

ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; HEPACIVIRUS; INDOLES; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PROTEIN BINDING; STEREOISOMERISM; VIRAL NONSTRUCTURAL PROTEINS;

EID: 10644269875     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049435d     Document Type: Article

References (22)

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20. The coordinates have been deposited in the PDB. Coordinate ID code: 1w3c. Structure factor code: r1w3csf.
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