Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 513-523

  Reid, Carolyn S ^a   Patrick, Donald A ^b   He, Shanshan ^a   Fotie, Jean ^a   Premalatha, Kokku ^a   Tidwell, Richard R ^b   Wang, Michael Zhuo ^c   Liu, Qiang ^b   Gershkovich, Pavel ^d   Wasan, Kishor M ^d   Wenzler, Tanja ^e,f   Brun, Reto ^e,f   Werbovetz, Karl A ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNC Hamner Institute for Drug Safety Sciences   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^f UNIVERSITY OF BASEL   (Switzerland)

Author keywords

African trypanosomiasis; Dihydroquinoline; Drug discovery

Indexed keywords

1 (2 METHOXYBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 OL HYDROCHLORIDE; 1 (2 METHOXYBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 (3,4 DIFLUOROBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN; 1 (3,4 DIFLUOROBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 OL; 1 (3,4 DIFLUOROBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 OL HYDROCHLORIDE; 1 (3,4 DIFLUOROBENZYL) 6 ETHOXY 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 1 (4 ISOPROPYLBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 OL; 1 (4 ISOPROPYLBENZYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 BENZYL 1,2 DIHYDRO 2,2 DIMETHYL 4 PHENYLQUINOLIN 6 YL ACETATE; 1 BENZYL 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 OL HYDROCHLORIDE; 1 BENZYL 1,2 DIHYDRO 2,2,4,7 TETRAMETHYLQUINOLIN 6 YL ACETATE; 1 BENZYL 1,2 DIHYDRO 2,2,4,8 TETRAMETHYLQUINOLIN 6 YL ACETATE; 1 BENZYL 1,2 DIHYDRO 8 METHOXY 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 BENZYL 5,7 DICHLORO 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 BENZYL 6 ETHOXY 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLINE; 1 BENZYL 7 (4 (TRIFLUOROMETHYL)PHENYL) 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1 BENZYL 7 CHLORO 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 YL ACETATE; 1,2 DIHYDRO 6 METHOXY 2,2,4,8 TETRAMETHYLQUINOLINE; 1,2 DIHYDRO 6,8 DIMETHOXY 2,2,4 TRIMETHYLQUINOLINE; 5,7 DICHLORO 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 OL; ANTIINFECTIVE AGENT; I (2 METHOXY) BENZYL 1,2 DIHYDRO 2,2,4 TRIMETHYLQUINOLIN 6 OL HYDROCHLORIDE; QUINOLONE DERIVATIVE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOLECULE; MOUSE; NONHUMAN; RAT; SOLID; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TRYPANOSOMA RHODESIENSE;

ANIMALS; CYCLIZATION; MICE; QUINOLINES; SALTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS;

TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 78650720085     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.003     Document Type: Article

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