Design, synthesis, and biological evaluation of novel water-soluble N-mustards as potential anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 471-485

  Kapuriya, Naval ^a,e   Kakadiya, Rajesh ^a   Dong, Huajin ^b   Kumar, Amit ^a   Lee, Pei Chih ^a   Zhang, Xiuguo ^b   Chou, Ting Chao ^b   Lee, Te Chang ^a   Chen, Ching Huang ^a   Lam, King ^d   Marvania, Bhavin ^a,e   Shah, Anamik ^e   Su, Tsann Long ^a,c  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d DEVELOPMENT CENTER FOR BIOTECHNOLOGY   (Taiwan)

^e SAURASHTRA UNIVERSITY   (India)

Author keywords

Anticancer agents; Cell cycle; DNA interstrand cross linking agents; Water soluble nitrogen mustards

Indexed keywords

1 [3 [(2 DIMETHYLAMINO)ETHYL]CARBAMOYL]PHENYL] 3 [4 [BIS(2 CHLOROETHYL)AMINO]PHENYL]UREA HYDROCHLORIDE; 1 [3 [(2 MORPHOLINOETHYL)CARBAMOYL]PHENYL] 3 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL]UREA HYDROCHLORIDE; 1 [3 [[2 (PIPERIDIN 1 YL)ETHYL]CARBAMOYL]PHENYL] 3 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL]UREA HYDROCHLORIDE; 1 [3 [[2 (PYRROLIDIN 1 YL)ETHYL]CARBAMOYL]PHENYL] 3 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL]UREA HYDROCHLORIDE; 1 [3 [[3 (DIMETHYLAMINO)PROPYL]CARBAMOYL]PHENYL] 3 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL]UREA; 1 [4 [[2 (DIMETHYLAMINO)ETHYL]CARBAMOYL]PHENYL] 3 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL]UREA HYDROCHLORIDE; 1 [4 [[2 (PIPERIDIN 1 YL)ETHYL]CARBAMOYL]PHENYL] 3 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL]UREA HYDROCHLORIDE; 1 [4 [[2 (PYRROLIDIN 1 YL)ETHYL]CARBAMOYL]PHENYL] 3 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL]UREA HYDROCHLORIDE; 1 [4 [[2 MORPHOLINOETHYL)CARBAMOYL]PHENYL] 3 [5 [BIS (2 CHLOROETHYL)AMINO]PHENYL] UREA HYDROCHLORIDE; 1 [4 [[3 (DIMETHYLAMINO)PROPYL]CARBAMOYL]PHENYL] 3 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL]UREA; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 3 [3 (2 MORPHOLINOETHOXY)PHENYL]UREA; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 3 [3 [2 (DIMETHYLAMINO)ETHOXY]PHENYL]UREA; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 3 [3 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL]UREA; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 3 [3 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL]UREA; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 3 [3 [3 (DIMETHYLAMINO)PROPOXY]PHENYL]UREA; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 3 [3 [4 (PIPERIDIN 1 YL)PIPERIDINE 1 CARBONYL]PHENYL]UREA HYDROCHLORIDE; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 3 [4 [4 (PIPERIDIN 1 YL)PIPERIDINE 1 CARBONYL]PHENYL]UREA HYDROCHLORIDE; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 4 [3 [2 (DIMETHYLAMINO)PHENYL]UREA HYDROCHLORIDE; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 4 [3 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL]UREA; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 4 [3 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL]UREA; 1 [4 [BIS (2 CHLOROETHYL)AMINO]PHENYL] 4 [3 [3 (DIMETHYLAMINO)PROPOXY]PHENYL]UREA HYDROCHLORIDE; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; CHLORMETHINE DERIVATIVE; CYCLOPHOSPHAMIDE; IRINOTECAN; PACLITAXEL; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BREAST CARCINOMA; CELL CYCLE ARREST; COLON CANCER; CONTROLLED STUDY; DNA CROSS LINKING; DRUG CLEARANCE; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG DNA BINDING; DRUG EFFICACY; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TOLERABILITY; GLIOMA; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OPTIMAL DRUG DOSE; PROSTATE ADENOCARCINOMA; RAT; STRUCTURE ACTIVITY RELATION; TUMOR REGRESSION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIMIT OF DETECTION; MALE; MICE; MICE, NUDE; MUSTARD COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; WATER; XENOGRAFT MODEL ANTITUMOR ASSAYS;

BRASSICACEAE; MUS MUSCULUS; RATTUS;

EID: 78650719442     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.005     Document Type: Article

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