메뉴 건너뛰기




Volumn 43, Issue 12, 2010, Pages 818-823

Rapid functional screening of effective siRNAs against Plk1 and its growth inhibitory effects in laryngeal carcinoma cells

Author keywords

Apoptosis; Cell cycle; Laryngeal carcinoma; Plk1; RNA silencing

Indexed keywords

CELL CYCLE PROTEIN; ONCOPROTEIN; POLO LIKE KINASE 1; POLO-LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA;

EID: 78650713406     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2010.43.12.818     Document Type: Article
Times cited : (7)

References (26)
  • 1
    • 0032535244 scopus 로고    scopus 로고
    • Polo-like kinases: A team that plays throughout mitosis
    • Glover, D.M., Hagan, I.M. and Tavares, A.A. (1998) Polo-like kinases: a team that plays throughout mitosis. Genes. Dev. 12, 3777-3787.
    • (1998) Genes. Dev. , vol.12 , pp. 3777-3787
    • Glover, D.M.1    Hagan, I.M.2    Tavares, A.A.3
  • 2
    • 0028243084 scopus 로고
    • Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5
    • Golsteyn, R.M., Schultz, S.J., Bartek, J., Ziemiecki, A., Ried, T. and Nigg, E.A. (1994) Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. J. Cell Sci. 107, 1509-1517.
    • (1994) J. Cell Sci. , vol.107 , pp. 1509-1517
    • Golsteyn, R.M.1    Schultz, S.J.2    Bartek, J.3    Ziemiecki, A.4    Ried, T.5    Nigg, E.A.6
  • 3
    • 33645316142 scopus 로고    scopus 로고
    • Targeting polo-like kinase 1 for cancer therapy
    • Strebhardt, K. and Ullrich, A. (2006) Targeting polo-like kinase 1 for cancer therapy. Nat. Rev. Cancer 6, 321-330.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 321-330
    • Strebhardt, K.1    Ullrich, A.2
  • 4
    • 72049090437 scopus 로고    scopus 로고
    • Polo-like kinase inhibitors: An emerging opportunity for cancer therapeutics
    • Chopra, P., Sethi, G., Dastidar, S.G. and Ray, A. (2010) Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics. Expert. Opin. Investig. Drugs 19, 27-43.
    • (2010) Expert. Opin. Investig. Drugs , vol.19 , pp. 27-43
    • Chopra, P.1    Sethi, G.2    Dastidar, S.G.3    Ray, A.4
  • 5
    • 74549116355 scopus 로고    scopus 로고
    • Targeting Pololike kinase in cancer therapy
    • Degenhardt, Y. and Lampkin, T. (2010) Targeting Pololike kinase in cancer therapy. Clin. Cancer Res. 16, 384-389.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 384-389
    • Degenhardt, Y.1    Lampkin, T.2
  • 7
    • 0033564832 scopus 로고    scopus 로고
    • Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck
    • Knecht, R., Elez R., Oechler, M., Solbach, C., von Ilberg, C. and Strebhardt, K. (1999) Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck. Cancer Res. 59, 2794-2797.
    • (1999) Cancer Res , vol.59 , pp. 2794-2797
    • Knecht, R.1    Elez, R.2    Oechler, M.3    Solbach, C.4    Von Ilberg, C.5    Strebhardt, K.6
  • 8
    • 0037132736 scopus 로고    scopus 로고
    • Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells
    • Spänkuch-Schmitt, B., Bereiter-Hahn, J., Kaufmann, M., and Strebhardt, K. (2002) Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells. J. Natl. Cancer Inst. 94, 1863-1877.
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 1863-1877
    • Spänkuch-Schmitt, B.1    Bereiter-Hahn, J.2    Kaufmann, M.3    Strebhardt, K.4
  • 9
    • 37049001639 scopus 로고    scopus 로고
    • Polo-like kinase 1 is involved in invasion through extracellular matrix
    • Rizki, A., Mott, J.D. and Bissell, M.J. (2007) Polo-like kinase 1 is involved in invasion through extracellular matrix. Cancer Res. 67, 11106-11110.
    • (2007) Cancer Res , vol.67 , pp. 11106-11110
    • Rizki, A.1    Mott, J.D.2    Bissell, M.J.3
  • 10
    • 0038624074 scopus 로고    scopus 로고
    • Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells
    • Liu, X. and Erikson, R.L. (2003) Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100, 5789-5794.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 5789-5794
    • Liu, X.1    Erikson, R.L.2
  • 11
    • 16344367736 scopus 로고    scopus 로고
    • Silencing of polo-like kinase (Plk) 1 via siRNA causes induction of apoptosis and impairment of mitosis machinery in human prostate cancer cells: Implications for the treatment of prostate cancer
    • Reagan-Shaw, S. and Ahmad, N. (2005) Silencing of polo-like kinase (Plk) 1 via siRNA causes induction of apoptosis and impairment of mitosis machinery in human prostate cancer cells: implications for the treatment of prostate cancer. FASEB J. 19, 611-613.
    • (2005) FASEB J , vol.19 , pp. 611-613
    • Reagan-Shaw, S.1    Ahmad, N.2
  • 12
    • 33644767315 scopus 로고    scopus 로고
    • Normal cells, but not cancer cells, survive severe Plk1 depletion
    • Liu, X., Lei, M. and Erikson, R.L. (2006) Normal cells, but not cancer cells, survive severe Plk1 depletion. Mol. Cell Biol. 26, 2093-2108.
    • (2006) Mol. Cell Biol. , vol.26 , pp. 2093-2108
    • Liu, X.1    Lei, M.2    Erikson, R.L.3
  • 13
    • 33751099034 scopus 로고    scopus 로고
    • RNAi therapeutics: A potential new class of pharmaceutical drugs
    • Bumcrot, D., Manoharan, M., Koteliansky, V. and Sah, D.W. (2006) RNAi therapeutics: a potential new class of pharmaceutical drugs. Nat. Chem. Biol. 2, 711-719.
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 711-719
    • Bumcrot, D.1    Manoharan, M.2    Koteliansky, V.3    Sah, D.W.4
  • 14
    • 77952043572 scopus 로고    scopus 로고
    • RNAi-based therapeutics-current status, challenges and prospects
    • Tiemann, K. and Rossi, J.J. (2009) RNAi-based therapeutics-current status, challenges and prospects. EMBO Mol. Med. 1, 142-151.
    • (2009) EMBO Mol. Med. , vol.1 , pp. 142-151
    • Tiemann, K.1    Rossi, J.J.2
  • 15
    • 49549100682 scopus 로고    scopus 로고
    • Silencing of polo-like kinase (Plk) 1 via siRNA causes inhibition of growth and induction of apoptosis in human esophageal cancer cells
    • Bu, Y., Yang, Z., Li, Q. and Song, F. (2008) Silencing of polo-like kinase (Plk) 1 via siRNA causes inhibition of growth and induction of apoptosis in human esophageal cancer cells. Oncology 74, 198-206.
    • (2008) Oncology , vol.74 , pp. 198-206
    • Bu, Y.1    Yang, Z.2    Li, Q.3    Song, F.4
  • 18
    • 0032102860 scopus 로고    scopus 로고
    • Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis
    • Juan, G., Traganos, F., James, W.M., Ray, J.M., Roberge, M., Sauve, D.M., Anderson, H. and Darzynkiewicz, Z. (1998) Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis. Cytometry 32, 71-77.
    • (1998) Cytometry , vol.32 , pp. 71-77
    • Juan, G.1    Traganos, F.2    James, W.M.3    Ray, J.M.4    Roberge, M.5    Sauve, D.M.6    Anderson, H.7    Darzynkiewicz, Z.8
  • 21
    • 33745200043 scopus 로고    scopus 로고
    • A novel siRNA validation system for functional screening and identification of effective RNAi probes in mammalian cells
    • Hung, C.F., Lu, K.C., Cheng, T.L., Wu, R.H., Huang, L.Y., Teng, C.F. and Chang, W.T. (2006) A novel siRNA validation system for functional screening and identification of effective RNAi probes in mammalian cells. Biochem. Biophys. Res. Commun. 346, 707-720.
    • (2006) Biochem. Biophys. Res. Commun. , vol.346 , pp. 707-720
    • Hung, C.F.1    Lu, K.C.2    Cheng, T.L.3    Wu, R.H.4    Huang, L.Y.5    Teng, C.F.6    Chang, W.T.7
  • 23
    • 0037172998 scopus 로고    scopus 로고
    • Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA
    • Liu, X. and Erikson, R.L. (2002) Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA. Proc. Natl. Acad. Sci. U.S.A. 99, 8672-8676.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 8672-8676
    • Liu, X.1    Erikson, R.L.2
  • 24
    • 0034048515 scopus 로고    scopus 로고
    • The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase
    • Roshak, A.K., Capper, E.A., Imburgia, C., Fornwald, J., Scott, G. and Marshall, L.A. (2000) The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. Cell Signal 12, 405-411.
    • (2000) Cell Signal , vol.12 , pp. 405-411
    • Roshak, A.K.1    Capper, E.A.2    Imburgia, C.3    Fornwald, J.4    Scott, G.5    Marshall, L.A.6
  • 26
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak, K.J. and Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.