Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase

Journal of Pharmacological Sciences

Volumn 107, Issue 3, 2008, Pages 270-276

  Yoshikawa, Masanobu ^a   Shinomiya, Takashi ^b   Takayasu, Naoko ^a   Tsukamoto, Hideo ^a   Kawaguchi, Mitsuru ^b   Kobayashi, Hiroyuki ^a   Oka, Tetsuo ^a   Hashimoto, Atsushi ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO DENTAL COLLEGE   (Japan)

Author keywords

D amino acid oxidase; D serine; Morphine; N methyl D aspartate receptor; Serine racemase

Indexed keywords

DEXTRO AMINO ACID OXIDASE; DEXTRO SERINE; DIZOCILPINE; GLYCINE; MESSENGER RNA; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RACEMASE; SERINE RACEMASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG MECHANISM; DRUG RECEPTOR BINDING; HIPPOCAMPUS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION;

EID: 47749102938     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08030FP     Document Type: Article

References (38)

1. Hashimoto A, Nishikawa T, Oka T, Takahashi K. Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging. J Neurochem. 1993;60:783-786.
2. Schell MJ, Molliver ME, Snyder SH. D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci U S A. 1995;92:3948-3952.
3. Hashimoto A, Oka T. Free D-aspartate and D-serine in the mammalian brain and periphery. Prog Neurobiol. 1997;52:325-353.
4. Hashimoto A, Oka T, Nishikawa T. Extracellular concentration of endogenous free D-serine in the rat brain as revealed by in vivo microdialysis. Neuroscience. 1995;66:635-643.
5. Wolosker H, Blackshaw S, Snyder SH. Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A. 1999;96:13409-13414.
6. Konno R. Rat cerebral serine racemase: amino acid deletion and truncation at carboxy terminus. Neurosci Lett. 2003;349:111-114.
7. Yoshikawa M, Kobayashi T, Oka T, Kawaguchi M, Hashimoto A. Distribution and MK-801-induced expression of serine racemase mRNA in rat brain by real-time quantitative PCR.Brain Res Mol Brain Res. 2004;128:90-94.
8. Horiike K, Tojo H, Arai R, Nozaki M, Maeda T. D-amino-acid oxidase is confined to the lower brain stem and cerebellum in rat brain: regional differentiation of astrocytes. Brain Res. 1994; 652:297-303.
9. Yoshikawa M, Oka T, Kawaguchi M, Hashimoto A. MK-801 upregulates the expression of d-amino acid oxidase mRNA in rat brain. Brain Res Mol Brain Res. 2004;131:141-144.
10. Mao J. NMDA and opioid receptors: their interactions in antinociception, tolerance and neuroplasticity. Brain Res Brain Res Rev. 1999;30:289-304.
11. Zhu H, Brodsky M, Gorman AL, Inturrisi CE. Region-specific changes in NMDA receptor mRNA induced by chronic morphine treatment are prevented by the co-administration of the competitive NMDA receptor antagonist LY274614. Brain Res Mol Brain Res. 2003;114:154-162.
12. Zhu H, Jang CG, Ma T, Oh S, Rockhold RW, Ho IK. Region specific expression of NMDA receptor NR1 subunit mRNA in hypothalamus and pons following chronic morphine treatment. Eur J Pharmacol. 1999;365:47-54.
13. Bajo M, Crawford EF, Roberto M, Madamba SG, Siggins GR. Chronic morphine treatment alters expression of N-methyl-D-aspartate receptor subunits in the extended amygdala. J Neurosci Res. 2006;83:532-537.
14. Ozawa T, Nakagawa T, Shige K, Minami M, Satoh M. Changes in the expression of glial glutamate transporters in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal. Brain Res. 2001;905:254-258.
15. Yoshikawa M, Andoh H, Ito K, Suzuki T, Kawaguchi M, Kobayashi H, et al. Acute treatment with morphine augments the expression of serine racemase and d-amino acid oxidase mRNAs in rat brain. Eur J Pharmacol. 2005;525:94-97.
16. Marek P, Ben-Eliyahu S, Gold M, Liebeskind JC. Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat. Brain Res. 1991;547:77-81.
17. Trujillo KA, Akil H. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science. 1991;251:85-87.
18. Elliott K, Minami N, Kolesnikov YA, Pasternak GW, Inturrisi CE. The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain. 1994;56:69-75.
19. Kolesnikov Y, Pasternak GW. Topical opioids in mice: analgesia and reversal of tolerance by a topical N-methyl-D-aspartate antagonist. J Pharmacol Exp Ther. 1999;290:247-252.
20. Martin G, Guadano-Ferraz A, Morte B, Ahmed S, Koob GF, De Lecea L, et al. Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. J Pharmacol Exp Ther. 2004;311:265-273.
21. Martin G, Przewlocki R, Siggins GR. Chronic morphine treatment selectively augments metabotropic glutamate receptor-induced inhibition of N-methyl-D-aspartate receptor-mediated neurotransmission in nucleus accumbens. J Pharmacol Exp Ther. 1999;288:30-35.
22. Liu J, Nickolenko J, Sharp FR. Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A. 1994;91:8537-8541.
23. Erdtmann-Vourliotis M, Mayer P, Riechert U, Grecksch G, Hollt V. Identification of brain regions that are markedly activated by morphine in tolerant but not in naive rats. Brain Res Mol Brain Res. 1998;61:51-61.
24. Nye HE, Nestler EJ. Induction of chronic Fos-related antigens in rat brain by chronic morphine administration. Mol Pharmacol. 1996;49:636-645.
25. Frankel PS, Harlan RE, Garcia MM. Chronic administration of morphine alters immediate-early gene expression in the forebrain of post-dependent rats. Brain Res. 1999;835:204-212.
26. Wu S, Barger SW. Induction of Serine Racemase by Inflammatory Stimuli Is Dependent on AP-1. Ann N Y Acad Sci. 2004;1035:133-146.
27. Hashimoto A, Yoshikawa M, Andoh H, Yano H, Matsumoto H, Kawaguchi M, et al. Effects of MK-801 on the expression of serine racemase and d-amino acid oxidase mRNAs and on the d-serine levels in rat brain. Eur J Pharmacol. 2007;555:17-22.
28. De Miranda J, Panizzutti R, Foltyn VN, Wolosker H. Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine. Proc Natl Acad Sci U S A. 2002;99:14542-14547.
29. Foltyn VN, Bendikov I, De Miranda J, Panizzutti R, Dumin E, Shleper M, et al. Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity. J Biol Chem. 2005;280:1754-1763.
30. Strisovsky K, Jiraskova J, Barinka C, Majer P, Rojas C, Slusher BS, et al. Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate. FEBS Lett. 2003;535:44-48.
31. Contreras PC. D-Serine antagonized phencyclidine- and MK-801-induced stereotyped behavior and ataxia. Neuropharmacology. 1990;291-293.
32. Tanii Y, Nishikawa T, Hashimoto A, Takahashi K. Stereoselective antagonism by enantiomers of alanine and serine of phencyclidine-induced hyperactivity, stereotypy and ataxia in the rat. J Pharmacol Exp Ther. 1994;269:1040-1048.
33. Snell K. Enzymes of serine metabolism in normal, developing and neoplastic rat tissues. Adv Enzyme Regul. 1984;22:325-400.
34. Yamashita N, Sakai K, Furuya S, Watanabe M. Selective expression of L-serine synthetic enzyme 3PGDH in Schwann cells, perineuronal glia, and endoneurial fibroblasts along rat sciatic nerves and its upregulation after crush injury. Arch Histol Cytol. 2003;66:429-436.
35. Hashimoto A. Effect of the intracerebroventricular and systemic administration of L-serine on the concentrations of D- and L-serine in several brain areas and periphery of rat. Brain Res. 2002;955:214-220.
36. Hashimoto A, Chiba Y. Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat. Eur J Pharmacol. 2004;495:153-158.
37. Hashimoto A, Nishikawa T, Konno R, Niwa A, Yasumura Y, Oka T, et al. Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase. Neurosci Lett. 1993;152:33-36.
38. Matsui T, Sekiguchi M, Hashimoto A, Tomita U, Nishikawa T, Wada K. Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J Neurochem. 1995;65:454-458.