Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7

Blood

Volumn 116, Issue 26, 2010, Pages 6133-6143

  Nichol, Donna ^a   Shawber, Carrie ^b   Fitch, Michael J ^c   Bambino, Kathryn ^a   Sharma, Anshula ^b   Kitajewski, Jan ^b   Stuhlmann, Heidi ^a,c  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR LIKE DOMAIN 7; MESSENGER RNA; MICRORNA; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD VESSEL; CELL PROLIFERATION; CELL STRAIN HEK293; COCULTURE; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HEAD; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MONOLAYER CULTURE; MORPHOGENESIS; MOUSE; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RETINA; SIGNAL TRANSDUCTION; THREE HYBRID SYSTEM; TRANSGENIC MOUSE; TWO HYBRID SYSTEM; UMBILICAL VEIN; WESTERN BLOTTING; YEAST; YOLK SAC;

EID: 78650652062     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-03-274860     Document Type: Article

References (40)

1. Phng LK, Gerhardt H. Angiogenesis: a team effort coordinated by notch. Dev Cell. 2009;16(2):196-208.
2. Fitch MJ, Campagnolo L, Kuhnert F, Stuhlmann H. Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Dev Dyn. 2004;230(2):316-324.
3. Parker LH, Schmidt M, Jin SW, et al. The endo-thelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature. 2004;428(6984):754-758.
4. Soncin F, Mattot V, Lionneton F, et al. VE-statin, an endothelial repressor of smooth muscle cell migration. EMBO J. 2003;22(21):5700-5711.
5. Schmidt MH, Bicker F, Nikolic I, et al. Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat Cell Biol. 2009;11(7):873-880.
6. Campagnolo L, Leahy A, Chitnis S, et al. EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury. Am J Pathol. 2005;167(1):275-284.
7. Schmidt M, Paes K, De Mazière A, et al. EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development. 2007;134(16):2913-2923.
8. De Mazière A, Parker L, Van Dijk S, et al. Egfl7 knockdown causes defects in the extension and junctional arrangements of endothelial cells during zebrafish vasculogenesis. Dev Dyn. 2008;237(3):580-591.
9. Fish JE, Santoro MM, Morton SU, et al. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008;15(2):272-284.
10. Kuhnert F, Mancuso MR, Hampton J, et al. Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development. 2008;135(24):3989-3993.
11. Wang S, Aurora AB, Johnson BA, et al. The endo-thelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008;15(2):261-271.
12. Schlaeger TM, Bartunkova S, Lawitts JA, et al. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult trans-genic mice. Proc Natl Acad Sci U S A. 1997;94(7):3058-3063.
13. Funahashi Y, Hernandez SL, Das I, et al. A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res. 2008;68(12):4727-4735.
14. Jaffe EA, Nachman RL, Minick CR, et al. Culture of human endothelial cells derived from umbilical veins: identification by morphologic and immuno-logic criteria. J Clin Invest. 1973;52:2745-2756.
15. Tung JJ, Hobert O, Berryman M, Kitajewski J. Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro. Angiogenesis. 2009;12(3):209-220.
16. Geback T, Schulz MM, Koumoutsakos P, et al. TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques. 2009;46(4):265-274.
17. Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T. Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 1998;10(8):1217-1227.
18. Benedito R, Roca C, Sörensen I, et al. The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell. 2009;137(6):1124-1135.
19. Hellstrom M, Phng LK, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature. 2007;445(7129):776-780.
20. Lobov IB, Renard RA, Papadopoulos N, et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A. 2007;104(9):3219-3224.
21. Suchting S, Freitas C, le Noble F, et al. The Notch ligand Delta-like 4 negatively regulates endothe-lial tip cell formation and vessel branching. Proc Natl Acad Sci U S A. 2007;104(9):3225-3230.
22. Henderson AM, Wang SJ, Taylor AC, Altkenhead M, Hughes CC. The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation. J Biol Chem. 2001;276(9):6169-6176.
23. Holderfield MT, Hughes CC. Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res. 2008;102(6):637-652.
24. Liu ZJ, Shirakawa T, Li Y, et al. Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol. 2003;23(1):14-25.
25. Noseda M, Chang L, McLean G, et al. Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol Cell Biol. 2004;24(20):8813-8822.
26. Sainson RC, Aoto J, Nakatsu MN, et al. Cell-autonomous notch signaling regulates endothe-lial cell branching and proliferation during vascular tubulogenesis. FASEB J. 2005;19(8):1027-1029.
27. Taylor KL, Henderson AM, Hughes CC. Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvasc Res. 2002;64(3):372-383.
28. Nakatsu MN, Sainson RC, Aoto JN, et al. Angio-genic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc Res. 2003;66(2):102-112.
29. Uyttendaele H, Marazzi G, Wu G, Yan Q, Sassoon D, Kitajewski J. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development. 1996;122(7):2251-2259.
30. Durrans A, Stuhlmann H. A role for Egfl7 during endothelial organization in the embryoid body model system. J Angiogenes Res. 2010;2:4.
31. Wu Y, Cain-Hom C, Choy L, et al. Therapeutic antibody targeting of individual Notch receptors. Nature. 2010;464(7291):1052-1059.
32. Lee S, Chen TT, Barber CL, et al. Autocrine VEGF signaling is required for vascular ho-meostasis. Cell. 2007;130(4):691-703.
33. Carlson TR, Yan Y, Wu X, et al. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A. 2005;102(28):9884-9889.
34. Trindade A, Kumar SR, Scehnet JS, et al. Over-expression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood. 2008;112(5):1720-1729.
35. Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N. Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell. 2009;16(1):58-69.
36. Wu F, Yang LY, Li YF, Ou DP, Chen DP, Fan C. Novel role for epidermal growth factor like-domain 7 in metastasis of human hepatocellular carcinoma. Hematology. 2009;50(6):1839-1850.
37. Hicks C, Ladi E, Lindsell C, et al. A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling. J Neurosci Res. 2002;68(6):655-667.
38. Hukriede NA, Gu Y, Fleming RJ. Adominant-negative form of Serrate acts as a general antagonist of Notch activation. Development. 1997;124(17):3427-3437.
39. Sun X, Artavanis-Tsakonas S. Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development. 1997;124(17):3439- 3448.
40. Glittenberg M, Pitsouli C, Garvey C, Delidakis C, Bray S. Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and en-docytosis. EMBO J. 2006;25(20):4697-4706.