-
1
-
-
0021983551
-
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments
-
Yancopoulos, G. D., and F. W. Alt. 1985. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell 40:271-281.
-
(1985)
Cell.
, vol.40
, pp. 271-281
-
-
Yancopoulos, G.D.1
Alt, F.W.2
-
2
-
-
8744314660
-
Assembly and analysis of the mouse immunoglobulin kappa gene sequence
-
Brekke, K. M., and W. T. Garrard. 2004. Assembly and analysis of the mouse immunoglobulin kappa gene sequence. Immunogenetics 56:490-505.
-
(2004)
Immunogenetics
, vol.56
, pp. 490-505
-
-
Brekke, K.M.1
Garrard, W.T.2
-
3
-
-
0035997348
-
V (D) J recombination: RAG proteins, repair factors, and regulation
-
Gellert, M. 2002. V (D) J recombination: RAG proteins, repair factors, and regulation. Annu. Rev. Biochem. 71:101-132.
-
(2002)
Annu. Rev. Biochem.
, vol.71
, pp. 101-132
-
-
Gellert, M.1
-
4
-
-
3242886298
-
Regulation of activation and recombination of the murine Igkappa locus
-
Schlissel, M. S. 2004. Regulation of activation and recombination of the murine Igkappa locus. Immunol. Rev. 200:215-223.
-
(2004)
Immunol. Rev.
, vol.200
, pp. 215-223
-
-
Schlissel, M.S.1
-
5
-
-
0021274530
-
Novel κ light-chain gene rearrangements in mouse λ light chain-producing B lymphocytes
-
Durdik, J. M., M. W. Moore, and E. Selsing. 1984. Novel κ light-chain gene rearrangements in mouse λ light chain-producing B lymphocytes. Nature 307:749-752.
-
(1984)
Nature
, vol.307
, pp. 749-752
-
-
Durdik, J.M.1
Moore, M.W.2
Selsing, E.3
-
6
-
-
0025093522
-
Murine lambda gene rearrangements: The stochastic model prevails over the ordered model
-
Nadel, B., P. A. Cazenave, and P. Sanchez. 1990. Murine lambda gene rearrangements: the stochastic model prevails over the ordered model. EMBO J. 9:435-440.
-
(1990)
EMBO J
, vol.9
, pp. 435-440
-
-
Nadel, B.1
Cazenave, P.A.2
Sanchez, P.3
-
7
-
-
0025729069
-
Deletions of immunoglobulin Cκ region characterized by the circular excision products in mouse splenocytes
-
Shimizu, T., T. Iwasato, and H. Yamagishi. 1991. Deletions of immunoglobulin Cκ region characterized by the circular excision products in mouse splenocytes. J. Exp. Med. 173:1065-1072.
-
(1991)
J. Exp. Med.
, vol.173
, pp. 1065-1072
-
-
Shimizu, T.1
Iwasato, T.2
Yamagishi, H.3
-
8
-
-
39149143650
-
Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production
-
Vela, J. L., D. Aït-Azzouzene, B. H. Duong, T. Ota, and D. Nemazee. 2008. Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production. Immunity 28:161-170.
-
(2008)
Immunity
, vol.28
, pp. 161-170
-
-
Vela, J.L.1
Aït-Azzouzene, D.2
Duong, B.H.3
Ota, T.4
Nemazee, D.5
-
9
-
-
0037031831
-
Chromatin structural analyses of the mouse Igkappa gene locus reveal new hypersensitive sites specifying a transcriptional silencer and enhancer
-
Liu, Z. M., J. B. George-Raizen, S. Li, K. C. Meyers, M. Y. Chang, and W. T. Garrard. 2002. Chromatin structural analyses of the mouse Igkappa gene locus reveal new hypersensitive sites specifying a transcriptional silencer and enhancer. J. Biol. Chem. 277:32640-32649.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32640-32649
-
-
Liu, Z.M.1
George-Raizen, J.B.2
Li, S.3
Meyers, K.C.4
Chang, M.Y.5
Garrard, W.T.6
-
10
-
-
0020561224
-
Immunoglobulin gene transcription is activated by downstream sequence elements
-
Queen, C., and D. Baltimore. 1983. Immunoglobulin gene transcription is activated by downstream sequence elements. Cell 33:741-748.
-
(1983)
Cell.
, vol.33
, pp. 741-748
-
-
Queen, C.1
Baltimore, D.2
-
11
-
-
0022968816
-
Transcription termination and chromatin structure of the active immunoglobulin κ gene locus
-
Xu, M., M. B. Barnard, S. M. Rose, P. N. Cockerill, S.-Y. Huang, and W. T. Garrard. 1986. Transcription termination and chromatin structure of the active immunoglobulin κ gene locus. J. Biol. Chem. 261:3838-3845.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 3838-3845
-
-
Xu, M.1
Barnard, M.B.2
Rose, S.M.3
Cockerill, P.N.4
Huang, S.-Y.5
Garrard, W.T.6
-
12
-
-
0024461826
-
The immunoglobulin κ locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region
-
Meyer, K. B., and M. S. Neuberger. 1989. The immunoglobulin κ locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region. EMBO J. 8:1959-1964.
-
(1989)
EMBO J
, vol.8
, pp. 1959-1964
-
-
Meyer, K.B.1
Neuberger, M.S.2
-
13
-
-
16244398049
-
Long-range interactions between three tran-scriptional enhancers, active Vkappa gene promoters, and a 3' boundary sequence spanning 46 kilobases
-
Liu, Z., and W. T. Garrard. 2005. Long-range interactions between three tran-scriptional enhancers, active Vkappa gene promoters, and a 3' boundary sequence spanning 46 kilobases. Mol. Cell. Biol. 25:3220-3231.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 3220-3231
-
-
Liu, Z.1
Garrard, W.T.2
-
14
-
-
70349334302
-
Divergent roles of RelA and c-Rel in establishing chromosomal loops upon activation of the Igkappa gene
-
Liu, Z., Z. Ma, L. S. Terada, and W. T. Garrard. 2009. Divergent roles of RelA and c-Rel in establishing chromosomal loops upon activation of the Igkappa gene. J. Immunol. 183:3819-3830.
-
(2009)
J. Immunol.
, vol.183
, pp. 3819-3830
-
-
Liu, Z.1
Ma, Z.2
Terada, L.S.3
Garrard, W.T.4
-
15
-
-
0029967078
-
Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish Vκ Jκ rearrangement
-
Xu, Y., L. Davidson, F. W. Alt, and D. Baltimore. 1996. Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish Vκ Jκ rearrangement. Immunity 4:377-385.
-
(1996)
Immunity
, vol.4
, pp. 377-385
-
-
Xu, Y.1
Davidson, L.2
Alt, F.W.3
Baltimore, D.4
-
16
-
-
0030222767
-
The Ig (kappa) enhancer influences the ratio of Ig (kappa) versus Ig (lambda) B lymphocytes
-
Gorman, J. R., N. van der Stoep, R. Monroe, M. Cogne, L. Davidson, and F. W. Alt. 1996. The Ig (kappa) enhancer influences the ratio of Ig (kappa) versus Ig (lambda) B lymphocytes. Immunity 5:241-252.
-
(1996)
Immunity
, vol.5
, pp. 241-252
-
-
Gorman, J.R.1
Van Der Stoep, N.2
Monroe, R.3
Cogne, M.4
Davidson, L.5
Alt, F.W.6
-
17
-
-
45549105961
-
The downstream transcriptional enhancer, Ed, positively regulates mouse Igκ gene expression and somatic hypermutation
-
Xiang, Y., and W. T. Garrard. 2008. The downstream transcriptional enhancer, Ed, positively regulates mouse Igκ gene expression and somatic hypermutation. J. Immunol. 180:6725-6732.
-
(2008)
J. Immunol.
, vol.180
, pp. 6725-6732
-
-
Xiang, Y.1
Garrard, W.T.2
-
18
-
-
0036097492
-
Essential roles of the κ light chain intronic enhancer and 3' enhancer in κ rearrangement and demethylation
-
Inlay, M., F. W. Alt, D. Baltimore, and Y. Xu. 2002. Essential roles of the κ light chain intronic enhancer and 3' enhancer in κ rearrangement and demethylation. Nat. Immunol. 3:463-468.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 463-468
-
-
Inlay, M.1
Alt, F.W.2
Baltimore, D.3
Xu, Y.4
-
19
-
-
0037352031
-
A highly efficient recombineering-based method for generating conditional knockout mutations
-
Liu, P., N. A. Jenkins, and N. G. Copeland. 2003. A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res. 13:476-484.
-
(2003)
Genome Res.
, vol.13
, pp. 476-484
-
-
Liu, P.1
Jenkins, N.A.2
Copeland, N.G.3
-
20
-
-
34250315750
-
A recombineering based approach for high-throughput conditional knockout targeting vector construction
-
Chan, W., N. Costantino, R. Li, S. C. Lee, Q. Su, D. Melvin, D. L. Court, and P. Liu. 2007. A recombineering based approach for high-throughput conditional knockout targeting vector construction. Nucleic Acids Res. 35: e64.
-
(2007)
Nucleic Acids Res.
, vol.35
-
-
Chan, W.1
Costantino, N.2
Li, R.3
Lee, S.C.4
Su, Q.5
Melvin, D.6
Court, D.L.7
Liu, P.8
-
21
-
-
0034114458
-
Epiblast-restricted Cre expression in MORE mice: A tool to distinguish embryonic vs. extra-embryonic gene function
-
Tallquist, M. D., and P. Soriano. 2000. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26:113-115.
-
(2000)
Genesis
, vol.26
, pp. 113-115
-
-
Tallquist, M.D.1
Soriano, P.2
-
22
-
-
0034487368
-
Widespread recombinase expression using FLPeR (flipper) mice
-
Farley, F. W., P. Soriano, L. S. Steffen, and S. M. Dymecki. 2000. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28:106-110.
-
(2000)
Genesis
, vol.28
, pp. 106-110
-
-
Farley, F.W.1
Soriano, P.2
Steffen, L.S.3
Dymecki, S.M.4
-
23
-
-
0024435908
-
Activation of immunoglobulin κ gene rearrangement correlates with induction of germline κ gene transcription
-
Schlissel, M. S., and D. Baltimore. 1989. Activation of immunoglobulin κ gene rearrangement correlates with induction of germline κ gene transcription. Cell 58:1001-1007.
-
(1989)
Cell.
, vol.58
, pp. 1001-1007
-
-
Schlissel, M.S.1
Baltimore, D.2
-
24
-
-
33745872600
-
Critical roles of the immu-noglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci
-
Inlay, M. A., T. Lin, H. H. Gao, and Y. Xu. 2006. Critical roles of the immu-noglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci. J. Exp. Med. 203:1721-1732.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1721-1732
-
-
Inlay, M.A.1
Lin, T.2
Gao, H.H.3
Xu, Y.4
-
25
-
-
0032487518
-
Receptor editing occurs frequently during normal B cell development
-
Retter, M. W., and D. Nemazee. 1998. Receptor editing occurs frequently during normal B cell development. J. Exp. Med. 188:1231-1238.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1231-1238
-
-
Retter, M.W.1
Nemazee, D.2
-
26
-
-
63149116657
-
The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling
-
Xu, C.-R., and A. J. Feeney. 2009. The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling. J. Immunol. 182:1362-1369.
-
(2009)
J. Immunol.
, vol.182
, pp. 1362-1369
-
-
Xu, C.-R.1
Feeney, A.J.2
-
27
-
-
0028027360
-
IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development
-
Rolink, A., U. Grawunder, T. H. Winkler, H. Karasuyama, and F. Melchers. 1994. IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int. Immunol. 6:1257-1264.
-
(1994)
Int. Immunol.
, vol.6
, pp. 1257-1264
-
-
Rolink, A.1
Grawunder, U.2
Winkler, T.H.3
Karasuyama, H.4
Melchers, F.5
-
28
-
-
0025868702
-
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
-
Hardy, R. R., C. E. Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213-1225.
-
(1991)
J. Exp. Med.
, vol.173
, pp. 1213-1225
-
-
Hardy, R.R.1
Carmack, C.E.2
Shinton, S.A.3
Kemp, J.D.4
Hayakawa, K.5
-
29
-
-
67349228524
-
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immu-noglobulin loci
-
Hewitt, S. L., B. Yin, Y. Ji, J. Chaumeil, K. Marszalek, J. Tenthorey, G. Salvagiotto, N. Steinel, L. B. Ramsey, J. Ghysdael, et al. 2009. RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immu-noglobulin loci. Nat. Immunol. 10:655-664.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 655-664
-
-
Hewitt, S.L.1
Yin, B.2
Ji, Y.3
Chaumeil, J.4
Marszalek, K.5
Tenthorey, J.6
Salvagiotto, G.7
Steinel, N.8
Ramsey, L.B.9
Ghysdael, J.10
-
30
-
-
77956630164
-
Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression
-
Ma, S., S. Pathak, M. Mandal, L. Trinh, M. R. Clark, and R. Lu. 2010. Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression. Mol. Cell. Biol. 30:4149-4158.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 4149-4158
-
-
Ma, S.1
Pathak, S.2
Mandal, M.3
Trinh, L.4
Clark, M.R.5
Lu, R.6
-
31
-
-
58849152743
-
Biallelic, ubiquitous transcription from the distal germline Igκ locus promoter during B cell development
-
Amin, R. H., D. Cado, H. Nolla, D. Huang, S. A. Shinton, Y. Zhou, R. R. Hardy, and M. S. Schlissel. 2009. Biallelic, ubiquitous transcription from the distal germline Igκ locus promoter during B cell development. Proc. Natl. Acad. Sci. USA 106:522-527.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 522-527
-
-
Amin, R.H.1
Cado, D.2
Nolla, H.3
Huang, D.4
Shinton, S.A.5
Zhou, Y.6
Hardy, R.R.7
Schlissel, M.S.8
-
32
-
-
0030792305
-
DNA methylation: Regulation of gene expression and role in the immune system
-
Mostoslavsky, R., and Y. Bergman. 1997. DNA methylation: regulation of gene expression and role in the immune system. Biochim. Biophys. Acta 1333: F29-F50.
-
(1997)
Biochim. Biophys. Acta
, vol.1333
-
-
Mostoslavsky, R.1
Bergman, Y.2
-
33
-
-
0032526136
-
κ chain monoallelic demethylation and the establishment of allelic exclusion
-
Mostoslavsky, R., N. Singh, A. Kirillov, R. Pelanda, H. Cedar, A. Chess, and Y. Bergman. 1998. κ chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 12:1801-1811.
-
(1998)
Genes Dev.
, vol.12
, pp. 1801-1811
-
-
Mostoslavsky, R.1
Singh, N.2
Kirillov, A.3
Pelanda, R.4
Cedar, H.5
Chess, A.6
Bergman, Y.7
-
34
-
-
0029983577
-
Rearrangement-enhancing element upstream of the mouse immunoglob-ulin kappa chain J cluster
-
Ferradini, L., H. Gu, A. De Smet, K. Rajewsky, C.-A. Reynaud, and J.-C. Weill. 1996. Rearrangement-enhancing element upstream of the mouse immunoglob-ulin kappa chain J cluster. Science 271:1416-1420.
-
(1996)
Science
, vol.271
, pp. 1416-1420
-
-
Ferradini, L.1
Gu, H.2
De Smet, A.3
Rajewsky, K.4
Reynaud, C.-A.5
Weill, J.-C.6
-
35
-
-
67449141681
-
A histone code for regulating V (D) J recombination
-
Schlissel, M. S., D. Schulz, and C. Vettermann. 2009. A histone code for regulating V (D) J recombination. Mol. Cell 34:639-640.
-
(2009)
Mol. Cell.
, vol.34
, pp. 639-640
-
-
Schlissel, M.S.1
Schulz, D.2
Vettermann, C.3
-
36
-
-
78249260638
-
Epigenetic and 3-dimensional regulation of V (D) J rearrangement of immunoglobulin genes
-
In press
-
Degner-Leisso, S. C., and A. J. Feeney. 2010. Epigenetic and 3-dimensional regulation of V (D) J rearrangement of immunoglobulin genes. Semin. Immunol. 22. In press.
-
(2010)
Semin. Immunol.
, pp. 22
-
-
Degner-Leisso, S.C.1
Feeney, A.J.2
-
37
-
-
2342450482
-
BAC engineering for the generation of ES cell-targeting constructs and mouse transgenes
-
Testa, G., K. Vintersten, Y. Zhang, V. Benes, J. P. P. Muyrers, and A. F. Stewart. 2004. BAC engineering for the generation of ES cell-targeting constructs and mouse transgenes. Methods Mol. Biol. 256:123-139.
-
(2004)
Methods Mol. Biol.
, vol.256
, pp. 123-139
-
-
Testa, G.1
Vintersten, K.2
Zhang, Y.3
Benes, V.4
Muyrers, J.P.P.5
Stewart, A.F.6
-
38
-
-
0027215522
-
RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development
-
Chen, J., R. Lansford, V. Stewart, F. Young, and F. W. Alt. 1993. RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc. Natl. Acad. Sci. USA 90:4528-4532.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 4528-4532
-
-
Chen, J.1
Lansford, R.2
Stewart, V.3
Young, F.4
Alt, F.W.5
-
39
-
-
0033519234
-
A targeted deletion of a region upstream from the Jkappa cluster impairs κ chain rearrangement in cis in mice and in the 103/bcl2 cell line
-
Cocea, L., A. De Smet, M. Saghatchian, S. Fillatreau, L. Ferradini, S. Schurmans, J.-C. Weill, and C.-A. Reynaud. 1999. A targeted deletion of a region upstream from the Jkappa cluster impairs κ chain rearrangement in cis in mice and in the 103/bcl2 cell line. J. Exp. Med. 189:1443-1450.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1443-1450
-
-
Cocea, L.1
De Smet, A.2
Saghatchian, M.3
Fillatreau, S.4
Ferradini, L.5
Schurmans, S.6
Weill, J.-C.7
Reynaud, C.-A.8
-
40
-
-
0029155607
-
Enhancers increase the probability but not the level of gene expression
-
Walters, M. C., S. Fiering, J. Eidemiller, W. Magis, M. Groudine, and D. I. Martin. 1995. Enhancers increase the probability but not the level of gene expression. Proc. Natl. Acad. Sci. USA 92:7125-7129.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 7125-7129
-
-
Walters, M.C.1
Fiering, S.2
Eidemiller, J.3
Magis, W.4
Groudine, M.5
Martin, D.I.6
-
41
-
-
77952415942
-
Memories of lost enhancers
-
Sen, R., and R. Grosschedl. 2010. Memories of lost enhancers. Genes Dev. 24:973-979.
-
(2010)
Genes Dev.
, vol.24
, pp. 973-979
-
-
Sen, R.1
Grosschedl, R.2
|