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Volumn 102, Issue 8, 2010, Pages 891-897

The neoadjuvant therapy of colorectal hepatic metastases and the role of biologic sensitizing and resistance factors

Author keywords

anti angiogenesis; bevacizumab; cetuximab; colorectal cancer metastasis; EGFR directed therapy; liver metastasis; neoadjuvant therapy; panitumumab; tyrosine kinase inhibitors

Indexed keywords

BEVACIZUMAB; BIOLOGICAL MARKER; CAPECITABINE; CELECOXIB; CETUXIMAB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; SORAFENIB; SUNITINIB; VANDETANIB;

EID: 78650636536     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21691     Document Type: Review
Times cited : (8)

References (73)
  • 1
    • 84873083022 scopus 로고    scopus 로고
    • SEER Cancer Statistics Review, 1975-2005, National Cancer Institute. Bethesda, MD based on November 2007 SEER data submission
    • Riles LAG, Melbert D, Krapcho M, et al.: SEER Cancer Statistics Review, 1975-2005, National Cancer Institute. Bethesda, MD based on November 2007 SEER data submission. Ann Surg Oncol 2010; 17: 492.
    • (2010) Ann Surg Oncol , vol.17 , pp. 492
    • Riles, L.A.G.1    Melbert, D.2    Krapcho, M.3
  • 2
    • 0037087690 scopus 로고    scopus 로고
    • Liver metastases from colorectal cancer: The turning point
    • Nordlinger B, Rougier P,: Liver metastases from colorectal cancer: The turning point. J Clin Oncol 2002; 20: 1442-1445. (Pubitemid 34260520)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.6 , pp. 1442-1445
    • Nordlinger, B.1    Rougier, P.2
  • 3
    • 77149163805 scopus 로고    scopus 로고
    • Systematic review of randomized and nonrandomized trials of the clinical response and outcomes of neoadjuvant systemic chemotherapy for resectable colorectal liver metastases
    • Chua TC, et al.: Systematic review of randomized and nonrandomized trials of the clinical response and outcomes of neoadjuvant systemic chemotherapy for resectable colorectal liver metastases. Ann Surg Oncol 17: 492-501.
    • Ann Surg Oncol , vol.17 , pp. 492-501
    • Chua, T.C.1
  • 4
    • 2542615200 scopus 로고    scopus 로고
    • Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    • Andre T, et al.: Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004; 350: 2343-2351.
    • (2004) N Engl J Med , vol.350 , pp. 2343-2351
    • Andre, T.1
  • 5
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, et al.: Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial. Lancet 2000; 355: 1041-1047.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1
  • 6
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg RM, et al.: A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2004; 22: 23-30.
    • (2004) J Clin Oncol , vol.22 , pp. 23-30
    • Goldberg, R.M.1
  • 7
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, et al.: Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009; 27: 663-671.
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1
  • 8
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, et al.: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1
  • 9
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, et al.: Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study. J Clin Oncol 2008; 26: 2013-2019.
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1
  • 10
    • 0041417909 scopus 로고    scopus 로고
    • Role of neoadjuvant chemotherapy in the treatment of multiple colorectal metastases to the liver
    • Tanaka K, et al.: Role of neoadjuvant chemotherapy in the treatment of multiple colorectal metastases to the liver. Br J Surg 2003; 90: 963-969.
    • (2003) Br J Surg , vol.90 , pp. 963-969
    • Tanaka, K.1
  • 11
    • 0035018397 scopus 로고    scopus 로고
    • Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal
    • Adam R, et al.: Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal. Ann Surg Oncol 2001; 8: 347-353.
    • (2001) Ann Surg Oncol , vol.8 , pp. 347-353
    • Adam, R.1
  • 12
    • 9744226672 scopus 로고    scopus 로고
    • Tumor progression while on chemotherapy: A contraindication to liver resection for multiple colorectal metastases?
    • discussion 1061-1064
    • Adam R, et al.: Tumor progression while on chemotherapy: A contraindication to liver resection for multiple colorectal metastases? Ann Surg 2004; 240: 1052-1061, discussion 1061-1064.
    • (2004) Ann Surg , vol.240 , pp. 1052-1061
    • Adam, R.1
  • 13
    • 40749149728 scopus 로고    scopus 로고
    • Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): A randomised controlled trial
    • Nordlinger B, et al.: Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): A randomised controlled trial. Lancet 2008; 371: 1007-1016.
    • (2008) Lancet , vol.371 , pp. 1007-1016
    • Nordlinger, B.1
  • 14
    • 43249130975 scopus 로고    scopus 로고
    • Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: Myth or reality?
    • Adam R, et al.: Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: Myth or reality? J Clin Oncol 2008; 26: 1635-1641.
    • (2008) J Clin Oncol , vol.26 , pp. 1635-1641
    • Adam, R.1
  • 15
    • 44149107591 scopus 로고    scopus 로고
    • Importance of response to neoadjuvant chemotherapy in potentially curable colorectal cancer liver metastases
    • Gruenberger B, et al.: Importance of response to neoadjuvant chemotherapy in potentially curable colorectal cancer liver metastases. BMC Cancer 2008; 8: 120.
    • (2008) BMC Cancer , vol.8 , pp. 120
    • Gruenberger, B.1
  • 16
    • 56749096759 scopus 로고    scopus 로고
    • Pathologic response to preoperative chemotherapy: A new outcome end point after resection of hepatic colorectal metastases
    • Blazer DG III, et al.: Pathologic response to preoperative chemotherapy: A new outcome end point after resection of hepatic colorectal metastases. J Clin Oncol 2008; 26: 5344-5351.
    • (2008) J Clin Oncol , vol.26 , pp. 5344-5351
    • Blazer III, D.G.1
  • 17
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • DOI 10.1038/nrd2115, PII NRD2115
    • Folkman J,: Angiogenesis: An organizing principle for drug discovery? Nat Rev Drug Discov 2007; 6: 273-286. (Pubitemid 46505878)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 18
    • 0035253739 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, et al.: Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 2001; 19: 843-850.
    • (2001) J Clin Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1
  • 19
    • 33646107369 scopus 로고    scopus 로고
    • VEGF receptor signalling-In control of vascular function
    • Olsson AK, et al.: VEGF receptor signalling-In control of vascular function. Nat Rev Mol Cell Biol 2006; 7: 359-371.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 359-371
    • Olsson, A.K.1
  • 20
    • 39149108869 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Updated results from the BICC-C study
    • Fuchs CS, Marshall J, Barrueco J,: Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Updated results from the BICC-C study. J Clin Oncol 2008; 26: 689-690.
    • (2008) J Clin Oncol , vol.26 , pp. 689-690
    • Fuchs, C.S.1    Marshall, J.2    Barrueco, J.3
  • 21
    • 20644432867 scopus 로고    scopus 로고
    • Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer
    • Hurwitz HI, et al.: Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer. J Clin Oncol 2005; 23: 3502-3508.
    • (2005) J Clin Oncol , vol.23 , pp. 3502-3508
    • Hurwitz, H.I.1
  • 22
    • 36048960109 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C Study
    • Fuchs CS, et al.: Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C Study. J Clin Oncol 2007; 25: 4779-4786.
    • (2007) J Clin Oncol , vol.25 , pp. 4779-4786
    • Fuchs, C.S.1
  • 23
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • Kabbinavar FF, et al.: Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 2005; 23: 3706-3712.
    • (2005) J Clin Oncol , vol.23 , pp. 3706-3712
    • Kabbinavar, F.F.1
  • 24
    • 70349690209 scopus 로고    scopus 로고
    • Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer First BEAT and the randomised phase-III NO16966 trial
    • Okines A, et al.: Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer First BEAT and the randomised phase-III NO16966 trial. Br J Cancer 2009; 101: 1033-1038.
    • (2009) Br J Cancer , vol.101 , pp. 1033-1038
    • Okines, A.1
  • 25
    • 66149120036 scopus 로고    scopus 로고
    • Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: The BEAT study
    • Van Cutsem E, et al.: Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: The BEAT study. Ann Oncol 2009; 20: 1842-1847.
    • (2009) Ann Oncol , vol.20 , pp. 1842-1847
    • Van Cutsem, E.1
  • 26
    • 77951936254 scopus 로고    scopus 로고
    • Monoclonal antibodies in the treatment of metastatic colorectal cancer: A review
    • Tol J, Punt CJ,: Monoclonal antibodies in the treatment of metastatic colorectal cancer: A review. Clin Ther 2010; 32: 437-453.
    • (2010) Clin Ther , vol.32 , pp. 437-453
    • Tol, J.1    Punt, C.J.2
  • 27
    • 0042783111 scopus 로고    scopus 로고
    • Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: Evidence for new therapeutic options
    • Kopp R, et al.: Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: Evidence for new therapeutic options. Recent Results Cancer Res 2003; 162: 115-132.
    • (2003) Recent Results Cancer Res , vol.162 , pp. 115-132
    • Kopp, R.1
  • 28
    • 0032934041 scopus 로고    scopus 로고
    • Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis
    • Damstrup L, et al.: Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. Br J Cancer 1999; 80: 1012-1019.
    • (1999) Br J Cancer , vol.80 , pp. 1012-1019
    • Damstrup, L.1
  • 29
    • 34247257760 scopus 로고    scopus 로고
    • The influence of invasive growth pattern and microvessel density on prognosis in colorectal cancer and colorectal liver metastases
    • Rajaganeshan R, et al.: The influence of invasive growth pattern and microvessel density on prognosis in colorectal cancer and colorectal liver metastases. Br J Cancer 2007; 96: 1112-1117.
    • (2007) Br J Cancer , vol.96 , pp. 1112-1117
    • Rajaganeshan, R.1
  • 30
    • 0032008385 scopus 로고    scopus 로고
    • Circulating vascular endothelial growth factor in patients with colorectal cancer
    • Fujisaki K, et al.: Circulating vascular endothelial growth factor in patients with colorectal cancer. Am J Gastroenterol 1998; 93: 249-252.
    • (1998) Am J Gastroenterol , vol.93 , pp. 249-252
    • Fujisaki, K.1
  • 31
    • 33644823334 scopus 로고    scopus 로고
    • Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer
    • Jubb AM, et al.: Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer. J Clin Oncol 2006; 24: 217-227.
    • (2006) J Clin Oncol , vol.24 , pp. 217-227
    • Jubb, A.M.1
  • 32
    • 0032402444 scopus 로고    scopus 로고
    • Clinical significance of plasma vascular endothelial growth factor in gastrointestinal cancer
    • Hyodo I, et al.: Clinical significance of plasma vascular endothelial growth factor in gastrointestinal cancer. Eur J Cancer 1998; 34: 2041-2045.
    • (1998) Eur J Cancer , vol.34 , pp. 2041-2045
    • Hyodo, I.1
  • 33
    • 77951643655 scopus 로고    scopus 로고
    • Clinical significance of VEGF levels in serums of colorectal cancer patients at stage IV
    • Huang N, et al.: Clinical significance of VEGF levels in serums of colorectal cancer patients at stage IV. Nan Fang Yi Ke Da Xue Xue Bao 2009; 29: 278-279.
    • (2009) Nan Fang Yi Ke da Xue Xue Bao , vol.29 , pp. 278-279
    • Huang, N.1
  • 34
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, et al.: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337-345.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1
  • 35
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung KY, et al.: Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005; 23: 1803-1810.
    • (2005) J Clin Oncol , vol.23 , pp. 1803-1810
    • Chung, K.Y.1
  • 36
    • 51649120733 scopus 로고    scopus 로고
    • KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: The CRYSTAL experience
    • Van Cutsem E, Lang I, D'haens G, et al.: KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: The CRYSTAL experience. J Clin Oncol 2008; 26: 2.
    • (2008) J Clin Oncol , vol.26 , pp. 2
    • Van Cutsem, E.1    Lang, I.2    D'Haens, G.3
  • 37
    • 77049122579 scopus 로고    scopus 로고
    • Panitumumab-An effective long-term treatment for patients with metastatic colorectal cancer and wild-type KRAS status
    • Elez E, Alsina M, Tabernero J,: Panitumumab-An effective long-term treatment for patients with metastatic colorectal cancer and wild-type KRAS status. Cancer Treat Rev 36: S15-S16.
    • Cancer Treat Rev , vol.36
    • Elez, E.1    Alsina, M.2    Tabernero, J.3
  • 38
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
    • Van Cutsem E, et al.: Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007; 25: 1658-1664.
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1
  • 39
    • 36148941301 scopus 로고    scopus 로고
    • Cetuximab for the treatment of colorectal cancer
    • Jonker DJ, et al.: Cetuximab for the treatment of colorectal cancer. N Engl J Med 2007; 357: 2040-2048.
    • (2007) N Engl J Med , vol.357 , pp. 2040-2048
    • Jonker, D.J.1
  • 40
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, et al.: Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 360: 1408-1417.
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1
  • 41
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, et al.: Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26: 1626-1634.
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1
  • 42
    • 77949542415 scopus 로고    scopus 로고
    • KRAS status analysis and anti-EGFR therapies: Is comprehensiveness a biologist's fancy or a clinical necessity?
    • author reply 1076-1077
    • Lopez-Crapez E, et al.: KRAS status analysis and anti-EGFR therapies: Is comprehensiveness a biologist's fancy or a clinical necessity? Br J Cancer 102: 1074-1075, author reply 1076-1077.
    • Br J Cancer , vol.102 , pp. 1074-1075
    • Lopez-Crapez, E.1
  • 43
    • 0032490124 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: The multicenter "rASCAL" study
    • Andreyev HJ, et al.: Kirsten ras mutations in patients with colorectal cancer: The multicenter "RASCAL" study. J Natl Cancer Inst 1998; 90: 675-684.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 675-684
    • Andreyev, H.J.1
  • 44
    • 0034830884 scopus 로고    scopus 로고
    • Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis
    • Takayama T, et al.: Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology 2001; 121: 599-611.
    • (2001) Gastroenterology , vol.121 , pp. 599-611
    • Takayama, T.1
  • 45
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein B, et al.: Genetic alterations during colorectal-tumor development. N Engl J Med 1988; 319: 525-532.
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.1
  • 46
    • 0037194728 scopus 로고    scopus 로고
    • Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
    • Rajagopalan H, et al.: Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002; 418: 934.
    • (2002) Nature , vol.418 , pp. 934
    • Rajagopalan, H.1
  • 47
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
    • Bardelli A, Siena S,: Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol 2010; 28: 1254-1261.
    • (2010) J Clin Oncol , vol.28 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2
  • 48
    • 73549121044 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF and EGFR status in determining benefit from cetuximab therapy in patients with metastatic colon cancer in wild-type KRAS patients
    • Denver, CO
    • Laurent-Puig P, Cayre A, Pezet D, et al.: Analysis of PTEN, BRAF and EGFR status in determining benefit from cetuximab therapy in patients with metastatic colon cancer in wild-type KRAS patients. Annual Meeting of the American Association for Cancer Research, Denver, CO, 2009.
    • (2009) Annual Meeting of the American Association for Cancer Research
    • Laurent-Puig, P.1    Cayre, A.2    Pezet, D.3
  • 49
    • 84878753371 scopus 로고    scopus 로고
    • Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer
    • Pander J, et al.: Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer. Eur J Cancer.
    • Eur J Cancer.
    • Pander, J.1
  • 50
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • Sartore-Bianchi A, et al.: PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res 2009; 69: 1851-1857.
    • (2009) Cancer Res , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1
  • 51
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • Laurent-Puig P, et al.: Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol 2009; 27: 5924-5930.
    • (2009) J Clin Oncol , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1
  • 52
    • 65649086786 scopus 로고    scopus 로고
    • PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer
    • Prenen H, et al.: PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer. Clin Cancer Res 2009; 15: 3184-3188.
    • (2009) Clin Cancer Res , vol.15 , pp. 3184-3188
    • Prenen, H.1
  • 53
    • 35348908314 scopus 로고    scopus 로고
    • PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
    • Frattini M, et al.: PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer 2007; 97: 1139-1145.
    • (2007) Br J Cancer , vol.97 , pp. 1139-1145
    • Frattini, M.1
  • 54
    • 59249107192 scopus 로고    scopus 로고
    • Impact of EGFR mutation analysis in non-small cell lung cancer
    • Yamamoto H, Toyooka S, Mitsudomi T,: Impact of EGFR mutation analysis in non-small cell lung cancer. Lung Cancer 2009; 63: 315-321.
    • (2009) Lung Cancer , vol.63 , pp. 315-321
    • Yamamoto, H.1    Toyooka, S.2    Mitsudomi, T.3
  • 55
    • 19944422060 scopus 로고    scopus 로고
    • Somatic mutations of EGFR in colorectal cancers and glioblastomas
    • Barber TD, et al.: Somatic mutations of EGFR in colorectal cancers and glioblastomas. N Engl J Med 2004; 351: 2883.
    • (2004) N Engl J Med , vol.351 , pp. 2883
    • Barber, T.D.1
  • 56
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford S, et al.: Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 2007; 25: 3230-3237.
    • (2007) J Clin Oncol , vol.25 , pp. 3230-3237
    • Khambata-Ford, S.1
  • 57
    • 17944370631 scopus 로고    scopus 로고
    • Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors
    • Shaheen RM, et al.: Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors. Br J Cancer 2001; 85: 584-589.
    • (2001) Br J Cancer , vol.85 , pp. 584-589
    • Shaheen, R.M.1
  • 58
    • 33646227448 scopus 로고    scopus 로고
    • Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy
    • Tonra JR, et al.: Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy. Clin Cancer Res 2006; 12: 2197-2207.
    • (2006) Clin Cancer Res , vol.12 , pp. 2197-2207
    • Tonra, J.R.1
  • 59
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
    • Saltz LB, et al.: Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study. J Clin Oncol 2007; 25: 4557-4561.
    • (2007) J Clin Oncol , vol.25 , pp. 4557-4561
    • Saltz, L.B.1
  • 60
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • Tol J, et al.: Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 2009; 360: 563-572.
    • (2009) N Engl J Med , vol.360 , pp. 563-572
    • Tol, J.1
  • 61
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, et al.: A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009; 27: 672-680.
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1
  • 62
    • 66249103944 scopus 로고    scopus 로고
    • Chemotherapy and immunotherapy in metastatic colorectal cancer
    • author reply 2135-2136.
    • Pohlmann PR, Mernaugh RL, Goff LW,: Chemotherapy and immunotherapy in metastatic colorectal cancer. N Engl J Med 2009; 360: 2134, author reply 2135-2136.
    • (2009) N Engl J Med , vol.360 , pp. 2134
    • Pohlmann, P.R.1    Mernaugh, R.L.2    Goff, L.W.3
  • 63
    • 76549126380 scopus 로고    scopus 로고
    • Antiangiogenic agents and late anastomotic complications
    • Deshaies I, et al.: Antiangiogenic agents and late anastomotic complications. J Surg Oncol 2010; 101: 180-183.
    • (2010) J Surg Oncol , vol.101 , pp. 180-183
    • Deshaies, I.1
  • 64
    • 77949612000 scopus 로고    scopus 로고
    • Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis
    • Rubbia-Brandt L, et al.: Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis. Histopathology 2010; 56: 430-439.
    • (2010) Histopathology , vol.56 , pp. 430-439
    • Rubbia-Brandt, L.1
  • 65
    • 63049105306 scopus 로고    scopus 로고
    • Bevacizumab protects against sinusoidal obstruction syndrome and does not increase response rate in neoadjuvant XELOX/FOLFOX therapy of colorectal cancer liver metastases
    • Klinger M, et al.: Bevacizumab protects against sinusoidal obstruction syndrome and does not increase response rate in neoadjuvant XELOX/FOLFOX therapy of colorectal cancer liver metastases. Eur J Surg Oncol 2009; 35: 515-520.
    • (2009) Eur J Surg Oncol , vol.35 , pp. 515-520
    • Klinger, M.1
  • 66
    • 63649142566 scopus 로고    scopus 로고
    • Patterns of chemotherapy-induced hepatic injury and their implications for patients undergoing liver resection for colorectal liver metastases
    • Khan AZ, Morris-Stiff G, Makuuchi M,: Patterns of chemotherapy-induced hepatic injury and their implications for patients undergoing liver resection for colorectal liver metastases. J Hepatobiliary Pancreat Surg 2009; 16: 137-144.
    • (2009) J Hepatobiliary Pancreat Surg , vol.16 , pp. 137-144
    • Khan, A.Z.1    Morris-Stiff, G.2    Makuuchi, M.3
  • 67
    • 36048992408 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
    • Saltz LB, et al.: Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol 2007; 25: 4793-4799.
    • (2007) J Clin Oncol , vol.25 , pp. 4793-4799
    • Saltz, L.B.1
  • 68
    • 35948981296 scopus 로고    scopus 로고
    • A phase i study of sunitinib in combination with FOLFIRI chemotherapy in treatment-naive, metastatic colorectal cancer
    • abstract 319
    • Starling N, Cunningham D, Vazquez F, et al.: A phase I study of sunitinib in combination with FOLFIRI chemotherapy in treatment-naive, metastatic colorectal cancer. ASCO Gastrointestinal Cancers Symposium, 2007, abstract 319.
    • (2007) ASCO Gastrointestinal Cancers Symposium
    • Starling, N.1    Cunningham, D.2    Vazquez, F.3
  • 69
    • 67650831206 scopus 로고    scopus 로고
    • Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms
    • Walker T, et al.: Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. Mol Pharmacol 2009; 76: 342-355.
    • (2009) Mol Pharmacol , vol.76 , pp. 342-355
    • Walker, T.1
  • 70
    • 84878749081 scopus 로고    scopus 로고
    • Vandetanib with mFOLFOX6 in advanced colorectal adenocarcinoma: An open-label multicenter phase i study
    • Michael M, Tebbutt N, Gibbs P, et al.: Vandetanib with mFOLFOX6 in advanced colorectal adenocarcinoma: An open-label multicenter phase I study. J Clin Oncol 2007; 25: 18.
    • (2007) J Clin Oncol , vol.25 , pp. 18
    • Michael, M.1    Tebbutt, N.2    Gibbs, P.3
  • 71
    • 77953494078 scopus 로고    scopus 로고
    • DCE-MRI assessment of the effect of vandetanib on tumor vasculature in patients with advanced colorectal cancer and liver metastases: A randomized phase i study
    • Mross K, et al.: DCE-MRI assessment of the effect of vandetanib on tumor vasculature in patients with advanced colorectal cancer and liver metastases: A randomized phase I study. J Angiogenes Res 2009; 1: 5.
    • (2009) J Angiogenes Res , vol.1 , pp. 5
    • Mross, K.1
  • 72
    • 42949130734 scopus 로고    scopus 로고
    • Bevacizumab, capecitabine, and oxaliplatin as neoadjuvant therapy for patients with potentially curable metastatic colorectal cancer
    • Gruenberger B, et al.: Bevacizumab, capecitabine, and oxaliplatin as neoadjuvant therapy for patients with potentially curable metastatic colorectal cancer. J Clin Oncol 2008; 26: 1830-1835.
    • (2008) J Clin Oncol , vol.26 , pp. 1830-1835
    • Gruenberger, B.1
  • 73
    • 55949084563 scopus 로고    scopus 로고
    • Preoperative bevacizumab does not significantly increase postoperative complication rates in patients undergoing hepatic surgery for colorectal cancer liver metastases
    • Kesmodel SB, et al.: Preoperative bevacizumab does not significantly increase postoperative complication rates in patients undergoing hepatic surgery for colorectal cancer liver metastases. J Clin Oncol 2008; 26: 5254-5260.
    • (2008) J Clin Oncol , vol.26 , pp. 5254-5260
    • Kesmodel, S.B.1


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