Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: Myth or reality?

Journal of Clinical Oncology

Volumn 26, Issue 10, 2008, Pages 1635-1641

  Adam, René ^a   Wicherts, Dennis A ^a   De Haas, Robbert J ^a   Aloia, Thomas ^a   Lévi, Francis ^a   Paule, Bernard ^a   Guettier, Catherine ^a   Kunstlinger, Francis ^a   Delvart, Valérie ^a   Azoulay, Daniel ^a   Castaing, Denis ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CETUXIMAB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; ANTINEOPLASTIC AGENT;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; LIVER METASTASIS; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; TREATMENT OUTCOME; TREATMENT RESPONSE; ADENOCARCINOMA; ADJUVANT THERAPY; CLINICAL TRIAL; COLORECTAL TUMOR; KAPLAN MEIER METHOD; LIVER TUMOR; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PATHOLOGY; PREOPERATIVE CARE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; PREOPERATIVE CARE;

EID: 43249130975     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2007.13.7471     Document Type: Article

References (25)

1. Steele G Jr, Ravikumar TS: Resection of hepatic metastases from colorectal cancer: Biologic perspectives. Ann Surg 210:127-138, 1989
2. Scheele J, Altendorf-Hofmann A: Resection of colorectal liver metastases. Langenbecks Arch Surg 384:313-327, 1999
3. Fong Y, Cohen AM, Fortner JG, et al: Liver resection for colorectal metastases. J Clin Oncol 15:938-946, 1997
4. Adam R, Avisar E, Ariche A, et al: Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal liver metastases. Ann Surg Oncol 8:347-353, 2001
5. Adam R, Pascal G, Castaing D, et al: Tumor progression while on chemotherapy: A contraindication to liver resection for multiple colorectal metastases? Ann Surg 240:1052-1064, 2004
6. Giacchetti S, Itzhaki M, Gruia G, et al: Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 10:663-669, 1999
7. Alberts SR, Horvath WL, Sternfeld WC, et al: Oxaliplatin, fluorouracil, and leucovorin for patients with unresectable liver-only metastases from colorectal cancer: A north central cancer treatment group phase II study. J Clin Oncol 23:9243-9249, 2005
8. Saltz LB, Cox JV, Blanke C, et al: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 343:905-914, 2000
9. Folprecht G, Lutz MP, Schöffski P, et al: Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma. Ann Oncol 17:450-456, 2006
10. Cunningham D, Humblet Y, Siena S, et al: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337-345, 2004
11. Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-2342, 2004
12. Benoist S, Brouquet A, Penna C, et al: Complete response of colorectal liver metastases after chemotherapy: Does it mean cure? J Clin Oncol 24:3939-3945, 2006
13. Elias D, Youssef O, Sideris L, et al: Evolution of missing colorectal liver metastases following inductive chemotherapy and hepatectomy. J Surg Oncol 86:4-9, 2004
14. Therasse P, Arbuck SG, Eisenhauer EA: New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92:205-216, 2000
15. Adam R, Bismuth H, Castaing D, et al: Repeat hepatectomy for colorectal liver metastases. Ann Surg 225:51-62, 1997
16. Cox DR: Regression models and life tables (with discussion). J R Stat Soc B 34:187-202, 1972
17. Breslow NE: Covariance analysis of censored survival data. Biometrics 30:89-99, 1974
18. Azoulay D, Castaing D, Krissat J, et al: Percutaneous portal vein embolization increases the feasibility and safety of major resection for hepatocellular carcinoma in injured liver. Ann Surg 232:665-672, 2000
19. Adam R, Laurent A, Azoulay D, et al: Two-stage hepatectomy: A planned strategy to treat irresectable liver tumors. Ann Surg 232:777-785, 2000
20. Adam R, Delvart V, Pascal G, et al: Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: A model to predict long-term survival. Ann Surg 240:644-657, 2004
21. Elias D, Sideris L, Pocard M, et al: Incidence of unsuspected and treatable metastatic disease associated with operable colorectal liver metastases discovered only at laparotomy (and not treated when performing percutaneous radiofrequency ablation). Ann Surg Oncol 12:298-302, 2005
22. Tan MC, Linehan DC, Hawkins WG, et al: Chemotherapy-induced normalization of FDG uptake by colorectal liver metastases does not usually indicate complete pathologic response. J Gastrointest Surg 11:1112-1119, 2007
23. Dy GK, Krook JE, Green EM, et al: Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: Results from Intergroup N9741. J Clin Oncol 25:3469-3474, 2007
24. Znajda T, Hayashi S, Horton P, et al: Postchemotherapy characteristics of hepatic colorectal metastases: Remnants of uncertain malignant potential. J Gastrointest Surg 10:483-489, 2006
25. Rubbia-Brandt L, Giostra E, Brezault C, et al: Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery. Ann Oncol 18:299-304, 2007