SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells

Radiation Research

Volumn 175, Issue 1, 2011, Pages 57-65

  Murley, Jeffrey S ^a   Kataoka, Yasushi ^a   Miller, Richard C ^a   Li, Jian Jian ^b   Woloschak, Gayle ^c   Grdina, David J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE;

ARTICLE; CANCER CELL; COLON CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IONIZING RADIATION; LOW ENERGY RADIATION; MICRONUCLEUS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION PROTECTION; X RAY;

ADAPTATION, PHYSIOLOGICAL; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; HUMANS; MERCAPTOETHYLAMINES; MICRONUCLEI, CHROMOSOME-DEFECTIVE; RADIATION-PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 78650614385     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2349.1     Document Type: Article

References (37)

1. R. Roots and S. Okada, Protection of DNA molecules of cultured mammalian cells from radiation induced single strand scissions by various alcohols and SH compounds. Int. J. Radiat. Biol. 21, 329-342 (1972).
2. J. F. Ward, DNA damage as the cause of ionizing radiation-induced gene activation. Radiat. Res. 138 (Suppl.), S85-S88 (1994).
3. K. J. Leach, G. Van Tuyle, P. S. Lin, R. Schmidt-Ullrich and R. B. Mikkelsen, Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen. Cancer Res. 61, 3894-3901 (2001).
4. R. B. Mikkelsen and P. Wardman, Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene 22, 5734-5754 (2003).
5. D. B. Zorov, C. R. Filburn, L. O. Klotz, J. L. Zweir and S. J. Sollott, Reactive oxygen species (ROS)-induced ROS release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J. Exp. Med. 192, 1001-1014 (2000).
6. D. B. Zorov, M. Juhaszova and S. J. Sollott, Mitochondrial ROS-induced ROS release: An update and review. Biochim. Biophys. Acta 1757, 509-517 (2006).
7. N. R. Brady, A. Hamacher-Brady, H. V. Westerhoff and R. A. Gottlieb, A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria. Antioxid. Redox Signal. 8, 1651-1665 (2006).
8. K. Hirose, D. L. Longo, J. J. Oppenheim and K. Matsushima, Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs and ionizing radiation. FASEB J. 7, 361-368 (1993).
9. J. Sun, Y. Chen, M. Li and Z. Ge, Role of antioxidant enzymes on ionizing radiation resistance. Free Radic. Biol. Med. 24, 586-593 (1998).
10. S. Motoori, H. J. Majima, M. Ebara, H. Kato, F. Hirai, S. Kakinuma, C. Yamaguchi, T. Ozawa, T. Nagano and H. Saisho, Overexpression of mitochondrial manganous superoxide dismutase protects against radiation-induced cell death in the human hepatocellular carcinoma cell line HLE. Cancer Res. 61, 5382-5388 (2001).
11. M. W. Epperly, J. E. Gretton, C. A. Sikora, M. Jefferson, M. Bernarding, S. Nie and J. S. Greenberger, Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage. Radiat. Res. 160, 568-578 (2003).
12. K. C. Das, Y. Lewis-Molock and C. W. White, Activation of NFkB and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells. Am. J. Physiol. 269, L588-L602 (1995).
13. J. Antras-Ferry, K. Maheo, M. Chevanne, M. P. Dubos, F. Morel, A. Guillouzo, P. Cillard and J. Cillard, Oltipraz stimulates the transcription of the manganese superoxide dismutase gene in rat hepatocytes. Carcinogenesis 18, 2113-2117 (1997).
14. J. S. Murley, Y. Kataoka, D. E. Hallahan, J. C. Roberts and D. J. Grdina, Activation of NFkB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells. Free Radic. Biol. Med. 30, 1426-1439 (2001).
15. J. R. Matthews, N. Wakasugi, J. L. Virelizier, J. Yodoi and R. T. Hay, Thioredoxin regulates the DNA binding activity of NFkB by reduction of the disulphide bond involving cysteine 62. Nucleic Acids Res. 20, 3821-3830 (1992).
16. Y. Xu, K. K. Kiningham, M. N. Devalaraja, C. C. Yeh, H. Majima, E. J. Kasarskis and D. K. St. Clair, An intronic NFkB element is essential for induction of human manganese superoxide dismutase gene by tumor necrosis factor-a and interleukin 1b. DNA Cell Biol. 18, 709-722 (1999).
17. J. S. Murley, Y. Kataoka, C. J. Weydert, L. W. Oberley and D. J. Grdina, Delayed cytoprotection after enhancement of SOD2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine. Radiat. Res. 158, 101-109 (2002).
18. J. S. Murley, Y. Kataoka, K. L. Baker, A. M. Diamond, W. F. Morgan and D. J. Grdina, Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor a. Radiat. Res. 167, 465-474 (2007).
19. J. S. Murley,Y. Kataoka, C. J. Weydert, L. W. Oberley and D. J. Grdina, Delayed radioprotection by nuclear transcription factor kB-mediated induction of manganese superoxide dismutase in human microvascular endothelial cells after exposure to the free radical scavenger WR-1065. Free Radic. Biol. Med. 40, 1004-1016 (2006).
20. J. S. Murley, D. Nantajit, K. L. Baker, Y. Kataoka, J. J. Li and D. J. Grdina, Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine. Radiat. Res. 169, 495-505 (2008).
21. G. J. Kim, G. M. Fiskum and W. F. Morgan, A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability. Cancer Res. 66, 10377-10383 (2006).
22. M. Fenech, Cytokinesis-block micronucleus cytome assay. Nat. Protoc. 2, 1084-1104 (2007).
23. H. Stopper and S. O. Muller, Micronuclei as a biological endpoint for genotoxicity: A minireview. Toxicol. In Vitro 11, 661-667 (1997).
24. D. J. Grdina, N. Shigematsu, P. Dale, G. L. Newton, J. A. Aguilera and R. C. Fahey, Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR2721 are linked to both its anticytotoxic and antimutagenic mechanisms of action. Carcinogenesis 16, 767-774 (1995).
25. J. Dziegielewski, J. E. Baulch, W. Goetz, M. C. Coleman, D. R. Spitz, J. S. Murley, D. J. Grdina and W. F. Morgan, WR1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free Radic. Biol. Med. 45, 1674-1681 (2008).
26. D. J. Grdina, B. Nagy, C. K. Hill, R. L. Wells and C. Peraino, The radioprotector WR1065 reduces radiation-induced mutations at the HGPRT locus in V79 cells. Carcinogenesis 6, 929-931 (1985).
27. B. Nagy, P. J. Dale and D. J. Grdina, Protection against cis-diammine-dichloroplatinum (II) cytotoxicity and mutagenicity in V79 cells by free radical scavenger 2-[(aminopropyl)amino] ethanethiol. Cancer Res. 46, 1132-1135 (1986).
28. G. Olivieri, Y. Bodycote and S. Wolff, Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science 223, 594-597 (1984).
29. B. J. S. Sanderson and A. A. Morley, Exposure of human lymphocytes to ionizing radiations reduces mutagenesis by subsequent ionizing radiations. Mutat. Res. 265, 347-351 (1986).
30. J. D. Shadley and G. Dai, Cytogenetic and survival adaptive response in G1 phase human lymphocytes. Mutat. Res. 265, 273-281 (1992).
31. 60Co gamma-ray irradiation. Carcinogenesis 7, 665-668 (1986).
32. G. Guo, Y. Yan-Sanders, B. D. Lyn-Cook, T. Wang, D. Tamae, J. Ogi, A. Khaletskiy, Z. Li, C. Weydert and J. J. Li, Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Mol. Cell. Biol. 23, 2362-2378 (2003).
33. K. M. Ahmed, D. Nantajit, M. Fan, J. S. Murley, D. J. Grdina and J. J. Li, Coactivation of ATM/ERK/NFkB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes. Free Radic. Biol. Med. 46, 1543-1550 (2009).
34. V. Baud and M. Karin, Signal transduction by tumor necrosis factor and its relatives. Trends in Cell Biol. 11, 372-377 (2001).
35. S. Huerta-Yepez, M. Vega, H. Garban and B. Bonavida, Involvement of the TNF-a autocrine-paracrine loop, via NF-kB and YY1, in the regulation of tumor cell resistance to Fas-induced apoptosis. Clin. Immunol. 120, 297-309 (2006).
36. R. A. Weisiger and I. Fridovich, Superoxide dismutase: organelle specificity. J. Biol. Chem. 248, 3582-3591 (1973).
37. J. F. Turrens, Mitochondrial formation of reactive oxygen species. J. Physiol. 552, 335-344 (2003).