Decreased GABAA and GABAB receptor functional activity in cannabinoid CB1 receptor knockout mice

Journal of Psychopharmacology

Volumn 25, Issue 1, 2011, Pages 105-110

  Urigüen, Leyre ^a,b   García Gutiérrez, María S ^c   Manzanares, Jorge ^c  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

35S GTP S binding; CB1 receptors; GABAA receptors; GABAB receptors; reverse transcriptase polymerase chain reaction

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; MUSCIMOL;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; BRAIN REGION; CINGULATE GYRUS; DRUG RECEPTOR BINDING; GABAERGIC SYSTEM; GENE EXPRESSION; HIPPOCAMPUS; MALE; MOTOR CORTEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THALAMUS;

ANIMALS; BACLOFEN; BRAIN; ENDOCANNABINOIDS; GABA-A RECEPTOR AGONISTS; GABA-B RECEPTOR AGONISTS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; MICE; MICE, KNOCKOUT; MUSCIMOL; RECEPTOR, CANNABINOID, CB1; RECEPTORS, GABA-A; RECEPTORS, GABA-B;

EID: 78650593104     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109358204     Document Type: Article

References (37)

1. Bailey SJ, Toth M. (2004) Variability in the benzodiazepine response of serotonin 5-HT1A receptor null mice displaying anxiety-like phenotype: evidence for genetic modifiers in the 5-HT-mediated regulation of GABA(A) receptors. J Neurosci 24: 6343-6351.
2. Bambico FR, Duranti A., Tontini A., Tarzia G., Gobbi G (2009) Endocannabinoids in the treatment of mood disorders: evidence from animal models. Curr Pharmaceut Des 15: 1623-1646.
3. Bowery NG, Enna SJ (2000) Gamma-aminobutyric acid(B) receptors: first of the functional metabotropic heterodimers. J Pharmacol Experimental Therapeutics 292: 2-7.
4. Cryan JF, Kaupmann K. (2005) Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. Trends Pharmacol Sci 26: 36-43.
5. Cryan JF, Kelly PH, Chaperon F., et al. (2004) Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N′-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4, 6-diamine). anxiolytic-like activity without side effects associated with baclofen or benzodiazepines. J Pharmacol Experimental Therapeutics 310: 952-963.
6. Davis M., Whalen PJ (2001) The amygdala: vigilance and emotion. Mol Psychiatry 6: 13-34.
7. Diana MA, Bregestovski P. (2005) Calcium and endocannabinoids in the modulation of inhibitory synaptic transmission. Cell Calcium 37: 497-505.
8. Haller J., Bakos N., Szirmay M., Ledent C., Freund TF (2002) The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. Eur J Neurosci 16: 1395-1398.
9. Katona I., Rancz EA, Acsady L., et al. (2001) Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission. J Neurosci 21: 9506-9518.
10. Kralic JE, O'Buckley TK, Khisti RT, Hodge CW, Homanics GE, Morrow AL (2002) GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem. Neuropharmacology 43: 685-694.
11. Ledent C., Valverde O., Cossu G., et al. (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283: 401-404.
12. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T). method. Methods 25: 402-408.
13. Low K., Crestani F., Keist R., et al. (2000) Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290: 131-134.
14. Manzanares J., Urigüen L., Rubio G., Palomo T. (2004) Role of endocannabinoid system in mental diseases. Neurotoxicity Res 6: 213-224.
15. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564.
16. McKernan RM, Rosahl TW, Reynolds DS, et al. (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nature Neurosci 3: 587-592.
17. McKernan RM, Whiting PJ (1996) Which GABAA-receptor subtypes really occur in the brain ? Trends Neurosci 19: 139-143.
18. Mombereau C., Kaupmann K., Froestl W., Sansig G., van der Putten H., Cryan JF (2004 a) Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior. Neuropsychopharmacology 29: 1050-1062.
19. Mombereau C., Kaupmann K., van der Putten H., Cryan JF (2004 b) Altered response to benzodiazepine anxiolytics in mice lacking GABAB1 receptors. Eur J Pharmacol 497: 119-120.
20. Morris HV, Dawson GR, Reynolds DS, Atack JR, Stephens DN (2006) Both alpha2 and alpha3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm. Eur J Neurosci 23: 2495-2504.
21. Pacher P., Batkai S., Kunos G. (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58: 389-462.
22. Palkovits M. (1983) Punch sampling biopsy technique. Methods Enzymol 103: 368-376.
23. Patel S., Hillard CJ (2006) Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling. J Pharmacol Experimental Therapeutics 318: 304-311.
24. Paxinos G., Franklin K. (2001) The Mouse Brain in Stereotaxic Coordinates. New York: Academic Press.
25. Pilc A., Lloyd KG (1984) Chronic antidepressants and GABA ''B'' receptors: a GABA hypothesis of antidepressant drug action. Life Sci 35: 2149-2154.
26. Pistis M., Perra S., Pillolla G., Melis M., Gessa GL, Muntoni AL (2004) Cannabinoids modulate neuronal firing in the rat basolateral amygdala: evidence for CB1- and non-CB1-mediated actions. Neuropharmacology 46: 115-125.
27. Pritchett DB, Sontheimer H., Shivers BD, et al. (1989) Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology. Nature 338: 582-585.
28. Reynolds DS (2008) The value of genetic and pharmacological approaches to understanding the complexities of GABA(A) receptor subtype functions: the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behavior 90: 37-42.
29. Reynolds DS, Rosahl TW, Cirone J., et al. (2003) Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. J Neurosci 23: 8608-8617.
30. Romero J., de Miguel R., Ramos JA, Fernandez-Ruiz JJ (1998) The activation of cannabinoid receptors in striatonigral GABAergic neurons inhibited GABA uptake. Life Sci 62: 351-363.
31. Rubino T., Guidali C., Vigano D., et al. (2008) CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour. Neuropharmacology 54: 151-160.
32. Rudolph U., Crestani F., Benke D., et al. (1999) Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature 401: 796-800.
33. Sibille E., Pavlides C., Benke D., Toth M. (2000) Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety. J Neurosci 20: 2758-2765.
34. Sim LJ, Selley DE, Childers SR (1995) In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5′-[gamma-[35S]thio]-triphosphate binding. Proc Natl Acad Sci U S A 92: 7242-7246.
35. Sur C., Wafford KA, Reynolds DS, et al. (2001) Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. J Neurosci 21: 3409-3418.
36. Urigüen L., Perez-Rial S., Ledent C., Palomo T., Manzanares J. (2004) Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors. Neuropharmacology 46: 966-973.
37. Warnault V., Houchi H., Barbier E., et al. (2007) The lack of CB1 receptors prevents neuroadaptations of both NMDA and GABA(A) receptors after chronic ethanol exposure. J Neurochem 102: 741-752.