Mood changes after delivery: Role of the serotonin transporter gene

British Journal of Psychiatry

Volumn 193, Issue 5, 2008, Pages 383-388

  Sanjuán, Julio ^a,m   Martin Santos, R ^b   Garcia Esteve, L ^b   Carot, J M ^c   Guillamat, R ^d   Gutierrez Zotes, A ^e   Gornemann, I ^f   Canellas, F ^g   Baca Garcia, E ^h   Jover, M ^a   Navines, R ^b   Valles, V ^d   Vilella, E ^e   De Diego, Y ^f   Castro, J A ^g   Ivorra, J L ^a   Gelabert, E ^b   Guitart, M ^d   Labad, A ^e   Mayoral, F ^g   Roca, M ^g   Gratacos, M ⁱ   Costas, J ^j   Van Os, J ^k,l   De Frutos, R ^a   more..

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^d Hospital Universitari Parc Taulí   (Spain)

^e IISPV   (Spain)

^f HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^g HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^h UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

ⁱ CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^j HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^k MAASTRICHT UNIVERSITY   (Netherlands)

^l KING'S COLLEGE LONDON   (United Kingdom)

^m UNIVERSITY OF VALENCIA   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHILDBIRTH; DELIVERY; DIAGNOSTIC ACCURACY; DNA POLYMORPHISM; DOSE RESPONSE; FEMALE; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MOOD CHANGE; PUERPERAL DEPRESSION; PUERPERIUM; SEROTONIN TRANSPORTER GENE; SPAIN; SYMPTOMATOLOGY;

DEPRESSION, POSTPARTUM; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION; HUMANS; POLYMORPHISM, GENETIC; PREGNANCY; PROSPECTIVE STUDIES; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPAIN; TRYPTOPHAN;

EID: 55949099580     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.107.045427     Document Type: Article

References (47)

1. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. A population-based study of major depression in women. The impact of varying definitions of illness. Arch Gen Psychiatry 1992; 49: 257-66.
2. O'Hara MW, Swain AM. Rates and risk of postnatal depression - a meta analysis. Int Rev Psychiatry 1996; 8: 37-54.
3. García-Esteve L, Ascaso C, Ojuel J, Navarro P. Validation of the Edinburgh Postnatal Depression Scale (EPDS) in Spanish mothers. J Affect Disord 2003; 75: 71-6.
4. Petrou S, Cooper P, Murray L, Davidson LL. Economic costs of post-natal depression in a high-risk British cohort. Br J Psychiatry 2002; 181: 505-12.
5. Wisner KL, Chambers C, Sit DK. Postpartum depression: a major public health problem. JAMA 2006; 296: 2616-8.
6. Bloch M, Daly RC, Rubinow DR. Endocrine factors in the etiology of postpartum depression. Compr Psychiatry 2003; 44: 234-46.
7. Serreti A, Olgiati P, Colombo C. Influence of postpartum onset on the course of mood disorders. BMC Psychiatry 2006; 6: 1-7.
8. Maes M, Ombelet W, Verkerk R, Bosmans E, Scharpé S. Effects of pregnancy and delivery on the availability of plasma tryptophan to the brain: relationships to delivery-induced immune activation and early post-partum anxiety and depression. Psychol Med 2001; 31: 847-58.
9. Payne JL. The role of estrogen in mood disorders in women. Int Rev Psychiatry 2003; 15: 280-90.
10. Baïlara KM, Henry C, Lestage J, Launay JM, Parrot F, Swendsen J, Sutter AL, Roux D, Dallay D, Demotes-Mainard J. Decreased brain tryptophan availability as a partial determinant of post-partum blues. Psychoneuroendocrinology 2006; 31: 407-13.
11. Van der Does AJ. The mood-lowering effect of tryptophan depletion: possible explanation for discrepant findings. Arch Gen Psychiatry 2001; 58: 200-2.
12. Moreno FA, Rowe DC, Kaiser B, Chase D, Michaels T, Gelernter J, Delgado PL Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Mol Psychiatry 2002; 7: 213-6.
13. Neumeister A, Hu XZ, Luckenbaugh DA, Sachwrz M, Nugent AC, Bonne O, Herscovitch P, Goldman D, Drevets WC, Charney DS. Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry 2006; 63: 978-86.
14. Jans LA, Riedel WJ, Markus CR, Blokland A. Serotonergic vulnerability and depression: assumptions, experimental evidence and implications. Mol Psychiatry 2007; 12: 522-43.
15. Murphy DL, Li Q, Engel S, Wichems C, Andrews A, Lesch KP, Uhl G. Genetic perspectives on the serotonin transporter. Brain Res Bull 2001; 56: 487-94.
16. Lesch KP, Gutknecht L. Pharmacogenetics of the serotonin transporter. Biol Psychiatry 2005; 29: 1062-73.
17. Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, Jernej B, Wildenauer D. Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry 2004; 55: 1090-4.
18. Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry 1987; 150: 782-6.
19. Navarro P, Ascaso C, García-Esteve L, Aguado J, Torres A, Martín-Santos R. Postnatal psychiatric morbidity: a validation study of the GHQ-12 and the EPDS as screening tools. Gen Hosp Psychiatry 2007; 29: 1-7.
20. Nurnberger JI, Blehar MC, Kaufmann J. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetic Initiative. Arch Gen Psychiatry 1994; 51: 849-59.
21. Roca M, Martín-Santos R, Sainz J, Obiols J, Serrano MJ, Torrens M, Subirà S, Gili M, Navinés R, Ibañez A, Nadal M, Barrantes N, Cañellas F. Diagnostic Interview for Genetics Studies (DIGS): inter-rater and test-retest reliability and validity in a Spanish population. Eur Psychiatry 2007; 22: 44-8.
22. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 2621-4.
23. Fiskerstrand CE, Lovejoy EA, Quinn JP. An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Letters 1999; 458: 171-4.
24. Mackenzie A, Quinn J. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer like properties in the mouse embryo. Proc Natl Acad Sci USA 1999; 96: 15251-5.
25. Nakamura M, Ueno S, Sano A, Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 2000; 5: 32-8.
26. Fan JB, Sklar P. Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia. Mol Psychiatry 2005; 10: 928-38.
27. Seyfried LS, Marcus SM. Postpartum mood disorders. Int Rev Psychiatry 2003; 15: 231-42.
28. Miller LJ, Rukstalis M. Beyond the 'blues'. Hypotheses about postpartum reactivity. In Postpartum Mood Disorder (ed LJ Miller): 3-19. American Psychiatric Press, 1999.
29. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorder (4th edn) (DSM-IV). APA, 1994.
30. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders. Diagnostic Criteria for Research. WHO, 1992.
31. Goldberg DP. A dimensional model for common mental disorders. Br J Psychiatry 1996; 168: 44-9.
32. Kendler KS, Gardner CO Jr. Boundaries of major depression: an evaluation of DSM-IV criteria. Am J Psychiatry 1998; 155: 172-7.
33. Aggen SH, Neale MC, Kendler KS. DSM criteria for major depression: evaluating symptom patterns using latent-trait item response models. Psychol Med 2005; 35: 475-87.
34. Roiser JP, Müller U, Clark L, Sahakian BJ. The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention. Int J Neuropsychopharmacol 2007; 10: 449-61.
35. Evans J, Heron J, Francomb H, Oke S, Golding J. cohort study of depressed mood during pregnancy and after childbirth. BMJ 2001; 323: 257-60.
36. Dennis CL. Can we identify mothers at risk for postpartum depression in the immediate postpartum period using the Edinburgh Postnatal Depression Scale? J Affect Disord 2004; 78: 163-9.
37. Forty L, Jones L, Macgregor S, Caesar S, Cooper C, Hough A, Dean L, Dave S, Farmer A, McGuffin P, Brewster S, Craddock N, Jones I. Familiality of postpartum depression in unipolar disorder: results of a family study. Am J Psychiatry 2006; 163: 1549-53.
38. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386-9.
39. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 2005; 62: 529-35.
40. Kaufman J, Yang BZ, Douglas-Palumberi H. Social supports and serotonin transporter gene moderate depression in maltreated children. Proc Natl Acad Sci USA 2004; 101: 17316-21.
41. Jacobs N, Kenis G, Peeters, Derom C, Vlietinck R, van Os J. Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression. Arch Gen Psychiatry 2006; 63: 989-96.
42. Zalsman G, Huang Y, Oquendo MA, Burke AK, Hu XZ, Brent DA, Ellis SP, Goldman D, Mann JJ. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 2006; 163: 1588-93.
43. Wilhelm K, Mitchell PB, Niven H. Finch A, Wedgwood L, Scimone A, Blair IP, Parker G, Schofield PR. Life events, first depression onset and the serotonin transporter gene. Br J Psychiatry 2006; 188: 210-5.
44. Cervilla J, Molina E, Rivera M. Torres-González F, Bellón JA, Moreno B, Luna JD, Lorente JA, Mayoral F, King M, Nazareth I. The risk for depression conferred by stressful life events is modified by variations at the serotonin transporter 5HTTLPR genotype: evidence from the Spanish PREDICT Gene cohort. Mol Psychiatry 2007; 12: 748-55.
45. Sun HS, Tsai HW, Ko HC, Chang FM, Yeh TL. Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women. Genes Brain Behav 2004; 3: 328-36.
46. Coyle N, Jones I, Robertson E, Lendon C, Craddock N. Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis. Lancet 2000; 356: 1490-1.
47. Scheid JM, Holzman CB, Jones N, Friderici KH, Nummy KA, Symonds LL, Sikorskii A, Regier MK, Fisher R. Depressive symptoms in mid-pregnancy, lifetime stressors and the 5-HTTLPR genotype. Genes Brain Behav 2007; 6: 453-64.