Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers

Neuroscience Letters

Volumn 446, Issue 2-3, 2008, Pages 88-92

  Maron, Eduard ^a,b   Tõru, Innar ^a   Tasa, Gunnar ^a   Must, Anne ^a   Toover, Egle ^a   Lang, Aavo ^a   Vasar, Veiko ^a   Shlik, Jakov ^c  

^a UNIVERSITY OF TARTU   (Estonia)

^b North Estonian Regional Hospital   (Estonia)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Challenge test; Cholecystokinin; Genetic polymorphism; Panic attacks; Tryptophan hydroxylase

Indexed keywords

TETRAGASTRIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PANIC; PRIORITY JOURNAL;

ADULT; BRAIN; BRAIN CHEMISTRY; CATECHOLAMINES; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOTYPE; HUMANS; MALE; MUTATION; PANIC DISORDER; POLYMORPHISM, GENETIC; TETRAGASTRIN; TRYPTOPHAN HYDROXYLASE; YOUNG ADULT;

EID: 53849122278     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.09.052     Document Type: Article

References (29)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR (Text Revision) (2000), American Psychiatric Association, Washington, DC
2. Bradwejn J., Koszycki D., and Shriqui C. Enhanced sensitivity to cholecystokinin tetrapeptide in panic disorder. Clinical and behavioral findings. Arch. Gen. Psychiatry 48 (1991) 603-610
3. Chen G.L., Vallender E.J., and Miller G.M. Functional characterization of the human TPH2 5′ regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Hum. Genet. 122 (2008) 645-657
4. Deckert J., Catalano M., Syagailo Y.V., Bosi M., Okladnova O., Di Bella D., Nöthen M.M., Maffei P., Franke P., Fritze J., Maier W., Propping P., Beckmann H., Bellodi L., and Lesch K.P. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum. Mol. Genet. 8 (1999) 621-624
5. Domschke K., Freitag C.M., Kuhlenbäumer G., Schirmacher A., Sand P., Nyhuis P., Jacob C., Fritze J., Franke P., Rietschel M., Garritsen H.S., Fimmers R., Nöthen M.M., Lesch K.P., Stögbauer F., and Deckert J. Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women. Int. J. Neuropsychopharmacol. 7 (2004) 183-188
6. Eser D., Schüle C., Baghai T., Floesser A., Krebs-Brown A., Enunwa M., de la Motte S., Engel R., Kucher K., and Rupprecht R. Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study. Psychopharmacology 192 (2007) 479-487
7. Hamilton S.P., Slager S.L., Helleby L., Heiman G.A., Klein D.F., Hodge S.E., Weissman M.M., Fyer A.J., and Knowles J.A. No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. Mol. Psychiatry 6 (2001) 59-65
8. Hettema J.M., Neale M.C., and Kendler K.S. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am. J. Psychiatry 158 (2001) 1568-1578
9. Inada Y., Yoneda H., Koh J., Sakai J., Himei A., Kinoshita Y., Akabame K., Hiraoka Y., and Sakai T. Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene. Psychiatry Res. 118 (2003) 25-31
10. Kennedy J.L., Bradwejn J., Koszycki D., King N., Crowe R., Vincent J., and Fourie O. Investigation of cholecystokinin system genes in panic disorder. Mol. Psychiatry 4 (1999) 284-285
11. Kessler R.C., Chiu W.T., Jin R., Ruscio A.M., Shear K., and Walters E.E. The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 63 (2006) 415-424
12. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Muller C.R., Hamer D.H., and Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
13. Lim J.E., Pinsonneault J., Sadee W., and Saffen D. Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. Mol. Psychiatry 12 (2007) 491-501
14. Maron E., Hettema J.H., and Shlik J. The genetics of human anxiety disorders. In: Huston J.P., Blanchard R.J., Blanchard C., Griebel G., and Nutt D. (Eds). Handbook of Anxiety and Fear vol. 17 (2008), Elsevier 475-510
15. Maron E., Lang A., Tasa G., Liivlaid L., Tõru I., Must A., Vasar V., and Shlik J. Associations between serotonin-related gene polymorphisms and panic disorder. Int. J. Neuropsychopharmacol. 8 (2005) 261-266
16. Maron E., Nikopensius T., Kõks S., Altmäe S., Heinaste E., Vabrit K., Tammekivi V., Hallast P., Koido K., Kurg A., Metspalu A., Vasar E., Vasar V., and Shlik J. Association study of 90 candidate genetic polymorphisms in panic disorder. Psychiatr. Genet. 15 (2005) 17-24
17. Maron E., and Shlik J. Serotonin function in panic disorder: important, but why?. Neuropsychopharmacology 1 (2006) 1-11
18. Maron E., Tasa G., Tõru I., Lang A., Vasar V., and Shlik J. Association between serotonin related genetic polymorphisms and CCK-4-induced panic attacks with or without 5 hydroxytryptophan pretreatment in healthy volunteers. World J. Biol. Psychiatry 5 (2004) 149-154
19. Maron E., Tõru I., Must A., Tasa G., Toover E., Vasar V., Lang A., and Shlik J. Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder. Neurosci. Lett. 411 (2007) 180-184
20. Maron E., Tõru I., Vasar V., and Shlik J. The effect of 5-hydroxytryptophan on cholecystokinin-4-induced panic attacks in healthy volunteers. J. Psychopharmacol. 18 (2004) 194-199
21. Nutt D.J. Antidepressants in panic disorder: clinical and preclinical mechanisms. J. Clin. Psychiatry 59 (1998) 24-28
22. Perna G., di Bella D., Favaron E., Cucchi M., Liperi L., and Bellodi L. Lack of relationship between CO2 reactivity and serotonin transporter gene regulatory region polymorphism in panic disorder. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 129B (2004) 41-43
23. Rothe C., Gutknecht L., Freitag C., Tauber R., Mössner R., Franke P., Fritze J., Wagner G., Peikert G., Wenda B., Sand P., Jacob C., Rietschel M., Nöthen M.M., Garritsen H., Fimmers R., Deckert J., and Lesch K.P. Association of a functional 1019C > G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia. Int. J. Neuropsychopharmacol. 7 (2004) 189-192
24. Rothe C., Koszycki D., Bradwejn J., King N., Deluca V., Tharmalingam S., Macciardi F., Deckert J., and Kennedy J.L. Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder. Neuropsychopharmacology 31 (2006) 2237-2242
25. Sabol S.Z., Hu S., and Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum. Genet. 103 (1998) 273-279
26. Schmidt N.B., Storey J., Greenberg B.D., Santiago H.T., Li Q., and Murphy D.L. Evaluating gene x psychological risk factor effects in the pathogenesis of anxiety: a new model approach. J. Abnorm. Psychol. 109 (2000) 308-320
27. Tõru I., Shlik J., Maron E., Vasar V., and Nutt D.J. Tryptophan depletion does not modify response to CCK-4 challenge in patients with panic disorder after treatment with citalopram. Psychopharmacology 186 (2006) 107-112
28. Zill P., Baghai T.C., Zwanzger P., Schule C., Eser D., Rupprecht R., Möller H.J., Bondy B., and Ackenheil M. SNP haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol. Psychiatry 9 (2004) 1030-1036
29. Zill P., Buttner A., Eisenmenger W., Bondy B., and Ackenheil M. Regional mRNA expression of a second tryptophan hydroxylase isoform in postmortem tissue samples of two human brains. Eur. Neuropsychopharmacol. 14 (2004) 282-284