Theophylline-loaded compritol microspheres prepared by ultrasound-assisted atomization

Journal of Pharmaceutical Sciences

Volumn 100, Issue 2, 2011, Pages 743-757

  Fini, Adamo ^a   Cavallari, Cristina ^a   Ospitali, Francesca ^a   Gonzalez Rodriguez, M Luisa ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Compritols; FTIR; Raman spectroscopy; Release test; Solid dispersion; Solubility parameter; Theophylline; Thermal analysis; X ray powder diffraction

Indexed keywords

GLYCEROL BEHENATE; MICROSPHERE; THEOPHYLLINE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; DRUG SOLUBILITY; INFRARED SPECTROSCOPY; MELTING POINT; NEBULIZATION; PARTICLE SIZE; TEMPERATURE SENSITIVITY; THERMAL ANALYSIS; ULTRASOUND; X RAY DIFFRACTION;

EID: 78650571374     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22312     Document Type: Article

References (38)

1. zur Mühlen A, Schwarz C, Mehnert W. 1998. Solid lipid nanoparticles (SLN) for controlled drug delivery-drug release and release mechanism. Eur J Pharm Pharmacol 45:149-155.
2. Savolainen M, Khoo C, Glad H, Dahlqvist C, Juppo A M. 2002. Evaluation of controlled-release polar lipid microparticles. Int J Pharm 244:151-161.
3. Ozyazici M, Gokce EH, Ozer O, Ay Z, Guneri T, Ertan G, Gokce G, Metin DY, Hilmioglu S, Durmaz G, Yalcin A, Pekcetin C, Ozyurt D. 2007. In vitro release-in vivo microbiological and toxicological studies on ketoconazole lipid granules. Pharm Dev Technol 12:581-590.
4. Barthelemy P, Laforêt JP, Farah N, Joachim J. 1999. Compritol 888 ATO: An innovative hot-melt coating agent for prolonged-release drug formulations. Eur J Pharm Biopharm 47:87-90.
5. Hamdani J, Moës AJ, Amighi K. 2002. Development and evaluation of prolonged release pellets obtained by the melt pelletization process. Int J Pharm 245:167-177.
6. Ratsimbazafy V, Brossard C. 1991. Les Gélucire et le ralentissement de la libération des principes actifs. Stp Pharma Prat 1:335-349.
7. Knezevic Z, Gosak D, Hraste M, Rausl D, Khan MZ. 2009. Application of hot-melt coating process for designing a lipid based controlled release drug delivery system for highly aqueous soluble drugs. Chem Pharm Bull (Tokyo) 57:464-471.
8. Jaspart S, Bertholet P, Piel G, Dogné JM, Delattre L, Evrard B. 2007. Solid lipid microparticles as a sustained release system for pulmonary drug delivery. Eur J Pharm Biopharm 65:47-56.
9. Hamdani J, Moës AJ, Amighi K. 2003. Physical and thermal characterisation of Precirol and Compritol as lipophilic glycerides used for the preparation of controlled-release matrix pellets. Int J Pharm 260:47-57.
10. Faham A, Prinderre P, Farah N, Eichler KD, Kalantzis G, Joachim J. 2000. Hot-melt coating technology. I. Influence of Compritol 888 Ato and granule size on theophylline release. Drug Dev Ind Pharm 26:167-176.
11. N'Diaye A, Jannin V, Bérard V, Andrès C, Pourcelot Y. 2003. Comparative study of the lubricant performance of Compritol HD5 ATO and Compritol 888 ATO: Effect of polyethylene glycol behenate on lubricant capacity. Int J Pharm 254:263-269.
12. Rodriguez L, Passerini N, Cavallari C, Cini M, Sancin P, Fini A. 1999. Description and preliminary evaluation of a new ultrasonic atomizer for spray-congealing processes. Int J Pharm 183:133-143.
13. Cohen JL. 1977. Theophylline. In Analytical profiles of drug substances; Florey K, Ed. Vol. IV. New York: Academic Press, pp 467-491.
14. Passerini N, Qi S, Albertini B, Grassi M, Rodriguez L, Craig DQM. 2010. Solid lipid microparticles produced by spray-congealing: Influence of the atomizer on microparticle characteristics and mathematical modeling of the drug release. J Pharm Sci 99:916-931.
15. Yolou S, Delarbre JL, Bourret E, Maury L, Abramovici B, Joachim J. 1992. Caractérisation physico-chimique d'excipients polymériques: les Gélucires Compritol 888, Compritol HD5 ATO et du lubrifiant WL 3284 ATO. Pharm Acta Helv 67(suppl):25-29.
16. Kaloustian J, Pauli AM, Pastor J, Joachim J. 1995. Joachim. Analyse thermique de mélanges binaires matrice lipidique/principe actif (15/85). Stp Pharma Sci 5:139-144.
17. Cianfarani G. 2006. Process for the preparation of tablets comprising s-adenosylmethionine. Patent US7087587.
18. Del Curto MD, Chicco DE. 2007. Amphiphilic lipid nanoparticles for peptide and/or protein incorporation. Patent EP20010995691.
19. Duclos E, Bourret CB. 1999. Rheology of polyol behenates and drug release from matrix monolithic capsules. Int J Pharm 182:145-154.
20. Passerini N, Perissutti B, Moneghini M, Voinovich D, Albertini B, Cavallari C, Rodriguez L. 2002. Characterization of carbamazepine-Gelucire 50/13 microparticles prepared by a spray-congealing process using ultrasound. J Pharm Sci 91:699-707.
21. Cavallari C, Rodriguez L, Albertini B, Passerini N, Rosetti F, Fini A. 2005. Thermal and fractal analysis of diclofenac/Gelucire 50/13 microparticles obtained by ultrasound-assisted atomization. J Pharm Sci 94:1124-1134.
22. Cavallari C, Luppi B, Di Pietra AM, Rodriguez L, Fini A. 2007. Enhanced release of indomethacin from PVP/stearic acid microcapsules prepared coupling freeze-drying and ultrasound assisted spray-congealing process. Pharm Res 24:521-529.
23. Greenhalgh DJ, Williams AC, Timmins P, York P. 1999. Solubility parameters as predictors of miscibility in solid dispersions. J Pharm Sci 88:1182-1190.
24. Martin A, Newburger J, Adjei A. 1980. Extended Hildebrand solubility approach: Solubility of theophylline in polar binary solvents. J Pharm Sci 69:487-491.
25. Sloan KB, Beal HD, Taylor HE, Getz JJ, Villanueva R, Nipper R, Smith K. 1998. Transdermal delivery of theophylline from alcohol vehicles. Int J Pharm 171:185-193.
26. Long C, Zhang L, Qian Y. 2006. Preparation and crystal modification of ibuprofen-loaded solid lipid microparticles. Chin J Chem Eng 14:518-525.
27. Serajuddin ATM. 1999. Solid dispersion of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs. J Pharm Sci 88:1058-1066.
28. Ochoa L, Igartua M, Hernandez RM, Gascón AR, Pedraz JL. 2005. Preparation of sustained release hydrophilic matrices by melt granulation in a high-shear mixer. J Pharm Pharm Sci 8:132-140.
29. Craig DQM. 1996. The physical characterization of gelucire 50/13. B.T. Gattefossé 89:39-50.
30. Laine E, Auramo P, Kahela P. 1988. On the structural behaviour of triglycerides with time. Int J Pharm 43:241-247.
31. Brubach JB, Jannin V, Mahler B, Bourgaux C, Lessieur P, Roy P, Ollivon D. 2007. Structural and thermal characterization of glyceryl behenate by X-ray diffraction coupled to differential calorimetry and infrared spectroscopy. Int J Pharm 336:248-256.
32. Souto EB, Mehnert W, Muller RH. 2006. Polymorphic behaviour of Compritol 888 ATO as bulk lipid and as SLN and NLC. J Microencapsul 23:417-433.
33. Fini A, Cavallari C, Ospitali F. 2008. Raman and thermal analysis of indomethacin/PVP solid dispersion enteric microparticles. Eur J Pharm Biopharm 70:409-420.
34. Pavel I, Szeghalmi A, Moringnio D, Cinta S, Kiefer W. 2003. Theoretical and pH dependent surface enhanced raman spectroscopy study in caffeine. Biopolym (Biospectrosc) 72:25-37.
35. Gunasekaran S, Sankari G, Ponnusamy S. 2005. Vibrational spectral investigation on xanthine and its derivatives-theophylline, caffeine and theobromine. Spectrochim Acta A Mol Biomol Spectrosc 61:117-127.
36. Edwards HGM, Munshi T, Anstis M. 2005. Raman spectroscopic characterisation and analytical discrimination between caffeine and demethylated analogues of pharmaceutical relevance. Spectrochim Acta Part A 61:1453-1459.
37. Jores K, Haberland A, Wartewig S, Mäder K, Mehnert W. 2005. Solid lipid nanoparticles (SLN) and oil-loaded SLN studied by spectrofluorometry and Raman spectroscopy. Pharm Res 22:1887-1897.
38. Peppas NA. 1985. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv 60:110-111.