Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells

Cancer Letters

Volumn 301, Issue 1, 2011, Pages 38-46

  Satelli, Arun ^a   Rao, Subrahmanyeswara ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Apoptosis; Colorectal cancer; Galectin 1; Galectins; LGALS1; Promoter hypermethylation; Wnt signaling

Indexed keywords

GALECTIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; WNT PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE ARREST; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; EPIGENETICS; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

APOPTOSIS; BUTYRATES; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DNA METHYLATION; GALECTIN 1; GENE SILENCING; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROMOTER REGIONS, GENETIC;

EID: 78650543813     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.10.027     Document Type: Article

References (35)

1. Rustgi A.K. Molecular genetics and colorectal cancer. Gastroenterology 1993, 104:1223-1225.
2. Issa J.P. The epigenetics of colorectal cancer. Ann. N. Y. Acad. Sci. 2000, 910:140-153. discussion 153-5.
3. Shen L., Issa J.P. Epigenetics in colorectal cancer. Curr. Opin. Gastroenterol. 2002, 18:68-73.
4. Wheeler J.M. Epigenetics, mismatch repair genes and colorectal cancer. Ann. Roy. Coll. Surg. Engl. 2005, 87:15-20.
5. Liu F.T., Rabinovich G.A. Galectins as modulators of tumour progression. Nat. Rev. Cancer 2005, 5:29-41.
6. Perillo N.L., Pace K.E., Seilhamer J.J., Baum L.G. Apoptosis of T cells mediated by galectin-1. Nature 1995, 378:736-739.
7. Thijssen V.L., Barkan B., Shoji H., Aries I.M., Mathieu V., Deltour L., Hackeng T.M., Kiss R., Kloog Y., Poirier F., Griffioen A.W. Tumor cells secrete galectin-1 to enhance endothelial cell activity. Cancer Res. 2010, 70:6216-6224.
8. Satelli A., Rao P.S., Gupta P.K., Lockman P.R., Srivenugopal K.S., Rao U.S. Varied expression and localization of multiple galectins in different cancer cell lines. Oncol. Rep. 2008, 19:587-594.
9. Rao P.S., Govindarajan R., Mallya K.B., West W., Rao U.S. Characterization of a new antibody raised against the NH2 terminus of P-glycoprotein. Clin. Cancer Res. 2005, 11:5833-5839.
10. Rao P.S., Satelli A., Zhang S., Srivastava S.K., Srivenugopal K.S., Rao U.S. RNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways. Proteomics 2009, 9:2776-2787.
11. Kuuselo R., Savinainen K., Azorsa D.O., Basu G.D., Karhu R., Tuzmen S., Mousses S., Kallioniemi A. Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification. Cancer Res. 2007, 67:1943-1949.
12. Lu Y., Lotan R. Transcriptional regulation by butyrate of mouse galectin-1 gene in embryonal carcinoma cells. Biochim. Biophys. Acta 1999, 1444:85-91.
13. Li L.C., Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics 2002, 18:1427-1431.
14. Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J. Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures. J. Cancer Res. Clin. Oncol. 2001, 127:375-386.
15. Bienz M., Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000, 103:311-320.
16. Polakis P. Wnt signaling and cancer. Genes Dev. 2000, 14:1837-1851.
17. Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G., Markman M., Lamers W., Destree O., Clevers H. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol. Cell. Biol. 1998, 18:1248-1256.
18. Tejpar S., Li C., Yu C., Poon R., Denys H., Sciot R., Van Cutsem E., Cassiman J.J., Alman B.A. Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour). Br. J. Cancer 2001, 85:98-101.
19. Sherr C.J. Cancer cell cycles. Science 1996, 274:1672-1677.
20. Zhang Z.W., Patchett S.E., Farthing M.J. Topoisomerase I inhibitor (camptothecin)-induced apoptosis in human gastric cancer cells and the role of wild-type p53 in the enhancement of its cytotoxicity. Anticancer Drugs 2000, 11:757-764.
21. Vander Heiden M.G., Chandel N.S., Williamson E.K., Schumacker P.T., Thompson C.B. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 1997, 91:627-637.
22. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., Earnshaw W.C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994, 371:346-347.
23. Rabinovich G.A. Galectin-1 as a potential cancer target. Br. J. Cancer 2005, 92:1188-1192.
24. Sanjuan X., Fernandez P.L., Castells A., Castronovo V., van den Brule F., Liu F.T., Cardesa A., Campo E. Differential expression of galectin 3 and galectin 1 in colorectal cancer progression. Gastroenterology 1997, 113:1906-1915.
25. Irimura T., Matsushita Y., Sutton R.C., Carralero D., Ohannesian D.W., Cleary K.R., Ota D.M., Nicolson G.L., Lotan R. Increased content of an endogenous lactose-binding lectin in human colorectal carcinoma progressed to metastatic stages. Cancer Res. 1991, 51:387-393.
26. Zhu X.L., Liang L., Ding Y.Q. Galectin-1 expression in human colorectal carcinoma and its clinical significance. Nan Fang Yi Ke Da Xue Xue Bao 2007, 27:1331-1334.
27. Hittelet A., Legendre H., Nagy N., Bronckart Y., Pector J.C., Salmon I., Yeaton P., Gabius H.J., Kiss R., Camby I. Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration. Int. J. Cancer 2003, 103:370-379.
28. Nagy N., Legendre H., Engels O., Andre S., Kaltner H., Wasano K., Zick Y., Pector J.C., Decaestecker C., Gabius H.J., Salmon I., Kiss R. Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting. Cancer 2003, 97:1849-1858.
29. Adams L., Scott G.K., Weinberg C.S. Biphasic modulation of cell growth by recombinant human galectin-1. Biochim. Biophys. Acta 1996, 1312:137-144.
30. van den Brule F., Califice S., Garnier F., Fernandez P.L., Berchuck A., Castronovo V. Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. Lab. Invest. 2003, 83:377-386.
31. Rabinovich G.A., Iglesias M.M., Modesti N.M., Castagna L.F., Wolfenstein-Todel C., Riera C.M., Sotomayor C.E. Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization. J. Immunol. 1998, 160:4831-4840.
32. Horiguchi N., Arimoto K., Mizutani A., Endo-Ichikawa Y., Nakada H., Taketani S. Galectin-1 induces cell adhesion to the extracellular matrix and apoptosis of non-adherent human colon cancer Colo201 cells. J. Biochem. 2003, 134:869-874.
33. Fischer C., Sanchez-Ruderisch H., Welzel M., Wiedenmann B., Sakai T., Andre S., Gabius H.J., Khachigian L., Detjen K.M., Rosewicz S. Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27. J. Biol. Chem. 2005, 280:37266-37277.
34. Ruemmele F.M., Schwartz S., Seidman E.G., Dionne S., Levy E., Lentze M.J. Butyrate induced Caco-2 cell apoptosis is mediated via the mitochondrial pathway. Gut 2003, 52:94-100.
35. Sakamoto K., Maeda S., Hikiba Y., Nakagawa H., Hayakawa Y., Shibata W., Yanai A., Ogura K., Omata M. Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth. Clin. Cancer Res. 2009, 15:2248-2258.