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Volumn 87, Issue 1, 2005, Pages 15-20

Epigenetics, mismatch repair genes and colorectal cancer

Author keywords

Colorectal cancer; Epigenetics; Hypermethylation; Mismatch repair genes; Replication error

Indexed keywords

CELL DNA; PROTEIN MLH1; UVOMORULIN;

EID: 12144280302     PISSN: 00358843     EISSN: None     Source Type: Journal    
DOI: 10.1308/1478708051423     Document Type: Article
Times cited : (30)

References (32)
  • 1
    • 0033946039 scopus 로고    scopus 로고
    • DNA mismatch repair genes and colorectal cancer
    • Wheeler JMD, Bodmer WF, Mortensen NJMcC. DNA mismatch repair genes and colorectal cancer. Gut 2000; 47: 148-53.
    • (2000) Gut , vol.47 , pp. 148-153
    • Wheeler, J.M.D.1    Bodmer, W.F.2    Mortensen, N.J.McC.3
  • 2
    • 0025848680 scopus 로고
    • The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)
    • Vasen HF, Mecklin JP, Khan PM, Lynch HT. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 1991; 34: 424-5.
    • (1991) Dis. Colon Rectum , vol.34 , pp. 424-425
    • Vasen, H.F.1    Mecklin, J.P.2    Khan, P.M.3    Lynch, H.T.4
  • 3
    • 0033063711 scopus 로고    scopus 로고
    • New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC
    • Vasen HFA, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC. Gastroenterology 1999; 116: 1453-6.
    • (1999) Gastroenterology , vol.116 , pp. 1453-1456
    • Vasen, H.F.A.1    Watson, P.2    Mecklin, J.P.3    Lynch, H.T.4
  • 5
    • 0027742295 scopus 로고
    • The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
    • Fishel R, Lescoe MK, Rao MR, Copeland NG, Jenkins NA, Garber J et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 1993; 75: 1027-38.
    • (1993) Cell , vol.75 , pp. 1027-1038
    • Fishel, R.1    Lescoe, M.K.2    Rao, M.R.3    Copeland, N.G.4    Jenkins, N.A.5    Garber, J.6
  • 6
    • 0027145633 scopus 로고
    • Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
    • Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993; 75:1215-25.
    • (1993) Cell , vol.75 , pp. 1215-1225
    • Leach, F.S.1    Nicolaides, N.C.2    Papadopoulos, N.3    Liu, B.4    Jen, J.5    Parsons, R.6
  • 7
    • 0028221943 scopus 로고
    • Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
    • Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 1994; 368: 258-61.
    • (1994) Nature , vol.368 , pp. 258-261
    • Bronner, C.E.1    Baker, S.M.2    Morrison, P.T.3    Warren, G.4    Smith, L.G.5    Lescoe, M.K.6
  • 9
    • 0032555020 scopus 로고    scopus 로고
    • Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease
    • Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomaki P et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med 1998; 338: 1481-7.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1481-1487
    • Aaltonen, L.A.1    Salovaara, R.2    Kristo, P.3    Canzian, F.4    Hemminki, A.5    Peltomaki, P.6
  • 10
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson Jr AG. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971; 68: 820-3.
    • (1971) Proc. Natl. Acad. Sci. USA , vol.68 , pp. 820-823
    • Knudson Jr., A.G.1
  • 11
    • 0028859671 scopus 로고
    • Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
    • Liu B, Nicolaides NC, Markowitz S, Willson JK, Parsons RE, Jen J et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet 1995; 9: 48-55.
    • (1995) Nat. Genet. , vol.9 , pp. 48-55
    • Liu, B.1    Nicolaides, N.C.2    Markowitz, S.3    Willson, J.K.4    Parsons, R.E.5    Jen, J.6
  • 12
    • 0032522658 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer: Different mutator phenotypes and the principal involvement of hMLH1
    • Thibodeau SN, French AJ, Cunningham JM, Tester D, Burgart LJ, Roche PC et al. Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res 1998; 58: 1713-8.
    • (1998) Cancer Res. , vol.58 , pp. 1713-1718
    • Thibodeau, S.N.1    French, A.J.2    Cunningham, J.M.3    Tester, D.4    Burgart, L.J.5    Roche, P.C.6
  • 13
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet 1999; 21: 163-7.
    • (1999) Nat. Genet. , vol.21 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 15
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman JG, Merlo A, Mao L, Lapidus RG, Issa JP, Davidson NE et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995; 55: 4525-30.
    • (1995) Cancer Res. , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.P.5    Davidson, N.E.6
  • 16
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995; 1: 686-92.
    • (1995) Nat. Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6
  • 17
    • 0030812206 scopus 로고    scopus 로고
    • Association between CpG island methylation and microsatellite instability in colorectal cancer
    • Ahuja N, Mohan AL, Li Q, Stolker JM, Herman JG, Hamilton SR et al. Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res 1997; 57: 3370-4.
    • (1997) Cancer Res. , vol.57 , pp. 3370-3374
    • Ahuja, N.1    Mohan, A.L.2    Li, Q.3    Stolker, J.M.4    Herman, J.G.5    Hamilton, S.R.6
  • 18
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997; 57: 808-11.
    • (1997) Cancer Res. , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3    Lipman, J.4    Mishra, R.5    Goldman, H.6
  • 20
    • 13144266670 scopus 로고    scopus 로고
    • Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    • Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 1998; 95: 6870-5.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6870-6875
    • Herman, J.G.1    Umar, A.2    Polyak, K.3    Graff, J.R.4    Ahuja, N.5    Issa, J.P.6
  • 22
    • 0034681117 scopus 로고    scopus 로고
    • Distinct genetic profiles in colorectal tumours with or without the CpG island methylator phenotype
    • Toyota M, Ohe-Toyota M, Ahuja N, Issa JP. Distinct genetic profiles in colorectal tumours with or without the CpG island methylator phenotype. Proc Natl Acad Sci USA 2000; 97: 710-5.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 710-715
    • Toyota, M.1    Ohe-Toyota, M.2    Ahuja, N.3    Issa, J.P.4
  • 23
    • 0036161851 scopus 로고    scopus 로고
    • Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability
    • Yamamoto H, Min Y, Itoh F, Imsumran A, Horiuchi S, Yoshida M et al. Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability. Genes Chromosom Cancer 2002, 33: 322-5.
    • (2002) Genes Chromosom. Cancer , vol.33 , pp. 322-325
    • Yamamoto, H.1    Min, Y.2    Itoh, F.3    Imsumran, A.4    Horiuchi, S.5    Yoshida, M.6
  • 24
    • 0031908348 scopus 로고    scopus 로고
    • Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours
    • Homfray TF, Cottrell SE, Ilyas M, Rowan A, Talbot IC, Bodmer WF et al. Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours. Hum Mutat 1998; 11: 114-20.
    • (1998) Hum. Mutat. , vol.11 , pp. 114-120
    • Homfray, T.F.1    Cottrell, S.E.2    Ilyas, M.3    Rowan, A.4    Talbot, I.C.5    Bodmer, W.F.6
  • 25
    • 13044251809 scopus 로고    scopus 로고
    • Mutated E-cadherin is associated with increased tumorigenicity, loss of adhesion and of responsiveness to the mitogenic trefoil factor 2 in colon carcinoma cells
    • Efsthathiou JA, Liu D, Wheeler JMD, Kim HC, Beck NE, Ilyas M et al. Mutated E-cadherin is associated with increased tumorigenicity, loss of adhesion and of responsiveness to the mitogenic trefoil factor 2 in colon carcinoma cells. Proc Natl Acad Sci USA 1999; 96: 2316-21.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2316-2321
    • Efsthathiou, J.A.1    Liu, D.2    Wheeler, J.M.D.3    Kim, H.C.4    Beck, N.E.5    Ilyas, M.6
  • 26
    • 0035058012 scopus 로고    scopus 로고
    • Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer
    • Wheeler JMD, Kim HC, Efstathiou JA, Ilyas M, Mortensen NJMcC, Bodmer WF. Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer. Gut 2001; 48: 367-71.
    • (2001) Gut , vol.48 , pp. 367-371
    • Wheeler, J.M.D.1    Kim, H.C.2    Efstathiou, J.A.3    Ilyas, M.4    Mortensen, N.J.McC.5    Bodmer, W.F.6
  • 27
    • 0036778630 scopus 로고    scopus 로고
    • Epigenetic control of the E-cadherin gene (CDH1) by CpG methylation in colectomy samples of patients with ulcerative colitis
    • Azarschab F, Porschen R, Gregor M, Blin N, Holzmann. Epigenetic control of the E-cadherin gene (CDH1) by CpG methylation in colectomy samples of patients with ulcerative colitis. Genes Chromosom Cancer 2002, 35: 121-6.
    • (2002) Genes Chromosom. Cancer , vol.35 , pp. 121-126
    • Azarschab, F.1    Porschen, R.2    Gregor, M.3    Blin, N.4    Holzmann, A.5
  • 28
    • 0032997736 scopus 로고    scopus 로고
    • MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers
    • Simpkins SB, Bocker T, Swisher EM, Mutch DG, Gersell DJ, Kovatich AJ et al. MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers. Hum Mol Genet 1999; 8: 661-6.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 661-666
    • Simpkins, S.B.1    Bocker, T.2    Swisher, E.M.3    Mutch, D.G.4    Gersell, D.J.5    Kovatich, A.J.6
  • 29
    • 0001119305 scopus 로고    scopus 로고
    • hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability
    • Leung SY, Yuen ST, Chung LP, Chu KM, Chan AS, Ho JC. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res 1999; 59: 159-64.
    • (1999) Cancer Res. , vol.59 , pp. 159-164
    • Leung, S.Y.1    Yuen, S.T.2    Chung, L.P.3    Chu, K.M.4    Chan, A.S.5    Ho, J.C.6
  • 32
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumour xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter
    • Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R. Reversal of drug resistance in human tumour xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res 2000; 60: 6039-44.
    • (2000) Cancer Res. , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3    Kaye, S.B.4    Brown, R.5


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