CiMutT, an asidian MutT homologue, has a 7, 8-dihydro-8-oxo-dGTP pyrophosphohydrolase activity responsible for sanitization of oxidized nucleotides in Ciona intestinalis

Genes and Genetic Systems

Volumn 85, Issue 4, 2010, Pages 287-295

  Yonekura, Shin Ichiro ^a,b   Sanada, U ^a   Zhang Akiyama, Qiu Mei ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

8 oxo dGTP; Ciona intestinalis; Development; Mutations; MutT homologue; Pyrophosphohydrolase; Sanitization

Indexed keywords

7,8 DIHYDRO 8 OXO DEOXYGUANOSINE TRIPHOSPHATE; 8 OXO DEOXYGUANOSINE PHOSPHATE; DEOXYGUANOSINE PHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; INORGANIC PYROPHOSPHATASE; MTH1 PROTEIN; MUTT PROTEIN; NUDIX HYDROLASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CIONA INTESTINALIS; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; GENOME; MUTT GENE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; OPEN READING FRAME; OXIDATION; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; PROTEIN PURIFICATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CIONA INTESTINALIS; DEOXYADENINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; DNA REPAIR; DNA REPAIR ENZYMES; ESCHERICHIA COLI PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PYROPHOSPHATASES; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT;

ASCIDIA; CIONA INTESTINALIS;

EID: 78650531527     PISSN: 13417568     EISSN: None     Source Type: Journal    
DOI: 10.1266/ggs.85.287     Document Type: Article

References (41)

1. Bjelland, S., and Seeberg, E. (2003) Mutagenicity, toxicity, and repair of DNA base damage induced by oxidation. Mutat. Res. 531, 37-80.
2. Boiteux, S., and Radicella, J. P. (1999) Base excision repair of 8-hydroxyguanine protects DNA from endogenous oxidative stress. Biochimie 81, 59-67.
3. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
4. Cadet, J., Douki, T., Gasparutto, D., and Ravanat, J.-L. (2003) Oxidative damage to DNA: formation, measurement and biochemical features. Mutat. Res. 531, 5-23.
5. Cupples, C. G., and Miller, J. H. (1989) A set of lacZ mutations in Escherichia coli that allow rapid detection of each the six base substitutions. Proc. Natl. Acad. Sci. USA 86, 5345-5349.
6. David, S. S., O'Shea, V. L., and Kundu, S. (2007) Base-excision repair of oxidative DNA damage. Nature 447, 941-950.
7. Dehal, P., Satou, Y., Campbell, R. K., Chapman, J., Degnan, B., Tomaso, A. D., Davidson, B., et al. (2002) The draft genome of Ciona intestinalis: Insights into chordate and vertebrate origins. Science 298, 2157-2167.
8. Fujikawa, K., Kamiya, H., Yakushiji, H., Fujii, Y., Nakabeppu, Y., and Kasai, H. (1999) The oxidized forms of dATP are substrates for the human MutT homologue, the MTH1 protein. J. Biol. Chem. 274, 18201-18205.
9. Furuichi, M., Yoshida, M. C., Oda, H., Tajiri, T., Nakabeppu, Y., Tsuzuki, T., and Sekiguchi, M. (1994) Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion. Genomics 24, 485-490.
10. Hayakawa, H., Taketomi, A., Sakumi, K., Kuwano, M., and Sekiguchi, M. (1995) Generation and elimination of 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate, a mutagenic substrate for DNA synthesis, in human cells. Biochemistry 34, 89-95.
11. Hirano, T. (2008) Repair system of 7, 8-dihydro-8-oxoguanine as a defense line against Carcinogenesis. J. Radiat. Res. 49, 329-340.
12. Hori, M., Fujikawa, K., Kasai, H., Harashima, H., and Kamiya, H. (2005) Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme. DNA Repair 4, 33-39.
13. Hsu, G. W., Ober, M., Carell, T., and Beese, L. S. (2004) Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature 431, 217-221.
14. Ishibashi, T., Hayakawa, H., and Sekiguchi, M. (2003) A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. EMBO Rep. 4. 479-483.
15. Jin, G., Zhang, Q-M., Satou, Y., Satoh, N., Kasai, H., and Yonei, S.(2006) Cloning and characterization of an ascidian homolog of the human 8-oxoguanine DNA glycosylase (Ogg1) that is involved in the repair of 8-oxo-7,8-dihy-droguanine in DNA in Ciona intestinalis. Int. J. Radiat. Biol. 82, 241-250.
16. Kamiya, H. (2004) Mutagenicity of 8-hydroxyguanine and 2-hydroxyadenine produced by reactive oxygen species. Biol. Pharm. Bull. 27, 475-479.
17. Kamiya, H., Iida, E., Murata-Kamiya, N., Yamamoto, Y., Miki, T., and Harashima, H. (2003) Suppression of spontaneous and hydrogen peroxide-induced mutations by a MutT-type nucleotide pool sanitization enzyme, the Escherichia coli Orf135 protein. Genes to Cells 8, 941-950.
18. Kamiya, H., Hori, M., Arimori, T., Sekiguchi, M., Yamagata, Y., and Harashima, H. (2009) NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity. DNA Repair 8, 1250-1254.
19. Maki, H., and Sekiguchi, M. (1992) MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature 355, 273-275.
20. McLennan, A. G. (2006) The Nudix hydrolase superfamily. Cell. Mol. Life Sci. 63, 123-143.
21. Ménézo, Y., Dale, B., and Cohen, M. (2010) DNA damage and repair in human oocytes and embryos: a review. Zygote 21, 1-9.
22. Michaels, M. L., Pham, L., Cruz, C., and Miller, J. H. (1991) MutM, a protein that prevents G:C→T:A transversions, is formamidopyrimidine-DNA glycosylase. Nucleic Acids Res. 19, 3629-3632.
23. Mildvan, A. S., Xia, Z., Azurmendi, H. F., Saraswat, V., Legler, P. M., Massiah, M. A., Gabelli, S. B., Bianchet, M. A., Kang, L.-W., and Amzel, L. M. (2005) Structures and mechanisms of Nudix hydrolases. Arch. Biochem. Biophys. 433, 129-143.
24. Nunoshiba, T., Ishida, R., Sasaki, M., Iwai, S., Nakabeppu, Y., and Yamamoto, K. (2004) A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae. Nucleic Acids Res. 32, 5339-5348.
25. O'Handley, S. F., Frick, D. N., Bullions, L. C., Mildvan A. S., and Bessman, M. J. (1996) Escherichia coli orf17 codes for a nucleoside triphosphate pyrophosphohydrolase member of the MutT family of proteins. J. Biol. Chem. 271, 24649-24654.
26. Rai, P., Onder, T. T., Young, J. J., Mcfaline, J. L., Pang, B., Dedon, P. C., and Weinberg, R. A, (2009) Continuous elimi-nation of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc. Natl. Acad. Sci. USA 106, 169-174.
27. Sakai, Y., Furuichi, M., Takahashi, M., Mishima, M., Iwai, S., Shirakawa, M., and Nakabeppu, Y. (2002) A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1. J. Biol. Chem. 277, 8579-8587.
28. Satoh, N. (2003) Ascidian embryos as a model system to analyze expression and function of development genes. Differentiation 68, 1-12.
29. Satou, Y., Takatori, N., Yamada, L., Mochizuki, Y., Hamaguchi, M., Ishikawa, H., Chiba, S., Imai, K., Kano, S., et al. (2001) Gene expression profiles in Ciona intestinalis tailbud embryos. Development 128, 2893-2904.
30. Sekiguchi, M., and Tsuzuki, T. (2002) Oxidative nucleotide dam-age: consequences and prevention. Oncogene 21,8895-8904.
31. Shimokawa, H., Fujii, Y., Furuichi, M., Sekiguchi, M., and Nakabeppu, Y. (2000) Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein. Nucleic Acids Res. 28, 3240-3249.
32. Simmen, M., Leitgeb, S., Clark, V. H., Jones, S. J., and Bird, A. (1998) Gene number in an invertebrate chordate, Ciona intestinalis. Proc. Natl. Acad. Sci. USA 95, 4437-4440.
33. Suzuki, T., Yamamoto, K., Harashima H., and Kamiya, H. (2008) Base excision repair enzyme endonuclease III sup-presses mutagenesis caused by 8-hydroxy-dGTP. DNA Repair 7, 88-94.
34. Tsuzuki, T., Egashira, A., Igarashi, H., Iwakuma, T., Nakatsuru, Y., Tominaga, Y., Kawate, H., Nakao, K., Nakamura, K., Ide, F., et al. (2001) Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proc. Natl. Acad. Sci. USA 98, 11456-11461.
35. Vinson, R. K., and Hales, B. F. (2002) DNA repair during organogenesis. Mutat. Res. 509, 79-91.
36. Wallace, S. S. (2002) Biological consequences of free radical- damaged DNA bases. Free Radic. Biol. Med. 33, 1-14.
37. Xia, Z., Azurmendi, H. F., and Mildvan, A. S. (2005) Transient state kinetic studies of the MutT-catalyzed nucleoside triph-osphate pyrophosphohydrolase reaction. Biochemistry 44, 15334-15344.
38. Yonekura, S., Nakamura, N., Doi, T., Sugiyama, H., Yamamoto, K., Yonei, S., and Zhang, Q-M. (2007) Recombinant Schizosaccharomyces pombe Nth1 protein exhibits DNA gly-cosylase activities for 8-oxo-7,8-dihydroguanine and thym-ine residues oxidized in the methyl group. J. Radiat. Res. 48, 417-424.
39. Yoshimura, D., Sakumi, K., Ohno, M., Sakai, Y., Furuichi, M., Iwai, S., and Nakabeppu, Y. (2003) An oxidized purine nucle-oside triphosphatase, MTH1, suppresses cell death caused by oxidative stress. J. Biol. Chem. 278, 37965-37973.
40. Yoshimura, K., Ogawa, T., Ueda, Y., and Shigeoka, S. (2007) AtNUDX1, an 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triph- osphate pyrophosphohydrolase, is responsible for eliminat-ing oxidized nucleotide in Arabidopsis. Plant Cell Physiol. 48, 1438-1449.
41. Zharkov, D. O. (2008) Base excision DNA repair. Cell. Mol. Life Sci. 65, 1544-1565.